Development of a Biopolymer by Chemical Modification of β-Cyclodextrin for Pharmaceutical Applications

作     者：Ghemit Rima Baitiche Milad Makhloufi Abdesselam 

作者机构：Faculty of Technology Ferhat Abbas University Sétif 19000 Algeria 

出 版 物：《材料科学与工程（中英文A版）》 (Journal of Materials Science and Engineering A)

年 卷 期：2014年第4卷第7期

页      面：209-215页

学科分类：0820[工学-石油与天然气工程] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070305[理学-高分子化学与物理] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 082002[工学-油气田开发工程] 

主　　题：环糊精 生物聚合物 化学改性 制药 应用 药物制备 FTIR光谱 反应产率 

摘      要：The need for effective and safe therapeutic systems comply deliverances medication with the patient, led to the development of new tools and strategies. Cyclodextrins (CDs) are widely used as an excipient in many pharmaceutical forms. In this work, the β-cyclodextrin (β-CD) has been modified in order to serve as a vehicle for the design of capsules with diclofenac sodium (DCFNa) is the active ingredient. This modification is based on the crosslinking of the β-cyclodextrin by citric acid in the presence of a catalyst. Modulation parameters of the reaction were carried out by varying the content of the polyacid and used this in order to have the best reaction yield. The resulting matrix of this method was used to prepare the inclusion complexes with the drug. The characterization of these systems is performed by FTIR spectroscopy and XRD. Then, the release of DCFNa (packed in capsules), from native and cross-linked matrices in a simulated gastric and intestinal environment (pH = 1.2, t = 2 h) and (pH = 6.8, t = 6 h), was done. The kinetics of drug were studied and the dissolution profiles for the cross-linked and native β-CD were compared.