Medicinal Properties of Foeniculum Vulgare Mill,in Traditional Iranian Medicine and Modern Phytotherapy

作     者：Roja Rahimi Mohammad Reza Shams Ardekani 

作者机构：Department of Traditional PharmacyFaculty of Traditional MedicineTehran University of Medical SciencesTehranIran Department of PharmacognosyFaculty of PharmacyTehran University of Medical SciencesTehranIran 

出 版 物：《Chinese Journal of Integrative Medicine》 (中国结合医学杂志（英文版）)

年 卷 期：2013年第19卷第1期

页      面：73-79页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：TheChineseJournalofIntegratedTraditionalandWesternMedicinePressandSpringer-VerlagBerlinHeidelberg2013 

主　　题：Foeniculum vulgare Mill. Fennel pharmacological activity traditional Iranian medicine modernphytotherapy 

摘      要：Foeniculum vu/gare Mill. （F. vu/gare）, commonly known as Fennel, is a popular medicinal plant with various pharmacological activities mentioned in traditional Iranian medicine （TIM） and modern phytotherapy such as antioxidant, cytotoxic, anti-inflammatory, antimicrobial, bronchodilatory, estrogenic, diuretic, lithontripic, galactogogue, emmenagogue, antithrombotic, hypotensive, gastroprotective, hepatoprotective, memory enhancing, and antimutagenic activities. No serious adverse events were recorded after ingestion of F. vu/gare except some cases of allergic reactions. The estrogenic activity of F. vu/gare brings some side effects such as decrease in protein concentration and acid and alkaline phosphatase in male genital organs, increase in weight of mammary glands and reproductive organs in women and premature thelarohe in girls. However, no evidence of teratogenicity was recorded, it is better not to use F. vulgare during pregnancy due to its estrogenic activity. Because of inhibition of cytochrome P450 3A4 （CYP3A4）, the pharmacokinetic parameters of drugs mainly metabolized by this isozyme may be affected by F. vu/gare. In addition, a significant interaction between cyprofloxacin and F. vu/gare was demonstrated. The aim of current paper is to review pharmacological properties, toxicity and adverse events, and drug interactions of ***/gare and brings conclusive results about the use of this plant in men, women and during pregnancy.