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Molecular Plant 2012年第4期5卷 948-950页

作者： Joanna K. Polko Mohamed-Ramzi Temanni Martijn van Zanten Wilbert van Workum Sven Iburg ronald Pierik Laurentius A.C.J. Voesenek Anton J.M. Peeters Plant Ecophysiology Institute of Environmental Biology Utrecht University Padualaan 8 3584 CH Utrecht The Netherlands ServiceXS BV Plesmanlaan ld 2333 BZ Leiden The Netherlands Department of Cell Biology and Molecular Genetics Maryland Pathogen Research Institute (MPRI) 3128 Biosciences Research Bldg University of Maryland College Park MD 20742 USA Molecular Plant Physiology Institute of Environmental Biology Utrecht University Padualaan 8 3584 CH Utrecht The Netherlands

Dear Editor, Forward genetic screens are commonly used as unbiased tools to isolate genes responsible for a phenotype of interest. In Arabidopsis thaliana, especially T-DNA activation tagging pop- ulations are frequently employed. These populations are gener- ated using vectors containing multiple copies of the constitutive 35S promoters derived from cau and often result in isolation i flower mosaic virus （35S CaMV） of dominant gain-of-function alleles （Weigel et al., 2000; Nakazawa et al., 2003）. This allows the study of members of large gene families that are often func- tionally redundant and, therefore, hard to identify in loss-of- function screens. Moreover, due to the dominant nature,

关键词： T-DNA 激活标签拟南芥测序技术插入位点 35S启动子识别中国农业大学

High-quality-factor tantalum oxide nanomechanical resonators by laser oxidation of TaSe2

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Nano Research 2015年第9期8卷 2842-2849页

作者： Santiago J. CartamiI-Bueno Peter G. Steeneken Frans D. Tichelaar Efren Navarro-Moratalla Warner J. Venstra ronald van Leeuwen Eugenio Coronado Herre S.J. van der Zant Gary A. Steele Andres Castellanos-Gomez Kavli Institute of Nanoscience Delft University of Technology Lorentzweg 1 2628 CJ Delft The Netherlands Kavli Institute of Nanoscience Delft University of Technology National Centre for HREM Lorentzweg 1 2628 CJ Delft The Netherlands Instituto Ciencia Molecular (ICMol) Univ. Valencia C/Catedrdtico Jos@ Beltrdn 2 E-46980 Paterna Spain

Controlling the strain in two-dimensional （2D） materials is an interesting avenue to tailor the mechanical properties of nanoelectromechanical systems. Here, we demonstrate a technique to fabricate ultrathin tantalum oxide nanomechanical resonators with large stress by the laser oxidation of nano-drumhead resonators composed of tantalum diselenide （TaSe2）, a layered 2D material belonging to the metal dichalcogenides. Before the study of their mechanical properties with a laser interferometer, we verified the oxidation and crystallinity of the freely suspended tantalum oxide using high-resolution electron microscopy. We demonstrate that the stress of tantalum oxide resonators increases by 140 MPa （with respect to pristine TaSe2 resonators）, which causes an enhancement in the quality factor （14 times larger） and resonance frequency （9 times larger） of these resonators.

关键词： TaSe2,tantalum oxide,mechanical resonators,laser oxidation,optical interferometer,high quality factor

Laparoscopic hepatectomy reduces postoperative complications and hospital stay in overweight and obese patients

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World Journal of Gastrointestinal Surgery 2021年第1期13卷 19-29页

作者： Daniel Heise Jan Bednarsch Andreas Kroh Sandra Schipper Roman Eickhoff Marielle Coolsen ronald van Dam Sven Lang Ulf Neumann Florian Ulmer Department of Surgery and Transplantation University Hospital RWTH AachenAachen 52074Germany Department of Surgery Maastricht University Medical CenterMaastricht 6229 HXNetherlands

