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Atherogenic Indices and HDL Particle Size as Laboratory Parameters to Evaluate Cardiovascular Risk in the Presence of Dyslipidemia

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Journal of Biophysical Chemistry 2014年第2期5卷 24-32页

作者： Ana Paula C.Santos Marcos S.Vieira Debora F.Deus Rogerio Jorge Bde Oliveira Aleksandra T.Morikawa roque aras Ajax M.Atta Fabio D.Couto Raul C.Maranhao Ricardo D.Couto Clinical Biochemistry Laboratory Department of Clinical and Toxicological AnalysisFaculty of PharmacyFederal University of Bahia/UFBASalvadorBrazil Naval Hospital of Salvador Brazilian Marine ForcesSalvadorBrazil Lipid Metabolism Laboratory of the Heart Institute(InCor-Clinical Hospital of Medical School) Faculty of PharmacyUniversity of Sao Paulo/USPSao PauloBrazil Ana Neri Hospital SESAB and Federal University of Bahia/UFBA Faculty of MedicineSalvadorBrazil Laboratory of Research in Immunology(LAPIM) Department of Clinical and Toxicological AnalysisFaculty of PharmacyFederal University of Bahia/UFBASalvadorBrazil Laboratory of Molecular Biology and Genetics at Center of Agricultural Environmental and Biological Sciences(CCAAB-UFRB)Cruz das AlmasBrazil Faculty of Pharmaceutical Sciences Clinical Chemistry DepartmentUniversity of Sao Paulo/USPSao PauloBrazil Central Clinical Laboratory of Professor Edgar Santos University Hospital Federal University of Bahia/UFBASalvadorBrazil

Dyslipidemia may influence enzymes and transfer proteins needed to the lipoprotein particle remodeling. Calculated indices and evaluation of lipoprotein particle size have widely been used to predict cardiovascular risk. The aim of this study was to evaluate HDL particle size and LDL particle size estimate based on TG/HDL-C as well as apoB/apoA-I ratio as possible marker and atherogenic indices, respectively, of cardiovascular disease risk in the presence of dyslipidemia. We evaluated 100 individuals of both gender, without treatment with lipid-lowering drugs, 27 normolipidemic and 73 dyslipidemic, such as isolated hypercholesterolemia (n = 16), isolated hypertriglyceridemia (n = 17), low HDL-C (n = 26) and mixed dyslipidemia (n = 14). The HDL particle size did not differ between groups. The TG/HDL-C ratio was higher in groups with isolated hypertriglyceridemia (4.2 ± 1.5), low HDL-C (5.2 ± 3.1) and mixed dyslipidemia (5.3 ± 1.6). The apoB/apoA-I ratio was increased in all groups of dyslipidemia (apoB/apoA-I > 0.5) when compared to normolipidemic (apoB/apoA-I = 0.5, p < 0.001). There was a positive linear correlation between the TG/HDL-C ratio and the apoB/apoA-I ratio in low HDL-C group (r = 0.507, p = 0.008, Spearman). The results suggest that the evaluations of lipoproteins particles remodeling markers and the use of calculated indices may contribute to the evaluation of cardiovascular disease risk when dyslipidemia take place.

关键词： Dyslipidemia Atherogenic Indices Cardiovascular Risk

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Low-Flow Polysulfone Hemodialysis Alters Lipoprotein Parameters, Paraoxonase Activity and <i>in Vitro</i>Incorporation of Phospholipids

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Journal of Biophysical Chemistry 2017年第3期8卷 23-38页

