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Kynurenine is an endothelium-derived relaxing factor produced during inflammation

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Kynurenine is an endothelium-derived relaxing factor produce...

Machine-learning driven global optimization of surface adsorbate geometries

中国生理学会第23届全国会员代表大会暨生理学学术大会

作者： Gavin McKenzie Paul K Witting Johannes-Peter Stasch Michael Hahn Dechaboon Changsirivathanathamrong Helen J Ball Shane R Thomas Vimal Kapoor David S Celermajer Andrew L Mellor John F Keaney,Jr Nicholas H Hunt roland stocker School of Medical Sciences University of New South WalesNSW 2052Australia School of Medical Sciences(Pathology)and Bosch Institute Faculty of MedicineUniversity of SydneyNSW 2006Australia Cardiovascular Research Bayer HealthCare WuppertalGermany Medicinal Chemistry Bayer HealthCareWuppertalGermany Centre for Vascular Research School of Medical Sciences(Pathology)and Bosch InstituteFaculty of MedicineUniversity of SydneyNSW 2006Australia Centre for Vascular Research University of New South WalesNSW 2052Australia School of Medicine and Pharmacology University of Western AustraliaPerth WA 6009Australia Royal Prince Alfred Hospital University of SydneyNSW 2006Australia Immunotherapy Center Medical College of GeorgiaAugusta GA 30912U.S.A

＜正＞Control of blood vessel tone is central to vascular *** we show that metabolism of tryptophan to kynurenine by indoleamine 2,3-dioxygenase（Ido） expressed in endothelial cells contributes to arterial vessel relaxation and the control of blood *** of mice with malarial parasites（Plasmodium berghei） or induction of endotoxemia in mice led to endothelial expression of Ido,decreased plasma tryptophan concentration, increased kynurenine concentration and *** inhibition of Ido increased blood pressure in systemically inflamed mice but not in mice deficient in Ido or interferon-γ,which is required for Ido *** tryptophan and kynurenine dilated preconstricted porcine coronary arteries;the dilating effect of tryptophan required the presence of active Ido and an intact endothelium,whereas the effect of kynurenine was endothelium *** arterial relaxation induced by kynurenine was mediated by activation of the adenylate and soluble guanylate cyclase *** administration decreased blood pressure in a dose-dependent manner in spontaneously hypertensive *** results identify tryptophan metabolism by Ido as a new pathway contributing to the regulation of vascular tone.

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npj Computational Materials 2023年第1期9卷 1196-1203页

作者： Hyunwook Jung Lena Sauerland Sina stocker Karsten Reuter Johannes T.Margraf Fritz-Haber-Institut der Max-Planck-Gesellschaft Faradayweg 4-6D-14195 BerlinGermany

The adsorption energies of molecular adsorbates on catalyst surfaces are key descriptors in computational catalysis *** the relatively large reaction intermediates frequently encountered,e.g.,in syngas conversion,a multitude of possible binding motifs leads to complex potential energy surfaces(PES),*** implies that finding the optimal structure is a difficult global optimization problem,which leads to significant uncertainty about the stability of many *** tackle this issue,we present a global optimization protocol for surface adsorbate geometries which trains a surrogate machine learning potential *** approach is applicable to arbitrary surface models and adsorbates and minimizes both human intervention and the number of required DFT calculations by iteratively updating the training set with configurations explored by the *** demonstrate the efficiency of this approach for a diverse set of adsorbates on the Rh(111)and(211)surfaces.

关键词： optimization global implies

治疗后早期MRI预测肝细胞癌放射性肝段切除术后的长期反应

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国际医学放射学杂志 2024年第2期 250-251页

作者： D.stocker M.J.King M.E.Homsi J.Gnerre B.Marinelli M.Wurnig 朱婉秋

摘要目的应用钇-90放射性肝段切除术治疗早期肝细胞癌（HCC）具有重要意义，然而治疗后MRI对疗效评估的价值尚不明确。旨在评估放射性肝段切除术后早期MRI疗

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The Ceneri Base Tunnel＂ Construction Experience with the Southern Portion of the Flat Railway Line Crossing the Swiss Alps

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Engineering 2018年第2期4卷 71-84页

作者： Davide Merlini Daniele stocker Matteo Falanesca Roberto Schuerch Pini Swiss Engineers Lugano 6900 Switzerland

