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Use of Microwave Radiances from Metop-C and Fengyun-3 C/D Satellites for a Northern European Limited-area Data Assimilation System

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Advances in Atmospheric Sciences 2021年第8期38卷 1415-1428页

作者： Magnus LINDSKOG Adam DYBBROE roger RANDRIAMAMPIANINA Swedish Meteorological and Hydrological Institute Folkborgsvägen 1760361 NorrköpingSweden Norwegian Meteorological Institute Henrik Mohns Plass 10371 OsloNorway

MetCoOp is a Nordic collaboration on operational Numerical Weather Prediction based on a common limited-area km-scale ensemble system. The initial states are produced using a 3-dimensional variational data assimilation scheme utilizing a large amount of observations from conventional in-situ measurements, weather radars, global navigation satellite system, advanced scatterometer data and satellite radiances from various satellite platforms. A version of the forecasting system which is aimed for future operations has been prepared for an enhanced assimilation of microwave radiances. This enhanced data assimilation system will use radiances from the Microwave Humidity Sounder, the Advanced Microwave Sounding Unit-A and the Micro-Wave Humidity Sounder-2 instruments on-board the Metop-C and Fengyun-3 C/D polar orbiting satellites. The implementation process includes channel selection, set-up of an adaptive bias correction procedure, and careful monitoring of data usage and quality control of observations. The benefit of the additional microwave observations in terms of data coverage and impact on analyses, as derived using the degree of freedom of signal approach, is demonstrated. A positive impact on forecast quality is shown, and the effect on the precipitation for a case study is examined. Finally, the role of enhanced data assimilation techniques and adaptions towards nowcasting are discussed.

关键词： data assimilation regional numerical weather prediction microwave radiances

Kinetic and morphology study of alginate-vineyard pruning waste biocomposite vs. non modified vineyard pruning waste for dye removal

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Journal of Environmental Sciences 2015年第12期27卷 158-167页

作者： Xanel Vecino Rosa Devesa-rey Salvador Villagrasa Jose M.Cruz Ana B.Moldes Chemical Engineering Department School of Industrial Engineering (EEI)University of VigoCampus As Lagoas-Marcosende Defense University Center Naval AcademyUniversity of Vigo Materials Engineering Department School of Industrial Engineering (EEI)University of VigoCampus As Lagoas-Marcosende

In this work a comparative bioadsorption study between a biocomposite consisting of hydrolysed vineyard pruning waste entrapped in calcium alginate spheres and non entrapped vineyard residue was carried *** have demonstrated that the biocomposite based on lignocellulose-calcium alginate spheres removed 77.3% of dyes,while non entrapped lignocellulose eliminated only removed 27.8% of colour *** experimental data were fitted to several kinetic models（pseudo-first order,pseudo-second order,Chien-Clayton model,intraparticle diffusion model and Bangham model）; being pseudo-second order the kinetic model that better described the adsorption of dyes onto both *** addition,a morphological study（roughness and shape） of alginate-vineyard biocomposite was established under extreme conditions,observing significant differences between hydrated and dehydrated alginate-vineyard *** techniques used to carry out this morphological study consisted of scanning electron microscopy（SEM）,perfilometry and 3D surface analysis.

关键词： Immobilized alginate-vineyard Dyes Kinetic studies Roughness Spherical shape

Science and Disaster Reduction

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International Journal of Disaster Risk Science 2010年第1期1卷 3-9页

作者： roger E.Kasperson Graduate School of Geography Clark University Worcester MA 01610 USA

A serious gap exists between science and disaster decision making, so that many scientific reports have little impact and fail to inform decision making. This article examines the complex linkages between science and disaster reduction, analyzing the barriers that prevent more effective use of science and suggesting how the gap between science and decision making may be narrowed.

关键词： disaster narrow decision

Nanoparticles for targeted cancer radiotherapy

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Nano Research 2020年第11期13卷 2887-2897页

作者： roger M.Pallares Rebecca J.Abergel Chemical Sciences Division Lawrence Berkeley National LaboratoryBerkeleyCA94720USA Department of Nuclear Engineering University of CaliforniaBerkeleyCA94720USA

Radiotherapy,where ionizing radiation is locally delivered either through an external beam or by surgically implanting radionuclide-based seeds in the tumor,is one of the gold standard treatments for *** to the non-selective nature of radiation,healthy tissue surrounding the cancerous region is usually affected by the ***,new strategies,including targeted alpha therapy,are being studied to improve the selectivity of the treatment and minimize side *** challenges,however,limit the current development of targeted radiotherapy,such as the functionalization of the therapeutic agent with targeting vectors and controlling the release of recoiling *** offer unique opportunities as drug delivery vehicles,since they are biocompatible,enhance the cellular uptake of drugs,and are easily functionalized with targeting *** this review,we examine how nanoparticles can be used for targeted radiotherapy,either as sensitizers of external beams or as delivery vehicles for therapeutic *** describe the clinical relevance of different types of nanoparticles,followed by an analysis of how these nanoconstructs can solve some of the main limitations of conventional ***,we critically discuss the current situation of nanoparticle-based radiotherapy in clinical settings and challenges that need to be overcome in the future for further development of the field.