作者： Franciane S. Marques Alysson Luiz M. Da Silva Ricardo J. C. Mattoso roque aras Rogério Jorge B. De Oliveira Júlio Cézar De Abreu Santos Fabio D. Couto Ricardo D. Couto PGBSMI/Goncalo Moniz Research Center (CPqGM) FIOCRUZ Foundation Center Salvador Brazil Department of Biofunction Health Institute of Science Federal University of Bahia/UFBA Salvador Brazil Clinical Biochemistry Laboratory Department of Clinical and Toxicological Analysis Faculty of Pharmacy Federal University of Bahia/UFBA Salvador Brazil Ana Neri Hospital SESAB and Federal University of Bahia/UFBA Salvador Brazil Naval Hospital of Salvador Brazilian Marine Forces Salvador Brazil Laboratory of Molecular Biology and Genetics at Center of Agricultural Environmental and Biological Sciences (CCAAB-UFRB) Cruz das Almas Brazil

End stage-renal-disease (ESRD) is associated with dyslipidemia and premature atherosclerosis. The study evaluates the effect of hemodialysis (HD) on HDL-remodeling between pre- and post-HD. Was conducted a cross-sectional study with 50 ESRD male patients, undergoing HD at Ana Neri Hospital, Salvador, Brazil. All individuals were on HD for at least 3 months, into a three sessions protocol for 3 - 4 hours per week, with a polysulfone low-flow basic-dialyzing-membrane and unfractionated-heparin. HDL Phospholipid-incorporation was measured by 14C-PL-scintillation-counting, expressed as %14C-PL/mL/hour. Paraoxonase (PON-1) activity was measured by spectrophotometry using paraoxon as substrate. Cardiovascular risk ratios and atherogenic index of plasma were calculated. Total cholesterol, HDL-C and non-HDL-C increased at post-HD on all age groups, but without triglycerides (TG) changes. TG/HDL-C decreased in 30 - 39 and 40 - 49 year (y) at post-HD (p 0.05). LDL-C/apoB increased in >60 y, after HD (p 60 (p 0.01). On the other hand, non-HDL-C/HDL-C reduced in 40 - 49 and >60 y, at post-HD (p 0.05). The linear-correlation between %14C-PL-incorporation and non-HDL-C/HDL-C was negative in 30 - 39 y, both at pre-HD (r = -0.90;p = 0.002) and post-HD (r = -0.78;p = 0.022). Linear-correlation between PON-1 and %14C-PL-incorporation was positive in >60 y, both at pre- (r = 0.63;p = 0.029) and post-HD (r = 0.65;p = 0.022). PON-1 activity increased at pre- (59 ± 30) and post-HD (73 ± 38) in 50 - 59 y (p 0.05). The %14C-PL-incorporation was reduced in >60 y (p 0.05), when compared to pre- and post-HD. ESRD patients undergoing HD shows important changes on lipid-profile, PON-1-activity, cardiac risk ratios and HDL-remodeling. These results demonstrate the influence of HD with a polysulfone low-flow basic-dialyzing-membrane and unfractionated-heparin on lipoprotein metabolism.

关键词： Hemodialysis Dyslipidemia Cardiovascular Risk Bioindices PLTP PON-1 HDL-Remodeling Low-Flow Polysulfone Dialyzing-Membrane

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G protein-coupled estrogen receptor 1(GPER) activation triggers different signaling pathways on neurons and astrocytes

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Neural Regeneration Research 2019年第12期14卷 2069-2070页

作者： Claudio roque Graca Baltazar CICS-UBI - Health Sciences Research Centre University of Beira Interior Covilh. Portugal Faculty of Health Sciences University of Beira Interior Covilh. Portugal

Estradiol (E2) is the most potent and prevalent form of estrogen, a well-known hormone that regulates multiple tissues and functions in humans. In the brain, E2 regulates processes as diverse as learning, memory, cognition, mood, as well as neurodevelopment and neurodegeneration. The actions of E2 are mediated by classical estrogen receptors (ERs;α and β), and by the G protein-coupled estrogen receptor 1 (GPER or GPR30)(Prossnitz and Arterburn, 2015). Classical ER are predominantly present in the nucleus and cytoplasm, with less than 2% present on the plasma membrane, and mediate genomic cellular effects that occur in the time frame of hours to days (Prossnitz and Arterburn, 2015).

