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Epidemiology and outcome of individuals with intraductal papillary neoplasms of the bile duct

World Journal of Gastrointestinal Oncology 2023年第5期15卷 843-858页

作者： rong-shou wu Wen-Jun Liao Jing-Sheng Ma Jia-Kun Wang Lin-Quan wu Ping Hou Department of Hepatobiliary and Pancreatic Surgery The Second Affiliated Hospital of Nanchang UniversityNanchang 330000Jiangxi ProvinceChina Department of Organ Transplantation The Second Affiliated Hospital of Nanchang UniversityNanchang 330000Jiangxi ProvinceChina Department of General Surgery The First Affiliated Hospital of Gannan Medical CollegeNo.23 Qingnian RoadZhanggong DistrictGanzhou 341000Jiangxi ProvinceChina

BACKGROUND Intraductal papillary neoplasm of the bile duct(IPNB)is a rare distinct subtype of precursor lesions of biliary *** is considered to originate from luminal biliary epithelial cells,typically displays mucin-hypersecretion or a papillary growth pattern,and results in cystic dilatation[1].IPNB develops anywhere in the intrahepatic and extrahepatic biliary tracts,and can occur in various pathological stages from low-grade dysplasia to invasive *** have similar phenotypic changes in the occurrence and development of all subtypes,and the prognosis is significantly better than that of traditional(nonpapillary)*** To evaluate the clinicopathological features of IPNB to provide evidence-based guidance for *** Invasive IPNB,invasive intraductal papillary mucinous neoplasm of the pancreas(IPMN),and traditional cholangiocarcinoma data for affected individuals from 1975 to 2016 were obtained from the Surveillance,Epidemiology,and End Results(SEER)*** percentage changes(APCs)in the incidence and incidence-based(IB)mortality were *** identified the independent predictors of overall survival(OS)and cancer-specific survival(CSS)in indivi duals with invasive *** The incidence and IB mortality of invasive IPNB showed sustained decreases,with an APC of-4.5%(95%CI:-5.1%to-3.8%)and-3.3%(95%CI:-4.1%to-2.6%)(P<0.001),*** decreases in incidence and IB mortality were seen for invasive IPMN but not for traditional *** OS and CSS for invasive IPNB were better than for invasive IPMN and traditional cholangiocarcinoma.A total of 1635 individuals with invasive IPNB were included in our prognosis *** most common tumor sites were the pancreaticobiliary ampulla(47.9%)and perihilar tract(36.7%),but the mucin-related subtype of invasive IPNB was the main type,intrahepatically(approximately 90%).In the univariate and multivariate Cox regression analysis,age,tum

关键词： Surveillance,Epidemiology,and End Results database Intraductal papillary neoplasms of the bile duct Subtype Annual percentage changes Prognosis

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PBX3 accelerates colorectal cancer cell proliferation and tumour progression through suppressing p53-induced apoptosis

PBX3 accelerates colorectal cancer cell proliferation and tu...

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中国生物化学与分子生物学会2020全国学术在线会议

作者： Arin Herkilini Wen-fang Li shou-rong wu Vivi Kasim The Key Laboratory of Biorheological Science and Technology Ministry of EducationCollege of BioengineeringChongqing University The111 Project Laboratory of Biomechanics and Tissue Repair College of BioengineeringChongqing University

Pre-B-cell leukemia transcription factor 3(PBX3) transcription factor is a member of the PBX family with the highly conserved homologous ***3 is involved in gastric cancer,colorectal cancer and prostate cancer;however,the detailed mechanism in promoting tumorigenesis remains to be ***,the role of PBX3 in apoptosis has not been widely ***,we found that PBX3 is highly expressed in colorectal cancer and closely related to ***3-silencing induces the expression of p21 and suppression of colorectal cancer cell proliferation as well as colony formation ***,p53 plays a critical role in PBX3 regulation of p21 *** chromatin immunoprecipitation and point mutation analysis in the predicted PBX3 binding site of the p53 promoter,we found that PBX3 directly binds to the p53 promoter and suppress its transcription,resulting in increased p53 expression in PBX3-silenced colorectal cancer ***,p53 is necessary for PBX3-induced regulation of *** together,our results not only describe a novel role for PBX3 in regulating the p53/p21 axis,but also underscoring its importance in promoting apoptosis.

关键词： pre-B-cell leukemia transcription factor 3(PBX3) p53 cyclin-dependent kinase inhibitor p21 apoptosis cell proliferation

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In vitro evaluation of a novel small-caliber vascular scaffold fabricated with acellular vascular matrix and Poly(Lactic-co-Glycolic Acid)

In vitro evaluation of a novel small-caliber vascular scaffo...

