Application of next-generation sequencing in clinical oncology to advance personalized treatment of cancer

作     者：Yan-Fang Guan Gai-Rui Li Rong-Jiao Wang Yu-Ting Yi Ling Yang Dan Jiang Xiao-Ping Zhang Yin Peng 

作者机构：Shenzhen Clinical Molecular Diagnostic Engineering Laboratory BGI-Shenzhen Shenzhen Guangdong 518083 P. R. China. 

出 版 物：《Chinese Journal of Cancer》 (Chin. J. Cancer)

年 卷 期：2012年第31卷第10期

页      面：463-470页

核心收录：

学科分类：090603[农学-临床兽医学] 080503[工学-材料加工工程] 08[工学] 09[农学] 0906[农学-兽医学] 0805[工学-材料科学与工程（可授工学、理学学位）] 

主　　题：癌症治疗 测序技术 临床实践 肿瘤学 个性化 应用 基因突变 基因组学 

摘      要：With the development and improvement of new sequencing technology,next-generation sequencing(NGS) has been applied increasingly in cancer genomics research over the past *** recently,NGS has been adopted in clinical oncology to advance personalized treatment of *** is used to identify novel and rare cancer mutations,detect familial cancer mutation carriers,and provide molecular rationale for appropriate targeted *** to traditional sequencing,NGS holds many advantages,such as the ability to fully sequence all types of mutations for a large number of genes(hundreds to thousands) in a single test at a relatively low ***,significant challenges,particularly with respect to the requirement for simpler assays,more flexible throughput,shorter turnaround time,and most importantly,easier data analysis and interpretation,will have to be overcome to translate NGS to the bedside of cancer ***,continuous dedication to apply NGS in clinical oncology practice will enable us to be one step closer to personalized medicine.