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Evaluation of adverse events reported in Traditional Iranian Medicine following administration of aqueous extract of Herba Portulacae Oleraceae seed

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Journal of Traditional Chinese Medicine 2013年第4期33卷 535-537页

作者： Mehran Mirabzadeh Zahra Sahraee roja rahimi Department of Traditional Pharmacy Faculty ofTraditional MedicineTehran University of Medical Sciences Department of Clinical Pharmacy School of Pharmacy Shahid Beheshti University of Medical Sciences

OBJECTIVE: To find scientific reasons for adverse events reported in Traditional Iranian Medicine (TIM) following administration of aqueous extract of Herba Portulacae Oleraceae seed including itching and tingling of whole body, tachycardia, anxiety, dyspnea and severe nausea. METHODS: Electronic databases including PubMed, Scopus, and Web of Science were searched up to April 2013 to find papers focused on phytochemistry and biological activities of this plant. RESULTS: Among chemical constituents present in Herba Portulacae oleraceae, catecholamines, adenosine and niacin can cause adverse events similar to those reported inTIM. CONCLUSION: Because of the short duration of action of adenosine, catecholamines and niacin seems to be the major role in appearance of ad-verse events reported in TIM for Herba Portulacae Oleraceae seed. Mechanisms with consideration of receptor types and pharmacokinetics of catecholamine and niacin are warranted to confirm this hypothesis.

关键词： Portulaca oleracea Drug toxicity Catecholamines Niacin Medicine Iranian traditional

A review of the efficacy of traditional Iranian medicine forinflammatory bowel disease

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World Journal of Gastroenterology 2010年第36期16卷 4504-4514页

作者： roja rahimi Mohammad Abdollahi Mohammad Reza Shams-Ardekani Faculty of Traditional Medicine Tehran University of Medical SciencesTehran ***Iran Faculty of Pharmacy Pharmaceutical Sciences Research CenterEndocrinology and Metabolism Research InstituteTehran University of Medical SciencesTehran ***Iran

The etiology of inflammatory bowel disease(IBD) is not yet known,but many factors such as defects in the immune system,oxidative stress,microbial content in the gastrointestinal tract,nuclear factor(NF)-κB,nitric oxide(NO),cyclooxygenase-2(Cox-2),and leukotriene B4(LB4) are thought to play a role in its *** traditional Iranian medicine(TIM),several medicinal plants are thought to be effective for the treatment of *** this study,information on all of these remedies were derived from all available old sources such as documents or notes and books and were added to the information derived from modern medical databases covering all in vitro,in vivo and clinical *** some of these plants,only one or two mechanisms of action have been found such as in Cassia fistula,Lepidium sativum,and Bunium ***,for some plants various mechanisms of action are *** example,Commiphora mukul is effective in IBD due to its immunomodulatory,antioxidant,and antibacterial properties and it decreases NF-κB,NO and *** herb,Plantago ovata,has immunomodulatory,antioxidant,anti-inflammatory and wound healing activities and decreases NO and *** the mechanisms of action of these plants,the combination of some of them may be useful because of their many mechanisms of action such as Pistacia lentiscus,Bunium persicum,Solanum nigrum,Plantago ovata,Boswellia,Solanum nigrum,Plantago ovata and Commiphora *** some of the herbal products used in TIM such as oleogum resin from Commiphora myrrha,seeds of Ocimum basilicum,seeds of Linum usitatissimum,gum resin of Dracaena cinnabari,seeds of Plantago major,seeds of Lallementia royleana,and seeds of Allium porrum,there is no or not enough studies to confirm their benefits in *** is suggested that an evaluation of the effects of these plants on different aspects of IBD should be performed.

关键词： Herbal medicine Inflammatory bowel disease Medicinal plants Traditional Iranian medicine

Medicinal Properties of Foeniculum Vulgare Mill,in Traditional Iranian Medicine and Modern Phytotherapy

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Chinese Journal of Integrative Medicine 2013年第1期19卷 73-79页

作者： roja rahimi Mohammad Reza Shams Ardekani Department of Traditional Pharmacy Faculty of Traditional MedicineTehran University of Medical SciencesTehranIran Department of Pharmacognosy Faculty of PharmacyTehran University of Medical SciencesTehranIran

