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Development of a Biopolymer by Chemical Modification of β-Cyclodextrin for Pharmaceutical Applications

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材料科学与工程（中英文A版） 2014年第7期4卷 209-215页

作者： Ghemit rima Baitiche Milad Makhloufi Abdesselam Faculty of Technology Ferhat Abbas University Sétif 19000 Algeria

Defect of insulin signal in peripheral tissues: important role of ceramide

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World Journal of Diabetes 2014年第3期5卷 244-257页

作者： rima Hage Hassan Olivier Bourron Eric Hajduch INSERM UMR-S 1138Centre de Recherche des CordeliersF-75006 ParisFrance UniversitéPierre et Marie Curie-Paris 6 UMR-S 872F-75006 ParisFrance Université Paris Descartes UMR-S 872F-75006 ParisFrance Olivier BourronDepartment de Diabétologie et Maladies métaboliquesAP-HPHopital Pitié-SalpêtrièreF-75006 ParisFrance

In healthy people,balance between glucose production and its utilization is precisely *** circulating glucose reaches a critical threshold level,pancreaticβcells secrete insulin that has two major actions:to lower circulating glucose levels by facilitating its uptake mainly into skeletal muscle while inhibiting its production by the ***,dietary triglycerides are the main source of fatty acids to fulfill energy needs of oxidative ***,the unconsumed fraction of excess of fatty acids is stored in lipid droplets that are localized in adipocytes to provide energy during fasting ***,adipose tissue acts as a trap for fatty acid excess liberated from plasma *** the buffering action of adipose tissue to store fatty acids is impaired,fatty acids that build up in othertissues are metabolized as sphingolipid derivatives such as *** studies suggest that ceramides are among the most active lipid second messengers to inhibit the insulin signaling pathway and this review describes the major role played by ceramide accumulation in the development of insulin resistance of peripherals tissues through the targeting of specific proteins of the insulin signaling pathway.

关键词： Diabetes Insulin resistance Lipids Insulin signaling Triglycerides Palmitate Sphingolipid Akt Ceramide synthase Protein phosphatase 2A Protein kinase C ζ/λ

计算概念设计：水凝胶石膏在炎热气候区四合院房屋中的应用研究——以阿尔及利亚M' ZAB房屋为例

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计算概念设计：水凝胶石膏在炎热气候区四合院房屋中的应用研究—...

作者： Boufendassa rima（瑞玛）天津大学

学位级别：硕士

当今建筑设计及技术在各领域有了长足的发展,使用新型智能建筑材料成为趋势。同时聚合物科学在不断发展,这导致了具有独特性能的新材料出现。其中,水凝胶材料因为具有特殊的物理性能,从一开始就引起了科学和工程界研究人员的关注。当Wic... 详细信息

当今建筑设计及技术在各领域有了长足的发展,使用新型智能建筑材料成为趋势。同时聚合物科学在不断发展,这导致了具有独特性能的新材料出现。其中,水凝胶材料因为具有特殊的物理性能,从一开始就引起了科学和工程界研究人员的关注。当Wichterle和Lim在1960年代开发出第一款合成水凝胶,即交联的聚(甲基丙烯酸2-羟乙酯)后直到今天,情况依然如此。当时,水凝胶在镜片中得到了广泛应用,且是第一个适用于人体的生物材料。聚合物科学的进步为水凝胶的生产提供了新的途径,带来了新的更具吸引力的特性,如今它们已涵盖了从农业到医学的广泛应用。水凝胶材料和常规建筑材料结合的复合结构可应用于环境响应智能建筑的。本论文的理论研究验证了该技术概念的有效性。该论文中研究了炎热气候下集成水凝胶的特殊复合建筑围护结构中水凝胶的热工性能物理特征,这种复合围护结构对建筑室内温度稳定性的影响,以及这种复合围护结构在阿尔及利亚当地庭院建筑中的潜在应用可能性。通过该研究,提出了水凝胶在地域化建筑中应用的新的可能性。尽管水凝胶材料不是一个新的材料科学课题,但是对于地域化建筑领域,这种新型材料可提供新的技术方案,理论上可创造出更加舒适节能的地域化被动式低能耗建筑。本论文结合当前可持续建筑发展潮流,利用新材料给地域化建筑提供了新的技术方案。研究中探索了将非传统材料的水凝胶与在阿尔及利亚当地庭院式住宅相结合的具体技术方案,通过复合围护结构水凝胶墙体热工性能的模拟分析验证了在夏季隔热的可行性。基于CFD模拟进行了分析,以验证这种集成水凝胶的建筑围护结构提升当地建筑热工性能的有效性。本论文研究中还提出了集成水凝胶的建筑围护结构原型,并使用CFD仿真模拟验证了其传热功效。研究结论表明水凝胶与粘土和石膏的复合围护结构可以提供良好的隔热效果,提升建筑围护结构的热工稳定性。通过降低内表面峰值温度来提升室内热舒适,同时还可以确保住宅内部中的天然采光满足要求。

