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World Journal of Transplantation 2024年第4期14卷 1-5页

作者： Cristian Lindner rodrigo San Martín Andrés Concha David Clemo Jorge Valenzuela Department of Radiology Faculty of MedicineUniversity of ConcepciónConcepción 4030000Chile Department of Radiology Hospital Regional Guillermo Grant BenaventeConcepción 4030000BiobíoChile

Liver transplantation(LT)remains the treatment of choice for early-stage hepato-cellular carcinoma(HCC)and offers the best long-term oncological ***,the increasing waiting list for LT has led to a significant dropout rate as patients experience tumor progression beyond the Milan ***,locoregional therapies,such as microwave ablation(MWA),have emerged as promising bridge treatments for patients awaiting *** therapies have shown promising results in preventing tumor progression,thus reducing the dropout rate of LT *** the efficacy of MWA in treating HCC,tumoral recurrence after ablation remains a major challenge and significantly impacts the prognosis of HCC ***,accurately diagnosing tumoral recurrence post-ablation is *** studies have developed novel imaging features based on magnetic resonance imaging of HCC,which could provide essential information for predicting early tumoral recurrence after *** advancements could address this unresolved challenge,improving the clinical outcomes of patients on the LT waiting *** article explored the current landscape of MWA as a bridge therapy for HCC within the Milan criteria,high-lighting the emerging role of novel imaging-based features aimed at improving the prediction of tumor recurrence after MWA.

关键词： Liver transplantation Hepatocellular carcinoma Ablation techniques Multiparametric magnetic resonance imaging Interventional oncology Liver disease Microwaves

Exercised blood plasma promotes hippocampal neurogenesis in the Alzheimer's disease rat brain

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Journal of Sport and Health Science 2024年第2期13卷 245-255页

作者： Cecilie Skarstad Norevik Aleksi M.Huuha Ragnhild N.RФsbjФrgen Linda Hildegard Bergersen Kamilla Jacobsen rodrigo Miguel-dos-Santos Liv Ryan Belma Skender Jose Bianco N.Moreira Asgeir Kobro-Flatmoen Menno P.Witter Nathan Scrimgeour Atefe R.Tari Cardiac Exercise Research Group(CERG) Department of Circulation and Medical ImagingNorwegian University of Science and Technology7491TrondheimNorway Department of Neurology and Clinical Neurophysiology St.Olavs University Hospital7030TrondheimNorway Institute of Oral Biology University of Oslo0372OsloNorway Department of Physiology Federal University of SergipeS~ao Cristov~ao49100-000SergipeBrazil Centre of Molecular Inflammation Research Department of Clinical and Molecular MedicineNorwegian University of Science and Technology7491TrondheimNorway Kavli Institute for Systems Neuroscience Centre for Neural Computationand Egil and Pauline Braathen and Fred Kavli Centre for Cortical MicrocircuitsNorwegian University of Science and Technology7030TrondheimNorway K.G.Jebsen Centre for Alzheimer’s Disease Norwegian University of Science and Technology7030TrondheimNorway

Background:Exercise training promotes brain plasticity and is associated with protection against cognitive impairment and Alzheimer’s disease(AD).These beneficial effects may be partly mediated by blood-borne *** we used an in vitro model of AD to investigate effects of blood plasma from exercise-trained donors on neuronal viability,and an in vivo rat model of AD to test whether such plasma impacts cognitive function,amyloid pathology,and ***:Mouse hippocampal neuronal cells were exposed to AD-like stress using amyloid-βand treated with plasma collected from human male donors 3 h after a single bout of high-intensity *** in vivo studies,blood was collected from exercise-trained young male Wistar rats(high-intensity intervals 5 days/week for 6 weeks).Transgenic AD rats(McGill-R-Thyl-APP)were inj ected 5 times/fortnight for 6 weeks at2 months or 5 months of age with either(a)plasma from the exercise-trained rats,(b)plasma from sedentary rats,or(c)*** function,amyloid plaque pathology,and neurogenesis were *** plasma used for the treatment was analyzed for 23 ***:Plasma from exercised donors enhanced cell viability by 44.1%(p=0.032)and reduced atrophy by 50.0%(p<0.001)in amyloid-β-treated *** vivo exercised plasma treatment did not alter cognitive function or amyloid plaque pathology but did increase hippocampal neurogenesis by~3 fold,regardless of pathological stage,when compared to saline-treated *** of 7 cytokines were significantly reduced in exercised plasma compared to sedentary ***:Our proof-of-concept study demonstrates that plasma from exercise-trained donors can protect neuronal cells in culture and promote adult hippocampal neurogenesis in the AD rat *** effect may be partly due to reduced pro-inflammatory signaling molecules in exercised plasma.

