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Efficacy of Bee Products(Anzer Honey,Pollen and Propolis)in Detection and Healing of Damage Induced by Antidiabetic Drug Vildagliptin/Metformin Hydrochloride in Healthy Human Pancreatic Cells:Cytotoxic,Genotoxic and Biochemical Studies

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Current Medical Science 2023年第6期43卷 1173-1182页

作者： ÖzlemÖzdemir ZinetÇöl Ömer ertürk Department of Internal Medicine Faculty of MedicineOrdu UniversityOrdu52200Turkey Department of Molecular Biology and Genetics Faculty of Sciences and LettersOrdu UniversityOrdu52200Turkey

Background and Objective Although drugs are powerful therapeutic agents,they have a range of side *** side effects are sometimes cellular and not clinically ***/metformin hydrochloride is one of the most widely used oral antidiabetic drugs with two active *** this study,we investigated its harmful effects on the metabolic activation system in healthy human pancreatic cells“hTert-HPNE”,and we aimed to improve these harmful effects by natural *** benefit from the healing effect,we used the unique natural products produced by the bees of the Anzer Plateau in the Eastern Black Sea Region of *** Cytotoxic and genotoxic effects of the drug were investigated by different tests,such as MTT,flow cytometry-apoptosis and comet *** honey,pollen and propolis were analyzed by gas chromatography/mass spectrometry(G/C-MS).A total of 19 compounds were detected,constituting 99.9%of the *** The decrease in cell viability at all drug concentrations was statistically significant compared to the negative control(Prochloride with the supplementation of Anzer honey,pollen and propolis in hTert-HPNE cells(Pro.erties of natural products against the side effects of oral antidiabetics in human *** particular,Anzer honey,pollen and propolis can be used as additional foods to maintain cell viability and improve heal damage and can be evaluated against side effects in other drug studies.

关键词： cell viability hTert-HPNE Anzer bee products drug side effect diabetes mellitus

Participatory Risk Governance for Seoul,South Korea's Flood Risk Management

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International Journal of Disaster Risk Science 2024年第3期15卷 317-331页

作者： Bokjin ro Gregg Garfin School of Geography Development and EnvironmentThe University of ArizonaTucsonAZ85721USA Interdisciplinary Program for Disaster Crisis and Risk ManagementSungkyunkwan UniversitySuwonGyeonggi-do16419Republic of Korea School of Natural Resources and the Environment The University of ArizonaTucsonAZ85721USA

Risk governance is a widely used framework in natural and societal risk management *** from natural hazards in urban areas call for the establishment of rigorous and participatory urban risk *** this study,we examined participatory risk governance(PRG)of flood risk management(FRM)in Seoul,South *** conducted key informant interviews and implemented a survey with citizens,to explore perceptions of flood risks and risk management,and to examine prospects for improving PRG in *** found a gap between the perceptions of key informants and *** informants believed that citizens'low awareness of flood risks hinders *** our research found that citizens'risk awareness was not low,and risk awareness may not be the main barrier to participation in ***,we found that citizens lacked knowledge of FRM actions,and they assigned government bodies a high level of responsibility for FRM,compared to the level of responsibility that citizens assigned to ***,the actors involved in FRM tended not to trust each other,which implies a lack of mutual *** increase the eff ectiveness of PRG,we suggest a polycentric governance structure anchored by a leading actor group,and active promotion of the participation of actors at multiple levels of *** between government and citizen participants,designed to foster improved understanding and recognition of one another's roles and contributions to FRM,will enhance trust and improve the implementation of PRG in Seoul.

关键词： Citizen participation-Flood risk management Participatory risk governance Risk awareness South Korea:Urban flood risk

Development of the modified k-ε turbulence model of power-law fluid for engineering applications

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Science China(Technological Sciences) 2012年第1期55卷 276-284页

作者： ro Kyoungchul RYOU HongSun Department of Mechanical Engineering Chung-Ang University

In the present study, a high Reynolds number version of a turbulence model was proposed by using drag reduction to analyze the turbulent flows of power-law fluid for engineering applications. In order to determine the model constants in the constitutive equation, numerical simulation was conducted under the same conditions that were applied to obtain the experiment re- suits and previous turbulence models. For validation of the modified turbulence model, numerical simulations were performed for power-law fluids of different viscosities. The results of the modified k-ε turbulence model showed better agreement with the experimental results than those of the standard k-ε turbulence model. In addition, computation time and computer resource of the modified k-ε turbulence model were reduced by about one third as compared to the low Reynolds number model for power-law fluids.

