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Evaluation of FGF10 as a candidate gene for high myopia in a Han Chinese population

Eye and Vision 2019年第1期6卷 284-290页

作者： Lingxi Jiang Dongyan Luo Tingting Wang rui zheng Yaru Zhai Xiaoqi Liu Bo Gong zhengzheng Wu Yin Yang zhenglin Yang Yi Shi Sichuan Provincial Key Laboratory for Human Disease Gene Study Department of Clinical LaboratorySichuan Academy of Medical Sciences&Sichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of China32 the First Ring Road West 2Chengdu 610072SichuanChina Department of Ophthalmology Sichuan Academy of Medical Sciences&Sichuan Provincial People’s HospitalChengduChina. Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital ChengduSichuanChina

Background:Fibroblast growth factor 10(FGF10)is implicated in the growth and development of the *** singles nucleotide polymorphisms(SNPs)in the FGF10 gene(including rs1384449,rs339501,rs12517396 and rs10462070)were found to be associated with extreme myopia(EM,refractive error≤−10.0 diopters)in Japanese and Chinese Taiwan *** case-control association study was conducted to explore the relationship between these four SNPs and high myopia in a western Chinese ***:A total of 869 high myopia patients(HM,including 485 EM patients)and 899 healthy controls were *** four SNPs were genotyped using the ABI SNaPshot *** genetic models(allelic,homozygous,heterozygous,dominant,and recessive)were applied to further evaluate the possible correlation between the SNPs and high *** linkage-disequilibrium block(LD)structure was tested by Haploview ***:In our study,no statistically significant differences were found between HM/EM patients and controls after Bonferroni multiple-correction(P>0.05)in the allele frequencies of these four SNPs in the FGF10 *** further found that rs12517396AA and rs10462070GG carriers showed a decreased risk of HM/EM compared with rs12517396AC+CC and rs10462070GA+AA carriers(P=0.045,OR=0.366;P=0.021,OR=0.131;P=0.03,OR=0.341;P=0.015,OR=0.122;respectively).Additionally,rs12517396AA and rs10462070GG carriers showed the same decreased risk of HM/EM compared with rs12517396CC and rs10462070AA carriers(P=0.048,OR=0.370;P=0.023,OR=0.133;P=0.032,OR=0.346;P=0.017,OR=0.126).However,these significant associations between rs12517396/rs10462070 and HM/EM disappeared after Bonferroni multiple-correction(P>0.05).Conclusion:Our findings indicate that rs12517396 and rs10462070 had marginal association with HM and *** other two common polymorphisms in FGF10 unlikely have significant effects in the genetic predisposition to HM/EM in western Chinese *** replication studies are needed

关键词： High myopia Extreme myopia Association study Fibroblast growth factor 10

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p38 MAPK mediates cardiovascular and behavioral responses induced by central IL-1β and footshock in conscious rats

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Acta Pharmacologica Sinica 2004年第3期25卷 12-16页

作者： rui-mao zheng,Chang-jiang ZOU,Shi-gong ZHU2 Department of Physiology and Pathophysiology,Health Science Center,Peking University,Beijing 100083,China Department of Physiology and Pathophysiology Health Science Center Peking University 北京 100083

AIM: To investigate the roles of p38 mitogen-activated protein kinase (p38 MAPK) in the cardiovascular and behavioral responses induced by intracerebral ventricular injection (icv) of interleukin-1β (IL-1β) or footshock. METHODS: We examined the effects of p38 MAPK on mean artery blood pressure (mABP), heart rate (HR), and motor activity (MA) during central administration of IL-1β, or footshock after icv SB203580 (a specific inhibitor of the p38 MAPK) with Cardiovascular and Behavior Telemetry System in conscious SD rats. RESULTS: (1) IL-1β (icv) or footshock remarkably rise the mABP, and the maximal changes are (7.8±1.8) and (12.3±3.5) mmHg, respectively, which was abrogated by the pretreatment with p38 inhibitor SB203580 intracerebroventricularly. (2) Compared with icv saline group, the motor activity was significantly decreased in SB203580 group with maximal changes (-7.6±1.1) counts/min after footshock. CONCLUSION: p38 MAPK plays an important role in the pres- sor response induced by central administration of IL-1β or footshock and change of motor activity after footshock in conscious rats.

