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Tibolone Reverses NAFLD in Ovariectomised Rats by Reducing Adiposity and Insulin Resistance

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Journal of Pharmacy and Pharmacology 2019年第4期7卷 148-164页

作者： Lilian Brites Campos-Shimada Eduardo Hideo Gilglioni Danielle Aparecida Munhos Hermoso Ana Julia dos Reis Buzzo rosangela fernandes garcia Elismari Rizato Martins-Maciel Emy Luiza Ishii-Iwamoto Clairce Luzia Salgueiro-Pagadigorria Laboratory of Experimental Steatosis Department of BiochemistryState University of MaringáMaringá87020900Brazil Department of Physiological Sciences State University of MaringáMaringá87020900Brazil Department of Biomedicine Centro Universitario IntegradoCampo Mourao 87300970Brazil

This study aimed to investigate the effects of tibolone,a synthetic steroid,on several metabolic dysfunctions induced by oestrogen deficiency,in ***(OVX)rats were used as animal model of postmenopausal metabolic *** OVX rats were treated with daily doses of tibolone(0.16 mg/kg)and the results were compared with control(sham-operated)and OVX untreated *** reduced the adiposity and the visceral adipocyte size in OVX *** insulin sensitivity was also improved,and a decrease in the activity of the adipose tissue hormone-sensitive lipase enzyme was *** lower lipolysis by visceral adipocytes,associated with the recovery of peroxisomalβ-oxidation by tibolone may have contributed to the reversion of NAFLD in treated OVX *** reduction of liver lipid contents resulted in a general improvement in the liver redox *** addition,tibolone reduced the mitochondrial ROS generation and restored the activity of glucose-6-phosphate *** also exerted antioxidant effects on inguinal adipose *** exerted several beneficial effects on cellular and metabolic dysfunctions induced by ovariectomy in *** important mode of action of tibolone was the reduction of the visceral adipocyte size,corroborating the relationship between this one and the development and progression of several comorbidities associated with metabolic syndrome.

关键词： Tibolone ovariectomy hepatic steatosis obesity oxidativestress

Agnuside Reduces Visceral Adipocyte Size,Improves Insulin Sensitivity and Reverses Hepatic Steatosis in Ovariectomized Rats

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Journal of Pharmacy and Pharmacology 2019年第4期7卷 133-147页

作者： Franciele Neves Moreno Eduardo Hideo Gilglioni rosangela fernandes garcia Naiara Cristina Lucredi Sandra Mara Ferreira Nilton Almeida Brito Marcia do Nascimento Brito Emy Luiza Ishii-Iwamoto Clairce Luzia Salgueiro-Pagadigorria Laboratory of Experimental Steatosis Department of BiochemistryState University of MaringaMaringa 87020-900PRBrazil Laboratory of Biological Oxidations Department of BiochemistryState University of MaringaMaringa 87020-900PRBrazil Department of Physiological Sciences State University of MaringaMaringa 87020-900PRBrazil Laboratory of Biological oxidations Department of BiochemistryFederal University of Santa CatarinaFlorianopolis 88040-900SCBrazil Department of Structural and Functional Biology Institute of BiologyState University of Campinas(UNICAMP)Campinas 13083-970SPBrazil

This study aimed to investigate the effects of agnuside(AGN),a phytoestrogen in Vitex agnus-castus,on cellular and metabolic alterations induced by ovariectomy in ***(OVX)Wistar rats were used as an animal model of postmenopausal metabolic *** visceral and subcutaneous adipocyte sizes,the peripheral insulin sensitivity and the occurrence of nonalcoholic fatty liver disease(NAFLD)and liver oxidative damage were *** results were compared with those obtained from control rats(sham-operated)and OVX rats treated daily with *** OVX rats exhibited visceral adipocyte hypertrophy and developed glucose intolerance,hyperinsulinemia,NAFLD and *** exerted beneficial effects on several metabolic parameters in OVX rats,including the improvement in glucose intolerance,hyperinsulinemia and ***,AGN promoted a general improvement in the liver redox *** the reduction of the mesenteric adipocyte size is very likely to be an important mode of action of AGN,some actions of AGN could also involve the interaction with estrogen receptors.