本文总结了在修建15.4 km长切内里基线隧道(CBT)期间获得的经验,这条隧道为从北向南跨越瑞士阿尔卑斯山脉的平轨铁路线的南段。该项目由直径为9 m的双管组成,双管之间每隔325 m设置一个联络通道。在线路中部及其南端,应后勤和运营要求,... 详细信息

本文总结了在修建15.4 km长切内里基线隧道(CBT)期间获得的经验,这条隧道为从北向南跨越瑞士阿尔卑斯山脉的平轨铁路线的南段。该项目由直径为9 m的双管组成,双管之间每隔325 m设置一个联络通道。在线路中部及其南端,应后勤和运营要求,开挖了大型洞室。总开挖长度大约为40 km。隧道穿越阿尔卑斯山处的岩层由各种岩石类型和若干断层带组成。最大埋深达850 m。主隧道和联络通道的开挖通过钻爆法(D&B)进行。支护由锚杆、钢筋网、纤维增强喷射混凝土和(必要时的)钢拱架构成。为开挖进口隧洞,使用了敞开式隧道掘进机(TBM)。大埋深导致岩石受到挤压,这种状况的特征为在穿越较弱岩层时产生较大的各向异性收敛。较弱岩层要求安装可变形支护。在北洞口,隧道(断面增大)穿过A2高速公路(连接瑞士北部和南部的主要道路轴线)下方,此处埋深较小,且隧道通过的是软地层。为限制地表沉降,成功采用了垂直和近水平喷射灌浆与分部开挖相结合的方法。南洞门位于人口密集的市区。开挖自南洞门开始,包括一条约220 m长的明挖隧道,接着是不良岩层内大约300 m长的钻爆法开挖隧道。由于埋深非常小、岩石质量较差且穿越既有公路隧道(垂直距离仅为4 m)的要求很高,所以需要采用特殊开挖法,以及采用特种爆破技术以限制爆破引起的振动。在开挖过程中应用了全面风险管理程序,实施了密集的隧道外测量并根据遇到的地质条件调整了隧道设计,从而使开挖工程得以顺利完工。

关键词：隧道混凝土施工管理施工方案

Agenda Setting on FAIR Guidelines in the European Union and the Role of Expert Committees

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Data Intelligence 2022年第4期4卷 724-746,1046-1047页

作者： Misha stocker Mia Stokmans Mirjam van Reisen Research Advisors and Experts Europe 1000 VODAN-Africa Tilburg University P.O.Box 901535000the Netherlands Leiden University 1310 Leidenthe Netherlands Leiden University Medical Centre(LUMC) Leiden University1310 Leidenthe Netherlands

The FAIR Guidelines were conceptualised and coined as guidelines for Findable, Accessible, Interoperable and Reusable(FAIR) data at a conference held at the Lorentz Centre in Leiden in 2014. A relatively short period of time after this conference, the FAIR Guidelines made it onto the public policy agenda of the European Union. Following the concept of Kingdon, policy entrepreneurs played a critical role in creating a policy window for this idea to reach the agenda by linking it to the policy of establishing a European Open Science Cloud(EOSC). Tracing the development from idea to policy, this study highlights the critical role that expert committees play in the European Union. The permeability of the complex governance structure is increased by these committees, which allow experts to link up with the institutions and use the committees to launch new ideas. The High Level Expert Groups on the EOSC provided the platform from which the FAIR Guidelines were launched, and this culminated in the adoption of the FAIR Guidelines as a requirement for all European-funded science. As a result, the FAIR Guidelines have become an obligatory part of data management in European-funded research in 2020 and are now followed by other funders worldwide.