关键词： power-law fluid turbulent flow drag reduction turbulence model computational fluid dynamics(CFD)

Video learning based image classification method for object recognition

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Journal of Central South University 2013年第9期20卷 2399-2406页

作者： LEE Hong-ro SHIN Yong-ju Department of NTIS Center Korea Institute of Science & Technology Information

Automatic image classification is the first step toward semantic understanding of an object in the computer vision *** key challenge of problem for accurate object recognition is the ability to extract the robust features from various viewpoint images and rapidly calculate similarity between features in the image database or video *** order to solve these problems,an effective and rapid image classification method was presented for the object recognition based on the video learning *** optical-flow and RANSAC algorithm were used to acquire scene images from each video *** the selection of scene images,the local maximum points on comer of object around local area were found using the Harris comer detection algorithm and the several attributes from local block around each feature point were calculated by using scale invariant feature transform （SIFT） for extracting local ***,the extracted local descriptor was learned to the three-dimensional pyramid match *** results show that our method can extract features in various multi-viewpoint images from query video and calculate a similarity between a query image and images in the database.

关键词： image classification multi-viewpoint image feature extraction video learning

Surgical repair of intractable chylous ascites following laparoscopic anterior resection

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World Journal of Gastroenterology 2015年第19期21卷 6077-6081页

作者： Gi Won Ha Min ro Lee Research Institute of Clinical Medicine Chonbuk National University Medical School

Chylous ascites is the accumulation of a milk-like peritoneal fluid rich in triglycerides and it is an unusual complication following surgical treatment of colorectal cancer. Conservative management is usually sufficientin patients with chylous ascites after surgery. However,we describe a patient with intractable chylous ascites after laparoscopic anterior resection for sigmoid colon cancer who failed initial conservative treatment. This patient was successfully managed by surgery.

关键词： Sigmoid colon cancer Laparoscopy Anteriorresection Chylous ascites Surgical repair

Prussian blue and its analogues as advanced supercapacitor electrodes

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Journal of Energy Chemistry 2020年第11期29卷 206-229页

作者： Emad S.Goda Seungho Lee Muhammad Sohail Kuk ro Yoon Organic Nanomarerials Lab Department of ChemistryHannam UniversityDaejeon 34054Republic of Korea Department of Chemistry Hannam UniversityDaejeon 34054Republic of Korea Fire Protection Laboratory National Institute of Standards136.Giza 12211Egypt Advanced Energy and System Engineering University of Science and TechnologyDaejeon 34113Republic of Korea

Remarkable attention has been directed to Prussian blue(PB) and its analogues(PBA) as one of the most widely used metal-organic frameworks(MOFs) especially in the field of energy storage devices due to their fabulous features such as 3D open framework, high surface area, controllable distribution of pores and the low cost. Nevertheless, their depressed conductivity causes some insulation when being used as an electrode for supercapacitors leading to be restricted in further applications particularly the electronics. To the best of our knowledge, our review aimed primarily to give a total picture of the research that was done on utilizing PB and PBA for fabricating the electrodes of supercapacitor, studying their synthesis approaches in addition to the hybridization with other materials such as graphene, CNTs and conducting polymer. It also addresses the transformation of PB or PBA into other interesting nanostructures such as oxides, sulfides, and bicomponent of graphitic carbon nitride/metal oxides, as well. Furthermore,It exhibits various avenues for overcoming their disadvantages of bad cycle life, retention rate and not achieving the desired values of energy/power densities opening the door for enlarging the number of researches on their application as supercapacitors.

