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Efficacy of Bee Products(Anzer Honey,Pollen and Propolis)in Detection and Healing of Damage Induced by Antidiabetic Drug Vildagliptin/Metformin Hydrochloride in Healthy Human Pancreatic Cells:Cytotoxic,Genotoxic and Biochemical Studies

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Current Medical Science 2023年第6期43卷 1173-1182页

作者： ÖzlemÖzdemir ZinetÇöl Ömer Ertürk Department of Internal Medicine Faculty of MedicineOrdu UniversityOrdu52200Turkey Department of Molecular Biology and Genetics Faculty of Sciences and LettersOrdu UniversityOrdu52200Turkey

Background and Objective Although drugs are powerful therapeutic agents,they have a range of side *** side effects are sometimes cellular and not clinically ***/metformin hydrochloride is one of the most widely used oral antidiabetic drugs with two active *** this study,we investigated its harmful effects on the metabolic activation system in healthy human pancreatic cells“htert-hpne”,and we aimed to improve these harmful effects by natural *** benefit from the healing effect,we used the unique natural products produced by the bees of the Anzer Plateau in the Eastern Black Sea Region of *** Cytotoxic and genotoxic effects of the drug were investigated by different tests,such as MTT,flow cytometry-apoptosis and comet *** honey,pollen and propolis were analyzed by gas chromatography/mass spectrometry(G/C-MS).A total of 19 compounds were detected,constituting 99.9%of the *** The decrease in cell viability at all drug concentrations was statistically significant compared to the negative control(Phtert-hpne cells(P<0.05).Conclusion This study can contribute to other studies testing the healing properties of natural products against the side effects of oral antidiabetics in human *** particular,Anzer honey,pollen and propolis can be used as additional foods to maintain cell viability and improve heal damage and can be evaluated against side effects in other drug studies.

关键词： cell viability htert-hpne Anzer bee products drug side effect diabetes mellitus

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