关键词： FAIR Guidelines EU expert committees Policy entrepreneurs Public agenda setting European Open Science Cloud EOSC

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Prix Ars Electronica

IPCC第五次评估报告第一工作组报告的亮点结论

2011年

作者： [editors] Hannes Leopoldseder Christine Schopf Gerfried stocker

来源：畅想之星图书光盘版（南... 评论

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气候变化研究进展 2014年第1期10卷 1-6页

作者：秦大河 Thomas stocker 中国科学院冰冻圈科学国家重点实验室兰州730000 中国气象局北京100081 University of Bern Bern 3012Switzerland

IPCC第h次评估报告（AR5）第一工作组（WGI）报告的亮点结论，是过去7年全世界气候变化科学研究成果凝练出来的精华。20世纪50年代以来全球气候变暖的一半以上是人类活动造成的。1971年以来人为排放温室气体产生热量的93％进入了海洋，... 详细信息

IPCC第h次评估报告（AR5）第一工作组（WGI）报告的亮点结论，是过去7年全世界气候变化科学研究成果凝练出来的精华。20世纪50年代以来全球气候变暖的一半以上是人类活动造成的。1971年以来人为排放温室气体产生热量的93％进入了海洋，海洋还吸收了大约30％人为排放的CO2，导致海表水pH值下降了0．1，等等。采用全球耦合模式比较计划第五阶段（CMIP5）的模式，预估未来全球气候变暖仍将持续，2l世纪宋全球平均地表温度往19862005年的基础上将升高0-3～4．8℃。限制气候变化需要大幅度持续减少温室气体排放。如果将18611880年以来的人为CO：累积排放控制在1000GtC，那么人类有超过66％的可能性把未来升温幅度控制征2℃以内（相对于1861-1880年）。

关键词：气候变化温室气体 IPCCAR5 WGI

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DRINKER of THE WIND

英语学习 1999年第1期 20-22页

作者： Joseph stocker 乐嘉辉

饮风之子:阿拉伯马,世界上最早的改良马品种,素以"耐力、骁勇、通人性"见称。这种马身材矮小而结实,毛色多样,以灰色为主。身高约152cm,体重360～450公斤。因快速、力强、体形美、温驯而受人珍爱。文中 he,the Arabian 均指阿拉伯马。

关键词：阿拉伯马 DRINKER of THE WIND

A Model of High-Speed Endovascular Sonothrombolysis with Vortex Ultrasound-Induced Shear Stress to Treat Cerebral Venous Sinus Thrombosis

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Research 2023年第1期2023卷 1-13页

作者： Bohua Zhang Huaiyu Wu Howuk Kim Phoebe J.Welch Ashley Cornett Greyson stocker Raul G.Nogueira Jinwook Kim Gabe Owens Paul A.Dayton Zhen Xu Chengzhi Shi Xiaoning Jiang Department of Mechanical&Aerospace Engineering North Carolina State UniversityRaleighNCUSA Department of Mechanical Engineering Inha University IncheonRepublic of Korea George W.Woodruff School of Mechanical Enginering Grgia lnstitute of TechnlogyAtlantaGAUSA Department of Biomedical Engineering University of Michigan Ann ArborMIUSA Department of Neurology Universityof Pittsburgh Medical CenterPttsburghPA USA Department of Biomedical Engineering University of North CarolinaChapel HillNCUSA Parker H.Petit Institute for Bioengineering and Bioscience Georgia Institute of TechnologyAtlantaGAUSA

This research aims to demonstrate a novel vortex ultrasound enabled endovascular thrombolysis method designed for treating cerebral venous sinus thrombosis(CVST).This is a topic of substantial importance since current treatment modalities for CVST still fail in as many as 20%to 40%of the cases,and the incidence of CvST has increased since the outbreak of the coronavirus disease 2019 *** with conventional anticoagulant or thrombolytic drugs,sonothrombolysis has the potential to remarkably shorten the required treatment time owing to the direct clot targeting with acoustic ***,previously reported strategies for sonothrombolysis have not demonstrated clinically meaningful outcomes(e.g.,recanalization within 30 min)in treating large,completely occluded veins or ***,we demonstrated a new vortex ultrasound technique for endovascular sonothrombolysis utilizing wavematter interaction-induced shear stress to enhance the lytic rate *** in vitro experiment showed that the lytic rate was increased by at least 64.3%compared with the nonvortex endovascular ultrasound treatment.A 3.1-g,7.5-cm-long,completely occluded in vitro 3-dimensional model of acute CVST was fully recanalized within 8 min with a record-high lytic rate of 237.5 mg/min for acute bovine clot ***,we confirmed that the vortex ultrasound causes no vessel wall damage over ex vivo canine *** vortex ultrasound thrombolysis technique potentially presents a new life-saving tool for severe CVST cases that cannot be efficaciously treated using existing therapies.

关键词： thrombolysis drugs vortex