Reduced striatal volumes in Parkinson’s disease:a magnetic resonance imaging study
在 Parkinson 的减少的 striatal 卷 ? s 疾病: 磁性的回声成像研究作者机构：Department of MedicineUniversity of OtagoChristchurchNew Zealand New Zealand Brain Research Institute66 Stewart StChristchurch 8011New Zealand Department of PsychologyUniversity of CanterburyChristchurchNew Zealand College of MedicineUniversity of VermontBurlingtonVTUSA Christchurch Radiology GroupChristchurchNew Zealand Department of NeurologyCanterbury District Health BoardChristchurchNew Zealand
出 版 物：《Translational Neurodegeneration》 (转化神经变性病（英文）)
年 卷 期：2012年第1卷第1期
页 面：132-139页
基 金：Funding was received from Lottery Health Research The Neurological Foundation Canterbury Research Foundation and The Neurology Trust
主 题：Magnetic resonance imaging Volumetry Caudate Putamen Parkinson’s disease
摘 要：Background:The presence and extent of structural changes in the brain as a consequence of Parkinson’s disease(PD)is still poorly ***:High-resolution 3-tesla T1-weighted structural magnetic resonance images in sixty-five PD and 27 age-matched healthy control participants were ***,caudate,and intracranial volumes were manually traced in the axial plane of 3D reconstructed *** nuclei volumes were normalized to intracranial volume for statistical *** status was assessed using the Unified Parkinson’s Disease Rating Scale and Hoehn and Yahr *** status was assessed using global status tests and detailed neuropsychological ***:Both caudate and putamen volumes were smaller in PD brains compared to controls after adjusting for age and *** volumes were reduced by 11%(p=0.001)and putamen volumes by 8.1%(p=0.025).PD striatal volumes were not found to be significantly correlated with cognitive or motor ***:Small,but significant reductions in the volume of both the caudate and putamen occur in PD *** reductions are independent of the effects of age and gender,however the relation of these reductions to the functional loss of dopamine,which is characteristic of PD,remains unclear.
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