关键词： Cytokines High-intensity interval training Inflammation Neurons Plasma transfusion

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仿制药保卫战

商业周刊（中文版） 2024年第1期 54-57页

作者： Amy Maxmen rodrigo Oliveira(摄影) 王湛(译) 不详

小韦里亚诺·特尔托(Veriano TertoJr.)的办公室墙上挂着一些褪了色的海报,上面记录了艾滋病历史上的重要时刻。其中一张海报宣告巴西于1980年4月举行第一次同性恋者大会。另一张是1988年世界艾滋病日的宣传海报,印有地球图案,葡萄牙文... 详细信息

小韦里亚诺·特尔托(Veriano TertoJr.)的办公室墙上挂着一些褪了色的海报,上面记录了艾滋病历史上的重要时刻。其中一张海报宣告巴西于1980年4月举行第一次同性恋者大会。另一张是1988年世界艾滋病日的宣传海报,印有地球图案,葡萄牙文字环绕其间,意思是要消除歧视。

关键词：世界艾滋病日宣传海报仿制药同性恋者艾滋病葡萄牙保卫战

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高雄凯旋青树社会住宅

建筑实践 2024年第4期 68-71页

作者： Dick van Gameren rodrigo Louro Rachel Lin Mecanoo

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Work Ability Index and Work Ability Score: A Comparation between both Scores in a Persistent COVID-19 Cohort

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Occupational Diseases and Environmental Medicine 2024年第1期12卷 49-57页

作者： Carmen Muñoz-Ruiperez Diego Alvaredo rodrigo Daniel Arroyo-Sánchez Juan Francisco Álvarez Zarallo Ignacio Sánchez-Arcilla Conejo José Lorenzo Bravo Grande Department of Occupational Health Hospital Universitario 12 de Octubre Madrid Spain Instituto de Investigación Biomédica Hospital 12 de Octubre (Imas12) Madrid Spain Department of Occupational Health Hospital Universitario Virgen Macarena Andalucía Sevilla Spain Department of Occupational Health Hospital Universitario Gregorio Mara&#241ón Madrid Spain Department of Occupational Health Complejo Asistencial Universitario de Salamanca Castilla y León Salamanca Spain

Aims: The present study aims to compare the assessment of work ability based on the use of the Work Ability Index (WAI) with another questionnaire base only on the use of WAI’s first item, termed as the “Work Ability Score” (WAS). Study design: A cohort of 384 Spanish workers included in a Post COVID-19 condition or persistent COVID-19 multicenter research was utilized. Place and Duration of Study: This cohort was enlisted in four hospitals (Hospital Universitario 12 de Octubre, Madrid;Hospital Universitario Virgen Macarena, Sevilla, Andalucía;Hospital Universitario Gregorio Marañón, Madrid and Complejo Asistencial Universitario de Salamanca, Castilla y León), since 2021 until 2022. Methodology: 384 Spanish workers (176 men and 208 women;aged 20 to 70 years) with Post COVID-19 condition or persistent COVID-19 were included. Descriptive analysis of primary scores was conducted. Given the non-normal distribution of data, the Mann-Whitney and Kruskal-Wallis tests were employed. Spearman and Kendall correlations were employed to assess the relationship between WAI and WAS, also used weighted Kappa to estimate the degree agreement between WAI and WAS. Logistic regression models were utilized to study determinants influencing WAI and WAS, categorized as poor or moderate. Results: WAI had an average score of 32.98 (SD = 10.28), whereas WAS had an average of 5.95 (SD = 2.77). Significant differences were observed in both WAI and WAS across the same variables. Strong and statistically significant correlations were evident between WAI and WAS (rs = 0.83, p < 0.001). All the variables used in the logistic regression model (gender, the sector employment, and previous chronic diseases) were statistically significant in both questionnaires. Conclusion: WAS questionnaire could be used as a tool for reliable assessment of work ability among Spanish workers with Post COVID-19 condition or Persistent CO-VID-19.