Foeniculum vu/gare Mill. （F. vu/gare）, commonly known as Fennel, is a popular medicinal plant with various pharmacological activities mentioned in traditional Iranian medicine （TIM） and modern phytotherapy such as antioxidant, cytotoxic, anti-inflammatory, antimicrobial, bronchodilatory, estrogenic, diuretic, lithontripic, galactogogue, emmenagogue, antithrombotic, hypotensive, gastroprotective, hepatoprotective, memory enhancing, and antimutagenic activities. No serious adverse events were recorded after ingestion of F. vu/gare except some cases of allergic reactions. The estrogenic activity of F. vu/gare brings some side effects such as decrease in protein concentration and acid and alkaline phosphatase in male genital organs, increase in weight of mammary glands and reproductive organs in women and premature thelarohe in girls. However, no evidence of teratogenicity was recorded, it is better not to use F. vulgare during pregnancy due to its estrogenic activity. Because of inhibition of cytochrome P450 3A4 （CYP3A4）, the pharmacokinetic parameters of drugs mainly metabolized by this isozyme may be affected by F. vu/gare. In addition, a significant interaction between cyprofloxacin and F. vu/gare was demonstrated. The aim of current paper is to review pharmacological properties, toxicity and adverse events, and drug interactions of ***/gare and brings conclusive results about the use of this plant in men, women and during pregnancy.

关键词： Foeniculum vulgare Mill. Fennel pharmacological activity traditional Iranian medicine modernphytotherapy

Effi cacy of tricyclic antidepressants in irritable bowel syndrome:A meta-analysis

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World Journal of Gastroenterology 2009年第13期15卷 1548-1553页

作者： roja rahimi Shekoufeh Nikfar Ali Rezaie Mohammad Abdollahi Pharmaceutical Sciences Research Center Tehran University of Medical Sciences Food & Drug Affairs and Food & Drug Laboratory Research CenterMinistry of Health & Medical Education Faculty of Medicine University of Alberta Faculty of Pharmacy and Pharmaceutical Sciences Research CenterTehran University of Medical Sciences

We aimed to evaluate the efficacy of tricyclic antidepressants(TCAs) as a therapeutic option for irritable bowel syndrome(IBS) through meta-analysis of randomized controlled *** the years 1966 until September 2008,PubMed,Scopus,Web of Science,and Cochrane Central Register of Controlled Trials were searched for double-blind,placebo-controlled trials investigating the effi cacy of TCAs in the management of *** randomized,placebo-controlled clinical trials met our criteria and were included in the *** used in the treatment arm of these trials included amitriptyline,imipramine,desipramine,doxepin and *** pooled relative risk for clinical improvement with TCA therapy was 1.93(95% CI:1.44 to 2.6,P<0.0001).Effect size of TCAs versus placebo for mean change in abdominal pain score among the two studies was -44.15(95% CI:-53.27 to -35.04,P<0.0001).It is concluded that low dose TCAs exhibit clinically and statistically signifi cant control of IBS symptoms.

关键词： Systematic review Meta-analysis Tricyclic antidepressants Irritable bowel syndrome Efficacy Clinical response Abdominal pain

Parsley: a review of ethnopharmacology, phytochemistry and biological activities

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Journal of Traditional Chinese Medicine 2013年第6期33卷 815-826页

作者： Mohammad Hosein Farzaei Zahra Abbasabadi Mohammad Reza Shams Ardekani roja rahimi Fatemeh Farzaei Faculty of Pharmacy Kermanshah University of Medical Science Department of Traditional Pharmacy Faculty ofTraditional MedicineTehran University of Medical Science Department of Pharmacognosy Faculty of Pharmacy Tehran University of Medical Science Department of Traditional Pharmacy Faculty of Traditional Medicine Tehran University of Medical Science College of Veterinary Medicine Kermanshah Razi University

OBJECTIVE:To summarize comprehensive information concerning ethnomedicinal uses, phytochemistry, and pharmacological activities of parsley. METHODS: Databases including PubMed, Scopus, Google Scholar, and Web of Science were searched for studies focusing on the ethnomedicinal use, phytochemical compounds and biological and pharmacological activities of parsley. Data were collected from 1966 to 2013. The search terms were: "Parsley" or "Petroselinum crispum" or "Petroseli-num hortence ". RESULTS: Parsley has been used as carminative, gastro tonic, diuretic, antiseptic of urinary tract, anti-urolithiasis, anti-dote and anti-inflammatory and for the treatment of amenorrhea, dysmenorrhea, gastrointestinal disorder, hypertension, cardiac disease, urinary disease, otitis, sniffle, diabetes and also various dermal disease in traditional and folklore medicines. Phenolic compounds and flavonoids particularly apigenin, apiin and 6"-Acetylapiin; essential oil mainly myristicin and apiol; and also coumarins are the active compounds identified in Petroselinum crispum. Wide range of pharmacological activity including antioxidant, hepatoprotective, brain protective, anti-diabetic, analgesic, spasmolytic, immunosuppressant, anti-platelet, gastroprotective, cytoprotective, laxative, estrogenic, diuretic, hypotensive, antibacterial and antifungal activities have been exhibited for this plant in modern medicine. CONCLUSION: It is expectant that this study resulted in improvement the tendencies toward Petroselinum crispum as a useful and important medicinal plant with wide range of proven medicinal activity.