关键词：水凝胶庭院住宅传热模拟

Correlation of Equol (7-Hydroxy-3-(4-Hydroxyphenyl)Chroman) in Woman Urine with the Symptoms of Menopause

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Journal of Biosciences and Medicines 2016年第1期4卷 132-138页

作者： rima Yulia Effriyanti Tita Husnitawati Madjid Hanom Husni Syam Department of Obstetrics and Gynecology Faculty of Medicine Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital Bandung Indonesia

Objective: In order to identify the correlation between equol excreted through human urine and the symptom of menopause. Methods: The method used is cross sectional study examined to 99 postmenopausal women fulfilling the inclusion criteria from February 2014 to July 2014. This research was taken in the Endocrinology Clinic, Department of Obstetrics and Gynecology, Hasan Sadikin Hospital and Unpad’s Pharmacokinetic Laboratory. All objects were interviewed using menopause rating scale (MRS) questionnaire. Their urine samples were analyzed using high performance liquid chromatography (HPLC). Then the results of questionnaire and HPLC test were evaluated. Results: The result is 97 objects (98%) detected having menopausal symptoms, produced equol. There is significant correlation between the level of equol in post-menopausal women that showed correlation (-0.71) which mean the higher the equol level, the lower the MRS score (p < 0.001) that mean the symptom is milder. Conclusion: Equol level in menopause women urine is a good predictor to identify the level of menopause symptoms.

关键词： Equol Menopause Symptoms Menopause Rating Scale

The Performance Analysis of the Wavelet-OFDM New Scheme in AWGN Channel

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Journal of Physical Science and Application 2014年第2期4卷 100-106页

作者： Alaa Ghaith rima Hatoum Hiba Mradand Ali Alaeddine Electronics and Physics Department Faculty of Sciences L Lebanese University Beirut Hadath 65 73-14 Lebanon

Orthogonal frequency division multiplexing （OFDM） is a special form of multi-carrier transmission that uses the policy of divide and rule. In this scheme, a large number of orthogonal, overlapping, narrow band sub-channels （subcarriers） are transmitted in parallel and divide the available transmission bandwidth. This techniqueis originally based on the Fast Fourier Transform of the information data. In order to improve the performance of the OFDM and overcome some limitations, an alternative OFDM approach based on the Wavelet Transform is proposed. In this paper, we study the performance of such systems in additive white Gaussian channel （AWGN）. MATLAB simulations are realized and performance comparisons are presented.

关键词： Multi-carrier modulation discrete wavelet transform OFDM. wavelet packet transform Fourier-based OFDM wavelet-based

Mild oxidative stress is beneficial for sperm telomere length maintenance

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World Journal of Methodology 2016年第2期6卷 163-170页

作者： Swetasmita Mishra Rajeev Kumar Neena Malhotra Neeta Singh rima Dada Laboratory for Molecular Reproduction and Genetics Department of Anatomy All India Institute of Medical Sciences Department of Urology All India Institute of Medical Sciences Department of Obstetrics and Gynaecology All India Institute of Medical Sciences

AIM:To evaluate telomere length in sperm DNA and its correlation with oxidative stress(normal,mild,severe).METHODS:The study included infertile men(n=112)and age matched fertile controls(n=102).The average telomere length from the sperm DNA was measured using a quantitative real time PCR based *** reactive oxygen species(ROS)and 8-Isoprostane(8-IP)levels were measured by chemiluminescence assay and ELISA ***:Average sperm telomere length in infertile men and controls was 0.609±0.15 and 0.789±0.060,respectively(P35 RLU/s/million sperm)average telomere length was decreased to 0.595±***:Mild oxidative stress results in lengthening of telomere length,but severe oxidative stress results in shorter *** telomere maintenance is a complex trait,the study shows that mild oxidative stress is beneficial in telomere length maintenance and thus a delicate balance needs to be established to maximize the beneficial effects of free radicals and prevent harmful effects of supra physiological *** molecular evaluation of telomere structure,its correlation with oxidative stress would aid in elucidating the cause of accelerated telomere length attrition.

