Defect of insulin signal in peripheral tissues: important role of ceramide

作     者：Rima Hage Hassan Olivier Bourron Eric Hajduch 

作者机构：INSERMUMR-S 1138Centre de Recherche des CordeliersF-75006 ParisFrance UniversitéPierre et Marie Curie-Paris 6UMR-S 872F-75006 ParisFrance Université Paris DescartesUMR-S 872F-75006 ParisFrance Olivier BourronDepartment de Diabétologie et Maladies métaboliquesAP-HPHopital Pitié-SalpêtrièreF-75006 ParisFrance 

出 版 物：《World Journal of Diabetes》 (世界糖尿病杂志（英文版）（电子版）)

年 卷 期：2014年第5卷第3期

页      面：244-257页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Supported by INSERM,the SociétéFrancophone du Diabète an Agence Nationale de la Recherche grant project(Crisalis) 

主　　题：Diabetes Insulin resistance Lipids Insulin signaling Triglycerides Palmitate Sphingolipid Akt Ceramide synthase Protein phosphatase 2A Protein kinase C ζ/λ 

摘      要：In healthy people,balance between glucose production and its utilization is precisely *** circulating glucose reaches a critical threshold level,pancreaticβcells secrete insulin that has two major actions:to lower circulating glucose levels by facilitating its uptake mainly into skeletal muscle while inhibiting its production by the ***,dietary triglycerides are the main source of fatty acids to fulfill energy needs of oxidative ***,the unconsumed fraction of excess of fatty acids is stored in lipid droplets that are localized in adipocytes to provide energy during fasting ***,adipose tissue acts as a trap for fatty acid excess liberated from plasma *** the buffering action of adipose tissue to store fatty acids is impaired,fatty acids that build up in othertissues are metabolized as sphingolipid derivatives such as *** studies suggest that ceramides are among the most active lipid second messengers to inhibit the insulin signaling pathway and this review describes the major role played by ceramide accumulation in the development of insulin resistance of peripherals tissues through the targeting of specific proteins of the insulin signaling pathway.