关键词： mitogen-activated protein kinase p38 interleukin-1 blood pressure motor activity

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Twist in a polar blowout jet

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Research in Astronomy and Astrophysics 2013年第3期13卷 253-258页

作者： Jun-Chao Hong Yun-Chun Jiang Jia-Yan Yang rui-Sheng zheng Yi Bi Hai-Dong Li Bo Yang Dan Yang National Astronomical Observatories/Yunnan Astronomical Observatory Chinese Academy of Sciences Graduate University of Chinese Academy of Sciences

It is well known that some coronal jets exhibit helical structures and un- twisting. We attempt to inspect the origin of twist in a blowout jet. By means of multiwavelength and multi-angle observations from Solar Dynamics Observatory （SDO） and Solar Terrestrial Relations Observatory-Ahead （STEREO-A）, we firstly report a polar untwisting jet that is a blowout jet which leads to a jet-like coronal mass ejection. From the viewpoint of SDO, the jet shows clear untwisting behavior and two jet-spires. However, from the viewpoint of STEREO-A the jet actually comes from the whiplike prominence eruption and is followed by a white-light jet. Our observations indicate that twist in blowout jets may result from the erupting mini-prominences/mini- filaments in the jet base.

关键词： Sun: corona -- Sun: coronal mass ejections -- Sun: prominences

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联合稀疏自适应滤波的水声通信双向迭代均衡算法

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声学学报 2024年第5期49卷 1041-1050页

作者：刘璐郑睿哈尔滨工程大学水声技术全国重点实验室哈尔滨150001 工业和信息化部海洋信息获取与安全工信部重点实验室(哈尔滨工程大学) 哈尔滨150001 哈尔滨工程大学水声工程学院哈尔滨150001

针对具有稀疏性的水声信道,提出了一种参数自适应调整稀疏迭代最小二乘自适应算法。通过联合优化遗忘因子和稀疏约束参数,实现不同结构特性稀疏信道的自适应匹配,使均衡算法更快地收敛到稳态;针对常规均衡算法和单一方向Turbo判决反馈... 详细信息

针对具有稀疏性的水声信道,提出了一种参数自适应调整稀疏迭代最小二乘自适应算法。通过联合优化遗忘因子和稀疏约束参数,实现不同结构特性稀疏信道的自适应匹配,使均衡算法更快地收敛到稳态;针对常规均衡算法和单一方向Turbo判决反馈均衡器存在误差传递的问题,设计了一种稀疏自适应迭代最小二乘算法与双向迭代Turbo判决反馈均衡器相结合的均衡器结构,改善了常规均衡算法和单一方向Turbo判决反馈均衡器误差传递的问题,提高了在稀疏水声信道条件中自适应均衡器的收敛速度和均衡性能。仿真和试验数据结果表明,在稀疏水声信道中,基于参数自适应调整稀疏迭代最小二乘算法的双向Turbo均衡算法具有更快的收敛性能、更低的误比特率和更好的均衡效果。

关键词：信道均衡稀疏性 Turbo 接收机双向均衡

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Influence of olfactory ensheathing cell transplantation on body temperature of patients with old spinal cord injury

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Neural Regeneration Research 2008年第7期3卷 805-808页

作者： Chao Liu Zuncheng zheng rui Gao Kun Zhang Liqing Zhang Lin Zhang Lei Zhang Shugang Wei Naifeng Kuang Yanjun Song Second Department of Surgery Taian Rongjun Hospital Taian 271000 Shandong Province China

