Efficacy of Bee Products(Anzer Honey,Pollen and Propolis)in Detection and Healing of Damage Induced by Antidiabetic Drug Vildagliptin/Metformin Hydrochloride in Healthy Human Pancreatic Cells:Cytotoxic,Genotoxic and Biochemical Studies

作     者：ÖzlemÖzdemir ZinetÇöl Ömer Ertürk Özlem Özdemir;Zinet Çöl;Ömer Ertürk

作者机构：Department of Internal MedicineFaculty of MedicineOrdu UniversityOrdu52200Turkey Department of Molecular Biology and GeneticsFaculty of Sciences and LettersOrdu UniversityOrdu52200Turkey 

出 版 物：《Current Medical Science》 (当代医学科学（英文）)

年 卷 期：2023年第43卷第6期

页      面：1173-1182页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Ordu University Scientific Project Coordination Department(ODUBAP No.B-2139) 

主　　题：cell viability hTERT-HPNE Anzer bee products drug side effect diabetes mellitus 

摘      要：Background and Objective Although drugs are powerful therapeutic agents,they have a range of side *** side effects are sometimes cellular and not clinically ***/metformin hydrochloride is one of the most widely used oral antidiabetic drugs with two active *** this study,we investigated its harmful effects on the metabolic activation system in healthy human pancreatic cells“hTERT-HPNE,and we aimed to improve these harmful effects by natural *** benefit from the healing effect,we used the unique natural products produced by the bees of the Anzer Plateau in the Eastern Black Sea Region of *** Cytotoxic and genotoxic effects of the drug were investigated by different tests,such as MTT,flow cytometry-apoptosis and comet *** honey,pollen and propolis were analyzed by gas chromatography/mass spectrometry(G/C-MS).A total of 19 compounds were detected,constituting 99.9%of the *** The decrease in cell viability at all drug concentrations was statistically significant compared to the negative control(P0.05).A statistically significant decrease was detected in the apoptosis caused by vildagliptin/metformin hydrochloride with the supplementation of Anzer honey,pollen and propolis in hTERT-HPNE cells(P0.05).Conclusion This study can contribute to other studies testing the healing properties of natural products against the side effects of oral antidiabetics in human *** particular,Anzer honey,pollen and propolis can be used as additional foods to maintain cell viability and improve heal damage and can be evaluated against side effects in other drug studies.