关键词： radiotherapy targeted cancer radiotherapy nanoparticles cancer targeted alpha therapy external beam

Environmental insults:critical triggers for amyotrophic lateral sclerosis

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Translational Neurodegeneration 2017年第1期6卷 147-156页

作者： Bing Yu roger Pamphlett Sydney Medical School(Central) The University of SydneyCamperdownNSW 2006Australia Department of Medical Genomics Royal Prince Alfred Hospital and NSW Health PathologyCamperdownNSW 2050Australia Discipline of Pathology Brain and Mind CentreThe University of Sydney94 Mallett StCamperdownNSW 2050Australia Department of Neuropathology Royal Prince Alfred HospitalCamperdownNSW 2050Australia

Background:Amyotrophic lateral sclerosis(ALS)is a fatal neurodegenerative disease characterised by a rapid loss of lower and upper motor *** a complex disease,the ageing process and complicated gene-environment interactions are involved in the majority of *** body:Significant advances have been made in unravelling the genetic susceptibility to ALS with massively parallel sequencing technologies,while environmental insults remain a suspected but largely unexplored source of *** studies applying the strategy of Mendelian randomisation have strengthened the link between environmental insults and ALS,but none so far has proved *** propose a new ALS model which links the current knowledge of genetic factors,ageing and environmental *** model provides a mechanism as to how ALS is initiated,with environmental insults playing a critical ***:The available evidence has suggested that inherited defect(s)could cause mitochondrial dysfunction,which would establish the primary susceptibility to *** study of the underlying mechanism may shed light on ALS *** insults are a critical trigger for ALS,particularly in the aged individuals with other toxicant susceptible *** identification of ALS triggers could lead to preventive strategies for those individuals at risk.

关键词： Amyotrophic lateral sclerosis Environmental risk factors Mendelian randomisation Mitochondrial dysfunction Trigger Initiation Spread

Insights on the crosstalk between dendritic cells and helper T cells in novel genetic etiology for mendelian susceptible mycobacterial disease

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Cellular & Molecular Immunology 2018年第12期15卷 1091-1094页

作者： Emma rey-Jurado Magdalena S.Pizarro-Ortega Alexis M.Kalergis Millennium Institute on Immunology and Immunotherapy Departamento de Genética Molecular y MicrobiologíaFacultad de Ciencias BiológicasPontificia Universidad Católica de ChileSantiago 8330644Chile Departamento de Endocrinología Facultad de MedicinaPontificia Universidad Católica de ChileSantiago 8330644Chile

Mendelian susceptibility to mycobacterial disease(MSMD)is an inherited predisposition to infections by Bacille-Calmette Guérin(BCG)vaccine or by environmental *** etiology of MSMD has been associated with up to nineteen different genetic mutations in interferon(IFN)-γ-related genes.1 Although mycobacteria susceptibility-associated genetic mutations are rare in the population,their diagnosis is crucial for an efficient and timely *** et al.2 have recently described an autosomal recessive deficiency in the signal peptidase-like 2 A(SPPL2-a)as a new genetic etiology for MSMD in three patients that had suffered BCG dissemination disease.

关键词： mendelian susceptibility to mycobacterial disease SPPL2a deficiency cDC2 mycobacterial-specific priming IFN-γ

New Food Safety Law of China and the special issue on food safety in China

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Journal of Integrative Agriculture 2015年第11期14卷 2136-2141页

作者： Shu Geng LIU Xu roger Beachy Journal of Integrative Agriculture Chinese Academy of Agricultural Sciences Sino-US Joint Food Safety Research Center Northwest A&F University Chinese Academy of Engineering World Food Center University of California

1. IntroductionThere have been a number of serious incidents of compro- mised food safety in China in recent years. To list a few, these include： a Salmonella outbreak, the use of horse- meat in burgers, the illegal use of phthalates as a clouding agent, the contamination of formula milk by melamine, the meat scandal of Shanghai Husi Food Company which sold reprocessed stale meat to many fast food chains includ- ing McDonald＇s, Burger King, and KFC across theworld,

关键词： New Food Safety Law of China and the special issue on food safety in China FSMA

Transplantation of primary and reversibly immortalized human liver cells and other gene therapies in acute liver failure and decompensated chronic liver disease

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World Journal of Gastroenterology 2000年第5期6卷 636-642页

作者： Stephen M.Riordan roger Williams Institute of Hepatology University College London and University College London HospitalsLondonEngland Department of GastroenterologyThe Prince of Wales HospitalSydneyAustralia Institute of Hepatology University College London and University College London HospitalsLondonEngland

Studies performed in experimental small animalswith hepatic-based metabolic disorders but nostructural liver disease,including Gunn andanalbuminaemic rats and rabbits with inherited low-density lipoprotein receptor deficiency,have shownthat up to 95% of hepatocytes transplanted into thespleen or liver remain in these sites,withimprovement in metabolic function

关键词： liver failure acute liver diseases liver transplantation gene therapy animals laboratory transfering growth factor beta

Is it time to abandon the biological species concept? No

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National Science Review 2020年第8期7卷 1400-1401页

作者： roger K.Butlin Sean Stankowski Department of Animal and Plant Sciences University of Sheffield Department of Marine Sciences University of Gothenburg

The Oxford English Dictionary defines a concept as, ‘an idea of a class of objects, a general notion’. It follows from this definition that a concept cannot be rejected in the way that a hypothesis might be rejected if its predictions are inconsistent with observations. Instead, a concept must be judged by its heuristic value:does it help in making sense of the natural world?

关键词： GENOMICS