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孩子毛病都是惯出来的

高血压合并微量白蛋白尿及非胰岛素依赖型糖尿病患者双重阻断肾素-血管紧张素系统的随机对照研究:candesartan和lisinopril对微量白蛋白尿的作用

2018年

作者： (美)理查德·瓦茨(richard watts)

本书认为当你为你的孩子准备好所有东西的时候，你也从他们身上剥夺了一部分。作为美国最成功家庭服务的资深私人顾问和法律顾问，理查德·瓦茨深深了解到权利的极端，并希望帮助读者避免这些极端现象在孩子身上的再现。本书将教你如何...

ISBN: (数字)9787505744905

本书认为当你为你的孩子准备好所有东西的时候，你也从他们身上剥夺了一部分。作为美国最成功家庭服务的资深私人顾问和法律顾问，理查德·瓦茨深深了解到权利的极端，并希望帮助读者避免这些极端现象在孩子身上的再现。本书将教你如何重新为你的孩子定向，为读者提供一些实用的方法策略，如设置边界、确保言行一致以及允许孩子自己照顾自己等。

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来源：汇雅图书（南通市图书馆... 评论

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英国医学杂志中文版 2001年第4期4卷 190-195页

作者： Carl Erik Mogensen Steen Neldam Ilkka Tikkanen Shmuel Oren Reuven Viskoper richard W watts Mark E Cooper 钟建泳 Department of Medicine MKommune hospitaletUniversity Hospital Helsinki University Hospital Clinic of Internal Diseases Barzilai Medical Centre Department of Medicine University of Melbourne(RepatriationCampus)

目的 :对存在微量白蛋白尿、高血压的 2型糖尿病患者 ,评估和比较candesartan、lisinopril或两者合用后 ,对血压、尿白蛋白排泄的影响。设计 :前瞻性、随机、平行组、双盲研究。先使用 4周的安慰剂 ,再以candesartan或lisinopril单独治... 详细信息

目的 :对存在微量白蛋白尿、高血压的 2型糖尿病患者 ,评估和比较candesartan、lisinopril或两者合用后 ,对血压、尿白蛋白排泄的影响。设计 :前瞻性、随机、平行组、双盲研究。先使用 4周的安慰剂 ,再以candesartan或lisinopril单独治疗 12周 ,随后再单独或两者合用治疗 12周。参与单位 :有 4个国家的三级医院和基本医疗中心参与了此项研究 (共 37个中心 )。研究对象 :共 199例患者 ,年龄 30～ 75岁。干预方法 :candesartan每日 1次 ,16mg ;lisinopril每日 1次 ,2 0mg。主要结局的测量指标 :血压和尿白蛋白肌酐比。结果 :第 12周时 ,candesartan组和lisinopril组舒张压降低的平均值 (95 %可信区间 )分别为 9 5mmHg(7 7mmHg～ 11 2mmHg ,P <0 0 0 1)及 9 7mmHg(7 9mmHg～ 11 5mmHg ,P <0 0 0 1) ,尿白蛋白肌酐比的降低值分别为 30 % (15 %～ 4 2 % ,P<0 0 0 1)及 4 6 % (35 %～ 5 6 % ,P <0 0 0 1)。第 2 4周时 ,联合用药组舒张压降低的平均值 (16 3mmHg,13 6mmHg～ 18 9mmHg,P <0 0 0 1)明显高于candesartan组 (10 4mmHg,7 7mmHg～ 13 1mmHg,P <0 0 0 1)或lisinopril组 (10 7mmHg,8 0mmHg～ 13 5mmHg ,P <0 0 0 1)。尿白蛋白肌酐比降低的平均值 (5 0 % ,36 %～ 6 1% ,P <0 0 0 1)

关键词：高血压 2型糖尿病微量白蛋白尿肾素-血管紧张素系统药物不良反应

Progesterone modulates m TOR in the hippocampus of mice after traumatic brain injury

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Neural Regeneration Research 2018年第3期13卷 434-439页

作者： richard Justin Garling Lora Talley watts Shane Sprague Murat Digicaylioglu Department of Neurosurgery Wayne State University Detroit MI USA School of Medicine The University of Texas Health Science Center at San Antonio San Antonio TX USA Department of Neurosurgery The University of Texas Health Science Center at San Antonio San Antonio TX USA

