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Effectiveness of rotavirus vaccines against rotavirus infection and hospitalization in Latin America: systematic review and metaanalysis

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Infectious Diseases of Poverty 2016年第1期5卷 764-775页

作者： Victor S.Santos Daniella P.Marques Paulo R.S.Martins-Filho Luis E.Cuevas ricardo q.gurgel Postgraduate Program in Health Sciences Federal University of SergipeRua Cláudio Batista s/nAracajuSergipe Zip code:49060-108Brazil Department of Medicine Federal University of SergipeAracajuSergipeBrazil Investigative Pathology Laboratory Federal University of SergipeAracajuSergipeBrazil Liverpool School of Tropical Medicine LiverpoolUK

Background:Rotavirus was the leading cause of childhood diarrhoea-related hospitalisations and death before the introduction of rotavirus ***:We describe the effectiveness of rotavirus vaccines to prevent rotavirus infections and hospitalizations and the main rotavirus strains circulating before and after vaccine introduction through a systematic review and meta-analysis of studies published between 1990 and 2014.203 studies were included to estimate the proportion of infections due to rotavirus and 10 to assess the impact of the vaccines.41 of 46 studies in the post-vaccination period were used for meta-analysis of genotypes,20 to calculate VE against infection,eight for VE against hospitalisation and seven for VE against severe ***:24.3%(95%CI 22.1–26.5)and 16.1%(95%CI 13.2–19.3)of cases of diarrhoea were due to rotavirus before and after vaccine introduction,*** most prevalent G types after vaccine introduction were G2(51.6%,95%CI 38–65),G9(14.5%,95%CI 7–23)and G1(14.2%,95%CI 7–23);while the most prevalent P types were P[4](54.1%,95%CI 41–67)and P[8](33%,95%CI 22–46).G2P[4]was the most frequent genotype combination after vaccine *** was 53%(95%CI 46–60)against infection,73%(95%CI,66–78)against hospitalisation and 74%(95%CI,68.0–78.0)against severe *** in hospitalisations and mortality due to diarrhoea were observed in countries that adopted universal rotavirus ***:Rotavirus vaccines are effective in preventing rotavirus-diarrhoea in children in Latin *** vaccines were associated with changes in genotype distribution.

关键词： Rotavirus vaccines Rotavirus vaccine effectiveness Rotavirus genotype Meta-analysis Latin America

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Pain and quality of life in leprosy patients in an endemic area of Northeast Brazil:a cross-sectional study

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Infectious Diseases of Poverty 2016年第1期5卷 161-164页

作者： Victor S.Santos Jamilly C.V.Santana Fabrícia D.N.Castro Laudice S.Oliveira Julianne C.V.Santana Vera L.C.Feitosa ricardo q.gurgel Luis E.Cuevas Federal University of Sergipe Rua Cláudio Batistas/nCidade NovaAracaju 49100-000SergipeBrazil.2 Liverpool School of Tropical MedicineLiverpoolUK

Background:Pain emerges as a challenge in the treatment of leprosy *** this study,we describe the prevalence and type of pain in patients with leprosy,and its effect on patients’quality of life in an endemic area of Northeast ***:A cross-sectional survey of 260 patients attending leprosy reference centres in Sergipe,Northeast Brazil was *** were assessed for the presence and type of pain,skin sensory loss,peripheral nerve enlargement,touch and pinprick sensations,mechanical allodynia and nerve *** completed the Douleur Neuropathique 4 questionnaire,and we also used the Brief Pain Inventory scale and the World Health Organization quality of Life-BREF instrument to arrive at our *** hundred and ninety-five(75%)patients reported pain,mostly of the neuropathic *** was moderate in 84(43.1%)and severe in 94(48.2%)*** presence of pain was associated with disability(p=0.001),leprosy reactions(p=0.004)and lower quality of *** patients with neuropathic pain were treated with steroids,despite their low efficacy for this type of ***:Pain is highly prevalent among leprosy patients and is associated with low quality of *** management should include a systematic assessment of the type of pain a patient experiences in order to provide adequate treatment.

