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Urban green spaces accessibility in two European cities:Vilnius(Lithuania)and Coimbra(Portugal)

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Geography and Sustainability 2022年第1期3卷 74-84页

作者： Luís Valença Pinto Carla sofia santos Ferreira Miguel Inácio Paulo Pereira Research Centre for Natural Resources Environment and Society(CERNAS)Polytechnic Institute of CoimbraCoimbra Agrarian Technical SchoolCoimbraPortugal Environmental Management Laboratory Mykolas Romeris UniversityVilniusLithuania Department of Physical Geography and Bolin Centre for Climate Research Stockholm UniversitySE-10691 StockholmSweden Navarino Environmental Observatory 24001 MessiniaGreece

Urban green spaces(UGS)are essential for human well-being,contributing towards quality of life and promoting social interactions and *** to recreational UGS is key to human well-being in urban ***,there is a lack of works focused on recreational UGS accessibility in cities from different countries,using different types of *** this work,we studied the accessibility to recreational UGS in Vilnius(Lithuania)and Coimbra(Portugal)through four transport modes(foot,bike,bus and car)within 5-and 10-minute *** results showed important differences between *** had higher accessibility to recreational UGS than Coimbra in all transport *** both cities,the accessibility was highest by car and lowest by ***,the percentage of population covered by 5-and 10-minute distance UGS accessibility in Vilnius is higher than in Coimbra,despite the lower population density in Vilnius.A large number of recreational UGS,their geographic distribution,the dispersed population pattern,and the location of several urbanizations near recreational UGS increased the inhabitant’s accessibility to recreational UGS in *** differences in accessibility between cities were mainly attributed to the large number of recreational UGS and higher road network density,cycleways and footways density,and bus lines in Vilnius,compared to *** work identified the areas where recreational UGS accessibility is difficult in using different transport modes and need to be improved in study *** is essential to support urban planners and increase cities’*** findings of this work will be important for the management of the studied urban areas.

关键词： Recreational UGS Accessibility Transport modes Urban planning Well-being

Bottom-Up Approach towards a Human Wellbeing Assessment for the Design of a Management Plan:A Study Case with Contributions to Improve Sustainable Management of Resources in a Northern Area of Mozambique

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Open Journal of Ecology 2014年第17期4卷 1102-1127页

作者： rita sofia anastácio Lúcia Nunes Schertenleib Jorge Paiva Jorge Ferrao Mário Jorge Pereira Departamento de Biologia e CESAM Universidade de AveiroAveiroPortugal Faculdade de Ciencias and Centre for Functional Ecology(CFE) Universidade de CoimbraCoimbraPortugal Lúrio University NampulaMozambique Maluane―Cabo Delgado Conservation and Tourism PembaMozambique AFPR―A For Plankton Research AveiroPortugal

The loss of biodiversity and ecosystem services disturbance will result in serious ecological and socioeconomic consequences. How can people be prepared to be more efficient in preserving ecosystems, its services and resources? The Messalo Wilderness Area (MWA) is an area lacking a bottom-up approach for the design of a management plan. This research intended to develop a strategy to gather people’s views to begin a human wellbeing assessment for the area, for which a Digital Questionnaire (DQ) was developed and tested. The specific objectives were to 1) verify the dispersion/distribution of people and elephants;2) study the natural resources used by the inhabitants;3) locate the areas from where the most important natural resources are extracted and where conflict between humans and animals occur;4) propose a Management Plan (MP) capable of mitigating the human-animals conflict, promoting the conservation of elephants and, consequently, of other types of biodiversity, thus working towards a better socio-economical development of the area. The elements gathered in the consulted references were used to design several maps and cartographic figures shown in this article, using the Map Window software. These maps describe: fresh water distribution, habitat distribution, population dispersal and main road connections, crop fields distribution and main exploitation spots of the different resources, orography and topography. The results from the DQ analysis helped to gather indicators to the human wellbeing assessment. The information gathered in the literature and by inquiry was effective in confirming the high dependency of local people on land and sea resources, as well as the conflicts between people and wild animals, such as elephants and African wild dogs, and the reasons for those conflicts. The DQ is effective in gathering people’s opinions and it constitutes an important tool in a bottom-up approach to the design of a management plan as to the design of the MP for

