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Increased activation of the Caudate nucleus and parahippocampal gyrus in Parkinson's disease patients with dysphagia after repetitive transcranial magnetic stimulation:a case-control study

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Neural Regeneration Research 2022年第5期17卷 1051-1058页

作者： Pei-Ling Huang Song-Jian Wang Rui-Feng Sun Zi-Man Zhu Xiao-Ling Li Wen-Shan Li Meng-Yue Wang Meng Lin Wei-Jun Gong Department of Neurological Rehabilitation Beijing Rehabilitation Hospital of Capital Medical UniversityBeijingChina Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application School of Biomedical EngineeringCapital Medical UniversityBeijingChina Department of Neurological Rehabilitation Beijing Rehabilitation Medicine AcademyCapital Medical UniversityBeijingChina

Repetitive transcranial magnetic stimulation(r TMS)has been shown to effectively improve impaired swallowing in Parkinson's disease(PD)patients with dysphagia.However,little is known about how r TMS affects the corresponding brain regions in this patient group.In this casecontrol study,we examined data from 38 PD patients with dysphagia who received treatment at Beijing Rehabilitation Medicine Academy,Capital Medical University.The patients received high-frequency r TMS of the motor cortex once per day for 10 successive days.Changes in brain activation were compared via functional magnetic resonance imaging in PD patients with dysphagia and healthy controls.The results revealed that before treatment,PD patients with dysphagia showed greater activation in the precentral gyrus,supplementary motor area,and cerebellum compared with healthy controls,and this enhanced activation was weakened after treatment.Furthermore,before treatment,PD patients with dysphagia exhibited decreased activation in the parahippocampal gyrus,Caudate nucleus,and left thalamus compared with healthy controls,and this activation increased after treatment.In addition,PD patients with dysphagia reported improved subjective swallowing sensations after r TMS.These findings suggest that swallowing function in PD patients with dysphagia improved after r TMS of the motor cortex.This may have been due to enhanced activation of the Caudate nucleus and parahippocampal gyrus.The study protocol was approved by the Ethics Committee of Beijing Rehabilitation Hospital of Capital Medical University(approval No.2018 bkky017)on March 6,2018 and was registered with Chinese Clinical Trial Registry(registration No.Chi CTR 1800017207)on July 18,2018.

关键词： brain regions Caudate clinical trial dysphagia functional magnetic resonance imaging parahippocampal gyrus Parkinson's disease precentral gyrus repetitive transcranial magnetic stimulation saliva swallowing task

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Hydrochloric acid enhanced radiofrequency ablation for treatment of large hepatocellular carcinoma in the Caudate lobe:Report of three cases

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World Journal of Clinical Cases 2019年第4期7卷 508-515页

作者： Han-Xia Deng Jin-Hua Huang Wan Yee Lau Fei Ai Min-Shan Chen Zhi-Mei Huang Tian-Qi Zhang Meng-Xuan Zuo Department of Minimally Invasive Interventional Therapy Cancer Centre of Sun Yat-sen University State Key Laboratory of Oncology in Southern China Department of Hepatobiliary Surgery Cancer Centre of Sun Yat-sen University Faculty of Medicine The Chinese University of Hong Kong Prince of Wales Hospital

BACKGROUND To report on the use of percutaneous hydrochloric acid(HCl) enhanced radiofrequency ablation(HRFA) for the treatment of large(maximum diameter ≥5 cm) hepatocellular carcinoma(HCC) in the Caudate lobe.CASE SUMMARY Between August 2013 and June 2016, three patients with a large HCC(maximum diameter: 5.0, 5.7, and 8.1 cm) in the Caudate lobe were treated by transarterial chemoembolization followed by computer tomography(CT) guided RFA using a monopolar perfusion RF electrode, which was enhanced by local infusion of 10%HCl at 0.2 mL/min(total volume, 3 to 12 mL). The output power of HRFA reached 100 W, and the average ablation time was 39 min(range, 15 to 60 min).Two patients each underwent one session of HRFA and one patient two sessions.After treatment, CT/magnetic resonance imaging showed that all the three lesions were completely ablated. There was no major complication. Two patients had asymptomatic bile duct dilatation. One patient died of tongue cancer 24 mo after ablation. The remaining two patients were alive and no area of enhancement is detected in the Caudate lobe at 28 and 60 mo after ablation, respectively.CONCLUSION Percutaneous CT-guided HRFA is safe and efficacious in treating large HCC in the Caudate lobe.

