G protein-coupled estrogen receptor 1(GPER) activation triggers different signaling pathways on neurons and astrocytes

作     者：Claudio Roque Graca Baltazar 

作者机构：CICS-UBI - Health Sciences Research Centre University of Beira Interior Covilh. Portugal Faculty of Health Sciences University of Beira Interior Covilh. Portugal 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2019年第14卷第12期

页      面：2069-2070页

核心收录：

学科分类：10[医学] 

基　　金：supported by FCT-Foundation for Science and Technology(UID/Multi/00709/2019) by ‘‘Programa Operacional do Centro,Centro 2020” through the Funding of the ICON Project(Interdisciplinary Challenges On Neurodegeneration CENTRO-01-0145-FEDER-000013) 

主　　题：multiple tissues functions astrocytes 

摘      要：Estradiol (E2) is the most potent and prevalent form of estrogen, a well-known hormone that regulates multiple tissues and functions in humans. In the brain, E2 regulates processes as diverse as learning, memory, cognition, mood, as well as neurodevelopment and neurodegeneration. The actions of E2 are mediated by classical estrogen receptors (ERs;α and β), and by the G protein-coupled estrogen receptor 1 (GPER or GPR30)(Prossnitz and Arterburn, 2015). Classical ER are predominantly present in the nucleus and cytoplasm, with less than 2% present on the plasma membrane, and mediate genomic cellular effects that occur in the time frame of hours to days (Prossnitz and Arterburn, 2015).