关键词： North of Mozambique Ecosystem Services Ecosystem Based-Management

Exploring the potential for an evolutionarily conserved role of the taste 1 receptor gene family in gut sensing mechanisms of fish

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Animal Nutrition 2022年第4期11卷 293-308页

作者： Anna rita Angotzi Esther Leal Sara Puchol José M. Cerdá-Reverter sofia Morais Department of Fish Physiology and Biotechnology Instituto de Acuicultura de Torre de la SalIATS-CSICTorre la Sal s/nRibera de Cabanes12595 CastellonSpain Lucta S.A. Innovation DivisionAnimal Science UnitUAB Research Park08193 BellaterraSpain

In this study,we investigated the transcriptional spatio-temporal dynamics of the taste 1 receptor(T1R)gene family repertoire in seabream(Sparus aurata[sa]),during larval ontogeny and in adult *** early larval development,sa T1R expression arises heterochronously,*** extraoral taste-related perception in the gastrointestinal tract(GIT)anticipates first exogenous feeding(at 9 days post hatching[dph]),followed by the buccal/intraoral perception from 14 dph onwards,supporting the hypothesis that the early onset of the molecular machinery underlying sa T1R expression in the GIT is not induced by food but rather genetically *** adulthood,we characterized the expression patterns of sa T1R within specific tissues(n=4)distributed in oropharingeal,GIT and brain regions substantiating their functional versatility as chemosensory signaling players to a variety of biological functions beyond oral taste ***,we provided for the first time direct evidences in fish for m RNA coexpression of a subset of sa T1R genes(mostly sa T1R3,*** common subunit of the heterodimeric T1R complexes for the detection of“sweet”and“umami”substances),with the selected gut peptides ghrelin(ghr),cholecystokinin(cck),hormone peptide yy(pyy)and proglucagon(pg).Each peptide defines the enteroendocrine cells(ECCs)identity,and establishes on morphological basis,a direct link for T1R chemosensing in the regulation of fish digestive ***,we analyzed the spatial gene expression patterns of 2 taste signaling components functionally homologous to the mammalian G(i)a subunit gustducin,namely sa G(i)a1 and sa G(i)a2,and demonstrated their co-localization with the sa T1R3in EECs,thus validating their direct involvement in taste-like transduction mechanisms of the fish *** conclusion,data provide new insights in the evolutionary conservation of gut sensing in fish suggesting a conserved role for nutrient sensors modulating entero-endocrine secretion.

关键词： Taste 1 receptor Fish larvae Gut nutrient sensing Gut peptides G(i)alpha protein subunits 1 and 2

Temporal and spatial differences in human activities performed in Urban Green Spaces of Vilnius(Lithuania)

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Geography and Sustainability 2024年第2期5卷 302-317页

作者： Luís Valença Pinto Carla sofia santos Ferreira Paulo Pereira Research Centre for Natural Resources Environment and Society(CERNAS) Polytechnic Institute of CoimbraBencanta3045-601 CoimbraPortugal Environmental Management Laboratory Mykolas Romeris UniversityVilniusLithuania Polytechnic Institute of Coimbra Applied Research InstituteRua da MisericórdiaLagar dos Cortiços-S.Martinho do Bispo3045-093 CoimbraPortugal

