Basic roles of key molecules connected with NMDAR signaling pathway on regulating learning and memory and synaptic plasticity

作     者：Hui Wang Rui-Yun Peng 

作者机构：Department of Experimental PathologyBeijing Institute of Radiation Medicine 

出 版 物：《Journal of Medical Colleges of PLA(China)》 (中国人民解放军军医大学学报（英文版）)

年 卷 期：2016年第31卷第4期

页      面：212-218页

学科分类：0710[理学-生物学] 1002[医学-临床医学] 07[理学] 071006[理学-神经生物学] 

基　　金：supported by the National Natural Science Foundation of China(61401497) 

主　　题：N-methyl-D-aspartic acid receptors Long-term potentiation Synaptic plasticity Learning and memory 

摘      要：With key roles in essential brain functions ranging from the long-term potentiation(LTP) to synaptic plasticity,the N-methyl-D-aspartic acid receptor(NMDAR) can be considered as one of the fundamental glutamate receptors in the central nervous *** role of NMDA R was first identified in synaptic plasticity and has been extensively *** molecules,such as Ca^(2+),postsynaptic density 95(PSD-95),calcium/calmodulin-dependent protein kinase II(Ca MK II),protein kinase A(PKA),mitogen-activated protein kinase(MAPK) and cyclic adenosine monophosphate(c AMP) responsive element binding protein(CREB),are of special importance in learning and *** review mainly focused on the new research of key molecules connected with learning and memory,which played important roles in the NMDAR signaling pathway.