关键词： Metabolic syndrome ovariectomized rats adipocyte size NAFLD agnuside

Goji Berry （Lycium barbarum） Extract Improves Biometric, Plasmatic and Hepatic Parameters of Rats Fed a High-Carbohydrate Diet

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Journal of Pharmacy and Pharmacology 2018年第10期6卷 877-889页

作者： Letícia Diniz Crepaldi Isabela Ramos Mariano Anna Julia P. C. Trondoli Franciele Neves Moreno Silvano Piovan Maysa Formigoni Clairce L. Salgueiro-Pagadigorria Vilma A. Ferreira de Godoi Márcia do Nascimento Brito rosangela fernandes garcia Department of Physiological Sciences State University of Maringá Maringá PR 87020-900 Brazil Laboratory of Experimental Steatosis Department of Biochemistry State University of Maringá Maringá PR 87020-900 Brazil Laboratory of Secretion Cell Biology Department of Biotechnology Genetics and Cell Biology State University of Maringá Maringá PR 87020-900 Brazil Nucleus of Research in Natural Products Department of Biochemistry State University of Maringá Maringá PR 87020-900 Brazil

GB （goji berry） has bioactive components capable of reversing the metabolic syndrome. This work investigated systemic, biometric and metabolic parameters of male rats fed with standard diet （group CD） or high-carbohydrate diet （group HC）. At 90 days of age the HC group was subdivided： one was given vehicle solution （HCD） and the other was given GB extract （HCDGB）, for 60 days. The vehicle was also given to the CD group. At 150 days of age, glucose tolerance test, tissue collection, plasmatic determinations, lipid content, in situ perfusion and oxidative stress of the liver were carried out. The GB supplementation improved the parameters of the metabolic syndrome caused by the HC diet, including decreased body weight gain, adiposity index, dyslipidemia, hyperinsulinemia, NAFLD, liver oxidative stress and gluconeogenesis. Together with the diminished insulin resistance, these results indicate the GB extract is an important adjuvant in the treatment of the metabolic syndrome.

关键词： Metabolic syndrome insulin resistance NAFLD liver metabolism goji berry.

Turning Industrial Waste into a Valuable Bioproduct:Starch from Mango Kernel Derivative to Oil Industry Mango Starch Derivative in Oil Industry

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Journal of Renewable Materials 2019年第2期7卷 139-152页

作者： Nívia do Nascimento Marques Caroline Suzy do Nascimento garcia Liszt Yeltsin Coutinho Madruga Marcos Antônio Villetti Men de SáMoreira de Souza Filho Edson Noriyuki Ito rosangela de Carvalho Balaban Instituto de Química Universidade Federal do Rio Grande do Norte-UFRNNatal59078970Brazil Departamento de Física Universidade Federal de Santa Maria-UFSMSanta Maria97105900Brazil Embrapa Agroindústria Tropical Fortaleza60511-110Brazil Departamento de Engenharia de Materiais Universidade Federal do Rio Grande do Norte-UFRNNatal59078970Brazil

After industrial mango processing,tons of residues such as peels and kernels are discarded as ***,almost 60% of the mango kernel is due to starch on a dry weight ***,starch from mango(Manguifera Indica L.)kernel was applied to obtain a starch fatty ester with vinyl laurate,in DMSO,under basic ***,1H and 13C NMR confirmed that a starch ester with a degree of modification of 2.6 was *** showed that the modified starch has higher thermal stability than its precursors and higher than a vinyl laurate/starch physical *** data showed that granular shape and smooth surface on mango starch changed after chemical modification to a continuous and shapeless *** industrial reject derivative behaved as an efficient alternative environmentally friendly fluid loss controller in oil drilling fluids,even in conditions of high temperatures and high pressures(HTHP)drilling.

关键词： Mango Starch oil drilling fluid transesterification vinyl laurate

Live and Inactivated Salmonella Enteritidis Vaccines:Immune Mechanisms in Broiler Breeders

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World Journal of Vaccines 2015年第4期5卷 155-164页

作者： Letícia Dal Bérto Breno C. B. Beirao Tobias fernandes Filho Max Ingberman Celso Favaro Jr. rosangela Tavella Rebeca Buest de Mesquita Silva Luiz Felipe Caron Campus UP Universidade PositivoCuritibaBrazil Imunova Análises Biologicas CuritibaBrazil Departamento de Patologia Basica Universidade Federal do ParanaCuritibaBrazil