BACKGROUND Laparoscopic liver surgery is currently considered the standard of care for various liver ***,studies focusing on perioperative outcome after laparoscopic hepatectomy(LH)in overweight patients are still sparse and its benefit compared to open hepatectomy(OH)is a matter of *** To analyze postoperative outcomes in overweight[body mass index(BMI)over 25 kg/m²]and obese(BMI over 30 kg/m²)patients undergoing LH and compare postoperative outcome with patients undergoing *** Perioperative data of 68 overweight(BMI over 25 kg/m²)including a subcohort of obese(BMI over 30 kg/m²)patients(n=27)who underwent LH at our institution between 2015 and 2019 were retrospectively analyzed regarding surgical outcome and compared to an equal number of patients undergoing *** The mean BMI was 29.8±4.9 kg/m2 in the LH group and 29.7±3.6 kg/m2 in the OH group with major resections performed in 20.6%(LH)and 26.5%(OH)of cases,*** time(194±88 min vs 275±131 min;P<0.001)as well as intensive care(0.8±0.7 d vs 1.1±0.8 d;P=0.031)and hospital stay(7.3±3.6 d vs 15.7±13.5 d;P<0.001)were significant shorter in the LH ***,overall complications(20.6%vs 45.6%;P=0.005)and major complications(1.5%vs 14.7%,P=0.002)were observed less frequently after *** additional investigation analyzing the subgroup of obese patients who underwent LH(n=27)and OH(n=29)showed a shorter operative time(194±81 min vs 260±137 min;P=0.009)and a reduced length of hospitalization(7.7±4.3 d vs 17.2±17 d;P<0.001)but no difference in postoperative complications or overall *** LH is safe and cost-effective in overweight and obese ***,LH is significantly associated with fewer postoperative complications and reduced hospital stay compared to OH in these patients.

关键词： Laparoscopic hepatectomy Obesity Overweight Morbidity Postoperative outcome Cost

Hyperactive learning for data-driven interatomic potentials

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npj Computational Materials 2023年第1期9卷 599-612页

作者： Cas van der Oord Matthias Sachs Dávid Péter Kovács Christoph Ortner Gábor Csányi University of Cambridge Cambridge CB21PZUK University of Birmingham Birmingham B152TTUK University of British Columbia VancouverBC V6T 1Z2Canada

Data-driven interatomic potentials have emerged as a powerful tool for approximating ab initio potential energy *** most time-consuming step in creating these interatomic potentials is typically the generation of a suitable training *** aid this process hyperactive learning(hal),an accelerated active learning scheme,is presented as a method for rapid automated training database *** adds a biasing term to a physically motivated sampler(*** dynamics)driving atomic structures towards uncertainty in turn generating unseen or valuable training *** proposed hal framework is used to develop atomic cluster expansion(ACE)interatomic potentials for the AlSi10 alloy and polyethylene glycol(PEG)polymer starting from roughly a dozen initial *** hal generated ACE potentials are shown to be able to determine macroscopic properties,such as melting temperature and density,with close to experimental accuracy.

关键词： starting generating consuming

Fibroadhesive scarring of grafted collagen scaffolds interferes with implant–host neural tissue integration and bridging in experimental spinal cord injury

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Regenerative Biomaterials 2019年第2期6卷 75-87页

作者： Haktan Altinova Sebastian Hammes Moniek Palm Jose Gerardo-Nava Pascal Achenbach ronald Deumens Emmanuel Hermans Tobias Fuhrmann Arne Boecker Sabien Geraldine Antonia van Neerven Ahmet Bozkurt Joachim Weis Gary Anthony Brook Department of Neurosurgery RWTH Aachen University HospitalAachenGermany Institute of Neuropathology RWTH Aachen University HospitalAachenGermany Police Headquarters Berlin Medical CommissionBerlinGermany Institute of Neuroscience Universite Catholique de LouvainBrusselsBelgium Donnelly Centre for Cellular&Biomolecular Research University of TorontoTorontoCanada Department of Hand- Plastic and Reconstructive SurgeryBurn Centre Trauma CentreBG Trauma Centre LudwigshafenUniversity of HeidelbergLudwigshafenGermany Department of Plastic Reconstructive and Hand SurgeryBurn CentreRWTH Aachen University HospitalAachenGermany Department of Plastic AestheticHand and Burn SurgeryHelios University Hospital WuppertalUniversity Witten/HerdeckeWuppertalGermany

Severe traumatic spinal cord injury(SCI)results in a devastating and permanent loss of function,and is currently an incurable *** is generally accepted that future intervention strategies will require combinational approaches,including bioengineered scaffolds,to support axon growth across tissue scarring and cystic ***,we demonstrated that implantation of a microporous type-I collagen scaffold into an experimental model of SCI was capable of supporting functional recovery in the absence of extensive implant–host neural tissue ***,we demonstrate the reactive host cellular responses that may be detrimental to neural tissue integration after implantation of collagen scaffolds into unilateral resection injuries of the adult rat spinal *** demonstrated scattered fibroblast-like cell infiltration throughout the scaffolds as well as the presence of variable layers of densely packed cells,the fine processes of which extended along the graft–host *** reactive astroglial or regenerating axonal profiles could be seen traversing this *** encapsulation-type behaviour around bioengineered scaffolds impedes the integration of host neural tissues and reduces the intended bridging role of the *** of the cellular and molecular mechanisms underpinning this behaviour will be pivotal in the future design of collagen-based bridging scaffolds intended for regenerative medicine.

