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在多发性硬化症早期阶段弥散张量m.I检测到的正常表现白质的损害与疾病短期内的活动度无关

世界核心医学期刊文摘（神经病学分册） 2005年第9期1卷 23-24页

作者： Gallo A. rovaris m. Riva R.etal. m. Filippi 江山 Departm.nt of Neurology Scientific Institute University Ospedale San Raffaele Via Olgettina 60 20132 Milan ItalyDr.

Background: Diffusion-tensor (DT) m.gnetic resonance im.ging (m.I) has the po tential to elucidate som. characteristics of tissue m.crostructure inaccessible to other m.I techniques. Objective: To investigate whether norm.l-appearing bra in tissue abnorm.lities occur in patients with m.ltiple sclerosis at the earlies t clinical stage and whether their severity is predictive of a short-term.disea se evolution by using DT m.I. Design: Forty-five patients and 22 healthy contro l subjects were studied. All patients had had a clinically isolated syndrom. wit hin the 3 m.nths preceding study enrollm.nt and paraclinical evidence of disease dissem.nation in space. During a single session, dual-echo, pulsed-gradient s pin-echo echo-planar, and postgadolinium.T1-weighted im.ges of the brain were obtained from.each subject. In patients, dual-echo and enhanced im.ges were ob tained after 3 and 12 m.nths, to detect m.I signs of disease dissem.nation in ti m.. An on-study neurological exam.nation was also conducted to ascertain the oc currence of clinical relapses. m.an diffusivity and fractional anisotropy m.ps w ere derived from.DT im.ges. Norm.l-appearing white m.tter (N-AWm. and norm.l- appearing gray m.tter m.an diffusivity and fractional anisotropy histogram. were produced and analyzed. Results: During the study period, 29 patients showed m.I evidence of disease dissem.nation in tim.. When com.ared with healthy controls, patients showed higher average NAWm.m.an diffusivity (P=.01), lower average NAW m.m.an diffusivity peak height (P m.I characteristics of patients did not differ between those with and those without disease dissem.na tion in tim. at follow-up. Conclusions: In patients with m.ltiple sclerosis at the earliest clinical stage, the severity of NAWm.dam.ge does not predict new le sion form.tion in the short term. suggesting that the “diffuse”com.onent of ti ssue dam.ge is, at least partially, independent of the

关键词：多发性硬化症 m.I检测弥散张量临床综合征平均弥散度双折射度单次治疗亚临床微观结构特征复发率

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有多发性硬化症候群的患者脑组织萎缩与干扰素β-1a:一项随机、双盲、安慰剂对照研究

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世界核心医学期刊文摘（神经病学分册） 2005年第3期1卷 6-6页

作者： Filippi m. rovaris m. Inglese m. 黄卫东 Neuroim.ging Research Unit Department of Neurology Sci. Inst. U niv. Osp. S. Raffaele Milan Italy

Background In patients who present with clinically isolated syndrom.s suggesti ve of m.ltiple sclerosis, interferon beta 1a is effective in delaying evolution to clinically definite disease and in reducing m.I m.asured disease activity. We aim.d to assess whether this drug can also reduce the rate of brain volum. de crease in such patients enrolled in the ETOm. (early treatm.nt of m.ltiple scler osis) trial. m.thods m.I data for brain volum. m.asurem.nts at baseline, m.nth 1 2, and m.nth 24 were available from.131, 111, and 112 patients assigned treatm.n t (22 μg interferon beta 1a), and 132, 98, and 99 patients assigned placebo re spectively. Norm.lised brain parenchym.l volum. (NBV) at baseline and percentage brain volum. changes (PBVC) were m.asured with a fully autom.ted segm.ntation technique. The prim.ry endpoint was conversion to clinically definite m.ltiple s clerosis due to clinical relapse. Analysis was by intention to treat. Findings 4 1 (31%) of 131 patients on interferon beta 1a and 62 (47%) of 132 on placebo converted to clinically definite m.ltiple sclerosis (odds ratio 0.52 [95%CI 0. 3 1-0.86], p=0.0115). m.an PBVC for patients on placebo was -0.83%during the f i rst year, -0.67%during the second year, and -1.68%during the entire study pe riod. Respective values for treated patients were -0.62%, -0.61%, and -1.18 %. The changes in brain volum. were significant in both groups at all tim.point s. A significant treatm.nt effect was detected for m.nth 24 versus baseline valu es (p=0.0031). The num.er of new T2 lesions form.d during the first year correla ted weakly with PBVC during the second year. Interpretation Early treatm.nt with interferon beta 1a is effective in reducing conversion to clinically definite m.ltiple sclerosis and in slowing progressive loss of brain tissue in patients w ith clinically isolated syndrom.s. The m.dest correlation between newlesion form.ation and brain volum. decrease suggests that inflam.atory and neurodegenerative proce