关键词： multiple tissues functions astrocytes

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A systematic review of clinical practice guidelines and best practice statements for the diagnosis and management of varicocele in children and adolescents

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Asian Journal of Andrology 2016年第2期18卷 262-268,J0006页

作者： Matheus roque Sandro C Esteves ORIGEN Center for Reproductive Medicine Rio de Janeiro Av. Rodolfo de Amoedo 140 Rio de Janeiro RJ 22620-330 Brazil ANDROFERT Center for Male Reproduction Av. Dr. Heitor Penteado 1464 Campinas SP 13075-460 Brazil.

A systematic review was conducted to identify and qualitatively analyze the methods as well as recommendations of Clinical Practice Guidelines （CPG） and Best Practice Statements （BPS） concerning varicocele in the pediatric and adolescent population. An electronic search was performed with the MEDLINE, EMBASE, Science Direct, and Scielo databases, as well as guidelines＇ Web sites until September 2015. Four guidelines were included in the qualitative synthesis. In general, the recommendations provided by the CPG/BPS were consistent despite the existence of some gaps across the studies. The guidelines issued by the American Urological Association （AUA） and American Society for Reproductive Medicine （ASRM） did not provide evidence-based levels for the recommendations given. Most of the recommendations given by the European Association of Urology （EAU） and European Society of Pediatric Urology （ESPU） were derived from nonrandomized clinical trials, retrospective studies, and expert opinion. Among all CPG/BPS, only one was specifically designed for the pediatric population. The studied guidelines did not undertake independent cost-effectiveness and risk-benefit analysis. The main objectives of these guidelines were to translate the best evidence into practice and provide a framework of standardized care while maintaining clinical autonomy and physician judgment. However, the limitations identified in the CPG/BPS for the diagnosis and management of varicocele in children and adolescents indicate ample opportunities for research and future incorporation of higher quality standards in patient care.

关键词： adolescent best practice statements child clinical practice guidelines varicocele systematic review

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Use of testicular sperm for intracytoplasmic sperm injection in men with high sperm DNA fragmentation： a SWOT analysis

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Asian Journal of Andrology 2018年第1期20卷 1-8页

作者： Sandro C Esteves Matheus roque Nicolas Garrido ANDROFERT Andrology and Human Reproduction Clinic Referral Center for Male Reproduction Av. Dr. Heitor Penteado 1464 Campinas SP 13075-460 Brazil ORIGEN Center for Reproductive Medicine Rio de Janeiro Brazil Andrology Laboratory and Sperm Bank IVI Foundation Valencia Spain

Spermatozoa retrieved from the testis of men with high levels of sperm DNA fragmentation （SDF） in the neat semen tend to have better DNA quality. Given the negative impact of SDF on the outcomes of Assisted Reproductive Technology （ART）, an increased interest has emerged about the use of testicular sperm for intracytoplasmic sperm injection （Testi-ICSI）. In this article, we used a SWOT （strengths, weaknesses, opportunities, and threats） analysis to summarize the advantages and drawbacks of this intervention. The rationale of Testi-ICSI is bypass posttesticular DNA fragmentation caused by oxidative stress during sperm transit through the epididymis. Hence, oocyte fertilization by genomically intact testicular spermatozoa may be optimized, thus increasing the chances of creating a normal embryonic genome and the likelihood of achieving a live birth, as recently demonstrated in men with high SDF. However, there is still limited evidence as regards the clinical efficacy of Testi-ICSI, thus creating opportunities for further confirmatory clinical research as well as investigation of Testi-ICSI in clinical scenarios other than high SDF. Furthermore, Testi-ICSI can be compared to other laboratory preparation methods for deselecting sperm with damaged DNA. At present, the available literature supports the use of testicular sperm when performing ICSI in infertile couples whose male partners have posttesticular SDF. Due to inherent risks of sperm retrieval, Testi-ICSI should be offered when less invasive treatments for alleviating DNA damage have failed. A call for continuous monitoring is nonetheless required concerning the health of generated offspring and the potential complications of sperm retrieval.

