Making cancer fat:reprogramming of lipid metabolism by CD147 in hepatocellular carcinoma

作     者：Hye-Lim Ju Simon Weonsang Ro 

作者机构：Institute of GastroenterologyYonsei University College of Medicine 

出 版 物：《Chinese Journal of Cancer Research》 (中国癌症研究（英文版）)

年 卷 期：2016年第28卷第3期

页      面：380-382页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the Basic Science Research Program through the National Research Foundation of Korea which is funded by the Alinistry of Education(NRF-2011-0021830 to SW Ro) 

主　　题：HCC CD Making cancer fat 

摘      要：Over the past few years, de novo lipogenesis has taken central stage in the field of cancer metabolism （1）. Large amount of lipids is needed for synthesis of membranes, signaling molecules, lipoproteins, etc. to support rapidly growing tumor cells （2-4）. Reports have shown that neoplastic tissues show aberrant activation of de novo lipogenesis and that inhibition of different enzymes within the fatty acid biosynthesis pathway can block cancer cell growth （2,5-9）. Meanwhile, the importance of fatty acid oxidation （FAO） in cancer metabolism is being increasingly recognized. FAO is the catabolic process by which lipids are utilized to produce energy. Recent studies implicated that the key regulatory enzymes in FAO such as carnitine palmitoyltransferase 1 （CPT1） and peroxisomal acyl-coenzyme A oxidase 1 （ACOX1） regulate cancer development （10,11）.