Salmonella is a ubiquitous pathogen which, in addition to causing poultry diseases, has a growing zoonotic impact. It has demanded the implementation of diverse control strategies, in which vaccines play a major role. The understanding of the immune pathways elicited by the different vaccines is important, contributing for the establishment of strong immune correlates of protection, for instance. With the purpose of determining the dynamics of the humoral and cellular immune responses to vaccination, broiler breeders (Cobb Slow) were immunized with live or inactivated vaccines against Salmonella Enteritidis. Lymphocyte and macrophage subsets were analyzed in the peripheral blood by flow cytometry and antigen-specific circulating IgY and mucosal IgA were quantified. The markers analyzed by flow cytometry were CD8/CD28, CD4/TCRVβ1, Kul/ MHC II and Bu-1. Both live and inactivated vaccines induced an increase in the proportion of circulating monocytes (Kul+MHCII+) in some time points compared to non-vaccinated controls. However, whereas the live vaccine leads to an increase in CD8-CD28+ and Bu-1+ lymphocytescompared to the control group, the inactivated vaccine prompteda reduction in the percentage of severalleucocyte subsets (Kul-MHCII+, Bu-1+, CD8+CD28+, CD8-CD28+, CD4+TCRVβ1-, CD4+TCRVβ1+, CD4-TCRVβ1+) after the boost dose. Both vaccines induced specific serum IgY and mucosal IgA production;however, the inactivated vaccine stimulated higher titers in a shorter period. These results contribute to the understanding of mechanisms of action of live and inactivated Salmonella vaccines in chickens.

关键词： Salmonella Enteritidis Humoral and Cellular Immunity Live Vaccine Bacterin Broiler Breeders

Pre-fire aboveground biomass, estimated from LiDAR, spectral and field inventory data, as a major driver of burn severity in maritime pine (Pinus pinaster) ecosystems

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Forest Ecosystems 2022年第2期9卷 234-246页

作者： Jose Manuel Fernandez-Guisuraga Susana Suarez-Seoane Paulo Mfernandes Victor Fernandez-garcia Alfonso Fernandez-Manso Carmen Quintano Leonor Calvo Area of Ecology Department of Biodiversity and Environmental ManagementFaculty of Biological and Environmental SciencesUniversity of Leon24071LeonSpain Centro de Investigacao e de Tecnologias Agroambientais e Biologicas Universidade de Tras-os-Montes e Alto Douro5000-801Vila RealPortugal Department of Organisms and Systems Biology(Ecology Unit)and Research Unit of Biodiversity(IMIB UO-CSIC-PA)University of OviedoOviedoMieresSpain Agrarian Science and Engineering Department School of Agricultural and Forestry EngineeringUniversity of Leon24400PonferradaSpain Electronic Technology Department School of Industrial EngineeringUniversity of Valladolid47011ValladolidSpain Sustainable Forest Management Research Institute University of Valladolid-Spanish National Institute for Agriculture and Food Research and Technology(INIA)34004PalenciaSpain

Background:The characterization of surface and canopy fuel loadings in fire-prone pine ecosystems is critical for understanding fire behavior and anticipating the most harmful ecological effects of ***,the joint consideration of both overstory and understory strata in burn severity assessments is often *** aim of this work was to assess the role of total,overstory and understory pre-fire aboveground biomass(AGB),estimated by means of airborne Light Detection and Ranging(LiDAR)and Landsat data,as drivers of burn severity in a megafire occurred in a pine ecosystem dominated by Pinus pinaster *** the western Mediterranean ***:Total and overstory AGB were more accurately estimated(R^(2) equal to 0.72 and 0.68,respectively)from LiDAR and spectral data than understory AGB(R^(2)=0.26).Density and height percentile LiDAR metrics for several strata were found to be important predictors of *** severity responded markedly and non-linearly to total(R^(2)=0.60)and overstory(R ^(2)=0.53)AGB,whereas the relationship with understory AGB was weaker(R ^(2)=0.21).Nevertheless,the overstory plus understory AGB contribution led to the highest ability to predict burn severity(RMSE=122.46 in dNBR scale),instead of the joint consideration as total AGB(RMSE=158.41).Conclusions:This study novelty evaluated the potential of pre-fire AGB,as a vegetation biophysical property derived from LiDAR,spectral and field plot inventory data,for predicting burn severity,separating the contri-bution of the fuel loads in the understory and overstory strata in Pinus pinaster *** evidenced relationships between burn severity and pre-fire AGB distribution in Pinus pinaster stands would allow the implementation of threshold criteria to support decision making in fuel treatments designed to minimize crown fire hazard.