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第十届全国生物力学学术会议暨第十二届全国生物流变学学术会议

作者： Zhi-ling Xu Shao-xi Cai Li Yang Yong-gang Lv Li Zhong shou-rong wu Key Laboratory of Biorheological Science and Technology Ministry of EducationBioengineering CollegeChongqing University “111”Project Laboratory of Biomechanics and Tissue Repair Bioengineering CollegeChongqing University "111"Project Laboratory of Biomechanics and Tissue Repair Bioengineering CollegeChongqing University

More and more small-caliber synthetic prostheses are in demand for operations.A physiological and biochemical stability of the extracellular matrix plays a pivotal role for metabolism,function and adhesion of cells .Porcine collagen is a biologic scaffold which is most widely used for therapeutic applications due to its availability and its history of successful ***(Lactic-co-Glycolic Acid)(PLGA) exhibit a high degree of biocompatibility, better mechanical strength and degradation rate in the *** research is to fabricate a novel small-calibervascular graft,comprising acellular vascular matrix(AVM) of swine origin and *** mechanical or biological characterizations of AVM-PLGA were tested in vitro by methods of histological examina-

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Contribution of PHD2 to therapeutic angiogenesis through HIF-dependent and HIF-independent manner

Contribution of PHD2 to therapeutic angiogenesis through HIF...

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第十届全国生物力学学术会议暨第十二届全国生物流变学学术会议

作者： shou-rong wu Vivi Kasim Yang-he Huang Er-fu Liu Zhi-ling Xu Li Yang The "111 Project"Laboratory of Biomechanics and Molecular Medicine College of BioengineeringUniversity of Chongqing

Ischemia occurs when blood vessels in tissues are blocked,and affects hundreds of millions of people *** vascular diseases include peripheral arterial disease,inferior limb ischemia,ischemic heart, *** strategy so far aims to improve neovascularization in ischemic tissues by delivering angiogenic factor proteins or DNA vectors encoding *** make the cells well adaptive to low oxygen tension(hypoxia) the cellular hypoxic response includes various alterations in gene *** them Hypoxia-in-

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Gut microbiota shifts in hepatitis B-related portal hypertension after transjugular intrahepatic portosystemic shunt:Mechanistic and clinical implications

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World Journal of Gastroenterology 2025年第3期31卷 134-137页

作者： Qi-rong Jiang Da-wu Zeng Department of Hepatology Hepatology Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhou 350005Fujian ProvinceChina Department of Infectious Diseases The First Affiliated Hospital of Fujian Medical UniversityFuzhou 350004Fujian ProvinceChina

In this article,we provide commentary on the recent article by Zhao et *** focus on the shifts in the gut microbiota of patients with hepatitis B virus(HBV)-associated cirrhosis/portal hypertension(PH)following transjugular intrahepatic portosystemic shunt(TIPS)and the implications for understanding the mechanisms,diagnosis,and *** comparing the gut microbiota composition and dynamic changes before and after TIPS in patients with and without hepatic encephalopathy,the authors found an increase in non-probiotic bacteria in those who developed hepatic encephalopathy post-TIPS,with Morganella species present only in the hepatic encephalopathy *** gut microbiota changes post-TIPS among patients without the occurrence of hepatic encephalopathy suggest potential therapeutic benefits through prophylactic microbiome ***,the specific gut microbiota alterations may hold promise to predict the risk of hepatic encephalopathy in individuals undergoing TIPS for HBVrelated *** these promising findings,future studies are needed to address limitations,including a small sample size,a relatively short evaluation period for gut microbiota alterations,the absence of data on dynamic alterations in gut microbiota post-TIPS and their correlation with blood ammonia levels,and the lack of validation in animal *** conclusion,Zhao et al's study has shed new light on the link of gut microbiota with post-TIPS hepatic encephalopathy,potentially through the intricate gut-liver axis,and has important clinical implications for improving the management of patients with HBV-related PH.

