Effi cacy of tricyclic antidepressants in irritable bowel syndrome:A meta-analysis

作     者：Roja Rahimi Shekoufeh Nikfar Ali Rezaie Mohammad Abdollahi 

作者机构：Pharmaceutical Sciences Research CenterTehran University of Medical Sciences Food & Drug Affairsand Food & Drug Laboratory Research CenterMinistry of Health & Medical Education Faculty of MedicineUniversity of Alberta Faculty of Pharmacyand Pharmaceutical Sciences Research CenterTehran University of Medical Sciences 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2009年第15卷第13期

页      面：1548-1553页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Supported by National Science Foundation  Tehran 

主　　题：Systematic review Meta-analysis Tricyclic antidepressants Irritable bowel syndrome Efficacy Clinical response Abdominal pain 

摘      要：We aimed to evaluate the efficacy of tricyclic antidepressants(TCAs) as a therapeutic option for irritable bowel syndrome(IBS) through meta-analysis of randomized controlled *** the years 1966 until September 2008,PubMed,Scopus,Web of Science,and Cochrane Central Register of Controlled Trials were searched for double-blind,placebo-controlled trials investigating the effi cacy of TCAs in the management of *** randomized,placebo-controlled clinical trials met our criteria and were included in the *** used in the treatment arm of these trials included amitriptyline,imipramine,desipramine,doxepin and *** pooled relative risk for clinical improvement with TCA therapy was 1.93(95% CI:1.44 to 2.6,P0.0001).Effect size of TCAs versus placebo for mean change in abdominal pain score among the two studies was -44.15(95% CI:-53.27 to -35.04,P0.0001).It is concluded that low dose TCAs exhibit clinically and statistically signifi cant control of IBS symptoms.