关键词： spinal cord injury CNS-scarring type-I collagen scaffold astrogliosis fibrosis encapsulation

Nutritional Support of Dogs and Cats after Surgery or Illness

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Open Journal of Veterinary Medicine 2014年第4期4卷 44-57页

作者： ronald J. Corbee Wim J. S. van Kerkhoven Department of Clinical Sciences of Companion Animals Faculty of Veterinary Medicine Utrecht University Yalelaan Utrecht The Netherlands Viyo International NV Ijzerenpoortkaai 3 Antwerpen Belgium

Nutritional support early during the postoperative period or after onset of illness decreases the mortality rate and shortens the duration of hospitalization of dogs and cats. The preferred feeding route is dependent on the condition of the patient. If there are no contraindications, every patient must receive nutritional support, at least consistent with the resting energy requirement (RER). Several nutrients may be beneficial during healing and recovery from illness or surgery, but further research is needed to empirically certify the effects of these nutrients in critically ill patients.

关键词： Recovery Food Supplementation Nutrition Nutraceuticals

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烟道吸附剂多重污染物干涸、导管注入技术

烟道吸附剂多重污染物干涸、导管注入技术

中美工业锅炉先进技术研讨会

作者： Sid Nelson Jr. Richard Oehlberg ronald Landreth David van Stone

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胆道胆泥铸形物阻塞

中国普通外科杂志 2015年第8期24卷 1065-1066页

作者： Stefan HEM.Clermonts ronald M.van Dam 蔡权宇荷兰里赫特大学医学中心外科

62岁女性,因化脓性胆管炎来急诊科就诊。患者因结肠癌肝转移行左半肝切除,术后肝门区局部复发接受过放化疗。肝脏磁共振成像检查显示肝内多发液性区/脓肿,合并明显的肝内胆管扩张,因严重肝功能损伤接受了抗生素治疗和经皮穿刺引流。鉴... 详细信息

62岁女性,因化脓性胆管炎来急诊科就诊。患者因结肠癌肝转移行左半肝切除,术后肝门区局部复发接受过放化疗。肝脏磁共振成像检查显示肝内多发液性区/脓肿,合并明显的肝内胆管扩张,因严重肝功能损伤接受了抗生素治疗和经皮穿刺引流。鉴别诊断包括肿瘤局部复发或放疗后纤维化引起肝门区胆道梗阻。在治疗期间血清胆红素值不断上升。术中外科医生决定行胆肠吻合术。术中肝切开术后,见绿-褐色油灰状物质。胆管内大部分铸型被取出。

关键词：胆管阻塞铸形物黄疸胆管炎,化脓性

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食物过敏的定义、流行性、诊断及治疗

中华预防医学杂志 2015年第1期49卷 87-92页

作者： ronald van Ree Lars K. Poulsen Gary WK Wong Barbara K. Ballmer-Weber 高中山贾旭东 DepartmentsofExperimentalImmunologyandOtorhinolaryngology AcademicMedicalCenterUniversityofAmsterdamNetherland AllergyClinic CopenhagenUniversityHospitalatGentofteDenmark 香港中文大学公卫学院儿科系 AllergyUnit DepartmentofDermatologyUniversityHospitalZurichSwitzerland 浙江大学过敏研究中心卫生部食品安全风险评估重点实验室国家食品安全风险评估中心

食物过敏是异质性群体相关疾病，会通过一种或多种方式对多个器官造成影响。其反应的严重程度可从轻度的局部反应到全身性的过敏反应。从机制上来看，食物过敏是Th2细胞驱动的免疫紊乱疾病，食物特异性IgE是这种速发型不良反应的基础。... 详细信息

