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关注混合型高脂血症的基层长期管理

中华全科医师杂志 2024年第9期23卷 905-906页

作者：赵宇黄榕翀首都医科大学附属北京友谊医院心内科北京100050

该文针对《混合型高脂血症基层诊疗中国专家共识(2024年)》进行了评述,强调了管理混合型高脂血症在基层医疗卫生工作中的重要性,并概述了共识的关键内容,特别强调了生活方式调整和药物治疗以及治疗过程中监测与随访的重要性。共识旨在... 详细信息

该文针对《混合型高脂血症基层诊疗中国专家共识(2024年)》进行了评述,强调了管理混合型高脂血症在基层医疗卫生工作中的重要性,并概述了共识的关键内容,特别强调了生活方式调整和药物治疗以及治疗过程中监测与随访的重要性。共识旨在提升基层医疗卫生工作者对混合型高脂血症的管理能力,从而降低此类患者的心血管疾病风险,改善预后。

关键词：混合型高脂血症共识诊断治疗疾病管理基层

Focus on HFpEF in heart failure

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Chinese Medical Journal 2022年第9期135卷 1041-1042页

作者： Chunhui He rongchong huang Department of Cardiology Fuwai HospitalChinese Academy of Medical SciencesBeijing 100037China Department of Cardiology Beijing Friendship HospitalCapital Medical UniversityBeijing 100053China

There are so many of our patients who have had heart failure with preserved ejection fraction(HFpEF)and management really remains *** half of the patients with heart failure have preserved left ventrical(LV)systolic function and usually have some degree of diastolic *** with reduced or preserved systolic function may have similar symptoms and it may be difficult to distinguish clinically between the two based on signs and *** developed countries,coronary artery disease(CAD)with resulting myocardial infarction and loss of functioning myocardium(ischemic cardiomyopathy)is the most common cause of systolic heart *** hypertension remains an important cause of heart failure and,even more commonly in the United States,an exacerbating factor in patients with cardiac dysfunction because of other causes,such as *** processes may present with dilated or congestive cardiomyopathy,which is characterized by LV or biventricular dilation and generalized systolic *** causes of dilated cardiomyopathy include infiltrative diseases(hemochromatosis,sarcoidosis,and amyloidosis),other infectious agents,metabolic disorders,cardiotoxins,and medication *** heart diseases—particularly degenerative aortic stenosis and chronic aortic or mitral regurgitation—are frequent causes of heart *** tachycardia,often related to atrial arrhythmias,can cause systolic dysfunction that may be reversible with controlling the *** cardiac dysfunction is associated with aging and related myocardial stiffening,as well as left ventricular hypertrophy(LVH),commonly resulting from *** such as hypertrophic or restrictive cardiomyopathy,diabetes,and pericardial disease can produce the same clinical *** fibrillation with or without rapid ventricular response may contribute to impaired left ventricular filling.

关键词： Focus impaired preserved

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BMI对慢性心力衰竭的预后价值

临床心血管病杂志 2024年第3期40卷 194-198页

作者：赵灿王刚刘霄燕张娜黄榕翀首都医科大学附属北京友谊医院心内科北京100050

目的:探讨BMI与慢性心力衰竭(心衰)预后的关系。方法:回顾性收集2015年5月—2020年6月在首都医科大学附属北京友谊医院住院的315例慢性心衰患者的临床资料,并进行2年随访。根据BMI将患者分为低体重组(BMI≤18.5 kg/m~2)14例、正常体重组... 详细信息

目的:探讨BMI与慢性心力衰竭(心衰)预后的关系。方法:回顾性收集2015年5月—2020年6月在首都医科大学附属北京友谊医院住院的315例慢性心衰患者的临床资料,并进行2年随访。根据BMI将患者分为低体重组(BMI≤18.5 kg/m~2)14例、正常体重组(18.5 kg/m~2

关键词：心力衰竭 BMI 危险因素预后

Global and national burden of atherosclerosis from 1990 to 2019:trend analysis based on the Global Burden of Disease Study 2019

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Chinese Medical Journal 2023年第20期136卷 2442-2450页

作者： Weihua Chen Zeya Li Yu Zhao Yitian Chen rongchong huang Department of Cardiology Beijing Friendship HospitalCapital Medical UniversityBeijing 100053China Department of Cardiology Longyan First Affiliated Hospital of Fujian Medical UniversityLongyanFujian 364000China

