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Verification and validation of detonation modeling

Defence Technology（防务技术） 2019年第3期15卷 398-408页

作者： Xiao liang rui-li wang Institute of Applied Physics and Computational Mathematics Beijing 100094 China College of Mathematics and Information Science Shandong University of Science and Technology Qingdao 266590 China

The mathematical model used to describe the detonation multi-physics phenomenon is usually given by highly coupled nonlinear partial differential equations. Numerical simulation and the computer aided engineering (CAE) technique has become the third pillar of detonation research, along with theory and experiment, due to the detonation phenomenon is difficult to explain by the theoretical analysis, and the cost required to accredit the reliability of detonation products is very high, even some physical experiments of detonation are impossible. The numerical simulation technique can solve these complex problems in the real situation repeatedly and reduce the design cost and time stunningly. But the reliability of numerical simulation software and the serviceability of the computational result seriously hinders the extension, application and the self-restoration of the simulation software, restricts its independently innovational ability. This article deals with the physical modeling, numerical simulation, and software development of detonation in a unified way. Verification and validation and uncertainty quantification (V&V&UQ) is an important approach in ensuring the credibility of the modeling and simulation of detonation. V&V of detonation is based on our independently developed detonation multiphysics software-LAD2D. We propose the verification method based on mathematical theory and program function as well as availability of its program execution. Validation is executed by comparing with the experiment data. At last, we propose the future prospect of numerical simulation software and the CAE technique, and we also pay attention to the research direction of V&V&UQ.

关键词： Verification and validation Detonation Equation of state Detonation diffraction Reaction rate law

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Recent Advances in Bio-Inspired Versatile Polydopamine Platforms for “Smart” Cancer Photothermal Therapy

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Chinese Journal of Polymer Science 2023年第5期41卷 699-712,I0007页

作者： Zhi-Yuan Ma Dan-Ya li Xin Jia rui-li wang Mei-Fang Zhu State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringDonghua UniversityShanghai 201620China Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan School of Chemistry and Chemical EngineeringShihezi UniversityShihezi 832003China

Although photothermal therapy(PTT)has been developed for fighting cancers,the degradative,toxic,and metabolic nature of photothermal conversion materials(PCMs)has prevented them from being clinically *** advantage of the surface modification strategy of mussel-inspired dopamine chemistry and its excellent photothermal conversion effect,polydopamine(Pdop)represents a versatile PTT platform,providing strategies and methods for the construction of novel Pdop-functionalized *** to its adhesion and secondary reactivity,Pdop can be deposited on virtually all substrates to improve their bioavailability and ***-based PCMs could not be only functionalized with small biomolecules via chemical bonds and/or noncovalent force but also modified with functional polymers via either the“grafting to”or“grafting from”*** review highlights the synthetic methods,therapeutic strategies,and designs of PCMs based on Pdop in recent years to explore its scope and limitations.

关键词： Polydopamine Photothermal therapy Drug delivery systems Polymers Tumor theranostics

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Effects of sampling strategies and DNA extraction methods on eDNA metabarcoding: A case study of estuarine fish diversity monitoring

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Zoological Research 2022年第2期43卷 192-204页

作者： Hui-Ting Ruan rui-li wang Hong-Ting li li liu Tian-Xu Kuang Min li Ke-Shu Zou University Joint Laboratory of Guangdong Province Hong Kong and Macao Region on Marine Bioresource Conservation and ExploitationCollege of Marine ScienceSouth China Agricultural UniversityGuangzhouGuangdong 510642China Key Laboratory for Sustainable Utilization of Open-sea Fishery Ministry of Agriculture and Rural AffairsSouth China Sea Fisheries Research InstituteChinese Academy of Fishery SciencesGuangzhouGuangdong 510300China Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) GuangzhouGuangdong 511458China Guangzhou CAOMUFAN Ecological Research limited company GuangzhouGuangdong 510520China College of Marine Sciences Shanghai Ocean UniversityShanghai 201306China