关键词： Hepatitis B virus Cirrhosis Portal hypertension Hepatic encephalopathy Transjugular intrahepatic portosystemic shunt Gut microbiota

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Characteristics of gut microbiota dysbiosis in patients with colorectal polyps

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 13-21页

作者： Xian-rong wu Xiao-Hong He Yong-Fang Xie School of Life Health Information Science and Engineering Chongqing Post and Communications UniversityChongqing 400065China

This editorial,inspired by a recent study published in the World Journal of Gastrointestinal Oncology,covers the research findings on microbiota changes in various *** recurrent colorectal polyps,the abundances of Klebsiella,Parvimonas,and Clostridium increase,while those of Bifidobacterium and Lactoba-cillus *** dysbiosis may promote the formation and recurrence of *** microbial changes have also been observed in colorectal cancer,inflammatory bowel disease,autism spectrum disorder,and metabolic syndrome,indicating the role of increased pathogens and decreased probiotics in these *** the gut microbiota,particularly by increasing probiotic levels,may help prevent polyp recurrence and promote gut *** microbial intervention strategy holds promise as an adjunctive treatment for patients with colorectal polyps.

关键词： Recurrent colorectal polyps Gut microbiota dysbiosis Klebsiella Probiotics Intestinal inflammation Microbial intervention strategy

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Inhibiting ceramide synthase 5 expression in microglia decreases neuroinflammation after spinal cord injury

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Neural Regeneration Research 2025年第10期20卷 2955-2968页

作者： Wei Zhang Yubao Lu Ruoqi Shen Yingjie wu Chenrui Liu Xingxing Fang Liangming Zhang Bin Liu Limin rong Department of Spine Surgery The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina National Medical Products Administration(NMPA)Key Laboratory for Quality Research and Evaluation of Cell Products GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Quality Control of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Engineering and Technology Research of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina

Microglia,the resident monocyte of the central nervous system,play a crucial role in the response to spinal cord ***,the precise mechanism remains *** investigate the molecular mechanisms by which microglia regulate the neuroinflammatory response to spinal cord injury,we performed single-cell RNA sequencing dataset analysis,focusing on changes in microglial *** found that the MG1 subpopulation emerged in the acute/subacute phase of spinal cord injury and expressed genes related to cell pyroptosis,sphingomyelin metabolism,and neuroinflammation at high ***,we established a mouse model of contusive injury and performed intrathecal injection of siRNA and molecular inhibitors to validate the role of ceramide synthase 5 in the neuroinflammatory responses and pyroptosis after spinal cord ***,we established a PC12-BV2 cell co-culture system and found that ceramide synthase 5 and pyroptosis-associated proteins were highly expressed to induce the apoptosis of neuron *** ceramide synthase 5 expression in a mouse model of spinal cord injury effectively reduced ***,ceramide synthase 5-induced pyroptosis was dependent on activation of the NLRP3 signaling *** ceramide synthase 5 expression in microglia in vivo reduced neuronal apoptosis and promoted recovery of neurological ***2g7 formed a“bridge”between sphingolipid metabolism and ceramide synthase 5-mediated cell death by inhibiting the NLRP3 signaling ***,these findings suggest that inhibiting ceramide synthase 5 expression in microglia after spinal cord injury effectively suppressed microglial pyroptosis mediated by NLRP3,thereby exerting neuroprotective effects.

关键词： ceramide synthase 5 gasdermin D microglia neuroinflammation NLRP3 nuclear factor kappa B Pla2g7 pyroptosis sphingomyelin metabolism spinal cord injury

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BIBR1532 inhibits proliferation and metastasis of esophageal squamous cancer cells by inducing telomere dysregulation

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 214-225页

作者： Qin Wang Qing-rong Li Lei Xu Zi-Chun Yuan Xiao Liu Mao-Ju Tang Man Luo Xiao-wu Zhong Qiang Ma Xiao-Lan Guo Department of Clinical Laboratory Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina School of Laboratory Medicine&Translational Medicine Research Center North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina

BACKGROUND Esophageal squamous cell carcinoma(ESCC)is a malignant tumor with high morbidity and mortality,and easy to develop resistance to chemotherapeutic *** are DNA-protein complexes located at the termini of chro-mosomes in eukaryotic cells,which are unreplaceable in maintaining the stability and integrity of ***,an RNA-dependent DNA polymerase,play vital role in telomere length maintain,targeting telomerase is a promising therapeutic strategy for ***150 and KYSE410 cells were cultured and exposed to various concentrations of *** viability was assessed at 48 hours and 72 hours to determine the IC50 *** effects of BIBR1532 on ESCC cell proliferation,migration,and cellular senescence were evaluated using the cell counting kit-8 assay,plate colony formation assay,scratch assay,transwell assay,andβ-galactosidase staining,*** blotting was performed to detect the expression of RESULTS The IC50 values for KYSE150 and KYSE410 cells after 48 hours of BIBR1532 exposure were 48.53μM and 39.59μM,*** values decreased to 37.22μM and 22.71μM,respectively,following a longer exposure of 72 ***1532 exhibited dose-dependent effects on KYSE150 and KYSE410 cells,including decreased hTERT expression,inhibition of proliferation and metastasis,and induction of cellular ***,BIBR1532 upregulated the expression of the DDR protein,γ-H2AX,and activated the ataxia telangiectasia and Rad3-related protein(ATR)/check point kinase 1(CHK-1)and ataxia-telangiectasia mutated gene(ATM)/CHK2 ***1532 downregulated the expression of telomere-binding proteins,including telomeric-repeat binding factor 1(TRF1),TRF2,protection of telomeres 1,and TIN2-interacting protein *** a nude mouse xenograft model,BIBR1532 significantly suppressed tumor growth,reduced hTERT expression,and increasedγ-H2AX protein *** and eosin staining of various organs,including the heart,liver,s