关键词： Aboveground biomass Burn severity Landsat LiDAR Pinus pinaster

Anal canal gastrointestinal stromal tumors:Case report and literature review

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World Journal of Gastroenterology 2014年第1期20卷 319-322页

作者： Nuno Carvalho Diogo Albergaria Rui Lebre Joo Giria Vitor fernandes Helena Vidal Maria José Brito Department of General Surgery Garcia de Orta Hospital2801-951 AlmadaPortugal Department of Gastroenterology Garcia de Orta Hospital2801-951 AlmadaPortugal Department of Radiology Garcia de Orta Hospital2801-951 AlmadaPortugal Department of Pathology Garcia de Orta Hospital2801-951 AlmadaPortugal

Gastrointestinal stromal tumors (GIST) are an uncommon group of tumors of mesenchymal origin. GIST of the anal canal is extremely rare. At present, only 10 cases of c-kit positive anal GIST have been reported in the literature. There is no widely accepted treatment approach for this neoplasia. Literature is sparse on imaging evaluation of anal canal GIST, usually described as a lesion in the intersphincteric space. We describe the case of a 73-year-old man with a mass in the anal canal, and no other symptoms. Endoanal ultrasound and magnetic resonance imaging showed a well circumscribed solid nodule in the intersphincteric space. The patient was treated by local excision. Gross pathological examination showed a 7 cm × 3.5 cm × 3 cm mass, and histological examination showed a proliferation of spindle cells, with prominent nuclear palisading. The mitotic count was of 12 mitoses/50 HPF. The tumor was positive for KIT protein, CD34 and vimentin in the majority of cells, and negative for desmin and S100. A diagnosis of GIST, with high risk aggressive behavior was made. An abdomino-perineal resection was discussed, but refused. The follow-up included clinical evaluation and anal ultrasound. After 5 years the patient is well, with maintained continence and no evidence of local recurrence.

关键词： Gastrointestinal stromal tumors Anal canal Endoanal ultrasound Magnetic resonance imaging C-Kit receptor Local excision

The Teaching of Sign Language in Undergraduate Nursing Courses: A Descriptive Study as an Attribute to the Integrality of Care

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Health 2015年第14期7卷 1824-1832页

作者： Wiliam César Alves Machado Carla Oliveira Shubert Athaynne Ramos de Aguiar Prado Edicléa Mascarenhas fernandes Teresa Tonini Míriam garcia Leoni Federal University of Rio de Janeiro State Rio de Janeiro Brazil Estácio de Sá University Rio de Janeiro Brazil Rio de Janeiro State University Rio de Janeiro Brazil

Background: Current and future generations of nurses must be prepared to communicate and properly care for deaf patients. The objective of this study is to describe how Brazilian Sign Language is taught in undergraduate Nursing courses. Method: This was a descriptive study with a qualitative approach, performed with fifteen professors from four universities, two public and two private and in the metropolitan region of Rio de Janeiro, through individual interviews with an analysis procedure guided by Content Analysis. Results: The teaching is restricted to the adoption of planned and established approaches to sign language and procedures to assess theoretical contents and practical domains sign language teaching exclusively in elective course often offered through the online platform. Conclusion: We conclude that professors are not prepared for the teaching of sign language and that curricula need to be appropriate to the demand of full and indistinct assistance to the population’s needs.

关键词： Undergraduate Nursing Programs Communication Barriers Deafness Sign Language

Prospective application of a bleeding and ischemic risks-adjusted antithrombotic protocol in elderly patients revascularized with everolimus-eluting stents:EPIC05-Sierra75 study

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Journal of Geriatric Cardiology 2022年第5期19卷 354-366页