关键词： Leprosy Pain Neuropathic pain quality of life Sergipe Braz

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Anti-inflammatory natural products modulate interleukins and their related signaling markers in inflammatory bowel disease:A systematic review

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Journal of Pharmaceutical Analysis 2023年第12期13卷 1408-1428页

作者： Gopalsamy Rajiv Gandhi Thiruchenduran Mohana Kumaraswamy Athesh Varghese Edwin Hillary Alan Bruno Silva Vasconcelos Mariana Nobre Farias de Franca Monalisa Martins Montalvão Stanislaus Antony Ceasar Gnanasekaran Jothi Gurunagarajan Sridharan ricardo queiroz gurgel Baojun Xu Division of Phytochemistry and Drug Design Department of BiosciencesRajagiri College of Social Sciences(Autonomous)KalamaserryKochi683104KeralaIndia Department of Biochemistry Meenakshi Ammal Dental College and Hospital(MAHER)Maduravoyal600095ChennaiTamil NaduIndia Department of Biochemistry Srimad Andavan Arts and Science College(Autonomous)Affiliated to Bharathidasan UniversityTiruchirapalli620005Tamil NaduIndia Division of Plant Molecular Biology and Biotechnology Department of BiosciencesRajagiri College of Social Sciences(Autonomous)KalamaserryKochi683104KeralaIndia Laboratory of Biology and Immunology of Cancer and Leishmania Department of MorphologyFederal University of SergipeSao CristovaoSergipeBrazil Postgraduate Program in Health Sciences(PPGCS) Federal University of Sergipe(UFS)Campus Prof.Joao Cardoso NascimentoAracajuCEP 49060.108SergipeBrazil Programme of Food Science and Technology Department of Life SciencesBNU-HKBU United International CollegeZhuhaiGuangdong519087China

This review aims to identify in vivo studies investigating the potential of plant substances and their natural molecules in managing inflammatory bowel disease(IBD).Specifically,the objective is to examine the impact of these substances on interleukins and other key inflammatory signaling *** articles published up to December 2022 were identified through a search of the PubMed,Scopus,Web of Science,and Embase *** search used keywords including“inflammatory bowel disease”,“medicinal plants”,“natural molecules”,“anti-inflammatory”,and“ulcerative colitis”,and identified 1,878 potentially relevant articles,of which 89 were included in this review after completion of the selection *** study provides preclinical data on natural products(NPs)that can potentially treat IBD,including ulcerative *** main actions of these NPs relate to their effects on nuclear factor kappa B(NF-κβ),the Janus kinase(JAK)/signal transducer and activator of transcription(STAT)signaling pathway,the regulation of T helper 17/regulatory T cells balance,and oxidative *** ability of these NPs to inhibit intestinal inflammation appears to be dependent on lowering levels of the pro-inflammatory cytokines tumor necrosis factor-alpha(TNF-α),interleukin(IL)-1β,and IL-17,via the Jun N-terminal kinase(JNK)1,NF-κβ-p65,and STAT3 *** addition,NPs were shown to reduce oxidative stress and the severity of ulcerative colitis,as well as increase the activity of antioxidant *** actions suggest that NPs represent a promising treatment for IBD,and potentially have greater efficacy and safety than current treatments.

关键词： Crohn's disease Inflammation Interleukins Oxidative stress Phytochemicals Ulcerative colitis

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镧系离子间无辐射能量传递速率的教程综述

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发光学报 2022年第12期43卷 1871-1891页

作者： Albano N Carneiro Neto Renaldo T Moura Jr Jorge A A Coelho Mauro E Silva-Junior Janderson L Costa Oscar L Malta ricardo L Longo 阿威罗大学物理系和CICECO-阿威罗材料研究所阿威罗葡萄牙3810-193 南卫理公会大学化学系达拉斯美国75275-0314 帕拉伊巴联邦大学化学与物理系阿雷亚巴西58397-000 伯南布哥联邦大学基础化学系累西腓巴西50740-560 伯南布哥联邦大学材料科学研究生院累西腓巴西50670-901

在本教程综述中,我们重新阐述和表达了镧系离子间无辐射能量传递(ET)速率的理论形式,并且强调了考虑镧系离子本身特异性所引发的与Förster和Dexter理论不同之处。所给出的表达式遵循了Judd-Ofelt的4f-4f跃迁理论框架之下的Kushida方法,... 详细信息