Spinal cord injury results in the loss of motor and sensory pathways and spontaneous regeneration of adult mammalian spinal cord neurons is limited. Chitosan and sodium alginate have good biocompatibility, biodegradability, and are suitable to assist the recovery of damaged tissues, such as skin, bone and nerve. Chitosan scaffolds, sodium alginate scaffolds and chitosan-sodium alginate scaffolds were separately transplanted into rats with spinal cord hemisection. Basso-Beattie-Bresnahan locomotor rating scale scores and electrophysiological results showed that chitosan scaffolds promoted recovery of locomotor capacity and nerve transduction of the experimental *** days after surgery, chitosan scaffolds retained the original shape of the spinal cord. Compared with sodium alginate scaffolds- and chitosan-sodium alginate scaffolds-transplanted rats, more neurofilament-H-immunoreactive cells （regenerating nerve fibers） and less glial fibrillary acidic protein-immunoreactive cells （astrocytic scar tissue） were observed at the injury site of experimental rats in chitosan scaffold-transplanted rats. Due to the fast degradation rate of sodium alginate, sodium alginate scaffolds and composite material scaffolds did not have a supporting and bridging effect on the damaged tissue. Above all, compared with sodium alginate and composite material scaffolds, chitosan had better biocompatibility, could promote the regeneration of nerve fibers and prevent the formation of scar tissue,and as such, is more suitable to help the repair of spinal cord injury.

关键词： nerve regeneration spinal cord injury chitosan sodium alginate functional recovery scaffold neurofilament-H glial fibrillary acidic protein scar tissue locomotor capacity neural regeneration

Lattice approaches to packed column simulations

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Particuology 2008年第6期6卷 404-411页

作者： richard Caulkin Mike Fairweather richard A. Williams Institute of Particle Science and Engineering School of ProcessEnvironmental and Materials EngineeringUniversity of Leeds

This work presents a review of the findings into the ability of a digitally based particle packing algorithm, called DigiPac, to predict bed structure in a variety of packed columns, for a range of generic pellet shapes frequently used in the chemical and process engineering industries. Resulting macroscopic properties are compared with experimental data derived from both invasive and non-destructive measurement techniques. Additionally, fluid velocity distributions, through samples of the resulting bed structures, are analysed using lattice Boltzmann method （LBM） simulations and are compared against experimental data from the literature.

关键词： Packing algorithm Bed structure Packed columns Macroscopic properties Lattice Boltzmann simulations

Expected adult lifespan in tropical trees: Long-term matrix demography in a large plot

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Forest Ecosystems 2022年第4期9卷 558-566页

作者： richard Condit Morton Arboretum 4100 Illinois Rte.53LisleIL60532USA Institute for Marine Sciences University of CaliforniaSanta CruzUSA

Background: Documenting the entire lifetime of long-lived organisms requires splicing together short-term observations. Matrix demography provides a tool to calculate lifetime statistics, but large samples from juvenile to adult are needed, and few such studies have been done in tropical trees because high species diversity limits sample sizes. The 50-ha plot at Barro Colorado in Panama was designed to provide large samples, and with 30years of censuses, accurate population matrices can be ***: In 31 abundant species, I divided all individuals≥1 cm dbh into 4 or 5 size class in each of seven censuses. Movements of stems between size classes over two censuses are termed transitions, and I constructed complete transition matrices for each species. From the matrices, I derived analytic solutions for lifetime demographic statistics. Expected adult lifespan from the sapling stage was the key ***: Expected adult lifespan from the sapling stage varied 100-fold over the 31 species, from 0.5 to 50 years,and maturation time varied from 19 to nearly 200 years. Species with the highest growth rates also had high death rates, and theoretical calculations of reproductive lifespan show that the fast-growing pioneer species have short expected adult lifespans relative to the average slow-growing, shade-tolerant species. Within the slowgrowth category, however, there was high variation in expected adult lifespan, and several shade-tolerant species under-performed the pioneers in terms of adult ***: Analytical solutions from population matrices allow theoretical analyses that integrate short-term growth records into lifespans of tropical trees. The analyses suggest that pioneer species must reproduce more successfully than shade-tolerant species to persist in the Barro Colorado forest. My next goal is to incorporate seed production and germination into lifetime matrix demography to test this hypothesis.

关键词： Tree lifespan Tropical tree Matrix demography

Does progesterone show neuroprotective effects on traumatic brain injury through increasing phosphorylation of Akt in the hippocampus?