作者： Jose M de la Torre Hernandez Ramon Lopez Palop Jesus M Jimenez Mazuecos Pilar Carrillo Sáez Alejandro Gutierez-Barrios Eduardo Pinar Belen Cid Luis Fernandez Tamara garcia Camarero Cristóbal Urbano-Carrillo Juan F Oteo Dominguez Victor A Jimenez Diaz Antonio EGomez Menchero Eladio Galindo Fernández Juan GCórdoba Soriano Raymundo Ocaranza Eduardo ArroyoÚcar Koldobika garcia San Roman Silvio Leal Ginés Martínez Cáceres Jose A Linares Vicente Georgina Fuertes Ferre Xavier Carrillo Juan CRama Merchán Catia Costa Juan Sanchis Renato fernandes Alberto Rodrigues Jose M Vegas Valle Hélder Pereira Armando Perez de Prado Cardiology Department Hospital Universitario Marqués de ValdecillaIDIVALSantanderSpain Cardiology Department Hospital Universitario San JuanAlicanteSpain Cardiology Department Complejo Hospitalario Universitario de AlbaceteAlbaceteSpain Cardiology Department Hospital Universitario Puerta del MarCadizSpain Cardiology Department Hospital Clínico Universitario Virgen de la ArrixacaMurciaSpain Cardiology Department Hospital Clinico Universitario de SantiagoCIBERCVSantiago de CompostelaSpain Cardiology Department Hospital Universitario de CrucesBilbaoSpain Cardiology Department Hospital Regional Universitario de MálagaMalagaSpain Cardiology Department Hospital Universitario Puerta de HierroMadridSpain Cardiology Department Hospital Alvaro CunqueiroVigoSpain Cardiology Department Hospital Juan Ramon JimenezHuelvaSpain Cardiology Department Hospital Universitario de BadajozBadajozSpain Cardiology Department Hospital Universitario Lucus AugustiLugoSpain Cardiology Department Hospital de Torrevieja/VinalopóRibera SaludTorreviejaSpain Cardiology Department Hospital Santa CruzLisboaPortugal Cardiology Department Hospital Clínico Universitario Lozano BlesaZaragozaSpain Cardiology Department Hospital Universitario Miguel ServetZaragozaSpain Cardiology Department Hospital Germans Trias i PujolBadalonaSpain Cardiology Department Hospital de MeridaMeridaSpain Cardiology Department Hospital São BernardoSetúbalPortugal Cardiology Department Hospital Clinico Universitario de ValenciaUniversidad de ValenciaCIBERCVValenciaSpain Cardiology Department Hospital do Espirito SantoEvoraPortugal Cardiology Department Centro Hospitalar de Vilanova de GaiaVilanova de GaiaPortugal Cardiology Department Hospital de CabueñesGijonSpain Cardiology Department Hospital Garcia de OrtaAlmadaPortugal Cardiology Department Complejo Asistencial Universitario de LeónLeonSpain

OBJECTIVES Elderly patients show a higher incidence of ischemic and bleeding events after percutaneous transluminal coron-ary intervention(PCI).We sought to investigate outcomes in elderly patients treated with antithrombotic strategy guided by bleeding and ischemic risks after revascularization with last generation everolimus-eluting stent(EES).METHODS Prospective multicenter registry including patients over 75 years revascularized with EES and antithrombotic ther-apy guided by clinical presentation,PCI complexity and PRECISE DAPT ***-primary safety endpoints were:(1)composite of cardiac death,myocardial infarction and stent thrombosis and;(2)bleeding(BARC 2-5).Primary efficacy endpoint was target lesion revascularization.A matched group of patients revascularized with current drug-eluting stents and no such tailored antith-rombotic therapy was used as *** Finally,1064 patients were included in SIERRA-75 cohort,80.8±4.2 years,36.6%women,71%acute coronary syn-dromes(ACS)and 53.6%complex ***-primary safety endpoint of major adverse cardiovascular events was met in 6.2%,co-primary safety endpoint of bleeding in 7.8%and primary efficacy endpoint of TKLR in 1.5%.The multivariable adjusted model showed no significant association of the prescribed short/long dual antiplatelet therapy(DAPT)durations with any endpoint suggesting a well tailored *** stent thrombosis reported in the subgroup with 1-3 months DAPT *** compared to control group,bleeding BARC 2-5 was significantly lower in SIERRA-75 group(7.4%vs.10.2%,P=0.04)as well as the net safety-efficacy endpoint(14.3%vs.18.5%,P=0.02).CONCLUSIONS In elderly population,the application of this risks-adjusted antithrombotic protocol after revascularization with last generation EES seems to be associated with an improved prognosis in terms of ischemic and bleeding outcomes.

关键词： patients bleeding antithrombotic