Urban green spaces(UGS)are relevant to city well-being,as recognized by the United Nations’Sustainable Development Goals(SDGs).However,few studies have studied the temporal use of *** work assessed the seasonal,weekly,and daily use of three urban green spaces(Vingis Park,Bernardino Garden,and Jomantas Park)in Vilnius(Lithuania).The study is based on an on-site observation-based survey,which recorded users’characteristics,activities,and weather conditions during summer and *** results showed that UGS’s seasonal,weekly,and daily use differed according to park and users’*** with a higher diversity of facilities had a high seasonal difference in the number of observed *** numbers were higher in the summer for activities with children,social activities,sports,and water activities than in the *** Park had the lowest variability in user *** variables were linked to changes in users’*** precipitation and lower temperature were associated with reducing the number of users and the diversity of registered *** of the stationary activities were observed during *** diversity of the observed activities was associated with the available facilities rather than the park *** distribution of stationary activities was spatially correlated with facility/equipment(benches,playgrounds,sports,and fitness equipment)and proximity to water *** results of this study are relevant for UGS design,planning,and management.

关键词： Urban parks Seasonal differences Temporal use Time of day Spatial distribution of UGS users

From regenerative strategies to pharmacological approaches:can we fine-tune treatment for Parkinson's disease?

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Neural Regeneration Research 2022年第5期17卷 933-936页

作者： rita Caridade Silva Helena sofia Domingues António J.Salgado Fábio G.Teixeira Life and Health Sciences Research Institute(ICVS) School of MedicineUniversity of MinhoBragaPortugal ICVS/3B’s Associate Lab PT Government Associated LabBraga/GuimarãesPortugal

Parkinson's disease is the second most prevalent neurodegenerative disorder ***,it is characterized by severe motor complications caused by progressive degeneration of dopaminergic *** treatment is focused on mitigating the symptoms through the administration of levodopa,rather than on preventing dopaminergic neuronal ***,the use and development of neuroprotective/disease-modifying strategies is an absolute need that can lead to promising gains on translational research of Parkinson's *** instance,N-acetylcysteine,a natural compound with strong antioxidant effects,has been shown to modulate oxidative stress,preventing dopamine-induced cell *** the evidence of neuroprotective and modulatory effects of this drug,as far as we know,it does not induce per se any regenerative ***,it would be of interest to combine the latter with innovative therapies that induce dopaminergic neurons repair or even differentiation,as stem cell-based *** cells secretome has been proposed as a promising therapeutic approach for Parkinson's disease,given its ability to modulate cell viability/preservation of dopaminergic *** approach represents a shift in the paradigm,showing that cell-transplantation free therapies based on the use of stem cells secretome may represent a potential alternative for regenerative medicine of Parkinson's ***,in this review,we address the current understanding of the potential combination of stem cell free-based strategies and neuroprotective/disease-modifying strategies as a new paradigm for the treatment of central nervous system neurodegenerative diseases,like Parkinson's disease.

关键词： disease-modifying strategies mesenchymal stem cells N-acetylcysteine neuroprotection Parkinson's disease stem cells secretome

Updated evidence of primary tumor resection in stage Ⅳ breast cancer:a systematic review and meta-analysis

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Journal of Cancer Metastasis and Treatment 2023年第1期9卷 1-19页

作者： Zacharoula Sidiropoulou Ana rita Martins Patricia Amaral Vasco Cardoso sofia Boligo Vasco Fonseca Breast Unit General SurgeryCentro Hospitalar Lisboa OcidentalLisboa 2790-134Portugal Medical Oncology Centro Hospitalar Lisboa OcidentalLisboa 2790-134Portugal

