Influence of olfactory ensheathing cell transplantation on body temperature of patients with old spinal cord injury

作     者：Chao Liu Zuncheng Zheng Rui Gao Kun Zhang Liqing Zhang Lin Zhang Lei Zhang Shugang Wei Naifeng Kuang Yanjun Song 

作者机构：Second Department of Surgery Taian Rongjun Hospital Taian 271000 Shandong Province China 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2008年第3卷第7期

页      面：805-808页

核心收录：

学科分类：08[工学] 09[农学] 0901[农学-作物学] 0836[工学-生物工程] 090102[农学-作物遗传育种] 

基　　金：Prof.Cong Cheng from the Department of Prevenmtive Medicine.Taishan Medical College 

主　　题：olfactory ensheathing cells cell transplantation functional evaluation body temperature 

摘      要：BACKGROUND： Olfactory ensheathing cell transplantation may transiently raise body temperature in some patients with old spinal cord injury. OBJECTIVE： To analyze the influence of olfactory ensheathing cell transplantation on body temperature changes and neurological functional recovery in patients with old spinal cord injury. DESIGN, TIME AND SETTING： A non-randomized self-controlled study, which was performed in the wards of the Department of Surgery, Taian Disabled Soldier＇s Hospital of Shandong Province, between June 2004 and July 2007. PARTICIPANTS： 119 inpatients with old spinal cord injury were selected for this study, including 110 males and 9 females, aged 5-58 years. METHODS： The olfactory bulb of an aborted fetus was digested into a single-cell suspension of olfactory ensheathing cells, which were then cultured and purified for 7-10 days, and once again made into a single-cell suspension. The olfactory ensheathing cell suspension was then transplanted in the juncture of the normal spinal cord and the abnormal spinal cord under surgical microscopy, with 1 × 10^6 cells per target point, with 2-5 target points in total. According to changes in postoperative temperature, 119 patients were divided into three groups： body temperature （T） ≤ 38.0 ℃ （n = 40）, 38.0 ℃ 〈 T ≤ 39.0 ℃ （n = 67）, T 〉 39.0℃ （n = 12）. In particular, T 〉 38℃ （n = 79） patients were divided into two subgroups according to duration of fever： ≤3 days （n = 61） and ≥ 4 days （n = 18）. MAIN OUTCOME MEASURES： Neurological function was evaluated by the American Spinal Cord Injury （ASIA） scale set by American Spinal Cord Injury Academy in 2000 one day prior to transplantation and one or two months after transplantation. RESULTS： 119 patients were included in the final analysis, without any loss. Following olfactory ensheathing cell transplantation, body temperatures changed as follows： T ≤ 38.0 ℃ （n = 40, 33.6%）, 38.0 ℃ 〈 T ≤ 39.0 ℃ （n = 67, 56.3%）, 〉 39.0 ℃ （n = 12, 10.1%）. Moreover, among