在本教程综述中,我们重新阐述和表达了镧系离子间无辐射能量传递(ET)速率的理论形式,并且强调了考虑镧系离子本身特异性所引发的与Förster和Dexter理论不同之处。所给出的表达式遵循了Judd-Ofelt的4f-4f跃迁理论框架之下的Kushida方法,并计入了如下电多极机制:偶极-偶极(W_(d-d))、偶极-四极(W_(d-q))和四极-四极(W_(q-q))。更为重要的是,当前的机制也扩展包括了交换(W_(ex))和磁偶极子-磁偶极子(W_(md-md))作用,并经过改进进一步包含了屏蔽效应以及给出了F因子(费米黄金规则中的态密度)的解析表达式。与Kushida的原始方法类似,我们只考虑了强制电偶极子(FED)对Judd-Ofelt强度参数的贡献,并细节性地讨论了磁偶极-磁偶极相互作用的选择定则以及相关矩阵元的计算。此外,我们还以Tb(Ⅲ)-Eu(Ⅲ)和Yb(Ⅲ)-Er(Ⅲ)的能量传递速率计算为例,逐步展示了计算过程、主要的计算支撑信息以及所使用的计算脚本。

关键词：无辐射能量传递镧系理论计算 Ln-Ln能量传递速率选择定则

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Assessment of periportal fibrosis in Schistosomiasis mansoni patients by proton nuclear magnetic resonance-based metabonomics models

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World Journal of Hepatology 2022年第4期14卷 719-728页

作者： Milena Lima Rodrigues Tatiane Priscila Santos Rodrigues da Luz Caroline Louise Diniz Pereira Andrea Dória Batista Ana Lúcia Coutinho Domingues ricardo Oliveira Silva Edmundo Pessoa Lopes Programa de Pós-Graduação em Medicina Tropical Centro de Ciências MédicasUniversidade Federal de PernambucoRecife 50670-901PernambucoBrazil Programa de Pós-Graduação em química Centro de Ciências Exatas e da NaturezaUniversidade Federal de PernambucoRecife 50670-740PernambucoBrazil Hospital das Clínicas Departamento de Medicina ClínicaUniversidade Federal de PernambucoRecife 50670-901PernambucoBrazil

BACKGROUND The evaluation of periportal fibrosis(PPF)is essential for a prognostic assessment of patients with Schistosomiasis *** WHO Niamey Protocol defines patterns of fibrosis from abdominal ultrasonography,^(1)H-nuclear magnetic resonance(NMR)-based metabonomics has been employed to assess liver fibrosis in some *** To build 1H-NMR-based metabonomics models(MM)to discriminate mild from significant periportal PPF and identify differences in the metabolite *** A prospective cross-sectional study was performed on schistosomiasis patients at a University Hospital in Northeastern *** evaluated 41 serum samples from 10 patients with mild PPF(C Niamey pattern)and 31 patients with significant PPF(D/E/F Niamey patterns).MM were built using partial least squares-discriminant analysis(PLS-DA)and orthogonal projections to latent structures discriminant analysis(OPLS-DA)*** PLS-DA and OPLS-DA resulted in discrimination between mild and significant PPF groups with R2 and q2 values of 0.80 and 0.38 and 0.72 and 0.42 for each model,*** OPLS-DA model presented accuracy,sensitivity,and specificity values of 92.7%,90.3%,and 100%to discriminate significant *** metabolites identified as responsible by discrimination were:Nacetylglucosamines,alanine,glycolaldehyde,carbohydrates,and *** MMs discriminated mild from significant PPF patterns in patients with Schistosomiasis mansoni through identification of differences in serum metabolites profiles.