关键词： Telomere Oxidative stress Reactive oxygen species Infertility 8-Isoprostane

Y chromosome microdeletions in azoospermic patients with Klinefelter's syndrome

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Asian Journal of Andrology 2006年第1期8卷 81-88页

作者： Anurag Mitra rima Dada Rajeev Kumar Narmada Prasad Gupta Kiran Kucheria Satish Kumar Gupta Gamete Antigen Laboratory National Institute of ImmunologyAruna Asaf Ali MargNew Delhi 110067India Department of Anatomy Department of Urology All India Institute of Medical SciencesAnsari NagarNew Delhi 110029India

Aim： To study the occurrence of Y chromosome microdeletions in azoospermic patients with Klinefelter＇s syndrome （KFS）. Methods： Blood and semen samples were collected from azoospermic patients with KFS （n = 14） and a control group of men of proven fertility （n = 13）. Semen analysis was done according to World Health Organization （WHO） guidelines. Blood samples were processed for karyotyping, fluorescent in situ hybridization （FISH） and measurement of plasma follicle stimulating hormone （FSH） by radioimmunoassay. To determine Y chromosome microdeletions, polymerase chain reaction （PCR） of 16 sequence tagged sites （STS） and three genes （DFFRY, XKRY and RBM1 Y） was performed on isolated genomic DNA. Testicular fine needle aspiration cytology （FNAC） was done in selected cases. Results： Y chromosome microdeletions spanning the azoospermia factor （AZF）a and AZFb loci were found in four of the 14 azoospermic patients with KFS. Karyotype and FISH analysis revealed that, of the four cases showing Y chromosome microdeletion, three cases had a 47,XXY/46,XY chromosomal pattern and one case had a 46,XY/47,XXY/48,XXXY/48,XXYY chromosomal pattern. The testicular FNAC of one sample with Y chromosome microdeletion revealed Sertoli cell-only type of morphology. However, no Y chromosome microdeletions were observed in any of the 13 fertile men. All patients with KFS had elevated plasma FSH levels. Conclusion： Patients with KFS may harbor Y chromosome microdeletions and screening for these should be a part of their diagnostic work-up, particularly in those considering assisted reproductive techniques. （Asian JAndrol 2006 Jan; 8： 81-88）

关键词： azoospermia azoospermia factor follicle stimulating hormone Klinefelter's syndrome Y chromosome microdeletion

Serum Ferritin: Is It an Independent Predictor of Reduced Bone Mineral Density among Elderly Women?

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Advances in Aging Research 2016年第6期5卷 142-150页

作者： Shereen M. Mousa Abeer A. Ibrahim rima A. Al Adsani Geriatric Department Faculty of Medicine Ain Shams University Cairo Egypt Department of Family Medicine Ahmadi Hospital Ahmadi Kuwait

Aim: In vitro studies have shown that iron promotes osteoclast differentiation and bone-resorbing activity by enhancing mitochondrial biogenesis, whereas it suppresses osteoblastogenesis. In postmenopausal women, serum ferritin increases by 2 - 3 times due to the lack of a major mechanism of iron excretion, while menstrual blood decreases. Based on this observation, it has been hypothesized that in addition to estrogen deficiency, increased iron as a result of menopause could contribute to bone loss in postmenopausal women. So our aim was to investigate the association between serum ferritin levels and bone mineral density (BMD) in elderly women at various skeletal sites. Methods: Retrospective analysis of the medical records of 71 postmenopausal women having a mean age of (66 ± 7) years (range 60 - 83 years) was done. The collected data included age of menopause, past medical history, smoking habits, physical activity, and medication use. BMD was measured at the lumbar spine and femur by dual-energy X-ray absorptiometry, and other biochemical markers including, serum ferritin, 25 hydroxyvitamin D3, serum alkaline phosphatase, and parathyroid hormone were assayed. Results: We found that serum ferritin levels are significantly related to BMD of the total hip and lumbar vertebrae [with a p value of (0.01) and ( Conclusion: This study suggests a positive association between serum ferritin levels and BMD in elderly women without hematologic disorders. Further study is warranted to verify the effects of iron on bone metabolism.

关键词： Bone Mineral Density Ferritin Iron Osteoporosis Women

Antibiotic residues in milk and milk products:A momentous challenge for the pharmaceutical industry and medicine

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World Journal of Pharmacology 2022年第4期11卷 48-55页

作者： rima Omairi Maha Krayem Sanaa Khaled Mohamed Salla Sami El Khatib Food Sciences&Technology Lebanese International UniversityKhiyara 1108Lebanon Biological Sciences Lebanese International UniversityKhiyara 1108Lebanon Chemical Sciences Lebanese International UniversityKhiyara 1108Lebanon Biomedical Sciences Lebanese International UniversityKhiyara 1108Lebanon

Dairy products are nutritious food items that contain various essential nutrients,however,it has been proven that residual antibiotics have contaminated such *** residues can cause several side effects on human *** increase antimicrobial resistance against several threatening microorganisms,as well as significant growth in allergenic *** methods,including heat treatments,have been applied to alleviate and reduce the effect of antibiotic residue level in milk and milk *** in drug levels were not sig-nificantly remarkable,obliging researchers to find new approaches to prevent or reduce their risk and limit their complications on human health.

关键词： Antibiotics residues Milk products Bacterial resistance Antimicrobial drugs Microorganisms Health effects