Environmental DNA(eDNA)integrated with metabarcoding is a promising and powerful tool for species composition and biodiversity assessment in aquatic ecosystems and is increasingly applied to evaluate fish *** date,however,no standardized eDNA-based protocol has been established to monitor fish *** this study,we investigated and compared two filtration methods and three DNA extraction methods using three filtration water volumes to determine a suitable approach for eDNA-based fish diversity monitoring in the Pearl River Estuary(PRE),a highly anthropogenically disturbed estuarine *** to filtration-based precipitation,direct filtration was a more suitable method for eDNA metabarcoding in the *** combined use of DNeasy Blood and Tissue Kit(BT)and traditional phenol/chloroform(PC)extraction produced higher DNA yields,amplicon sequence variants(ASVs),and Shannon diversity indices,and generated more homogeneous and consistent community composition among *** to the other combined protocols,the PC and BT methods obtained better species detection,higher fish diversity,and greater consistency for the filtration water volumes of 1000 and 2000 mL,*** eDNA metabarcoding protocols were more sensitive than bottom trawling in the PRE fish surveys and combining two techniques yielded greater taxonomic ***,combining traditional methods with eDNA analysis enhanced *** results indicate that methodological decisions related to eDNA metabarcoding should be made with caution for fish community monitoring in estuarine ecosystems.

关键词： eDNA metabarcoding Fish diversity Sampling strategies DNA extraction Estuarine ecosystem

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Analysis and Forecast of the Mortality of Diabetes Mellitus in China

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环境与职业医学 2003年第3期20卷 168-171页

作者： li rui, wang Zhen guo Shanghai Municipal Center for Disease Control and Prevention ShanghaiChina

[目的 ]分析 1990～ 1999年我国城市和农村居民糖尿病死亡率的现况特点并预测未来 5年的变化趋势。 [方法 ]根据《全国卫生统计年报》资料 ,对我国 1990至 1999年糖尿病死亡率的现况进行流行病学分析 ,并利用灰色动态模型GM( 1 1)预测我... 详细信息

[目的 ]分析 1990～ 1999年我国城市和农村居民糖尿病死亡率的现况特点并预测未来 5年的变化趋势。 [方法 ]根据《全国卫生统计年报》资料 ,对我国 1990至 1999年糖尿病死亡率的现况进行流行病学分析 ,并利用灰色动态模型GM( 1 1)预测我国 2 0 0 0至 2 0 0 5年城市和农村糖尿病死亡率趋势。[结果 ]城市 1999年糖尿病死亡率为 15 3 7/ 10万而农村为5 13 / 10万 ,分别是 1990年死亡率的 1 89倍和 1 71倍 ;女性的死亡率高于男性 ,城市和农村男女死亡率之比分别为 0 63∶1和0 76∶1;根据 1990～ 1999死亡率所建立的城市的灰色模型预测方程为 ^Xt=-10 6.4817× ( 1-e0 .0 7458t) -Yt-1(t =1,2 ,...,N) ,而农村的方程为 ^Xt=-3 3 .60 5 3× ( 1-e0 .0 753 7t) -Yt-1(t=1,2 ,...,N) ;预测到 2 0 0 5年我国城市和农村糖尿病死亡率将分别达到 2 5 2 4/ 10万人和 8 15 / 10万人 ;精度检验证明了城市和农村的预测模型拟合良好而外推测值可信。 [结论 ]我国人群糖尿病死亡率上升趋势明显 ,提示有关部门应加强防治力度 ;灰色模型GM( 1 1)能够较好地预测糖尿病死亡率的近期变化趋势。

关键词：糖尿病城市居民农村居民流行病学死亡率灰色模型中国

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Attachment of tyrosinase on mixed self-assembled monolayers for the construction of electrochemical biosensor

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Chinese Chemical Letters 2010年第10期21卷 1239-1242页

作者： Xue Ping Ji Xian rui li Na wang rui Xing Ni Xiao Hong liu Hua Ai Xiong Department of Medical Chemistry Hebei Medical University Shijiazhuang 050017 China

A mixed self-assembled monolayers （SAMs） of thioctic acid （T-COOH） and thioctic acid amide （T-NH2） were used to immobilize tyrosinase for fabricating biosensor. The results showed that the mixed SAMs prepared from solution at the ratio of 1：4 provided an excellent microenvironment for enzymatic reaction between tyrosinase and substrate. The biosensor exhibited a fast response and high sensitivity for sensing substrate.