Background:In stage Ⅳ breast cancer,surgical resection of the primary tumor was traditionally performed solely to palliate symptoms such as bleeding,infection,or *** ongoing discussion has shown that there are many research gaps in the current literature and differences in clinical ***,this systematic review and meta-analysis was designed to evaluate how primary tumor resection(PTR)affects the overall survival(OS)of patients with stage Ⅳ breast ***:A thorough literature search was completed using different databases(PubMed,Google Scholar,Scopus,ScienceDirect,and Cochrane Library)to find papers contrasting PTR with no *** quality of research articles was evaluated using the Cochrane Risk of Bias 2.0 Tool and the Newcastle-Ottawa Scale(NOS).Review Manager 5.4 was used to determine how much demographic and clinical factors contribute to heterogeneity through subgroup and meta-regression ***:Data derived from 44 observational studies(OS)and four randomized controlled trials(RCTs)including 227,889 patients were *** all cases,150,239 patients were included in the non-PTR group,and 70,795 patients in the PTR group(37 observational studies and 4 randomized control trials).The pooled outcomes of four RCT studies(Hazard Ratio(HR)=1.03,95%CI:0.67-1.58;I2=88%;P<0.0001;chi-square 24.57)favor *** pooled outcomes of 43 observational studies showed PTR significantly improved OS(HR=0.66,95%CI:0.61-0.71;I2=87%;P<0.00001;chi-square 359.12).Additionally,subgroup analysis that compared PTR with non-PTR in patients with stage IV breast cancer for progression free-survival(HR=0.89,95%CI:0.62-1.28;P=0.03;I2=71%)and locoregional progression-free survival(LPFS)(HR=0.33,95%CI:0.14-0.74;P=0.0004;I^(2)=87%)was found to be significant favoring the PTR *** progression-free survival(DPFS)had a non-significant relationship(HR=0.42,95%CI:0.29-0.60;P=0.12;I^(2)=53%),while overall,there was a significant relationship(HR=0.49,95%CI:0

关键词： PTR primary tumor resection breast cancerⅣstage breast cancer overall survival metastatic disease

Congenital heart diseases trends in S?o Paulo State,Brazil:a national live birth data bank analysis

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World Journal of Pediatrics 2022年第7期18卷 472-481页

作者： Paola Soares Fernandes Larissa Rosario Magalhaes Tainara rita Pezzini Edige Felipe de Sousa santos Mauricio Giusti Calderon Medical School Nine of July University(Uni9).Sao Bernardo do CampoSPBrazil Epidemiology Department Public Health SchoolSao Paulo University(USP)Sao PauloSPBrazil Pediatric Surgery Department Hospital Benficencia Portuguesa de Sao PauloRua Maestro Cardim768Sao PauloSP CEP 01323-011Brazil Pediatric Surgery Department Hospital Santa Catarina PaulistaAv.Paulista200.Sao PauloSP CEP:01310-000Brazil

Background Congenital heart diseases(CHD)are the most common type of birth defects,affecting millions of newborns every year;no prevalence data are available in S?o Paulo State,Brazil's most populous *** objective is to identify trends in prevalence and risk factors for CHD in Sao Paulo State,*** We developed a population-based study to estimate the CHD trend of prevalence in recent years,stratified by maternal age and geographical clusters,using all cases of CHD identified by the Live Births Information System(SINASC-Sistema de Informa??o Sobre Nascidos Vivos)from January 1,2005,to December 31,*** calculated the trends of prevalence,the regression coefficient(β),the annual percent change(APC),and 95%confidence interval using the Prais-Winsten regression model,with the Durbin-Watson *** We found 10,594 cases of CHD among 8,536,101 live births(LB),a prevalence of 12.4/10,000 *** was no difference in the sex distribution;they are primarily Caucasian(60.2%),75.2%born at term,and 74.4%weight>2500 g,66.9%of births were by cesarean section.S?o Paulo State presented an increasing CHD trend of prevalence(APC=18.9%).The highest CHD prevalence rate was in mothers aged≥35 years(22.2/10,000 LB).There were 12,271 specific congenital heart defects among 10,594 patients(1.16 CHD/patient).Atrial septal defect has the highest number of cases(3835),with a prevalence of 4.49/10,000 LB,corresponding to 31.3%of all *** CHD had an increasing prevalence trend in recent years,being highest in S?o Paulo City and≥35-year mothers.