食物过敏是异质性群体相关疾病，会通过一种或多种方式对多个器官造成影响。其反应的严重程度可从轻度的局部反应到全身性的过敏反应。从机制上来看，食物过敏是Th2细胞驱动的免疫紊乱疾病，食物特异性IgE是这种速发型不良反应的基础。过敏的部位和症状并不一定相同。食物过敏常会与自身免疫性（如乳糜泻）和非免疫性（如乳糖不耐受）的其他食物不良反应相混淆。为了正确诊断食物过敏，需要详细了解患者病史，检测特异性IgE，并进行经口激发试验来确诊。一些辅助因素（如运动、药物和酒精）有助于诱发食物过敏，会进一步增加诊断的复杂性。以食物提取物为基础的诊断试验并不能反映症状的严重程度，而检测单个食物致敏原IgE的新一代分子诊断技术，则能够为临床医生和患者提供可靠的症状严重程度依据。分子诊断还有助于确定食物过敏是直接源于对食物的暴露还是间接源于花粉过敏（交叉反应）。流行病学调查表明，桃过敏在欧洲主要是源于对桃的食用，而在中国则是源于对艾蒿花粉的初级致敏。但这两种情况都是由来自同一家族的致敏原分子介导的。流行病学调查深入揭示了食物过敏的病因、流行性及其所包含的风险因素，为预防食物过敏提供了循证策略。过去的十年中，食物过敏在发达国家盛行。经济发展和城市化进程都被认为会导致食物过敏流行性的增加，而且饮食习惯不同，过敏的食物也不同。目前，分子变态反应学和生物技术正在开发安全的免疫治疗方法，有望能够减轻日益加重的食物过敏负担。一种使用低致敏性突变重组分子的免疫疗法已经开始进行第一阶段临床试验的评估。食物致敏原名单的不断完善为转基因食品致敏性的评估提供了坚实基础。

关键词：食物过敏流行病学诊断免疫治疗

Crystal Structures of Two New Monoprotonated Products of 1,4,7 trimethyl-1,4,7-triazacyclononane: （Me3〔9〕aneN3H）(SO3CF3) and （Me3〔9〕aneN3H）I

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Chinese Journal of Structural Chemistry 2000年第1期19卷 48-52页

作者： DENG Dao Lia * ZHANG Yan Hui a DAI Cong Yun a ZENG Hong a YAN Zhi Qing a YE Chang Qing a ronald Ha\|Ge ba (Unilever Research SIOC, 354 Fenglin Road, Shanghai 200032. China) b (Unilever Research Laboratorium, Olivier van Noor Unilever Research SIOC 上海 2 0 0 0 32 Unilever Research Laboratorium 荷兰 Vlaardinge

Two new monoprotonated products of macrocyclic polyamine 1,4,7 trimethyl 1,4,7 triazacyclononane(Me 3〔9〕aneN 3), (Me 3〔9〕aneN 3H)(SO 3CF 3) 1 (C 10 H 22 N 3O 3SF 3, M r =321.36) and (Me 3〔9〕aneN 3H)I 2 (C 9H 22 N 3I, M r =299.20) were obtained by the reactions of Me 3〔9〕aneN 3 and yttrium triflate or ytterbium diiodide as the unexpected products. The crystal structures of compounds 1 and 2 have been determined. Crystal 1 is orthorhombic, space group P2 12 12 1(#19), a =12.609(3), b=13.531(1), c=9.225(3) , V=1573.9(7)  3, Z=4, D c= 1.356 g/cm 3, μ =2.47 cm -1 , F (000)=680 and R=0.052, R w =0.052 for 807 unique reflections with I>2σ(I) . Crystal 2 belongs to the orthorhombic system with space group P2 12 12 1(#19), a=11.417(2), b=13.099(3), c=8.762(2) , V=1310.5(4)  3, Z=4, D c =1\^516 g/cm 3, μ =24.14 cm -1 , F (000)=600 and R=0.035, R w =0.042 for 1427 unique reflections with I>3σ(I) . The two structures contain the same cyclic framework in which the acid proton is bonded to an amine nitrogen. This proton exhibits strong intramolecular hydrogen bonds with the other two nitrogen atoms. The methyl groups are directed away from the ring cavity. The bond distance between acid proton and an amine nitrogen in compound 2 is extremely short. The bond angles for 1 and 2 also exhibit obvious diversity inside of triazacyclononae.

关键词： formation crystal structure protonation triazacyclononane