关键词： Biosensor Tyrosinase Catechol Self-assembled monolayers Gold electrode

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A General Strategy for Efficiently Constructing Multifunctional Cluster Fillers Using a Three-Fluid Nozzle Spray Drying Technique for Dental Restoration

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Engineering 2022年第1期8卷 138-147页

作者： Dan-Lei Yang Dan wang Hao Niu rui-li wang Mei liu Fei-Min Zhang Jie-Xin wang Mei-Fang Zhu State Key Laboratory of Organic–Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029China Research Center of the Ministry of Education for High Gravity Engineering and Technology Beijing University of Chemical TechnologyBeijing 100029China State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringDonghua UniversityShanghai 201620China Jiangsu Key Laboratory of Oral Diseases Department of ProsthodonticsAffiliated Hospital of StomatologyNanjing Medical UniversityNanjing 210029China

Multifunctional fillers are greatly required for dental resin composites(DRCs).In this work,a spray dryer with a three-fluid nozzle was applied for the first time to construct high-performance complex nanoparticle clusters(CNCs)consisting of different functional nanofillers for dental *** application of a three-fluid nozzle can effectively avoid the aggregation of different nanoparticles with opposite zeta potentials before the spray drying process in order to construct regularly shaped *** a SiO_(2)–ZrO_(2) binary system,the SiO_(2)–ZrO_(2) CNCs constructed using a three-fluid nozzle maintained their excellent mechanical properties((133.3±4.7)MPa,(8.8±0.5)GPa,(371.1±13.3)MPa,and(64.5±0.7)HV for flexural strength,flexural modulus,compressive strength,and hardness of DRCs,respectively),despite the introduction of ZrO_(2) nanoparticles,whereas their counterparts constructed using a two-fluid nozzle showed significantly decreased mechanical ***,heat treatment of the SiO_(2)-ZrO_(2) CNCs significantly improved the mechanical properties and radiopacity of the *** DRCs containing over 10%mass fraction ZrO_(2) nanoparticles can meet the requirement for radiopaque *** importantly,this method can be expanded to ternary or quaternary *** filled with SiO_(2)-ZrO_(2)-ZnO CNCs with a ratio of 56:10:4 displayed high antibacterial activity(antibacterial ratio>99%)in addition to excellent mechanical properties and ***,the three-fluid nozzle spray drying technique holds great potential for the efficient construction of multifunctional cluster fillers for DRCs.

关键词： Multifunctional cluster fillers Three-fluid nozzle spray drying Mechanical properties Antibacterial activity Radiopacity Dental resin composites

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Production of CCHF Virus-like Particle by a Baculovirus-Insect Cell Expression System

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Virologica Sinica 2011年第5期26卷 338-346页

作者： Zhao-rui Zhou Man-li wang Fei Deng Tian-xian li Zhi-hong Hu Hua-lin wang State Key Laboratory of Virology Wuhan Institute of Virology Chinese Academy of Sciences Wuhan 430071 China

Crimean-Congo Haemorrhagic Fever Virus (CCHFV) is a tick-born virus of the Nairovirus genus within the Bunyaviridae family,which is widespread and causes high *** nucleocapsid of CCHFV is comprised of N proteins that are encoded by the S *** this research,the N protein of CCHFV was expressed in insect cells using a recombinant *** an electron microscope,Virus-like Particles (VLPs) with various size and morphology were observed in cytoplasmic vesicles in the infected ***-gradient purification of the cell lysate indicated that the VLPs were mainly located in the upper fraction after ultracentrifugation,which was confirmed by Western blot analysis and immuno-electron microscopy (IEM).

关键词： Crimean-Congo hemorrhagic fever virus (CCHFV) Virus-like Particle (VLP) Nucleocapsid (N)protein

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Spatial heterogeneity of fine root biomass of Pinus massoniana forests in the Three Gorges Reservoir Area, China

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Forestry Studies in China 2013年第1期15卷 13-23页

作者： rui-li wang rui-Mei CHENG Wen-Fa XIAO Xiao-Hui FENG Ze-Bin liU Xiao-Rong wang Zhi-Bo wang Key Laboratory of Forest Ecology and Environment of State Forestry Administration Research Institute of Forest Ecology Environment and Protection Chinese Academy of Forestry Center for Agricultural Resources Research Institute of Genetics and Developmental Biology Chinese Academy of Sciences Hubei Forestry Academy Research Institute of Forest Resource Information Techniques Chinese Academy of Forestry