关键词： Hydrochloric acid Radiofrequency ablation Hydrochloric acid enhanced radiofrequency ablation Caudate lobe Large hepatocellular carcinoma Case report

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Feasibility of laparoscopic isolated Caudate lobe resection for rare hepatic mesenchymal neoplasms

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World Journal of Clinical Cases 2019年第20期7卷 3194-3201页

作者： Yang Li Kai-Ning Zeng Dan-Yun Ruan Jia Yao Yang Yang Gui-Hua Chen Gen-Shu Wang Department of Liver Surgery and Liver Transplantation Guangzhou Clinical Research and Translation Center for Liver DiseaseThe Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630Guangdong ProvinceChina Department of Medical Oncology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630Guangdong ProvinceChina

BACKGROUND Mesenchymal tumors such as perivascular epithelioid cell neoplasm(PEComa)and inflammatory pseudotumor-like follicular dendritic cell sarcoma(IPT-like FDC sarcoma)are relatively uncommon in the liver and are particularly rare in the Caudate lobe.The clinical manifestations and available imaging tests lack specificity for hepatic mesenchymal tumors.To the best of our knowledge,no Caudate PEComa or IPT-like FDC sarcoma has been completely resected by laparoscopy.The standard laparoscopic technique,surgical approaches,and tumor margins for potentially malignant or malignant Caudate mesenchymal tumors are still being explored.AIM To assess both the safety and feasibility of laparoscopic resection for rare Caudate mesenchymal neoplasms.METHODS Eleven patients who underwent isolated Caudate lobe resection from 2003 to 2017 were identified from a prospective database.Three consecutive patients with rare Caudate mesenchymal tumors underwent laparoscopic resection.Patient demographic data,intraoperative parameters,and postoperative outcomes were assessed and compared with the open surgery group.RESULTS All procedures for the three resection patients with Caudate mesenchymal tumors were completed using a total laparoscopic technique by two different approaches.The average operative time was 226 min,and the estimated blood loss was 133 mL.The average length of postoperative hospital stay was 6.3±0.3 d for the laparoscopy group and 15.5±2.3 d for the open surgery group(PCaudate lobe resection for rare mesenchymal neoplasms is a feasible and curative surgical option in selected patients.

关键词： Laparoscopic liver resection Caudate lobe Perivascular epithelioid cell neoplasm Inflammatory pseudotumor-like follicular dendritic cell sarcoma

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Management of hepatocellular carcinoma rupture in the Caudate lobe

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World Journal of Gastroenterology 2015年第26期21卷 8163-8169页

作者： De-Fei Hong Ying-Bin Liu Shu-You Peng Jin-Zhong Pang Zhi-Fei Wang Jian Cheng Guo-Liang Shen Yuan-Biao Zhang Department of Hepatobiliary Pancreatic Surgery and Minimally Invasive SurgeryZhejiang Provincial People’s Hospital Department of General Surgery Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Department of General Surgery the First People’s Hospital of Qingdao Economic and Technical Department Zone

AIM: To demonstrate that Caudate lobectomy is a valid treatment in cases of hepatocellular carcinoma(HCC) rupture in the Caudate lobe based on our experience with the largest case series reported to date.METHODS: A retrospective study of eight patients presenting with spontaneous rupture and hemorrhage of HCC in the Caudate lobe was conducted.Two patients underwent ineffective transarterial embolization preoperatively.Caudate lobectomy was performed in all eight patients.Bilateral approach was taken in seven cases for isolated complete Caudate lobectomy.Left-sided approach was employed in one case for isolated partial Caudate lobectomy.Transarterial chemoembolization was performed postoperatively in all patients.RESULTS: Caudate lobectomy was successfully completed in all eight cases.The median time delay from the diagnosis to operation was 5 d(range: 0.25-9).Median operating time was 200 min(range: 120-310) with a median blood loss of 900 m L(range: 300-1500).Five patient remained in long-term follow-up,with one patient becoming lost to followup at 3 years and two patients currently alive at 7 and 19 mo.One patient required reoperation due to recurrence.Gamma knife intervention was performed for brain metastasis in another case.Two patients survived for 10 and 84 mo postoperatively,ultimately succumbing to multiple organ metastases.CONCLUSION: Caudate lobectomy is the salvage choice for HCC rupture in the Caudate lobe.Local anatomy and physiologic features of the disease render Caudate lobectomy a technically difficult operation.Postponement of surgical intervention is thus recommended while the rupture remains hemodynamically stable until an experienced surgeon becomes available.Prognosis is confounded by numerous factors,but long-term survival can be expected in the majority of cases.