关键词： intracytoplasmic sperm injection male infertility sperm DNA fragmentation sperm retrieval SWOT analysis testicular sperm

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Outcome of varicocele repair in men with nonobstructive azoospermia： systematic review and meta-analysis

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Asian Journal of Andrology 2016年第2期18卷 246-253,J0005,J0006页

作者： Sandro C Esteves Ricardo Miyaoka Matheus roque Ashok Agarwal ANDROFERT Center for Male Reproduction Av. Dr. Heitor Penteado 1464 Campinas SP 13075-460 Brazil ORLGEN Center for Reproductive MedicineRio de Janeiro Aw Rodolfo de Amoedo 140 Rio de Janeiro RJ 22620-330 Brazil American Center for Reproductive Medicine 10681. Carnegie Avenue X-11Cleveland OH 44195 USA.

The objective of this systemic review was to evaluate the benefit of repairing clinical varicocele in infertile men with nonobstructive azoospermia （NOA）. The surgically obtained sperm retrieval rate （SRR） and pregnancy rates following assisted reproductive technology （ART） with the use of retrieved testicular sperm were the primary outcomes. The secondary outcomes included the presence of viable sperm in postoperative ejaculate to avoid the testicular sperm retrieval and pregnancy rates （both assisted and unassisted） using postoperative ejaculated sperm. An electronic search to collect the data was performed using the MEDLINE and EMBASE databases until April 2015. Eighteen studies were included in this systematic review and accounted for 468 patients who were diagnosed with NOA and varicocele. These patients were subjected to either surgical varicocele repair or percutaneous embolization. Three controlled studies evaluating sperm retrieval outcomes indicated that in patients who underwent varicocelectomy, SRR increased compared to those without varicocele repair （OR： 2,65; 95% Cl. 1.69-4.14; P 〈 0.001）. Although pregnancy rates with the use of testicular sperm favored the varicocelectomy group, results were not statistically significant （clinical pregnancy rate OR： 2.07; 95% CI： 0.92-4.65; P = 0.08; live birth rate OR： 2.19; 95% CI： 0.99-4.83; P = 0.05）. The remaining fifteen studies reported postoperative semen analysis results. In 43.9% of the patients （range： 20.8%-55.0%）, sperm were found in postoperative ejaculates. Pregnancy rates for unassisted and assisted （after IVF/ICSI） were 13.6% and 18.9% in the group of men with sperm in postoperative ejaculates, respectively. Our findings indicate that varicocelectomy in patients with NOA and clinical varicocele is associated with improved SRR. In addition, approximately 44% of the treated men will have enough sperm in the ejaculate to avoid sperm retrieval. Limited data on pregnancy outcomes with both postoperative

关键词： azoospermia male infertility meta-analysis sperm retrieval systematic review varicocele varicocelectomy

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Antimicrobial peptides as a feed additive alternative to animal production, food safety and public health implications: An overview

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Animal Nutrition 2021年第3期7卷 896-904页

作者： Raiza F.Silveira Cesar A.roque-Borda Eduardo F.Vicente Sao Paulo State University School of Agricultural and Veterinarian SciencesJaboticabalSao PauloBrazil Sao Paulo State University School of Sciences and EngineeringTupaSao PauloBrazil

In the last few years,feed additives have been used in animal nutrition to improve nutrient utilization,health parameters and animal ***,the use of antibiotics as feed additives has allowed the occurrence of antimicrobial resistance(AMR),which can bring as a consequence,an increase in the morbidity and mortality of diseases that were previously treatable with *** this context,antimicrobial peptides(AMP)have appeared as a promising strategy because they have multiple bio-logical activities and represent a powerful strategy to prevent the development of resistant *** the small number of studies applied in vivo,AMP appear as a potent alternative to the use of antibiotics in animal nutrition,due to an increase in feed efficiency and the prevention/treatment of some animal *** review discusses the problems associated with antimicrobial resistance and the use of AMP as a strong candidate to replace conventional antibiotics,mainly in the animal industry.