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Neural Regeneration Research 2014年第21期9卷 1891-1896页

作者： richard Justin Garling Lora Talley watts Shane Sprague Lauren Fletcher David F.Jimenez Murat Digicaylioglu Department of Neurosurgery University of Texas Health Science CenterSan AntonioTXUSA Research Imaging Institute University of Texas Health Science CenterSan AntonioTXUSA Department of Cellular and Structural Biology University of Texas Health Science CenterSan AntonioTXUSA Department of Neurology University of Texas Health Science CenterSan AntonioTXUSA

There are currently no federally approved neuroprotective agents to treat traumatic brain injury. Progesterone, a hydrophobic steroid hormone, has been shown in recent studies to exhibit neu-roprotective effects in controlled cortical impact rat models. Akt is a protein kinase known to play a role in cell signaling pathways that reduce edema, inlfammation, apoptosis, and promote cell growth in the brain. This study aims to determine if progesterone modulates the phosphor-ylation of Aktvia its threonine 308 phosphorylation site. Phosphorylation at the threonine 308 site is one of several sites responsible for activating Akt and enabling the protein kinase to carry out its neuroprotective effects. To assess the effects of progesterone on Akt phosphorylation, C57BL/6 mice were treated with progesterone （8 mg/kg） at 1 （intraperitonally）, 6, 24, and 48 hours （subcutaneously） post closed-skull traumatic brain injury. The hippocampus was harvest-ed at 72 hours post injury and prepared for western blot analysis. Traumatic brain injury caused a signiifcant decrease in Akt phosphorylation compared to sham operation. However, mice treat-ed with progesterone following traumatic brain injury had an increase in phosphorylation of Akt compared to traumatic brain injury vehicle. Our ifndings suggest that progesterone is a viable treatment option for activating neuroprotective pathways after traumatic brain injury.

关键词： nerve regeneration Akt traumatic brain injury progesterone apoptosis neuroprotec-tion brain injury western blotting controlled cortical impact neural regeneration

Bound and Resonating Multiquark Configurations

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Chinese Physics Letters 2024年第8期41卷 8-12页

作者： Jean-Marc richard Institut de Physique des 2 Infinis de Lyon Université Claude Bernard(Lyon 1) CNRS-IN2P34 rue Enrico Fermi69622 VilleurbanneFrance

We review the predictions of quark models for multiquark configurations that are bound or resonant states,and compare different methods for estimating the properties of resonances.

关键词： quark Configuration resonant

CONTROLLING ROBOT MANIPULATORS BY DYNAMIC PROGRAMMING

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Acta Mechanica Sinica 1995年第1期11卷 20-33页

作者： MarcJ.richard Department

A certain number of considerations should be taken into account in the dynamic control of robot manipulators as highly complex non-linear *** this article,we provide a detailed presentation of the mechanical and electrical impli- cations of robots equipped with DC motor *** model takes into account all non-linear aspects of the ***,we develop computational algorithms for optimal control based on dynamic *** robot's trajectory must be predefined,but performance criteria and constraints applying to the system are not limited and we may adapt them freely to the robot and the task being *** an example,a manipulator arm with 3 degrees of freedom is analyzed.

关键词： dynamic programming robot manipulators optimal control dynamic modelling method

Large scale manufacture of magnetic polymer particles using membranes and microfluidic devices

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China Particuology 2007年第1期5卷 26-42页

作者： richard A. Williams Institute of Particle Science and Engineering School of Process Environmental and Materials Engineering University of Leeds Clarendon Road Leeds LS2 9JT United Kingdom

Magnetic polymer particles have found applications in diverse areas such as biomedical treatments, diagnosis and separation technology. These applications require the particles to have controlled sizes and narrow size distributions to gain better control and reproducibility in use. This paper reviews recent developments in the preparation of magnetic polymer particles at nano- and micro-scales by encapsulating magnetic components with dissolved or in situ formed polymers. Particle manufacture using emulsification and embedment methods produces magnetic polymer particles at micro-scale dimensions. However, the production of particles in this range using conventional emulsification methods affords very limited control over particle sizes and polydispersity. We report on alternative routes using membrane and microfluidics emulsification techniques, which have a capability to produce monodisperse emulsions and polymer microspheres （with coefficients of variation of less than 10%） in the range from submicrometer to a few 100 μm. The performance of these manufacturing methods is assessed with a view to future applications.

关键词： Magnetic polymer particles Membrane emulsification Microfluidics emulsification Large scale manufacture