Coconut Oil Reduces Visceral Adipocyte Size and Improves the Metabolic Profile of Rats Fed a High-Carbohydrate Diet

作     者：Valéria Schoffen Romao-Carrascoza Rosangela Fernandes Garcia Lorena Lima Garo Maria Montserrat Diaz Pedrosa Nilton de Almeida Brito Clairce Luzia Salgueiro-Pagadigorria Márcia do Nascimento Brito 

作者机构：Department of Physiological SciencesState University of MaringáMaringá87020900PRBrazil Department of MedicineState University of MaringáMaringá87020900PRBrazil 

出 版 物：《Journal of Pharmacy and Pharmacology》 (药剂与药理学（英文版）)

年 卷 期：2019年第7卷第3期

页      面：98-109页

学科分类：10[医学] 

主　　题：Adipocyte hypertrophy metabolic syndrome insulin resistance NAFLD coconut oil 

摘      要：This work aimed to evaluate the effects of the food supplementation with coconut oil(CO)on biometric and metabolic parameters in an animal model of *** rats fed a high-carbohydrate diet(HCD rats)develop metabolic disorders very similar to those found in human metabolic syndrome,including increased adiposity,insulin resistance(IR),non-alcoholic fatty liver disease(NAFLD)and *** HCD rats had normal fasting glycemia,they developed IR as revealed by Homa-IR index and,after glucose overload,exhibited higher peaks of insulinemia and *** alterations were accompanied by a higher formation of advanced glycated end products(AGEs).The supplementation with CO improved IR,reduced AGEs formation and reverted *** effects could be due to CO action of reducing visceral adipocyte size and take place without undesirable collateral effects on lipid profile,placing CO as an adjuvant in the treatment of the metabolic syndrome.