关键词： Caudate lobectomy Hepatocellular carcinoma Emergency Rupture transarterial embolization

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Prognostic factors in the surgical treatment of Caudate lobe hepatocellular carcinoma

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World Journal of Gastroenterology 2010年第9期16卷 1123-1128页

作者： Peng Liu,Jia-Mei Yang,Wen-Yang Niu,Tong Kan,Feng Xie,Dian-Qi Li,Ye Wang,Yan-Ming Zhou,Department of Special Treatment and Liver Transplantation,Eastern Hepatobiliary Surgery Hospital,Second Military Medical University,Shanghai 200438,China Peng Liu,Department of Hepatobiliary Surgery,Navy General Hospital,Beijing 100037,China Department of Special Treatment and Liver Transplantation Eastern Hepatobiliary Surgery Hospital Second Military Medical University Shanghai 200438 China.

AIM:To evaluate the short-and long-term outcomes of liver resection for Caudate lobe hepatocellular carcinoma (HCC).METHODS:We retrospectively analyzed 114 consecutive patients with HCC,originating from the Caudate lobe,who underwent resection between January 2001 and January 2007.Univariate and multivariate analyses were performed on several clinicopathologic variables to determine the factors affecting long-term outcome and intrahepatic recurrence.RESULTS:Overall mortality and morbidity were 0% and 18%,respectively.After a median follow-up of 31 mo (interquartile range,11-66 mo),tumor recurrence had occurred in 76 patients (66.7%).The 1-,3-,and 5-year disease-free survival rates were 65.7%,38.1%,and 18.4%,respectively.The 1-,3-,and 5-year overall survival rates were 76.1%,54.7%,and 31.8%,respectively.Univariate analysis showed that subsegmental location of the tumor (45.7% vs 16.2%,P=0.01),liver cirrhosis (12.3% vs 47.9%,P=0.03),surgical margin (18.5% vs 54.6%,P=0.04),vascular invasion (37.9% vs 23.2%,P=0.04) and extended Caudate resection (42.1% vs 15.4%,P=0.04) were related to poorer long-term survival.Multivariate analysis showed that only subsegmental location of the tumor,liver cirrhosis and surgical margin were significant independent prognostic factors.CONCLUSION:Hepatectomy was an effective treatment for HCC in the Caudate lobe.The subsegmental location of the tumor,liver cirrhosis and surgical margin affected long-term survival.

关键词： Hepatectomy Hepatocellular carcinoma Caudate lobe Prognostic factors

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Caudate Volume in Offspring at Ultra High Risk for Alcohol Dependence: COMT Val158Met, DRD2, Externalizing Disorders, and Working Memory

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Advances in Molecular Imaging 2013年第4期3卷 43-54页

作者： Shirley Y. Hill Sarah Lichenstein Shuhui Wang Howard Carter Michael McDermott Department of Psychiatry University of Pittsburgh School of Medicine Pittsburgh USA Department of Psychiatry University of Pittsburgh School of Medicine Pittsburgh USA Department of Psychology University of Pittsburgh Pittsburgh USA