关键词： Metal hexacyanoferrates Supercapacitors Electrolyte Energy density Cyclic stability

Making cancer fat:reprogramming of lipid metabolism by CD147 in hepatocellular carcinoma

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Chinese Journal of Cancer Research 2016年第3期28卷 380-382页

作者： Hye-Lim Ju Simon Weonsang ro Institute of Gastroenterology Yonsei University College of Medicine

Over the past few years, de novo lipogenesis has taken central stage in the field of cancer metabolism （1）. Large amount of lipids is needed for synthesis of membranes, signaling molecules, lipoproteins, etc. to support rapidly growing tumor cells （2-4）. Reports have shown that neoplastic tissues show aberrant activation of de novo lipogenesis and that inhibition of different enzymes within the fatty acid biosynthesis pathway can block cancer cell growth （2,5-9）. Meanwhile, the importance of fatty acid oxidation （FAO） in cancer metabolism is being increasingly recognized. FAO is the catabolic process by which lipids are utilized to produce energy. Recent studies implicated that the key regulatory enzymes in FAO such as carnitine palmitoyltransferase 1 （CPT1） and peroxisomal acyl-coenzyme A oxidase 1 （ACOX1） regulate cancer development （10,11）.

关键词： HCC CD Making cancer fat

Breast cancer metastasizing to the stomach mimicking primary gastric cancer: A case report

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World Journal of Gastroenterology 2017年第12期23卷 2251-2257页

作者： Kwangil Yim Sang Mi ro Jieun Lee Department of Hospital Pathology Seoul St.Mary’s HospitalCollege of MedicineThe Catholic University of Korea Division of Medical Oncology Department of Internal MedicineSeoul St.Mary’s HospitalCollege of MedicineThe Catholic University of Korea Cancer Research Institute the Catholic University of Korea

Breast cancer with stomach metastasis rare with an incidence of 1% or less among metastatic breast cancer patients. We experienced a case of breast cancer metastasizing to the stomach in 65-year-old female patient. She experienced dyspepsia and poor oral intake before visiting the clinic. Diffuse infiltration with nodular mucosal thickening of the stomach wall was observed, suggesting advanced gastric cancer based on gross endoscopic finding. Spread of poorly cohesive tumor cells in the gastric mucosa observed upon hematoxylin and eosin stain resembled signet ring cell carcinoma, but diffuse positive staining for GATA3 in immunohistochemical stain allowed for a conclusive diagnosis of breast cancer metastasizing to the stomach. Based on the final diagnosis, systemic chemotherapy was administered instead of primary surgical resection. After 2 cycles of docetaxel administration, she showed a partial response based on abdominal computed tomography scan. This case is an unusual presentation of breast cancer metastasizing to the gastrointestinal tract.

关键词： Gastric cancer Breast cancer Metastasis Immunohistochemical stain GATA3 GCDFP-15

Value of screening endoscopy in evaluation of esophageal,gastric and colon cancers

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World Journal of Gastroenterology 2015年第33期21卷 9693-9706页

作者： Tae H ro Michelle A Mathew Subhasis Misra Division of Surgical Oncology Texas Tech University Health Science Center School of MedicineAmarilloTX 79106United States

Esophageal,gastric,and colorectal cancers are deadly diseases that continue to plague our world *** value of screening endoscopy in evaluating these types of cancers is a critical area of discussion due to a potential reduction in morbidity and *** article describes how to identify a good screening test and explains what are important criteria in the field of screening ***,the current status and progress of screening endoscopy for esophageal,gastric,and colorectal cancer will be evaluated and *** screening programs have not been implemented for esophageal and gastric carcinomas in those with average or low risk ***,studies of high-risk populations have found value and a cost-benefit in conducting screening *** cancer,on the other hand,has had mass screening programs in place for many years due to the clear evidence of improved *** the role of endoscopy as a screening tool has continued to develop,newer technology and techniques have emerged to improve its *** new image enhancement techniques and computer processing programs have shown promise and may have a significant role in the future of endoscopic *** developments are paving the way for improving the diagnostic and therapeutic capability of endoscopy in the field of gastroenterology.

关键词： Endoscopic screening Esophageal cancer Gastric can