关键词： Metabolomics Portal hypertension Schistosoma mansoni Biomarkers Neglected disease Nuclear magnetic resonance

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Molecular characterization and functional analysis of two new lysozyme genes from soybean cyst nematode(Heterodera glycines)

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Journal of Integrative Agriculture 2019年第12期18卷 2806-2813页

作者： WANG Ning PENG Huan LIU Shi-ming HUANG Wen-kun ricardo Holgado Jihong Liu-Clarke PENG De-liang State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural SciencesBeijing 100193P.R.China NIBIO Norwegian Institute of Bioeconomy ResearchPb 115N0-1431 AsNorway

Soybean cyst nematode(SCN, Heterodera glycines(I.)) is one of the most important soil-borne pathogens for soybeans. In plant parasitic nematodes, including SCN, lysozyme plays important roles in the innate defense system. In this study, two new lysozyme genes(Hg-lys1 and Hg-lys2) from SCN were cloned and characterized. The in situ hybridization analyses indicated that the transcripts of both Hg-lys1 and Hg-lys2 accumulated in the intestine of SCN. The q RT-PCR analyses showed that both Hg-lys1 and Hg-lys2 were upregulated after SCN second stage juveniles(J2 s) were exposed to the Grampositive bacteria Bacillus thuringiensis, Bacillus subtilis or Staphylococcus aureus. Knockdown of the identified lysozyme genes by in vitro RNA interference caused a significant decrease in the survival rate of SCN. All of the obtained results indicate that lysozyme is very important in the defense system and survival of SCN.

关键词： soybean cyst nematode lysozyme Hg-lys1 Hg-lys2 innate defense against bacteria

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Multiple Criteria Analysis for Energy Storage Selection

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Energy and Power Engineering 2011年第4期3卷 557-564页

作者： Alexandre Barin Luciane N. Canha Alzenira R. Abaide Karine F. Magnago Breno Wottrich ricardo q. Machado 不详

In view of the current and predictable energy shortage and environmental concerns, the exploitation of renewable energy sources offers great potential to meet increasing energy demands and to decrease depend- ence on fossil fuels. However, introducing these sources will be more attractive provided they operate in conjunction with energy storage systems (ESS). Furthermore, effective energy storage management is essential to achieve a balance between power quality, efficiency, costs and environmental constraints. This paper presents a method based on the analytic hierarchy process and fuzzy multi-rules and multi-sets. By exploiting a multiple criteria analysis, the proposed methods evaluate the operation of storage energy systems such as: pumped hydro and compressed air energy storage, H2, flywheel, super-capacitors and lithium-ion storage as well as NaS advanced batteries and VRB flow battery. The main objective of the study is to find the most appropriate ESS consistent with a power quality priority. Several parameters are used for the investigation: efficiency, load management, technical maturity, costs, environmental impact and power quality.

关键词： Multiple Criteria Analysis Fuzzy Sets AHP Method Energy Storage Systems Power quality

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Another Record: Ocean Warming Continues through 2021 despite La Nina Conditions

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Advances in Atmospheric Sciences 2022年第3期39卷 373-385页

作者： Lijing CHENG John ABRAHAM Kevin ETRENBERTH John FASULLO Tim BOYER Michael EMANN Jiang ZHU Fan WANG ricardo LOCARNINI Yuanlong LI Bin ZHANG Zhetao TAN Fujiang YU Liying WAN Xingrong CHEN Xiangzhou SONG Yulong LIU Franco RESEGHETTI Simona SIMONCELLI Viktor GOURETSKI Gengxin CHEN Alexey MISHONOV Jim REAGAN International Center for Climate and Environment Sciences Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Center for Ocean Mega-Science Chinese Academy of SciencesQingdao 266071China University of St.Thomas School of EngineeringMinnesota 55105USA National Center for Atmospheric Research BoulderColorado 80307USA National Oceanic and Atmospheric Administration National Centers for Environmental InformationSilver SpringMaryland 20910USA Department of Meteorology&Atmospheric Science The Pennsylvania State UniversityUniversity ParkPennsylvania 16802USA Institute of Oceanology Chinese Academy of SciencesQingdao 266071China National Marine Environmental Forecasting Center Ministry of Natural Resources of ChinaBeijing 100081China College of Oceanography Hohai UniversityNanjing 210098China National Marine Data and Information Service Tianjin 300171China Italian National Agency for New Technologies Energy and Sustainable Economic DevelopmentS.Teresa Research CenterLerici 19032Italy Istituto Nazionale di Geofisica e Vulcanologia Sede di BolognaBologna 40128Italy South China Sea Institute of Oceanology Chinese Academy of SciencesGuangzhou 510301China ESSIC/CISESS-MD University of MarylandCollege ParkMD 20742USA