Background: There is emerging evidence that the increased susceptibility to developing alcohol and substance use dis- orders in those with a family history of Alcohol Dependence (AD) may be related to structural differences in brain circuits that influence the salience of rewards or modify the efficiency of information processing. Externalizing disorders of childhood including Attention Deficit Hyperactivity Disorder, Conduct and Oppositional Disorders are a prominent feature of those with a positive family history. The Caudate nuclei have been implicated in both the salience of rewards and in the pathophysiology of alcohol dependence and these often antecedent childhood disorders. Methods: Adolescent/young adult high and low-risk for AD offspring (N = 130) were studied using magnetic resonance imaging. Volumes of the Caudate nucleus were obtained using manual tracing with BRAINS2 software and neuropsychological functioning determined. Childhood disorders were assessed as part of a long-term longitudinal follow-up that includes young adult assessment. Dopaminergic variation was assessed using genotypic variation in the catechol-O-methyltransferase (COMT) and DRD2 genes. Results: High-risk subjects showed poorer Working Memory functioning. Caudate volume did not differ between high and low-risk subjects, but those with externalizing disorders of childhood showed reduced Caudate volume. Variation in COMT and DRD2 genes was associated with Working Memory performance and Caudate volume. Conclusions: Caudate volume is reduced in association with externalizing disorders of childhood/adolescence. Working Memory deficits appear in familial high-risk offspring and those with externalizing disorders of childhood. The dopaminergic system appears to be involved in both working memory performance and externalizing disorders of childhood.

关键词： Caudate High-Risk COMT DRD2 MRI Working Memory

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Emergency Caudate lobectomy for ruptured hepatocellular carcinoma with multiple primary cancers

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World Journal of Gastroenterology 2013年第3期19卷 418-421页

作者： Long-Hao Sun Hong-Qiu Han Peng-Zhi Wang Wei-Jun Tian Department of General Sugery Tianjin Medical University General Hospital

We report a case of metachronous multiple primary malignancies involving both rectum and liver with colonic metastasis from hepatocellular carcinoma(HCC) through hematogenous pathway.A 72-year-old woman was admitted to the emergency department with right upper abdominal pain for 4 h.Considering her surgical history of Mile's procedure plus liver resection for rectal cancer with liver metastasis three years ago and the finding of urgent computed tomography scan on admission,the preoperative diagnosis was spontaneous rupture of rectal liver metastasis located in Caudate lobe and colonic metastasis from rectal cancer. The patient underwent an emergency isolated Caudate lobectomy at a hemorrhagic shock status.Pathology reported a primary HCC in the Caudate lobe and colonic metastasis of HCC with tumor embolus in the surrounding vessels of the intestine.No regional lymph node involvement was found.It is hypothesized that HCC may disseminate hematogenously to the ascending colon,thus making it a rare case.

关键词： Emergency isolated Caudate lobectomy Multiple primary malignancies Rectal adenocarcinoma Hepatocellular carcinoma Hematogenous metastasis

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Testing whether adrenal steroids mediate phenotypic and physiologic effects of elevated salinity on larval tiger salamanders

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Integrative Zoology 2023年第1期18卷 27-44页

作者： Brian J.TORNABENE Erica J.CRESPI Creagh W.BREUNER Blake R.HOSSACK Wildlife Biology Program W.A.Franke College of Forestry&ConservationUniversity of MontanaMissoulaMontanaUSA School of Biological Sciences Center for Reproductive SciencesWashington State UniversityPullmanWashingtonUSA U.S.Geological Survey Northern Rocky Mountain Science CenterMissoulaMontanaUSA

Salinity(sodium chloride,NaCl)from anthropogenic sources is a persistent contaminant that negatively affects freshwater taxa.Amphibians can be susceptible to salinity,but some species are innately or adaptively tolerant.Physiological mechanisms mediating tolerance to salinity are still unclear,but changes in osmoregulatory hor-mones such as corticosterone(CORT)and aldosterone(ALDO)are prime candidates.We exposed larval barred tiger salamanders(Ambystoma mavortium)to environmentally relevant NaCl treatments(<32–4000 mg·L-1)for 24 days to test effects on growth,survival,and waterborne CORT responses.Of those sampled,we also quantiﬁed waterborne ALDO from a subset.Using a glucocorticoid antagonist(RU486),we also experimentally suppressed CORT signaling of some larvae to determine if CORT mediates effects of salinity.There were no strong differ-ences in survival among salinity treatments,but salinity reduced dry mass,snout–vent length,and body condition while increasing water content of larvae.High survival and sublethal effects demonstrated that salamanders were physiologically challenged but could tolerate the experimental concentrations.CORT signaling did not attenuate sublethal effects of salinity.Baseline and stress-induced(after an acute stressor,shaking)CORT were not inﬂu-enced by salinity.ALDO was correlated with baseline CORT,suggesting it could be difﬁcult to decouple the roles of CORT and ALDO.Future studies comparing ALDO and CORT responses of adaptively tolerant and previously unexposed populations could be beneﬁcial to understand the roles of these hormones in tolerance to salinity.Nev-ertheless,our study enhances our understanding of the roles of corticosteroid hormones in mediating effects of a prominent anthropogenic stressor.

