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Natural products,PGC-1α,and Duchenne muscular dystrophy

Acta Pharmaceutica Sinica B 2020年第5期10卷 734-745页

作者： Ipek Suntar[ Antoni Sureda Tarun Belwal Ana Sanches Silva rosa anna vacca Devesh Tewari Eduardo Sobarzo-Sánchez Seyed Fazel Nabavi Samira Shirooie Ahmad Reza Dehpour Suowen Xu Bahman Yousefi Maryam Majidinia Maria Daglia Giuseppe D’Antona Seyed Mohammad Nabavi Department of Pharmacognosy Faculty of PharmacyGazi UniversityEtilerAnkara 06330Turkey Research Group in Community Nutrition and Oxidative Stress Health Research Institute of the Balearic Islands(IdISBa)and CIBEROBN(Physiopathology of Obesity and Nutrition)University of Balearic IslandsPalmaBalearic Islands E-07122Spain G.B.Pant National Institute of Himalayan Environment and Sustainable Development AlmoraUttarakhand 263643India National Institute for Agricultural and Veterinary Research(INIAV) VairaoVila do CondePortugal Center for Study in Animal Science(CECA) ICETAUniversity of PortoPortoPortugal Institute of Biomembranes Bioenergetics and Molecular BiotechnologiesNational Council of ResearchBari 70126Italy Department of Pharmacognosy School of Pharmaceutical SciencesLovely Professional UniversityPhagwaraPunjab 144411India Laboratory of Pharmaceutical Chemistry Faculty of PharmacyUniversity of Santiago de CompostelaSantiagode Compostela 15782Spain Department of Organic Chemistry Faculty of PharmacyUniversity of Santiago de CompostelaSantiago de Compostela 15782Spain Applied Biotechnology Research Center Baqiyatallah University of Medical SciencesTehran ***Iran Pharmaceutical Sciences Research Center Health InstituteKermanshah University of Medical SciencesKermanshah ***Iran Department of Pharmacology Faculty of MedicineTehran University of Medical SciencesTehran ***Iran Experimental Medicine Research Center Tehran University of Medical SciencesTehran ***Iran The First Affiliated Hospital of USTC Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Molecular Medicine Research Center Tabriz University of Medical SciencesTabriz 516615731Iran Drug Applied Research Center Tabriz University of Medical SciencesTabriz 516615731Iran Solid Tumor Research Center Urmia University of Medical SciencesUrmia 571478334Iran Department of Pharmacy University of Naples FedericoⅡNaples 80138Italy International Research Center for Foo

Peroxisome proliferator-activated receptorγ(PPARγ)is a transcriptional coactivator that binds to a diverse range of transcription ***γcoactivator 1(PGC-1)coactivators possess an extensive range of biological effects in different tissues,and play a key part in the regulation of the oxidative metabolism,consequently modulating the production of reactive oxygen species,autophagy,and mitochondrial *** to these findings,a large body of studies,aiming to establish the role of PGC-1 in the neuromuscular system,has shown that PGC-1 could be a promising target for therapies targeting neuromuscular *** these,some evidence has shown that various signaling pathways linked to PGC-1αare deregulated in muscular dystrophy,leading to a reduced capacity for mitochondrial oxidative phosphorylation and increased reactive oxygen species(ROS)*** the light of these results,any intervention aimed at activating PGC-1 could contribute towards ameliorating the progression of muscular ***-1αis influenced by different patho-physiological/pharmacological *** products have been reported to display modulatory effects on PPARγactivation with fewer side effects in comparison to synthetic *** together,this review summarizes the current knowledge on Duchenne muscular dystrophy,focusing on the potential effects of natural compounds,acting as regulators of PGC-1α.

关键词： Muscular dystrophy Natural product Peroxisome proliferator-activated receptor Y coactivator la PPARγactivation Reactive oxygen species Mitochondrial oxidative phosphorylation

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On the Use of Monotonicity-Preserving Interpolatory Techniques in Multilevel Schemes for Balance Laws

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Communications on Applied Mathematics and Computation 2024年第2期6卷 1319-1341页

作者： Antonio Baeza rosa Donat anna Martinez-Gavara Department de Matematiques Universitat de ValenciaDr.Moliner5046100 BurjassotValenciaSpain Department d'Estadistica i Investigacio Operativa Universitat de ValenciaDr.Moliner5046100BurjassotValenciaSpain

Cost-effective multilevel techniques for homogeneous hyperbolic conservation laws are very successful in reducing the computational cost associated to high resolution shock capturing numerical *** they do not involve any special data structure,and do not induce savings in memory requirements,they are easily implemented on existing codes and are recommended for 1D and 2D simulations when intensive testing is *** multilevel technique can also be applied to balance laws,but in this case,numerical errors may be induced by the *** present a series of numerical tests that point out that the use of monotonicity-preserving interpolatory techniques eliminates the numerical errors observed when using the usual 4-point centered Lagrange interpolation,and leads to a more robust multilevel code for balance laws,while maintaining the efficiency rates observed forhyperbolic conservation laws.