关键词： Petroselinum Jafari Medicine, tradition-al Pharmacological processes Chemistry

Efficacy and safety of Hemoheal cream in patients with hemorrhoids:a randomized double-blind placebo controlled clinical trial

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Journal of Traditional Chinese Medicine 2021年第2期41卷 301-307页

作者： Mehdi Zobeiri Fatemeh Parvizi roja rahimi Fatemeh Heydarpour Hamid Reza Sheikhan Jafar Navabi Mohammad Hosein Farzaei Internal Medicine Department Imam Reza HospitalKermanshah University of Medical SciencesKermanshah ***Iran Pharmaceutical Sciences Research Center Kermanshah University of Medical SciencesKermanshah ***Iran Department of Traditional Pharmacy School of Persian MedicineTehran University of Medical SciencesTehran ***Iran Medical Biology Research Center Health Technology InstituteKermanshah University of Medical SciencesKermanshah ***Iran Clinical Research Development Center Imam Khomeini Hospital and Department of Internal MedicineKermanshah University of Medical SciencesKermanshah ***Iran Medical Technology Research Center Health Technology InstituteKermanshah University of Medical SciencesKermanshah ***Iran

OBJECTIVE:To evaluate the efficacy and safety of Hemoheal cream,an anti-hemorrhoid herbal preparation,(inspired by Persian medicine literatures in a double-blind,randomized placebo-controlled ***:Hemoheal cream consists of aqueous extract of Allium ampeloprasum L.,Commiphora mukul(*** Stocks)Engl and the oil of Sesamum indicum ***-two patients with symptomatic hemorrhoids were randomized to receive hemoheal cream or placebo for 3 *** patients were evaluated before and after the intervention in terms of the severity of anal irritation,bleeding,anal itching,pain,defecation discomfort and swelling sense,and overall subjective improvement(%),as well as any reported adverse ***:The results showed that after 3 weeks of treatment,distribution of anal irritation,bleeding,pain as well as swelling sense were significantly different(P0.05).Furthermore,a significant difference was observed between the overall subjective improvement of Hemoheal cream and placebo groups(P=0.012).One patient in the treatment group complained of rashes on the application ***:The present study showed a positive effect of Hemoheal cream in improving clinical signs and symptoms in patients with hemorrhoids.

关键词： Hemorrhoids Allium Commiphora Sesamum Medicine,Iranain traditional Controlled clinical trial

Traditional medical uses of Drimia species in terms of phytochemistry,pharmacology and toxicology

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Journal of Traditional Chinese Medicine 2017年第1期37卷 124-139页

作者： Mahbubeh Bozorgi Gholamreza Amin Maryam Shekarchi roja rahimi Department of Traditional Pharmacy School of Traditional MedicineTehran University of Medical SciencesTehran ***Iran Pharmaceutical Sciences Research Center Teh-ran University of Medical SciencesTehran ***Iran Department of Pharmacognosy Faculty of PharmacyTehran University of Medical SciencesTehran ***Iran Food and Drug Laboratory Research Center and Food and Drug Control Laboratories MOH and METehran ***Iran

Drimia genus includes plants that used from ancient time for various ailments such as dropsy, respiratory ailment, bone and joint complications,skin disorders, epilepsy and cancer. Toxic properties of some Drimia species also were noted by ancient scientists and these plants have been traditionally used for rat control. Bufadienolides have been identified as the main constituents in the genus of Drimia. Phenolics, sterols, protein and some of other phytochemicals have been also isolated from these plants. Pharmacological and clinical studies have strongly approved their effect on cardiovascular system. Extracts and compounds isolated from Drimia species showed biological activities such as antibacterial, antifungal, antiviral, antioxidant, anti-inflammatory and insecticidal effects throughseveral in vivo and in vitro studies. Moreover, cytotoxic and antitumor activities which may be related to bufadienolide content of these plants have been considered by many researchers. Traditional therapeutic values of these plants for treating respiratory and rheumatic ailments as well as skin disorders are needed to be validated through more researches. Toxic effects of these plants and isolated compounds have been investigated through several in vivo studies. Drimia plants and their isolated compounds have narrow therapeutic index, so patients should be prohibited from applying these plants without medical supervision and should be informed about the main intoxication symptoms before starting treatment. Moreover, interaction of Drimia plants with other constituents of traditional herbal mixtures as well as chemical and biological modalities for reducing toxicity of bufadienolide compounds can be subjected for future studies.