关键词： Work Ability Index Work Ability Score Post COVID-19 Condition Occupational Health Occupational Medicine

Materials as activator of future global science and technology challenges

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Progress in Natural Science:Materials International 2021年第6期31卷 785-791页

作者： rodrigo Martins Full Professor at FCT-NOVA President of the International Union of Materials Research Societies President of the European Academy of Sciences

The aim of this statement is to give a contribution towards the future, where for all, materials are the driven force for the transformations we aim to reach and for which a global common house is imperative to be established, as the International Union of Materials Research Societies, IUMRS aims to be the central vehicle for such, aiming to boost innovation to its maxima, without compromising vital global principles of opening science to the *** is consolidated by 4 main principles: Circular Economy; Trans disciplinarity; Horizontal cross cutting synergy(the introduced Metro Station concept); look always to the Big Picture and not to silos. This means that the traditional vertical thematic topics that were essential to define so far, the so-called road maps for something should be revisited and reconverted towards much larger horizontal scenarios.

关键词： Materials science and engineering Green technologies and products Materials activator Materials accelerator of progress changes

Comparison of Surgical Techniques Used in Treating Acromioclavicular Dislocation in Patients Participating in Sports: A Systematic Review

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Open Journal of Orthopedics 2024年第1期14卷 41-52页

作者： Walter Hugo Brandão Nascimento Paulo Renan Matos Sucupira Cunha João Pedro Pimentel Abreu Lethycia Pereira Rosa Kamilly Iêda Silva Veigas rodrigo Martins Silva Caetano Orthopedic and Trauma Surgeon Brazilian Army Rio de Janeiro Brazil Orthopedic and Trauma Surgeon S&atildeo Luís Brazil Scholarship Holder National Council for Scientific and Technological Development (CNPq) S&atildeo Luís Brazil School of Medicine Federal University of Maranh&atildeo (UFMA) S&atildeo Luís Brazil Orthopedic and Trauma Surgeon Shoulder and Elbow Surgery Specialist University Hospital of the Federal University of Maranh&atildeo (HUUFMA/EBSERH) S&atildeo Luís Brazil

Introduction: The acromioclavicular joint is a superficial diarthrodial joint that surrounds the medial articular facet of the acromion and the distal portion of the clavicle. Due to its anatomy and biomechanics, it is highly susceptible to trauma and in young men who play contact sports, acromioclavicular dislocation is common. This article aimed to systematically review the literature and compare the surgical techniques used in the treatment of acromioclavicular dislocation in patients who practice sports. Methods: This systematic review was conducted according to the International Preferred Reporting Items for Systematic Review and Meta-Analyses guidelines. Eligible studies for this systematic review included articles in English or Spanish published between 2013 and 2023, which mention the occurrence of acromioclavicular dislocation during sports practices. Additionally, only studies that addressed the surgical treatment of acromion-clavicular dislocation and contained original data on the topic were included. Results: We found 144 eligible studies after searching the LILACS and PubMed databases. Based on the inclusion and exclusion criteria and the reviewers’ consensus, we selected four studies for the systematic review. 133 patients with AC joint displacement were evaluated. Mean Age: approximately 31.90 years. 81.92 of these injuries occurred during sports practice. Surgical Procedures Used: titanium plates fixation (49 patients), arthroscopy (24), single tunnel technique (30) and coracoid sling technique (30). The results of the visual analog scale and Constant-Murley scores varied between the techniques used. Twenty-two complications after surgical treatment were identified. Conclusion: A significant variability of operative techniques can be used in the surgical approach of acromioclavicular dislocation, such as arthroscopy, single tunnel, coracoid sling and titanium plates. Although it presented excellent functional results compared to the other three tech

关键词： Acromioclavicular Joint Shoulder Dislocation Surgical Procedure Postoperative Complications Postoperative Care

Concerns about the application of resistance exercise with blood-flow restriction and thrombosis risk in hemodialysis patients

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Journal of Sport and Health Science 2024年第4期13卷 548-558,F0003页