关键词： Hyperbolic balance laws Well-balanced schemes Multilevel schemes Harten's multiresolution

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Environmental degradation through mining for energy resources:The case of the shrinking Laguna Santa rosa wetland in the Atacama Region of Chile

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Energy Geoscience 2022年第2期3卷 182-190页

作者： Mohammad Ayaz Alam rosa Sepúlveda Departamento de Geología Facultad de IngenieríaUniversidad de AtacamaAvenida Copayapu 485CopiapoRegion de AtacamaChile

As the world strives to replace fossil fuels with clean energy e reflected by global surge in the number of electric vehicles e the environmental impact of mining all the lithium(Li)needed to enable such a transformation has become a problem in its own *** South America,the biggest problem is the excessive use of water in Li extraction process in one of the driest areas in the *** from causing severe friction over water rights between local communities and mining companies,it puts enormous pressure on the region's fragile and poorly understood wetland *** are one of the most threatened ecosystems on the Earth,despite their great importance as habitats for a vast number of species and corresponding to one of the most productive *** work is the outcome of an investigation on Laguna Santa rosa's(LSR)vulnerability resulting from ongoing metal mining operations in its surroundings that require a large volume of water extracted from local aquifers,in addition to a high evaporation rate in the *** groundwater-dependent wetland will soon be further vulnerable with the commencement of water-intensive Li mining at Salar de Maricunga,with the extraction project already having an environmental impact study *** of this wetland protected under the Ramsar Convention and home to numerous wildlife species habiting this highland sector of the Andean Cordillera is vital for the associated *** variation in the water surface area of LSR has been deciphered through the application of a Landsat-5 Thematic Mapper(TM)satellite image *** has been done both for the hydrological year 2016e2017 and 1993-2014 period.A decreasing trend in the water surface area of LSR,a hypersaline lake at the southern extreme of Salar de Maricunga,a salt flat in the Atacama Region of Chile,was observed through the study of satellite images between 1993 and 2014,showing shrinking of this ***,this shrinking t

关键词： Laguna Santa rosa Salar de Maricunga Lithium Water Wetland Ecosystem

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First evidence of heteroplasmy in Grey Partridge(Perdix perdix)

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Avian Research 2020年第3期11卷 363-365页

作者： Claudia Pizzirani Paolo Viola Federica Gabbianelli anna Fagotti Francesca Simoncelli Ines Di rosa Paolo Salvi Andrea Amici Livia Lucentini Department of Chemistry Biology and Biotechnologies(DCBB)University of Perugia06100 PerugiaItaly Department of Agriculture and Forest Science(DAFNE) University of Tuscia01100 ViterboItaly Department for Innovation in Biological Agro-food and Forest Systems(DIBAF) University of Tuscia01100 ViterboItaly Parco Nazionale dei Monti Sibillini 62039 VissoMCItaly

We report for the first time the occurrence of heteroplasmy in Grey Partridge(Perdix perdix)revealed by means of two mitochondrial *** possible serious biological and management implications of this exception to unila... 详细信息

关键词： Galliformes Grey Partridge Heteroplasmy Hybridization Perdix perdix

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Atmospheric and ecosystem big data providing key contributions in reaching United Nations’Sustainable Development Goals

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Big Earth Data 2021年第3期5卷 277-305页

作者： Markku Kulmala anna Lintunen Ilona Ylivinkka Janne Mukkala rosa Rantanen Joni Kujansuu Tuukka Petäjä Hanna K.Lappalainen Institute for Atmospheric and Earth System Research(INAR)/Physics Faculty of ScienceUniversity of HelsinkiFinland Joint International Research Laboratory of Atmospheric and Earth System Sciences School of Atmospheric SciencesNanjing UniversityNanjingChina Aerosol and Haze Laboratory Beijing Advanced Innovation Center for Soft Matter Sciences and EngineeringBeijing University of Chemical Technology(BUCT)BeijingChina Faculty of Geography Lomonosov Moscow State UniversityMoscowRussia Tyumen State University Department of CryosphereTyumenRussia fGuangzhou Institute of Geography Guangzhou Academy of SciencesGuangzhouChina Institute for Atmospheric and Earth System Research University of Helsinki Finland Aerospace Information Research Institute Chinese Academy of SciencesBeijingChina