关键词： Esophageal squamous cell carcinoma BIBR1532 Human telomerase reverse transcriptase DNA damage response Telomere-binding proteins

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Success of intravenous immunoglobulin and steroids in managing severe COVID-19 following lung transplantation:A case report

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World Journal of Transplantation 2025年第1期15卷 178-184页

作者： Yen-shou Kuo Kuan-Hsun Lin Ying-Yi Chen Yuan-Ming Tsai Ti-Hui wu Hsu-Kai Huang Tsai-Wang Huang Division of Thoracic Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114202Taiwan

BACKGROUND Coronavirus disease 2019(COVID-19)pneumonia with severe septic shock and acute respiratory distress syndrome(ARDS)are critical illnesses for patients following *** immunoglobulin(IVIG)plays a role in both immune support and inflammation control,especially in immunocompromised *** case report describes the first successful experience using IVIG and pulse steroids to manage this critical condition following lung *** SUMMARY A 65-year-old male patient reported a history of chronic obstructive pulmonary disease and poor lung function and received bilateral sequential lung ***,he developed COVID-19 pneumonia,severe septic shock,and *** recovered from this critical condition after empirical antibiotics administration and veno-venous extracorporeal membrane oxygenation,in addition to IVIG and pulse *** IVIG is a valuable adjunct in managing severe sepsis in lung transplant recipients after COVID-19 *** aim,for the first time,to report the success of such a management approach for COVID-19 ARDS and sepsis in the post-lung transplant *** further investigations,this is a starting point for wider analysis of such an approach in this setting and consequently helps guide clinical practice for such a challenging patient population moving forward.

关键词： COVID-19 Septic shock Intravenous immunoglobulin Lung transplantation Post-transplant complications Case report

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Trends of alkaline phosphatase to prealbumin ratio in patients with hepatitis B linked to hepatocellular carcinoma development

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World Journal of Gastroenterology 2025年第2期31卷 42-51页

作者： Wen-Chong Zhen Jing Sun Xue-Ting Bai Qian Zhang Zi-Han Li Yi-Xin Zhang rong-Xuan Xu Wei wu Zhi-Han Yao Chun-Wen Pu Xiao-Feng Li School of Public Health Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Graduate School Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Dalian Public Health Clinical Center Dalian Municipal Research Institute for Public HealthDalian 116001Liaoning ProvinceChina Department of Epidemiology and Health Statistics Dalian Medical UniversityDalian 116044Liaoning ProvinceChina

BACKGROUND Chronic hepatitis B often progresses silently toward hepatocellular carcinoma(HCC),a leading cause of mortality *** detection of HCC is crucial,yet *** To investigate the role of dynamic changes in alkaline phosphatase to prealbumin ratio(APR)in hepatitis B progression to *** Data from 4843 patients with hepatitis B(January 2015 to January 2024)were *** incidence rates in males and females were compared using the log-rank *** were evaluated using Kaplan–Meier *** Linear Mixed-Effects Model was applied to track the fluctuation of APR levels over ***,Joint Modeling of Longitudinal and Survival data was employed to investigate the temporal relationship between APR and HCC *** The incidence of HCC was higher in *** ensure the model’s normality assumption,this study applied a logarithmic transformation to APR,yielding *** levels were higher in females(t=5.26,P<0.01).A 1-unit increase in ratio correlated with a 2.005-fold higher risk of HCC in males(95%CI:1.653-2.431)and a 2.273-fold higher risk in females(95%CI:1.620-3.190).CONCLUSION Males are more prone to HCC,while females have higher APR *** no baseline APR link,rising APR indicates a higher HCC risk.

关键词： Alkaline phosphatase to prealbumin ratio Chronic hepatitis B patients Hepatocellular carcinoma Retrospective cohort study Linear Mixed-Effect Mode Joint Modelling of Longitudinal and Survival data

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