BACKGROUND： Olfactory ensheathing cell transplantation may transiently raise body temperature in some patients with old spinal cord injury. OBJECTIVE： To analyze the influence of olfactory ensheathing cell transplantation on body temperature changes and neurological functional recovery in patients with old spinal cord injury. DESIGN, TIME AND SETTING： A non-randomized self-controlled study, which was performed in the wards of the Department of Surgery, Taian Disabled Soldier＇s Hospital of Shandong Province, between June 2004 and July 2007. PARTICIPANTS： 119 inpatients with old spinal cord injury were selected for this study, including 110 males and 9 females, aged 5-58 years. METHODS： The olfactory bulb of an aborted fetus was digested into a single-cell suspension of olfactory ensheathing cells, which were then cultured and purified for 7-10 days, and once again made into a single-cell suspension. The olfactory ensheathing cell suspension was then transplanted in the juncture of the normal spinal cord and the abnormal spinal cord under surgical microscopy, with 1 × 10^6 cells per target point, with 2-5 target points in total. According to changes in postoperative temperature, 119 patients were divided into three groups： body temperature （T） ≤ 38.0 ℃ （n = 40）, 38.0 ℃ 〈 T ≤ 39.0 ℃ （n = 67）, T 〉 39.0℃ （n = 12）. In particular, T 〉 38℃ （n = 79） patients were divided into two subgroups according to duration of fever： ≤3 days （n = 61） and ≥ 4 days （n = 18）. MAIN OUTCOME MEASURES： Neurological function was evaluated by the American Spinal Cord Injury （ASIA） scale set by American Spinal Cord Injury Academy in 2000 one day prior to transplantation and one or two months after transplantation. RESULTS： 119 patients were included in the final analysis, without any loss. Following olfactory ensheathing cell transplantation, body temperatures changed as follows： T ≤ 38.0 ℃ （n = 40, 33.6%）, 38.0 ℃ 〈 T ≤ 39.0 ℃ （n = 67, 56.3%）, 〉 39.0 ℃ （n = 12, 10.1%）. Moreover, among

关键词： olfactory ensheathing cells cell transplantation functional evaluation body temperature

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Lower alanine aminotransferase levels are associated with increased all-cause and cardiovascular mortality in nonalcoholic fatty liver patients

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World Journal of Hepatology 2023年第6期15卷 813-825页

作者： Jia-rui zheng Zi-Long Wang Su-Zhen Jiang Hong-Song Chen Bo Feng Peking University Hepatology Institute Peking University People's HospitalBeijing 100044China

BACKGROUND Serum alanine aminotransferase(ALT) levels are often considered a marker to evaluate liver disease and its *** To investigate the association between ALT levels and all-cause and cause-specific mortality in patients with nonalcoholic fatty liver disease(NAFLD).METHODS The Third National Health and Nutrition Examination Survey(NHANES-Ⅲ) from 1988 to 1994 and NHANES-Ⅲ-related mortality data from 2019 onward were used to obtain the necessary data for the study. NAFLD was defined as hepatic steatosis, as diagnosed by ultrasound, with no other liver diseases. ALT levels were categorized into four groups according to the different recommended upper limits of normal(ULN) in men and women: < 0.5 ULN, 0.5-1 ULN, 1-2 ULN, and ≥ 2 ULN. The hazard ratios for all-cause mortality and cause-specific mortality were analyzed using the Cox proportional hazard *** Multivariate logistic regression analysis demonstrated that the odds ratio of NAFLD correlated positively with increased serum ALT levels. In patients with NAFLD, all-cause mortality and cardiovascular mortality were the highest when ALT was < 0.5 ULN, yet cancer-related mortality was the highest when ALT was ≥ 2 ULN. The same results could be found in both men and women. Univariate analysis showed that severe NAFLD with normal ALT levels had the highest allcause and cause-specific mortality, but the difference was not statistically significant after adjustment for age and multivariate *** The risk of NAFLD was positively correlated with ALT level, but all-cause and cardiovascular mortality were the highest when ALT was < 0.5 ULN. Regardless of the severity of NAFLD, normal or lower ALT levels were associated with higher mortality than elevated ALT levels. Clinicians should be aware that high ALT levels indicate liver injury, but low ALT levels are associated with a higher risk of death.

