Exogenous dendritic cells aggravate atherosclerosis via P-selectin/PSGL-1 pathway

作     者：LEI ZHONG LEI GUO ZHISHUAI YE SHANFENG ZHANG RONGCHONG HUANG 

作者机构：Department of CardiologyThe First Affiliated Hospital of Dalian Medical UniversityDalian116011China Cardiac Center/Division of Cardiovascular DiseasesBeijing Friendship HospitalCapital Medical UniversityBeijing100050China Dalian Medical UniversityDalian Medical UniversityDalian116044China 

出 版 物：《BIOCELL》 (生物细胞（英文）)

年 卷 期：2020年第44卷第2期

页      面：225-236页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：the National Natural Science Foundation of China(Grant Nos.81770340 81100220) 

主　　题：Glycoprotein ligand Toll-like receptor 4 Coronary heart disease 

摘      要：Studies have found that a large number of inflammatory cells,P-selectin,and mature dendritic cells(DCs)are expressed in the damaged and shoulder parts of atherosclerotic plaque,which demonstrates that P-selectin and mature DCs participate in the immune inflammatory response leading to the development of ***,it is unclear how the above factors interact in this *** this study,we investigated the role of P-selectin and its receptor,P-selectin glycoprotein ligand(PSGL)-1 in atherosclerosis,with the finding that DC surface marker expression was consistently high in the P-selectin group while consistently low in the PGSL-1+DCs group,with CD40 and CD86 expressed by 3.84%and 2.05%for the *** highest expression of CD80,CD83,and MHC II was discovered in the DC group,at 7.49%,3.68%,and 8.98%,*** of this study are similar to those obtained previously by Ye et al.(2017),which showed larger atherosclerotic lesions in mice that received exogenous DCs,compared with those treated with *** this study,the greatest level of atherosclerosis,fibrosis,and lipid deposition was also seen in mice that received exogenous DCs.