关键词： Additive Antimicrobial peptide Broiler Cattle Laying hen Pig

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The effects of habitat fragmentation on the reproduction and abundance of Angadenia berteroi

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Journal of Plant Ecology 2017年第2期10卷 340-348页

作者： Beyte Barrios roque Suzanne Koptur Jay P.Sah Plant Ecology Lab Department of Biological SciencesFlorida International University11200 SW 8th StMiamiFL 33199USA South Florida Terrestrial Ecosystems Lab Southeast Environmental Research CenterFlorida International University11200 SW 8th STMiamiFL 33199USA

Aims The pine rocklands of southern Florida are a fire-dependent forest associated with outcrops of *** rockland plants have sev-eral adaptations to fire,and for many species,burning increases plant growth,flowering and seedling *** pine rockland forest has been reduced and fragmented in recent *** of Everglades National Park,only 2%of the original pine rocklands remain,and they are in the form of small *** objective is to investigate the effects of fragmentation and habitat quality on abun-dance and plant reproductive fitness of Angadenia berteroi(A.D.C.)Miers,a threatened species of the southern Florida pine *** We estimated the density of plants using a stratified random sam-pling design,and reproductive fitness(in terms of percentage of plants with flowers and fruit)by walking transects in an array of habitat fragments of different sizes and degrees of isolation(distance to the nearest fragment)as well as in continuous *** equation modeling(SEM)was employed to investigate how *** reproductive fitness was affected by fragmentation and habitat *** Findings Habitat fragment size was correlated with the density of ***,but did not have a great impact on its reproductive ***,habitat quality represented by litter depth and subcan-opy cover had strong negative effects on the reproductive fitness of ***,suggesting that increased light availability and low litter cover resulting from recent fires may favor reproduction.

关键词： habitat fragmentation habitat quality isolation fire structural equation modeling reproductive fitness abundance

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TRANSIENT ANALYSIS OF COMPOSITE PLATES BY A LOCAL RADIAL BASIS FUNCTIONS-FINITE DIFFERENCE TECHIQUE

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Acta Mechanica Solida Sinica 2012年第1期25卷 22-36页

作者： C.M.C.roque D.Cunha A.J.M.Ferreira INEGI Faculdade de Engenharia da Universidade do PortoRua Dr.Roberto Frias Departamento de Engenharia Mecnica Faculdade de Engenharia da Universidade do PortoRua Dr.Roberto Frias

The use of local numerical schemes,such as finite differences produces much better conditioned matrices than global collocation radial basis functions ***,finite differ-ence schemes are limited to special *** scattered points,a combination of finite differences and radial basis functions would be a possible *** this paper,we use a higher-order shear deformation plate theory and a radial basis function-finite difference technique for predicting the transient behavior of thin and thick composite *** numerical experiments on beams and composite plates,the accuracy and efficiency of this collocation technique is demonstrated.

关键词： meshless beam composite plate

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Resveratrol effects on neural connectivity during aging

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Neural Regeneration Research 2016年第7期11卷 1067-1068页

作者： Gonzalo Flores Rubén Antonio Vázquez-roque Alfonso Diaz Instituto de fisiología Benemerita Universidad autónoma de Puebla.14 Sur 6301PueblaMexico Departamento de Farmacia Facultad de Ciencias químicasbenemérita Universidad autónoma de PueblaPueblaMexico

Aging has been considered a natural process of any living *** rate of aging depends on many factors,including genetic and environmental *** this reason,many researchers in this field suggest that aging is an epigeneti... 详细信息

关键词： resveratrol connectivity older hippocampus neuronal metabolism cortical Aging cortex PPAR

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