Big open data comprising comprehensive,long-term atmospheric and ecosystem in-situ observations will give us tools to meet global grand challenges and to contribute towards sustainable *** Nations’Sustainable Development Goals(UN SDGs)provide framework for the *** present synthesis on how Station for Measuring Earth Surface-Atmosphere Relations(SMEAR)observation network can contribute to UN *** describe SMEAR II flagship station in Hyytiälä,*** more than 1200 variables measured in an integrated manner,we can under-stand interactions and feedbacks between biosphere and *** contributes towards understanding impacts of climate change to natural ecosystems and feedbacks from ecosys-tems to *** benefits of SMEAR concept are highlighted through outreach project in Eastern Lapland utilizing SMEAR I observations from Värriöresearch *** contrast to boreal environment,SMEAR concept was also deployed in *** underline the benefits of comprehensive observations to gain novel insights into complex interactions between densely popu-lated urban environment and *** observations enable work towards solving air quality problems and improve the quality of life inside *** network of comprehensive stations with various measurements will enable science-based deci-sion making and support sustainable development by providing long-term view on spatio-temporal trends on atmospheric compo-sition and ecosystem parameters.

关键词： Grand challenges in-situ observations big open data SMEAR concept SDGs

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Relationship between nonalcoholic fatty liver disease and chronic kidney disease could start in childhood

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World Journal of Gastroenterology 2021年第34期27卷 5793-5795页

作者： anna Di Sessa Stefano Guarino rosa Melone Rossella Francesca De Simone Pierluigi Marzuillo Emanuele Miraglia del Giudice Department of Woman Childand General and Specialized SurgeryUniversity of Campania Luigi VanvitelliNaples 80138Italy

The relationship between nonalcoholic fatty liver disease(NAFLD)and chronic kidney disease(CKD)has gained considerable scientific interest in adults over the past few ***,this association has recently emerged in *** published studies have suggested a role for NAFLD as a risk factor for CKD from the earliest age,with a potential influence of the major NAFLD risk polymorphisms,resulting in an increased risk of both cardiovascular and metabolic *** view of the progressive course and increased cardiometabolic risk closely related to NAFLD and CKD,we focused on the link between these diseases in childhood.

关键词： Nonalcoholic fatty liver disease Chronic kidney disease Children Liver

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Chronic hepatitis C virus infection and atherosclerosis: Clinical impact and mechanisms

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World Journal of Gastroenterology 2014年第13期20卷 3410-3417页

作者： Luigi E Adinolfi rosa Zampino Luciano Restivo Amedeo Lonardo Barbara Guerrera Aldo Marrone Fabio Nascimbeni anna Florio Paola Loria Department of Medical SurgicalNeurologicalMetabolicand Geriatric SciencesSecond University of Naples80100 NaplesItaly Department of Internal Medicine EndocrinologyMetabolism and GeriatricsUniversity of Modena and Reggio Emilia41126 Modena Italy Vascular Surgery Second University of Naples80100 NaplesItaly

Hepatitis C virus(HCV)infection represents a major health issue worldwide due to its burden of chronic liver disease and extrahepatic manifestations including cardiovascular diseases,which are associated with excess *** of published studies supports the view that HCV infection should be considered a risk factor for the development of carotid atherosclerosis,heart failure and *** contrast,findings from studies addressing coronary artery disease and HCV have yielded conflicting ***,meta-analytic reviews and prospective studies are *** pathogenic mechanisms connecting HCV infection,chronic liver disease,and atherogenesis are not completely ***,it has been hypothesized that HCV may promote atherogenesis and its complications through several direct and indirect biological mechanisms involving HCV colonization and replication within arterial walls,liver steatosis and fibrosis,enhanced and imbalanced secretion of inflammatory cytokines,oxidative stress,endotoxemia,mixed cryoglobulinemia,perturbed cellular and humoral immunity,hyperhomocysteinemia,hypo-adiponectinaemia,insulin resistance,type 2 diabetes and other components of the metabolic *** these complex mechanisms is of fundamental importance for the development of novel therapeutic approaches to prevent and to treat vascular complications in patients with chronic HCV ***,it seems that HCV clearance by interferon and ribavirin treatment significantly reduces non-liver-related mortality;moreover,interferon-based treatment appears to decrease the risk of ischemic stroke.

关键词： Hepatitis C virus Atherosclerosis Coronary artery disease Stroke Inflammation

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In vitro Metabolomic Approaches to Investigating the Potential Biological Effects of Phenolic Compounds:An Update

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Genomics, Proteomics & Bioinformatics 2017年第4期15卷 236-245页

作者： Ursula Catalan Laura Barrubes rosa Maria Vails rosa Soila Laura Rubio Functional Nutrition Oxidation and Cardiovascular Diseases Group(NFOC-Salut)Technological Center of Nutrition and Health(CTNS)lnstitut d'lnvestigacio Sanitaria Pere Virgili(IISPV)Faculty of Medicine and ttealth SciencesUniversitat Rovira i VirgiliReus 43201Spain Food Technology Department Universitat de Lleida-AGROTECNIO CenterLleida 25198Spain

