A novel microcurrent dressing for wound healing in a rat skin defect model

作     者：Chao Yu Zhi-Xiu Xu Yan-Hui Hao Ya-Bing Gao Bin-Wei Yao Jing Zhang Bing Wang Zong-Qian Hu RuiYun Peng Chao Yu;Zhi-Xiu Xu;Yan-Hui Hao;Ya-Bing Gao;Bin-Wei Yao;Jing Zhang;Bing Wang;Zong-Qian Hu;Rui-Yun Peng

作者机构：Department of Experimental PathologyBeijing Institute of Radiation MedicineBeijing 100850China department of Internal NeurologyThe First Affiliated Hospital/Xinxiang Medical UniversityXinxiang 453100HenanChina department of BiotechnologyBeijing Institute of Radiation MedicineBeijing 100850China 

出 版 物：《Military Medical Research》 (军事医学研究（英文版）)

年 卷 期：2020年第7卷第2期

页      面：190-198页

核心收录：

学科分类：1002[医学-临床医学] 08[工学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(61402486) 

主　　题：Microcurrent dressing Electric stimulation Skin Wound healing 

摘      要：Background:The exogenous application of low-intensity electric stimulation(ES)may mimic a natural endogenous bioelectric current and accelerate the repair process of skin *** study designed a novel microcurrent dressing(MCD)and evaluated its potential effects on wound healing in a rat skin defect ***:First,wireless ES was integrated into a medical cotton cushion to fabricate the MCD,and its electrical property was examined by using a universal power ***,animal experiments were conducted to evaluate the MCD’s ***-five rats were randomized into control(Con)group,Vaseline gauze(VG)group and MCD group.A full-thickness round skin incision 1.5 cm in diameter was made on the back of each *** from routine disinfection,the Con rats were untreated,whereas the other two groups were treated with VG or *** days 3,7 and 14 post injury,the wound areas were observed and measured using image analysis software following photography,and the skin samples were harvested from wound ***,histopathological morphology was observed routinely by hematoxylin and eosin(HE)staining;tumor necrosis factorα(TNF-α)and interleukin(IL)-1βexpression were detected by Western *** endothelial growth factor(VEGF)and epidermal growth factor(EGF)expression were detected with ***:The MCD generated a sf electric potential greater than 0.95 *** experiments showed that the woundhealing rate in the MCD group was significantly increased compared with the Con and VG groups(P0.05 or P0.01).Histopathological observation revealed an alleviated inflammatory response,induced vascular proliferation and accelerated epithelization in the MCD ***,samples from the MCD group expressed reduced TNF-αand IL-1βlevels and increased VEGF and EGF levels compared with those of the other two groups(P0.05 or P0.01).However,no significant difference was noted between the Con and VG groups at each time ***:The MCD