Background:Atherosclerosis-related diseases represent significant health issues among adults *** their widespread impact,comprehensive data concerning the global and national burden and trends of these diseases remain *** objective is to examine the trends in the burden of atherosclerosis among adults from 1990 to 2019 at both global and national ***:We reported the average annual percentage changes(AAPCs)in prevalence,incidence,mortality,and disabilityadjusted life years(DALYs)of atherosclerosis-related diseases(ischemic heart disease[IHD],ischemic stroke,and peripheral arterial disease[PAD])at the global and national levels among individuals based on a trend analysis of the Global Burden of Diseases Study(GBD)*** further analyzed these global trends as a function of age,gender,and the social development *** also used joinpoint regression analysis to identify the year with the most substantial changes in global ***:Globally,the AAPC of IHD incidence rose from 1990 to 2019(0.20;95%confidence interval[CI],0.12-0.28),with substantial surges in 1995,2001,2005,2010,and ***,AAPC of IHD mortality rates exhibited a different trend until a rise in *** AAPC of incidence rates of ischemic stroke and PAD also escalated during the same period,with respective 0.43(95%CI,0.39-0.48)and 0.13(95%CI,0.06-0.21).For ischemic stroke,both incidence and mortality soared in 2014,while PAD incidence declined in 1994 and 1998,then sharply climbed in ***,the Northern Mariana Islands experienced the steepest increase in IHD and PAD incidence and mortality between 1990 and *** saw a significant rise in ischemic stroke incidence,whereas the highest mortality rate increase occurred in *** sociodemographic index(SDI)quintile,low-middle-,middle-,and high-middle-SDI countries all showed upward trends in IHD,ischemic stroke,and PAD ***,IHD and ischemic stroke mortality rates,as well

关键词： Atherosclerosis Disability-adjusted life years(DALYs) Global Disease Burden 2019 Incidence Mortality

Human umbilical cord blood mesenchymal stem cells conditioned media inhibits hypoxia-induced apoptosis in H9c2 cells by activation of the survival protein Akt

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BIOCELL 2020年第3期44卷 329-336页

作者： XUHE GONG GUANGPU FAN HUI LIU SIJIA WANG rongchong huang Department of Cardiology Beijing Friendship Hospital Affiliated to Capital Medical UniversityBeijing100190China Department of Cardiac Surgery Peking University People’s HospitalBeijing100190China Emergency Department Beijing Friendship Hospital Affiliated to Capital Medical UniversityBeijing100190China

This work aimed to study the beneficial role of human umbilical cord blood-derived mesenchymal stem cellconditioned medium(MSC-CM)in hypoxia-induced apoptosis in H9c2 cardiomyoblasts,in which the serine/heroine kinases(Akt)pathway would be *** this,CM was collected by culturing MSCs in serum-free DMEM medium for 24 h,and paracrine factors were analyzed by protein chip.H9c2 cells were divided into the following groups:control group,hypoxia group,MSC-CM intervention group(CM group),MSC-CM+Akt phosphorylation inhibitor(LY294002)group(LY group).Apoptosis of the H9c2 cells was tested with chromatin dye Hoechst 33342 and FITC-conjugated Annexin V apoptosis detection kit by flow cytometer after a hypoxia/serum deprivation(H/SD)for 24 *** apoptosis-related proteins were evaluated by Western ***-CM displayed significantly elevated levels of growth factors,anti-inflammatory,and anti-apoptosis *** Hoechst 33342 apoptosis staining,the H9c2 cell morphology displayed a lower proportion of apoptosis in the CM group than those in the hypoxia group,while apoptosis was increased in LY *** cytometer analysis revealed the apoptosis ratio in the CM group was lower than the hypoxia group(12.34±2.00%vs.21.73±2.58%,p<0.05),while the LY group was significantly higher(22.54±3.89%).Active caspase-3 expression was increased in hypoxia group than control group(p<0.05),but decreased in CM group(p<0.01).Umbilical cord blood-derived mesenchymal stem cell-conditioned media secrete multiple paracrine factors that are able to inhibit hypoxia-induced H9c2 cardiomyoblasts apoptosis,and in which the activation of Akt phosphorylation is involved to achieve the protective effect.

关键词： Umbilical cord blood mesenchymal stem cells paracrine actions H9c2 cells anti-apoptosis caspase-3 Akt

Exogenous dendritic cells aggravate atherosclerosis via P-selectin/PSGL-1 pathway

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BIOCELL 2020年第2期44卷 225-236页

作者： LEI ZHONG LEI GUO ZHISHUAI YE SHANFENG ZHANG rongchong huang Department of Cardiology The First Affiliated Hospital of Dalian Medical UniversityDalian116011China Cardiac Center/Division of Cardiovascular Diseases Beijing Friendship HospitalCapital Medical UniversityBeijing100050China Dalian Medical University Dalian Medical UniversityDalian116044China

Studies have found that a large number of inflammatory cells,P-selectin,and mature dendritic cells(DCs)are expressed in the damaged and shoulder parts of atherosclerotic plaque,which demonstrates that P-selectin and mature DCs participate in the immune inflammatory response leading to the development of ***,it is unclear how the above factors interact in this *** this study,we investigated the role of P-selectin and its receptor,P-selectin glycoprotein ligand(PSGL)-1 in atherosclerosis,with the finding that DC surface marker expression was consistently high in the P-selectin group while consistently low in the PGSL-1+DCs group,with CD40 and CD86 expressed by 3.84%and 2.05%for the *** highest expression of CD80,CD83,and MHC II was discovered in the DC group,at 7.49%,3.68%,and 8.98%,*** of this study are similar to those obtained previously by Ye et al.(2017),which showed larger atherosclerotic lesions in mice that received exogenous DCs,compared with those treated with *** this study,the greatest level of atherosclerosis,fibrosis,and lipid deposition was also seen in mice that received exogenous DCs.