关键词： Congenital abnormalities Epidemiology Heart defects Interrupted time series PrevalencePublic health

Spatiotemporal Variability of Methane over the Amazon from Satellite Observations

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Advances in Atmospheric Sciences 2016年第7期33卷 852-864页

作者： Igor Oliveira RIBEIRO] Rodrigo Augusto Ferreira de SOUZA rita Valeria ANDREOLI Mary Toshie KAYANO Patrfcia dos santos COSTA Post-Graduate Program in Climate and Environment CLIAMBINPA/UEAAv.Andre Araujo2936Campus 11Aleixo69060-001ManausAMBrasil Amazonas State University Superior School of TechnologyAv.Darcy Vargas1200Parque 10 de Novembro69065-020ManausAMBrasil National Institute for Space Research Center For Weather Forecasting and Climate ResearchAv.dos Astronautas175812227-010Sao Josd dos CamposSPBrasil

The spatiotemporal variability of the greenhouse gas methane （CH4） in the atmosphere over the Amazon is studied using data from the space-borne measurements of the Atmospheric Infrared Sounder on board NASA＇s AQUA satellite for the period 2003-12. The results show a pronounced variability of this gas over the Amazon Basin lowlands region, where wetland areas occur. CH4 has a well-defined seasonal behavior, with a progressive increase of its concentration during the dry season, followed by a decrease during the wet season. Concerning this variability, the present study indicates the important role of ENSO in modulating the variability of CH4 emissions over the northern Amazon, where this association seems to be mostly linked to changes in flooded areas in response to ENSO-related precipitation changes. In this region, a CH4 decrease （increase） is due to the E1 Nifio-related （La Nifia-related） dryness （wetness）. On the other hand, an increase （decrease） in the biomass burning over the southeastern Amazon during very dry （wet） years explains the increase （decrease） in CH4 emissions in this region. The present analysis identifies the two main areas of the Amazon, its northern and southeastern sectors, with remarkable interannual variations of CH4. This result might be useful for future monitoring of the variations in the concentration of CH4, the second-most important greenhouse gas, in this area.

关键词： climate variability methane satellite data Amazon region

Cardiovascular rehabilitation in patients aged 70-year-old or older:benefits on functional capacity,physical activity and metabolic profile in younger *** patients

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Journal of Geriatric Cardiology 2020年第9期17卷 544-553页

作者： Marta Fontes-Oliveira Maria Trêpa Patrícia Rodrigues Preza Fernandes Sandra Magalhães sofia Cabral Mário santos Severo Torres Cardiology Department University Hospital Centre of PortoPortoPortugal Cardiac Rehabilitation Unit Cardiology DepartmentUniversity Hospital Centre of PortoPortoPortugal Pulmonary Vascular Disease Unit University Hospital Centre of PortoPortoPortugal

Background The benefits of exercise-based cardiac rehabilitation(EBCR)programs in post-acute myocardial infarction(AMI)patients have been *** aim was to assess the impact of EBCR in³70-years-old *** post-AMI *** We retrospectively evaluated patients who underwent a supervised EBCR protocol,twice a week during 6-12 *** evaluated changes in several outcomes based on pre-and post-CRP *** Of a total of 1607 patients,333(21%)were³*** the EBCR,an overall improvement on functional capacity,daily physical activity,lipid profile,body mass index,glycated hemoglobin(HbA1c),N-terminal pro-brain natriuretic peptide(NT-pro-BNP)and C-reactive protein was observed in both younger and older patients(P<0.05).Older patients showed a smaller benefit on the increment of daily physical activity and lipid profile improvement,but a larger reduction in *** the multivariate analysis,only improvements on daily physical activity and HbA1c were dependent on *** As their younger counterparts,older patients,significantly improved functional capacity,metabolic parameters and level of daily physical activity after EBCR.

关键词： Aging Cardiovascular prevention Exercise-based cardiac rehabilitation