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Decoding complexity: the need to enhance precision and streamline spatial understanding in neuroscience

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Neural Regeneration Research 2025年第3期20卷 801-802页

作者： Sameehan Mahajani Armita Salahi Brenda gonzalez Charlotte Nelson Frank Hsiung Biology&Applications Division NodexusSan JoseCAUSA

Neuroscience is the ultimate frontier in our quest for a comprehensive understanding of human behavior. Since its launch in 2009, the Human Connectome Project has emerged as a pioneering force, making heroic strides i... 详细信息

关键词： behavior frontier dating

Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali Tfaily Firas Kobeissy Juanmarco Gutierrez gonzalez Daniel Refai Gerald R.Rodts Christian Mustroph David Gimbel Jonathan Grossberg Daniel L.Barrow Matthew F.Gary Ali M.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

Computing the topology of an arrangement of implicitly defined real algebraic plane curves~§

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第12期9卷 1685-1693页

作者： Jorge CARAVANTES Laureano gonzalez-VEGA Department of Mathematics Statistics and ComputationUniversity of CantabriaSantander39005CantabriaSpain

We introduce a new algebraic approach dealing with the problem of computing the topology of an arrangement of a finite set of real algebraic plane curves presented implicitly. The main achievement of the presented method is a complete avoidance of irrational numbers that appear when using the sweeping method in the classical way for solving the problem at hand. Therefore, it is worth mentioning that the efficiency of the proposed method is only assured for low-degree curves.

关键词： Topology computation Real plane curves Sweeping method

＂Takeaway＂ drug delivery： A new nanomedical paradigm

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Nano Research 2017年第7期10卷 2234-2243页

作者： Elena gonzalez-Domfnguez Benito Rodriguez-gonzalez Moises Perez-Lorenzo Miguel A. Correa-Duarte Department of Physical Chemistry Biomedical Research Center (CINBIO) and Southern Galicia Institute of Health Research (IISGS)Universidade de Vigo 36310 Vigo Spain

An alternative model to the well-established paradigm of the externally switchable drug delivery systems is herein proposed. In contrast to the on--off archetype, here the amount of released drug is pre-set by the application of an external stimulus, and is gradually released after the withdrawal of the exogenous signal. These attributes are achieved through an innovative approach featuring the integration of plasmonic nanovehicles in a polymer-based film. Such a platform is provided with optically responsive capabilities together with multiple diffusional barriers, allowing for an ＂on-demand＂ time-limited release where light acts as a therapeutic ＂starting shot＂. These nanoarchitectured depots have great potential as implantable drug delivery systems in clinical scenarios where a recurrent, sustained, and yet, on--off administration of medication is required. The application of these hybrid materials may extend the implementation of nanomedicine strategies beyond the point-of-care setting.

关键词： release plasmonic nanocapsule hydrogel near infrared (NIR)

Folate Metabolism Interferes with Plant Immunity through 1C Methionine Synthase-Directed Genome-wide DNA Methylation Enhancement

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Molecular Plant 2019年第9期12卷 1227-1242页

作者： Beatriz gonzalez Pablo Vera Instituto de Biologia Molecular y Celular de Plantas Universidad Politecnica de Valencia-C.S.I.CCiudad Politecnica de la InnovacionEdificio 8EIngeniero Fausto Elios/n.46022 ValenciaSpain

Plants rely on primary metabolism for flexible adaptation to environmental ***,through a combination of chemical genetics and forward genetic studies in Arabidopsis plants,we identified that the essential folate metabolic pathway exerts a salicylic acid-independent negative control on plant *** of the folate pathway promotes enhanced resistance to Pseudom onas syringae DC3000 via activation of a primed immune state in plants,whereas its implementation results in enhanced *** proteomics analysis using immune-defective mutants identified a methionine synthase(METS1),in charge of the synthesis of Met through the folate-dependent 1C metabolism,acting as a nexus between the folate pathway and plant *** of METS1 represses plant immunity and is accompanied by genome-wide global increase in DNA methylation,revealing that imposing a methylation pressure at the genomic level compromises plant *** together,these results indicate that the folate pathway represents a new layer of complexity in the regulation of plant defense responses.