关键词： Non-alcoholic fatty liver disease Alanine aminotransferase Mortality NHANES-Ⅲ

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The anti-inflammatory regulation of calcitonin gene-related peptide in mouse Aspergillus fumigatus keratitis

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International Journal of Ophthalmology(English edition) 2020年第5期13卷 701-707页

作者： Ming Xu Cui Li Gui-Qiu Zhao Jing Lin Min Yin Heng-rui zheng Li Zhang Meng-Qi Wu Department of Ophthalmology the Affiliated Hospital of Qingdao UniversityQingdao 266003Shandong ProvinceChina

AIM:To analyze the impact of calcitonin gene-related peptide(CGRP)in mouse keratitis after Aspergillus fumigatus(***)***:C57 BL/6 mice were treated subconjunctivally with different concentrations of exogenous CGRP,and BALB/c mice were treated with CGRP8-37(a CGRP antagonist)before corneas were infected with *** cornea was assessed under the slit-lamp and the clinical score was *** mRNA levels of IL-1β,TNF-α,IL-6,and MIP-2 were detected by quantitative real-time polymerase chain reaction(PCR),while the protein level of IL-1βwas determined by Western *** vitro,RAW264.7 cells were used to investigate NLRP3 and IL-1βexpression induced by *** after the pretreatment of exogenous CGRP or *** expression in RAW264.7 cells was evaluated by real-time PCR and Western ***:Using exogenous CGRP resulted in downregulated synthesis of IL-1βand MIP-2 stimulated by *** in C57 BL/6 mice keratitis,and the synthesis of IL-1β,MIP-2 and IL-6 was up-regulated in BALB/c mice corneas after the pretreatment with *** with exogenous CGRP and CGRP8-37 did not influence TNF-αmRNA levels either in BALB/c or C57 BL/6 mice *** levels of NLRP3 and IL-1βwere both reduced in *** stimulated-macrophages after treatment with exogenous *** CGRP8-37 pretreatment would increase NLRP3 and IL-1β***:CGRP may alleviate the inflammatory reaction in mice keratitis after infection with *** anti-inflammatory effect may be related to the inhibition of NLRP3 expression by CGRP.

关键词： calcitonin gene-related peptide fungal keratitis NLRP3 mice

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Laminar Distribution of Neurochemically-Identified Interneurons and Cellular Co-expression of Molecular Markers in Epileptic Human Cortex

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Neuroscience Bulletin 2018年第6期34卷 992-1006页

作者： Qiyu Zhu Wei Ke Quansheng He Xiongfei Wang rui zheng Tianfu Li Guoming Luan Yue-Sheng Long Wei-Ping Lia Yousheng Shu State Key Laboratory of Cognitive Neuroscience and Learning and IDG/McGovern Institute for Brain Research Beijing Normal UniversityBeijing 100875China College of Pharmaceutical Sciences Brain InstituteCapital Medical UniversityBeijing 100069China Department of Neurosurgery Epilepsy CenterSanbo Brain Hospital of Capital Medical UniversityBeijing Key Labo-ratory of EpilepsyEpilepsy InstitutionBeijing Institute for Brain DisordersBeijing 100093China Institute of Neuroscience and Department of Neurology of the Second Affiliated Hospital of Guangzhou Medical University Key Laboratory of Neurogenetics and Chan-nelopathies of Guangdong Province and the Ministry of Education of ChinaGuangzhou 501260China