关键词： Caudate conservation physiology glucocorticoids sodium chloride tolerance

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Regional gray matter abnormality in hepatic myelopathy patients after transjugular intrahepatic portosystemic shunt: a voxel-based morphometry study

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Neural Regeneration Research 2019年第5期14卷 850-857页

作者： Kang Liu Gang Chen Shu-Yao Ren Yuan-Qiang Zhu Tian-Lei Yu Ping Tian Chen Li Yi-Bin Xi Zheng-Yu Wang Jian-Jun Ye Guo-Hong Han Hong Yin Department of Radiology Xijing Hospital Air Force Military Medical University (Fourth Military Medical University) Department of Radiology Lanzhou General Hospital Lanzhou Military Command Xijing Hospital of Digestive Diseases Air Force Military Medical University (Fourth Military Medical University) Life Sciences Research Center School of Life Sciences and Technology Xidian University

Hepatic myelopathy is a complication seen in patients with chronic liver failure with physiologic or iatrogenic portosystemic shunting. The main symptom is progressive lower limb dyskinesia. The role of the brain motor control center in hepatic myelopathy is unknown. This study aimed to investigate the gray matter changes in patients with hepatic myelopathy secondary to transjugular intrahepatic portosystemic shunt and to examine their clinical relevance. This was a cross-sectional study. Twenty-three liver failure patients with hepatic myelopathy(hepatic myelopathy group), 23 liver failure patients without hepatic myelopathy(non-hepatic myelopathy group) after transjugular intrahepatic portosystemic shunt, and 23 demographically matched healthy volunteers were enrolled from March 2014 to November 2016 at Xijing Hospital, Air Force Military Medical University(Fourth Military Medical University), China. High-resolution magnetization-prepared rapid gradient-echo brain imaging was acquired. Group differences in regional gray matter were assessed using voxel-based morphometry analysis. The relationship between aberrant gray matter and motor characteristics was investigated. Results demonstrated that compared with the non-hepatic myelopathy group, gray matter volume abnormalities were asymmetric, with decreased volume in the left insula(P = 0.003), left thalamus(P = 0.029), left superior frontal gyrus(P = 0.006), and right middle cingulate cortex(P = 0.021), and increased volume in the right Caudate nucleus(P = 0.017), corrected with open-source software. The volume of the right Caudate nucleus in the hepatic myelopathy group negatively correlated with the lower limb clinical rating of the Fugl-Meyer Assessment(r = –0.53, P = 0.01). Compared with healthy controls, patients with and without hepatic myelopathy exhibited overall increased gray matter volume in both thalami, and decreased gray matter volume in both putamen, as well as in the globus pallidus, cerebellum, and vermis. The gray matter abnormalities we found p

关键词： portosystemic shunt hepatic myelopathy hepatic encephalopathy magnetic resonance imaging gray matter lower limb Fugl-Meyer Assessment basal ganglia Caudate nucleus voxel-based morphometry

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EFFECT OF INTRAVENTRICULAR INJECTION OF DOPAMINE ON PAIN-EXCITATION AND PAIN-IN HIBITION NEURONS IN Caudate NUCLEUS OF RAT

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Chinese Science Bulletin 1989年第16期34卷 1386-1389页

作者：马玉羡谷瑞民孙明智 Department of Physiology Harbin Medical University

Many experiments have shown that the central dopaminergic system is closely related with acupuncture and morphine analgesia. However, there are certain divergences among different authors. Some reported that the central dopaminergic system abates acupuncture and morphine analgesia while others reported that the dopaminergic system coorperates with acupuncture analgesia. The aim of this work is to go further into the relationships of the dopaminergic system in the Caudate nucleus (N. Cd.) with pain sensation.

关键词： intraventricle Caudate nucleus dopamine

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