关键词： Urginea Ethnopharmacology Toxicolo-gy Cardiac glycosides

Role of dietary polyphenols in the management of peptic ulcer

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World Journal of Gastroenterology 2015年第21期21卷 6499-6517页

作者： Mohammad Hosein Farzaei Mohammad Abdollahi roja rahimi Faculty of Pharmacy Kermanshah University of Medical Sciences Faculty of Pharmacy and Pharmaceutical Sciences Research Center Tehran University of Medical Sciences Department of Traditional Pharmacy School of Traditional MedicineTehran University of Medical Sciences

Peptic ulcer disease is a multifactorial and complex disease involving gastric and duodenal *** medical advances,the management of peptic ulcer and its complications remains a challenge,with high morbidity and death rates for the *** accumulating body of evidence suggests that,among a broad reach of natural molecules,dietary polyphenols with multiple biological mechanisms of action play a pivotal part in the management of gastric and duodenal *** current review confirmed that dietary polyphenols possess protective and therapeutic potential in peptic ulcer mediated by:improving cytoprotection,re-epithelialization,neovascularization,and angiogenesis; up-regulating tissue growth factors and prostaglandins; down-regulating anti-angiogenic factors; enhancing endothelial nitric oxide synthasederived NO; suppressing oxidative mucosal damage; amplifying antioxidant performance,antacid,and antisecretory activity; increasing endogenous mucosal defensive agents; and blocking Helicobacter pylori colonization associated gastric morphological changes and gastroduodenal inflammation and *** addition,anti-inflammatory activity due to downregulation of proinflammatory cytokines and cellular and int e r c e llular adhe s ion age nt s,s uppr e s s ing leukocyte-endothelium interaction,inhibiting nuclear signaling pathways of inflammatory process,and modulating intracellular transduction and transcription pathways have key roles in the anti-ulcer action of dietary *** conclusion,administration of a significant amount of dietary polyphenols in the human diet or as part of dietary supplementation along with conventional treatment can result in perfect security and treatment of peptic *** welldesigned preclinical and clinical tests are recommended in order to recognize higher levels of evidence for the confirmation of bioefficacy and safety of dietary polyphenols in the management of peptic ulcer.

关键词： Anti-inflammatory Dietary supplement Helicobacter pylori Inflammatory cytokines Naturalmedicine Non-steroidal anti-inflammatory drugs Pepticulcer Polyphenols Ulcer healing

Induction of clinical response and remission of inflammatory bowel disease by use of herbal medicines:A meta-analysis

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World Journal of Gastroenterology 2013年第34期19卷 5738-5749页

作者： roja rahimi Shekoufeh Nikfar Mohammad Abdollahi Department of Traditional Pharmacy Faculty ofTraditional MedicineTehran University of Medical Sciences Pharmaceutical Sciences Research Center Tehran University of Medical Sciences Department of Pharmacoeconomics and Pharmaceutical Administration Faculty of PharmacyTehran University of Medical Sciences Food and Drug Organisation Ministry of Health and Medical Education Department of Toxicology and Pharma-cology Faculty of PharmacyTehran University of Medical Sciences

AIM:To evaluate the efficacy and tolerability of herbal medicines in inflammatory bowel disease(IBD)by conducting a ***:Electronic databases were searched for studies investigating efficacy and/or tolerability of herbal medicines in the management of different types of *** search terms were:"herb"or"plant"or"herbal"and"inflammatory bowel disease".Data were collected from 1966 to 2013(up to Feb).The"clinical response","clinical remission","endoscopic response","endoscopic remission","histological response","histological remission","relapse","any adverse events",and"seriousadverse events"were the key outcomes of *** used the Mantel-Haenszel,Rothman-Boice method for fixed effects and DerSimonian-Laird method for *** subgroup analyses,we separated the studies by type of IBD and type of herbal medicine to determine confounding factors and ***:Seven placebo controlled clinical trials met our criteria and were included(474 patients).Comparison of herbal medicine with placebo yielded a significant RR of 2.07(95%CI:1.41-3.03,P=0.0002)for clinical remission;a significant RR of 2.59(95%CI:1.24-5.42,P=0.01)for clinical response;a non-significant RR of 1.33(95%CI:0.93-1.9,P=0.12)for endoscopic remission;a non-significant RR of 1.69(95%CI:0.69-5.04)for endoscopic response;a non-significant RR of 0.64(95%CI:0.25-1.81)for histological remission;a non-significant RR of 0.86(95%CI:0.55-1.55)for histological response;a non-significant RR of 0.95(95%CI:0.52-1.73)for relapse;a non-significant RR of 0.89(95%CI:0.75-1.06,P=0.2)for any adverse events;and a non-significant RR of 0.97(95%CI:0.37-2.56,P=0.96)for serious adverse ***:The results showed that herbal medicines may safely induce clinical response and remission in patients with IBD without significant effects on endoscopic and histological outcomes,but the number of studies is limited to make a strong conclusion.

关键词： Herbal medicine Inflammatory bowel disease Efficacy Relapse Adverse events Meta-analysis