Inhibitory GABAergic interneurons are fundamental elements of cortical circuits and play critical roles in shaping network activity. Dysfunction of interneurons can lead to various brain disorders, including epilepsy,schizophrenia, and anxiety. Based on the electrophysiological properties, cell morphology, and molecular identity,interneurons could be classified into various subgroups. In this study, we investigated the density and laminar distribution of different interneuron types and the coexpression of molecular markers in epileptic human *** found that parvalbumin(PV) and somatostatin(SST)neurons were distributed in all cortical layers except layer I, while tyrosine hydroxylase(TH) and neuropeptide Y(NPY) were abundant in the deep layers and white ***(CCK) neurons showed a high density in layers IV and VI. Neurons with these markers constituted*7.2%(PV), 2.6%(SST), 0.5%(TH), 0.5%(NPY), and4.4%(CCK) of the gray-matter neuron population. Doubleand triple-labeling revealed that NPY neurons were also SST-immunoreactive(97.7%), and TH neurons were more likely to express SST(34.2%) than PV(14.6%). A subpopulation of CCK neurons(28.0%) also expressed PV, but none contained SST. Together, these results revealed the density and distribution patterns of different interneuron populations and the overlap between molecular markers in epileptic human cortex.

关键词： Interneuron Epilepsy Human cortex Cell type Immunostaining Parvalbumin Somatostatin Tyrosine hydroxylase Neuropeptide Y Cholecystokinin

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Cellular DNA repair cofactors affecting hepatitis B virus infection and replication

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World Journal of Gastroenterology 2008年第32期14卷 5059-5065页

作者： Fan Zhao Ning-Bo Hou Ting Song Xiang He Zi-rui zheng Qing-lun Ma Li Li Yan-Hong Zhang Hui Zhong Beijing Institute of Biotechnology Room 841 East District Building No. 27 Taiping Road Haidian District Beijing 100850 China

AIM： To investigate whether hepatitis B virus （HBV） infection activates DNA damage response and DNA repair cofactors inhibit HBV infection and replication. METHODS： Human hepatocyte cell line HL7702 was studied. Immunoblotting was performed to test the expression of ataxia telangiectasia-mutated （ATM）- Rad3-related protein （ATR）, p21 and the level of phosphorylation of Chkl, p53, H2AX, ATM in HBV-infected or non-infected-cells. Special short RNAi oligos was transfected to induce transient ATR knockdown in HL7702. ATR-ATN chemical inhibitors caffeine （CF） and theophylline （TP）, or Chkl inhibitor 7-hydroxystaurosporine （UCN01） was studied to determine whether they suppress cellular DNA damage response and NG132 inhibits proteasome. RESULTS： The ATR checkpoint pathway, responding to single-strand breaks in DNA, was activated in response to HBV infection. ATR knockdown cells decreased the HBV DNA yields, implying that HBV infection and replication could activate and exploit the activated DNA damage response. CF/TP or UCN01 reduced the HBV DNA yield by 70% and 80%, respectively. HBV abrogated the ATR-dependent DNA damage signaling pathway by degrading p21, and introduction of the p21 protein before HBV infection reduced the HBV DNA yield. Consistent with this result, p21 accumulation after NG132 treatment also sharply decreased the HBV DNA yield. CONCLUSION： HBV infection can be treated with therapeutic approaches targeting host cell proteins by inhibiting a cellular gene required for HBV replication or by restoring a response abrogated by HBV, thus providing a potential approach to the prevention and treatment of HBV infection.

关键词： Hepatitis B virus DNA damage response Hepatitis B virus infection Caffeine RNAi

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Flat-top laser beam generated by coherent beam combining of Gaussian lasers

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Chinese Optics Letters 2010年第1期8卷 45-47页

作者：高昆许立新郑睿陈国梁郑欢明海 Institute of Photonics Department of PhysicsUniversity of Science and Technology of China

We present a fiat-top laser beam generation scheme using coherent beam combining of hexagonally arranged Gaussian lasers. To produce a beam with a flat-top profile, we optimize the amplitude and phase of each unit laser using the least-square method. Simulation results show that with 13 unit lasers, a beam with the flatness of less than 1% in the optimizing region can be achieved. The main lobe contains over 95% of the total power. The scheme requires no external beam shaping element and has the potential to be designed for high-power applications.

关键词： Laser beams

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