Environmental heterogeneity is a constant presence in the natural world that significantly affects plant behavior at a variety of levels of complexity. In order to estimate the spatial pattern of fine root biomass in the Three Gorges Reservoir Area, the spatial heterogeneity of fine root biomass in the upper layer of soils （0-10 cm） in three Mas- son pine （Pinus massoniana） stands in the Three Gorges Reservoir Area, China, was studied in 30 m x 30 m plots with geostatistical analysis. The results indicate that 1） both the live and dead fine root biomass of stand 2 were less than those of other stands, 2） the spatial variation of fine roots in the three stands was caused together by structural and ran- dom factors with moderate spatial dependence and 3） the magnitude of spatial heterogeneity of live fine roots ranked as： stand 3 〉 stand 1 〉 stand 2, while that of dead fine roots was similar in the three stands. These findings suggested that the range of spatial autocorrelation for fine root biomass varied considerably in the Three Gorges Reservoir Area, while soil properties, such as soil bulk density, organic matter and total nitrogen, may exhibit great effect on the spatial distribution of fine roots. Finally, we express our hope to be able to carry out further research on the quantitative relation- ship between the spatial heterogeneous patterns of plant and soil properties.

关键词： spatial heterogeneity geostatistics Pinus massoniana fine root biomass Three Gorges Reservoir Area

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Forest fire danger ratings in the 2040s for northeastern China

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Forestry Studies in China 2011年第2期13卷 85-96页

作者： TIAN Xiao-rui SHU li-fu wang Ming-yu ZHAO Feng-jun Key Open Laboratory of Forest Protection of the State Forestry Administration Research Institute of Forest Ecology Environment and Protection Chinese Academy of Forestry Beijing 100091 E R. China

The average temperature of northeastern China is expected to increase 2.22 and 2.55℃ under two scenarios selected from the Intergovemmental Panel on Climate Change （IPCC）, i.e., A2 and B2, during the 2040s （2041-2050）, which will have an impact on fire activities in those areas. We calculated the output of regional climate models, using the Canadian Forest Fire Weather Index （FWI） on a scale of 50 km × 50 km. Meteorological data and fire weather index were interpolated to a scale of 1 km × 1 km by using ANUSPliN software. The results show that the model of Providing Regional Climate for Impacts Studies （PRECIS） had the ability to provide good temperature and precipitation estimates of the study area in the baseline period, by simulation. In the 2040s the mean FWI values of the study area will increase during most of the fire seasons under both selected scenarios, compared with the baseline period. Under scenario B2 the peak fire season will appear in advance. The changes of FWI ratio （2×CO2/l ×CO2） show that the potential burned areas will increase 20% under scenario B2 and lightly increase under scenario A2 in 2040s. The days of high, very high and extreme fire danger classes will add 5 and 18 d under scenarios A2 and B2, respectively. It suggests adapting the climate change through improving fuel management and enhancing the fighting abilities.

关键词： climate change forest fire danger fire season FWI northeastern China

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Application of next-generation sequencing in clinical oncology to advance personalized treatment of cancer

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Chinese Journal of Cancer 2012年第10期31卷 463-470页

作者： Yan-Fang Guan Gai-rui li Rong-Jiao wang Yu-Ting Yi ling Yang Dan Jiang Xiao-Ping Zhang Yin Peng Shenzhen Clinical Molecular Diagnostic Engineering Laboratory BGI-Shenzhen Shenzhen Guangdong 518083 P. R. China.

With the development and improvement of new sequencing technology,next-generation sequencing(NGS) has been applied increasingly in cancer genomics research over the past *** recently,NGS has been adopted in clinical oncology to advance personalized treatment of *** is used to identify novel and rare cancer mutations,detect familial cancer mutation carriers,and provide molecular rationale for appropriate targeted *** to traditional sequencing,NGS holds many advantages,such as the ability to fully sequence all types of mutations for a large number of genes(hundreds to thousands) in a single test at a relatively low ***,significant challenges,particularly with respect to the requirement for simpler assays,more flexible throughput,shorter turnaround time,and most importantly,easier data analysis and interpretation,will have to be overcome to translate NGS to the bedside of cancer ***,continuous dedication to apply NGS in clinical oncology practice will enable us to be one step closer to personalized medicine.

关键词：癌症治疗测序技术临床实践肿瘤学个性化应用基因突变基因组学

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