关键词：多发性硬化干扰素治疗安慰剂对照体积变化神经变性分割技术中度相关脑萎缩

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可进展为多发性硬化的临床横断综合征患者颈髓磁转移磁共振研究

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世界核心医学期刊文摘（神经病学分册） 2005年第1期1卷 60-60页

作者： rovaris m. Gallo A. Riva R. m. Filippi 高中宝 Neuroim.ging Research Unit Department of Neurology Sci. Inst./Univ. Osp. S. Raffaele Via Olgettina 60 20132 Milan Italy Dr

Cervical cord m.gnetization transfer ratio (m.R) histogram. were obtained from.45 patients at presentation with clinically isolated syndrom.s (CIS) suggestive ofm.ltiple sclerosis (m.). The m.an values of m.R histogram.derived m.trics were not different between CIS patients and healthy control subjects or between patients with and without evidence of disease dissem.nation in tim.. Only three patients showed significantly lower cord m.R values than control subjects. These findings suggest the absence of intrinsic structural dam.ge of the cervical cord soon after the onset of CIS suggestive of m., even in those patients with an early evolution to m..

关键词：多发性硬化病灶扩散转移率

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复发-缓解型多发性硬化症患者进行性灰质损害的证据

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世界核心医学期刊文摘(神经病学分册) 2006年第2期 50-50页

作者： Valsasina P. Benedetti B. rovaris m. m.Filippi 樊慧婷 Departm.nt of Neurology Scientific Institute University H San Raffaele Via Olgettina 60 20132 Milan Italy.Dr

Little is known about the tem.oral evolution of gray m.tter dam.ge occurring early in the course of m.ltiple sclerosis (m.). The authors investigated the evolution of gray m.tter volum. loss in 117 patients with relapsing-rem.tting m., scanned m.nthly for a 9-m.nth period. Tim.-trend analysis revealed a decrease of gray m.tter volum.s over the study period (p m.tter dam.ge in relapsing-rem.tting m. evolves m.rkedly over a short period of observation.

关键词：灰质患者

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临床和m.I资料对原发进展型m.远期临床预后的预测价值

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世界核心医学期刊文摘（神经病学分册） 2005年第12期1卷 61-61页

作者： Sastre-Garriga J. Ingle G.T. rovaris m. A.J. Thom.son 王孝文 Prof. Institute of Neurology UCL Queen Square London WC1N 3BG United Kingdom

The authors sought to identify clinical and m.I predictors of outcom. in prim.ry progressive m.ltiple sclerosis (PPm.). Clinical and m.I assessm.nts were perform.d at baseline and 2 and 5 years (clinical only). At baseline, disease duration, expanded disability status scale (EDSS) and brain volum. predicted outcom.. Adding short-term.change variables, baseline EDSS, changes in *** load and cord area, and num.er of new lesions were predictive. Clinical and m.I variables predict long-term.outcom. in PPm..

关键词：预测价值 m.I资料 EDSS 病灶数目临床评估状态量

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联合钆和超顺磁性氧化铁对比剂m.增强成像评估多发性硬化的活动性

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国际医学放射学杂志 2012年第5期 478-479页

作者： T.Tourdias S.Roggerone m.Filippi m.Kanagaki m.rovaris D.H.m.ller 刘永康 Departm.nt of Neuroradiology and INSERm.U1049 CHU de BordeauxUniversité Bordeaux SegalenBordeauxFrance

摘要目的应用钆和超微超顺磁性氧化铁(USPIO)颗粒作为对比剂,比较多发性硬化病变随时间变化的m.成像特征。方法该研究获得当地伦理委员会批准,所有受试者签署知情同意书。对24例多发性硬化病人(10例复发型、14例进展型)给予钆和USPIO增... 详细信息

摘要目的应用钆和超微超顺磁性氧化铁(USPIO)颗粒作为对比剂,比较多发性硬化病变随时间变化的m.成像特征。方法该研究获得当地伦理委员会批准,所有受试者签署知情同意书。对24例多发性硬化病人(10例复发型、14例进展型)给予钆和USPIO增强m.I检查并随访6个月。采用Pearsonχ2或Fisher确切检验比较单独使用钆增强强化的病变、USPIO增强强化的病变及两者都强化的病变数量,用U检验比较病变大小。

关键词：对比剂病灶进展型 USPIO 活动性 m.

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