关键词： Glycoprotein ligand Toll-like receptor 4 Coronary heart disease

Extracorporeal simulate oxidative stress of acute myocardial infarction to demonstrate the effect of Tenascin C on proliferation, migration and differentiation of mice bone marrow mesenchymal stem cells

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中国循环杂志 2016年第Z1期31卷 -页

作者： rongchong huang Mingyu Jin Shengnan Zhu Dai Liu The First Af iliated Hospitalof Dalian MedicalUniversity Dalian China

Objective In the microenvironment that extracorporeal hydrogen peroxide simulates oxidative stress of acute myocardial infarction, we investigate the effect of different concentration of tenascin-c on survival, migration and differentiated for bone marrow stem cells. And certify that whether tenascin-c exert biological effect via bonding to TLR-4 expressed on the cytomembrane of bone marrow stem cells and then activate MAPK, AKT, Wnt signaling pathway。[第一段]

关键词：蛋白激酶类干细胞骨髓间充质基质细胞心肌梗死氧化性应激移民(移出和移入) 腱糖蛋白小鼠

Association of blood pressure variability with target organ damage in older patients with essential hypertension

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Chronic Diseases and Translational Medicine 2023年第4期9卷 320-328页

作者： Zhiquan Jing Gang Wang Zeya Li Shanshan Wu Xiang Qiu rongchong huang Department of Cardiology Beijing Friendship HospitalCapital Medical UniversityBeijingChina Department of Clinical Epidemiology and EBM Beijing Friendship HospitalCapital Medical UniversityBeijingChina Department of Cardiology Beijing Fangshan First HospitalBeijingChina

Background:Although multiple measures of blood pressure variability(BPV)have been proposed,whether they are better than mean blood pressure in predicting target organs is *** aimed to determine the relationship between short term BPV and target organ ***:This study was a retrospective study,and 635 inpatients in the Department of Cardiology from 2015 to 2020 were *** divided participants into four groups on the basis of the quartiles of ***-way analysis of variance was used to compare the differences between the groups,and linear regression was used to analyze the relationship between BPV and target organ ***:The average age of 635 patients was 74.36±6.50 years *** them,354 of 627 patients had diminished renal function(56.5%),221of 604 patients had associated left ventricular hypertrophy(36.6%),and 227 of 231 patients had carotid plaque formation(98.3%).The baseline data indicated significant differences in fasting glucose,total cholesterol,low-density lipoprotein,creatinine,glomerular filtration rate,sex,calcium channel blocker use,and the rate of diminished renal *** linear regression analysis showed that BPV was negatively correlated with renal injury(creatinine:r=0.306,p<0.01;estimated glomerular filtration rate:r=0.058,p<0.01),and BPV is positively correlated with cardiac injury(r=0.083,p<0.01).Elevated BPV was not found to be associated with ***:Renal function decreases with increasing BPV and left ventricular mass increases with increasing BPV.

关键词： ambulatory blood pressure monitoring blood pressure variability hypertension target organ damage

QRS score:A simple marker to quantify the extent of myocardial scarring in patients with chronic total arterial occlusion

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Chronic Diseases and Translational Medicine 2022年第1期8卷 51-58页

作者： Hongzhou Guo Xuan Zhou Jiaying Xu Zhishuai Ye Lei Guo rongchong huang Cardiac Center Division of Cardiovascular DiseasesBeijing Friendship HospitalCapital Medical UniversityBeijing 100050China Department of Cardiology The First Affiliated Hospital of Dalian Medical UniversityDalianLiaoning 116011China

Background:Chronic total occlusion(CTO)is a critical and unique subgroup of coronary *** study aimed to investigate the correlation between the Selvester QRS score and late gadolinium enhancement cardiac magnetic resonance imaging(LGE-CMRI)in quantifying myocardial scarring to provide a simple and feasible method for treating ***:The medical records of 134 patients with absolute CTO who underwent coronary angiography between May 1,2014 and December 30,2017 were retrospectively *** patients were grouped according to the CTO location(right coronary artery[RCA]CTO,left artery descending[LAD]CTO,left circumflex[LCX]CTO,and multivessel CTO groups).The degree of myocardial scarring was determined according to the Selvester QRS score and using the *** patients were followed up for at least 12 ***:Among the 62 CTO patients,55 had occlusion of a single vessel and seven had occlusion of multiple vessels,of which 27(43.55%)were in the RCA CTO group,16(25.81%)in the LAD CTO group,12(19.35%)in the LCX CTO group,and 7(11.29%)in the multivessel CTO *** area under the receiver operating characteristic curve for the QRS score that was used to determine the degree of myocardial scarring was 0.806,with a sensitivity and specificity of 94.7%and 42.1%,*** Selvester QRS score and LGE-CMRI measures of scar size were correlated in the RCA CTO,LCX CTO,and multivessel CTO groups(r=0.466,0.593,and 0.775,respectively).Conclusion:The Selvester QRS score was feasible for detecting myocardial scarring in patients with CTO.

关键词： chronic total occlusion late gadolinium enhancement cardiac magnetic resonance imaging myocardial scar Selvester QRS score