Dietary phenolic compounds （PCs） have been receiving intercst lor their presumcd roles ill disease prevention. However, there is a lack of studies on the underlying molecular mechanisnls. In this regard, in vitro metabolomic approaches are suitable for the investigation o1 the molecular changes in response to PC exposure. Up to date, the biological effects of PCs have only been cxalnined for PCs from rosemary （Rosmarinus officinalis）, olive oil, and reSVCl-atrol using cell-based mctabolomic approach, although transcriptomic and/or proteomic studies have also been conducted in the same in vi[ro cell experiment in some cases. Our integral analysis of the reviewed studies suggest that PCs may be involved not only in basic cellular processes or macro-and micro-nutrient meta- bolism, but also in specific metabolic pathways that have been thoroughly investigated. These modulated pathways could have a clinical impact on neurodegenerativc diseases, type 2 diabetes, cancer, and cardiovascular diseases. In conclusion, the in vitro metabolomic approaches provide additional information of the molecular mechanisms involved in disease risk reduction of dietary PCs. In order to elucidate the mechanisms of action of PCs, more metabolomic cell-based studies are nccdcd and testing the physiological conjugated forms of PCs in these cell systems could be of special interest.

关键词： Cell-based Metabolomics Phenolic compounds Mechanism of action Disease prevention

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Irritable bowel syndrome:A clinical review

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World Journal of Gastroenterology 2014年第34期20卷 12144-12160页

作者： rosa LS Soares Internal Medicine Department Faculty of MedicineFederal Fluminense UniversityRio de Janeiro 24030-210Brazil

Irritable bowel syndrome (IBS) remains a clinical challenge in the 21st century. It’s the most commonly diagnosed gastrointestinal condition and also the most common reason for referral to gastroenterology clinics. Its can affect up to one in five people at some point in their lives, and has a significantly impact of life quality and health care utilization. The prevalence varies according to country and criteria used to define IBS. Various mechanisms and theories have been proposed about its etiology, but the biopsychosocial model is the most currently accepted for IBS. The complex of symptoms would be the result of the interaction between psychological, behavioral, psychosocial and environmental factors. The diagnosis of IBS is not confirmed by a specific test or structural abnormality. It is made using criteria based on clinical symptoms such as Rome criteria, unless the symptoms are thought to be atypical. Today the Rome Criteria III is the current gold-standard for the diagnoses of IBS. Secure positive evidence of IBS by means of specific disease marker is currently not possible and cannot be currently recommended for routine diagnosis. There is still no clinical evidence to recommend the use of biomarkers in blood to diagnose IBS. However, a number of different changes in IBS patients were demonstrated in recent years, some of which can be used in the future as a diagnostic support. IBS has no definitive treatment but could be controlled by non-pharmacologic management eliminating of some exacerbating factors such certain drugs, stressor conditions and changes in dietary *** traditional pharmacologic management of IBS has been symptom based and several drugs have been used. However, the cornerstone of its therapy is a solid patient physician relationship. This review will provide a summary of pathophysiology, diagnostic criteria and current and emerging therapies for IBS.

关键词： Irritable bowel syndrome Clinical review Pathogenesis Diagnostic Treatment Biopsychosocial model

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Analysis of hydrodynamic effects on biofilm thickness in fluidized-bed tapered bioreactors

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Particuology 2021年第5期19卷 48-57页

作者： Daniela Maria Koerich Leonardo Machado da rosa Chemical Engineering Department University of Blumenau(FURB)3250 Sao Paulo Street89030-000 BlumenauSanta CatarinaBrazil

Fluidized beds in tapered geometries provide advantages such as a broad range of optimum operating ***,the dynamics of the flow inside these bioreactors is significantly more complex,as they promote non-uniform bioparticles *** this end,the CFD technique can give a detailed description of the flow in the ***,the aim of this work is to assess the influence of the hydrodynamic on the steady-state biofilm thickness through numerical simulations of liquid–solid fluidized *** geometries of tapered bioreactors in the operating conditions used to develop *** were run to solve the two-phase RANS equations using the open-source software OpenFOAM in *** SST k−ω model was used to estimate the turbulent features of the *** and bioparticles distribution inside the reactor were analyzed for different inlet velocities,while bioparticles collision frequency and shear stresses were evaluated for various operating *** comparison between the turbulent kinetic energy and the granular temperature indicated that the fluid flow is more turbulent than the bioparticles *** hydrodynamics influence on the steady-state biofilm thickness was assessed,and results led to the conclusion that biofilm is more sensitive to hydrodynamic shear stress than bioparticles collisions.

关键词： Liquid-solid fluidization Shear stress Particles collisions Computational fluid dynamics Biofilm Tapered bioreactors

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