关键词： folate pathway plant immunity methionine DNA methylation

Impact of emulated inertia from wind power on under-frequency protection schemes of future power systems

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Journal of Modern Power Systems and Clean Energy 2016年第2期4卷 211-218页

作者： Francisco Manuel gonzalez-LONGATT Loughborough University Loughborough LE652JGUK

Future power systems face several *** of them is the use of high power converters that decouple new energy sources from the AC power *** situation decreases the total system inertia affecting its ability to overcome system frequency *** wind power industry has created several controllers to enable inertial response on wind turbines generators:artificial,emulated,simulated,or synthetic *** paper deals with the issues related to the emulated inertia of wind turbines based on full-converters and their effect on the under-frequency protection schemes during the recovery period after system frequency disturbances *** main contribution of this paper is to demonstrate the recovery period of under-frequency transients in future power systems which integrate wind turbines with emulated inertia capability does not completely avoid the worse scenarios in terms of under-frequency load *** extra power delivered from a wind turbine during frequency disturbances can substantially reduce the rate of frequency *** it provides time for the active governors to respond.

关键词： Frequency controller Frequency stability Power system Protection scheme Wind turbine generator

A review of the current state of biofuels production from lignocellulosic biomass using thermochemical conversion routes

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Chinese Journal of Chemical Engineering 2019年第7期27卷 1523-1535页

作者： Paola Ibarra-gonzalez Ben-Guang Rong Department of Chemical Engineering Biotechnology and Environmental Technology University of Southern Denmark

The rapid increase in energy demand,the extensive use of fossil fuels and the urgent need to reduce the carbon dioxide emissions have raised concerns in the transportation *** renewable and sustainable sources have become the ultimate solution to overcome the expected depletion of fossil *** conversion of lignocellulosic biomass to liquid(BtL)transportation fuels seems to be a promising path and presents advantages over first generation biofuels and fossil ***,development of BtL systems is critical to increase the potential of this resource in a sustainable and economic *** of lignocellulosic BtL transportation fuels,such as,gasoline,diesel and jet fuel can be accomplished through various thermochemical processes and processing *** major steps for the production of BtL fuels involve feedstock selection,physical pretreatment,production of bio-oil,upgrading of bio-oil to transportation fuels and recovery of value-added *** present work is aiming to give a comprehensive review of the current process technologies following these major steps and the current scenarios of biomass to liquid facilities for the production of biofuels.

关键词： Biofuels Lignocellulosic biomass Process route Thermochemical conversion Upgrading Separation

PLANE WAVES NUMERICAL STABILITY OF SOME EXPLICIT EXPONENTIAL METHODS FOR CUBIC SCHRODINGER EQUATION

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Journal of Computational Mathematics 2016年第4期34卷 385-406页

作者： Begona Cano Adolfo gonzalez-Pachon Departamento de Matemdtica Aplicada Universidad de Valladolid IMUVA Paseo de Beldn 7 47011 VaUadolid Spain Departamento de Matemdtica Aplicada Universidad de Valladolid IMUVA Paseo de Beldn 7 47011 Valladolid Spain

Numerical stability when integrating plane waves of cubic SchrSdinger equation is thor- oughly analysed for some explicit exponential methods. We center on the following second- order methods： Strang splitting and Lawson method based on a one-parameter family of 2-stage 2nd-order explicit Runge-Kutta methods. Regions of stability are plotted and numerical results are shown which corroborate the theoretical results. Besides, a tech- nique is suggested to avoid the possible numerical instabilities which do not correspond to continuous ones.

关键词： Numerical stability Exponential splitting Lawson methods Projection ontoinvariant quantities Plane waves SchrSdinger equation.

SPLITTING SCHEMES FOR A NAVIER-STOKES-CAHN-HILLIARD MODEL FOR TWO FLUIDS WITH DIFFERENT DENSITIES

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Journal of Computational Mathematics 2014年第6期32卷 643-664页

作者： Francisco Guillen-gonzalez Giordano Tierra Departamento de Ecuaciones Diferenciales y Andlisis Numgrico and IMUS Universidad de Sevilla 41012 Seville Spain Department of Applied and Computational Mathematics and Statistics University of Notre Dame Notre Dame IN 46556 USA

In this work, we focus on designing efficient numerical schemes to approximate a ther- modynamically consistent Navier-Stokes/Cahn-Hilliard problem given in [3] modeling the mixture of two incompressible fluids with different densities. The model is based on a diffuse-interface phase-field approach that is able to describe topological transitions like droplet coalescense or droplet break-up in a natural way. We present a splitting scheme, decoupling computations of the Navier-Stokes part from the Cahn-Hilliard one, which is unconditionally energy-stable up to the choice of the potential approximation. Some nu- merical experiments are carried out to validate the correctness and the accuracy of the scheme, and to study the sensitivity of the scheme with respect to different physical pa- rameters.

关键词： Two-phase flow Diffuse-interface phase-field Cahn-Hilliard Navier-Stokes,Energy stability Variable density Mixed finite element Splitting scheme.