作者： Hugo de Luca Correa Lysleine Alves Deus Dahan da Cunha Nascimento Nicholas Rolnick rodrigo Vanerson Passos Neves Andrea Lucena Reis Thais Branquinho de Araujo Carmen Tzanno-Martins Fernanda Silveira Tavares Luiz Sinesio Silva Neto Claudio Avelino Rodrigues Santos Paolo Lucas Rodrigues-Silva Fernando Honorato Souza Vitoria Marra da Motta Vilalva Mestrinho Rafael Lavarini dos Santos Rosangela Vieira Andrade Jonato Prestes Thiago dos Santos Rosa Post-graduate Program of Physical Education Catholic University of BrasıliaBrasılia 71966-700Brazil The Human Performance Mechanic Lehman CollegeNew YorkNY 10011USA Clinical Group Home Dialysis Center and RenalClass Sao Paulo 01239-040Brazil Department of Medicine Catholic University of BrasıliaBrasılia 71966-700Brazil Faculty of Medicine Federal University of TocantinsTocantins 77001-090Brazil Embrapa Genetic Resources and Biotechnology Brasılia 70770-917Brazil Graduate Program of Genomic Sciences and Biotechnology Brasılia 71966-700Brazil

Background:Hemodialysis(HD) per se is a risk factor for *** the growing body of evidence on blood-flow restriction(BFR) exercise in HD patients,identification of possible risk factors related to the prothrombotic agent D-dimer is required for the safety and feasibility of this training *** aim of the present study was to identify risk factors associated with higher D-dimer levels and to determine the acute effect of resistance exercise(RE) with BFR on this ***:Two hundred and six HD patients volunteered for this study(all with a glomerular filtration rate of 70 years old),and HD ***,RE+BFR significantly increases D-dimer after 4 *** with borderline baseline D-dimer levels(400-490 ng/mL) displayed increased risk of elevating D-dimer over the normal range(≥500 ng/mL).Conclusion:These results identified factors associated with a heightened prothrombotic state and may assist in the screening process for HD patients who wish to undergo RE+BFR.D-dimer and/or other fibrinolysis factors should be assessed at baseline and throughout the protocol as a precautionary measure to maximize safety during RE+BFR.

关键词： Blood-flow restriction Chronic kidney disease Coagulation Hemodialysis Vascular occlusion exercises

Cross-talk between T-cells and gut-microbiota in neurodegenerative disorders

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Neural Regeneration Research 2019年第12期14卷 2091-2092页

作者： rodrigo Pacheco Departamento de Ciencias Biológicas Facultad de Ciencias de la Vida Universidad Andres Bello Laboratorio de Neuroinmunología Fundación Ciencia & Vida

The emerging role of gut microbiota as a key player in the development of neurodegenerative disorders: Mammals have evolved together with commensal microbiota to establish a symbiotic relationship in which they regulate reciprocally by synthesizing and responding to several common chemical substances. In this regard, gut microbiota constitutes a consortium of bacteria that not only participates in the degradation of nutrients, but also produces metabolites, fatty acids and neurotransmitters that can act on the enzymes and receptors expressed in eukaryotic cells, which considerably affects the physiology of the host and contribute to maintaining homeostasis (Lyte, 2013).

关键词： Cross-talk T-cells neurodegenerative disorders

The status of research and utilisation on the subtidal kelp along the Chilean coast:A literature review

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Acta Oceanologica Sinica 2022年第12期41卷 7-17页

作者： Simona Laukaityte rodrigo Riera School of Natural Sciences Macquarie UniversitySydney 2109Australia Groningen Institute for Evolutionary Life-Sciences University of GroningenGroningen 9747 AGthe Netherlands Biodiversity and Conservation Group(BIOCON) Instituto Universitario de Investigación en Acuicultura Sostenible y Ecosistemas Marinos(IU-ECOAQUA)Universidad de Las Palmas de Gran CanariaGran Canaria 35001Spain Departamento de Ecología Facultad de CienciasUniversidad Católica de la Santísima ConcepciónConcepción 2850Chile

The most important marine coastal ecosystem in the Chilean coast are kelp *** review is based on ecological studies regarding different aspects of subtidal kelp ecosystems along the Chilean *** highlights the most interesting findings in(1)biology of subtidal kelp in Chile,with particular reference to(2)habitats formed by kelp,and considered the successful examples and promising results in the(3)kelp as an industrial resource(Biotechnological approach of kelps and aquaculture).The impact caused by(4)El Niño-Southern Oscillation is discussed as an important climatic event that could help to forecast the future of the kelp *** addition,this literature review outlines the knowledge gaps on subtidal kelp along the Southeast Pacific Coast of Chile,so that research can be strengthened in the future.

关键词： kelp macroalgae harvesting commercial kelp subtidal SE Pacific Ocean