The increased concentration of greenhouse gases in the atmosphere from human activities traps heat within the climate system and increases ocean heat content(OHC). Here, we provide the first analysis of recent OHC changes through 2021 from two international groups. The world ocean, in 2021, was the hottest ever recorded by humans, and the 2021 annual OHC value is even higher than last year’s record value by 14 ± 11 ZJ(1 zetta J = 1021 J) using the IAP/CAS dataset and by16 ± 10 ZJ using NCEI/NOAA dataset. The long-term ocean warming is larger in the Atlantic and Southern Oceans than in other regions and is mainly attributed, via climate model simulations, to an increase in anthropogenic greenhouse gas concentrations. The year-to-year variation of OHC is primarily tied to the El Nino-Southern Oscillation(ENSO). In the seven maritime domains of the Indian, Tropical Atlantic, North Atlantic, Northwest Pacific, North Pacific, Southern oceans,and the Mediterranean Sea, robust warming is observed but with distinct inter-annual to decadal variability. Four out of seven domains showed record-high heat content in 2021. The anomalous global and regional ocean warming established in this study should be incorporated into climate risk assessments, adaptation, and mitigation.

关键词： La Nina ocean heat ocean warming attribution observation

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Submegahertz spectral width photon pair source based on fused silica microspheres

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Photonics Research 2021年第11期9卷 2237-2252页

作者： ERASTO ORTIZ-ricardo CESAR BERTONI-OCAMPO MONICA MALDONADO-TERRON ARTURO GARCIA ZURITA ROBERTO RAMIREZ-ALARCON HECTOR CRUZ RAMIREZ R.CASTRO-BELTRAN ALFRED B.U’REN Instituto de Ciencias Nucleares Universidad Nacional Autonoma de MexicoApartado Postal 70-54304510 MexicoD.F.Mexico Centro de Investigaciones en Optica A.C. Loma del Bosque 115Colonia Lomas del Campestre37150 LeonGuanajuatoMexico Departamento de Ingenieria Fisica Cuerpo Academico de Mecanica EstadisticaDivison de Ciencias e IngenieriasUniversidad de Guanajuato37150 LeonGuanajuatoMexico

High-efficiency submegahertz bandwidth photon pair generators will enable the field of quantum technology to transition from laboratory demonstrations to transformational applications involving information transfer from photons to *** spontaneous parametric processes are able to achieve high-efficiency photon pair generation,the spectral bandwidth tends to be relatively large,as defined by phase-matching *** solve this fundamental limitation,we use an ultrahigh quality factor(q)fused silica microsphere resonant cavity to form a photon pair *** present the full theory for the spontaneous four-wave mixing(SFWM)process in these devices,fully taking into account all relevant source characteristics in our *** exceptionally narrow(down to kilohertz-scale)linewidths of these devices result in a reduction in the bandwidth of the photon pair generation,allowing submegahertz spectral bandwidth to be ***,using a pump source centered around 1550 nm,photon pairs with the signal and idler modes at wavelengths close to 1540 and 1560 nm,respectively,are *** herald a single idler-mode photon by detecting the corresponding signal photon,filtered via transmission through a wavelength division multiplexing channel of *** demonstrate the extraction of the spectral profile of a single peak in the single-photon frequency comb from a measurement of the signal–idler time of emission *** improvements in device design and experimental methods enabled the narrowest spectral width(Δν=366 k Hz)to date in a heralded single-photon source based on SFWM.

关键词： fused silica spectral

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Association between IGF-2 gene and fat-free mass in response to resistance training

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Health 2013年第6期5卷 1003-1009页

作者： Andrea Carmem Guimaraes Rinaldo Wellerson Pereira ricardo Moreno Lima Michel Santos Silva Victor Machado dos Reis Nuno Domingos Garrido Romulo Maia ricardo Jacode Oliveira College of Physical Education Catholic University of BrasiliaBrasiliaBrazil College of Physical Education University of BrasiliaBrasiliaBrazil Health Sciences Postgraduate Program University of BrasiliaBrasiliaBrazil Department of Sports Sciences Exercise and HealthUniversity of Tras-os-Montes and Alto DouroVila RealPortugal Research Center for Sports Health&Human DevelopmentCIDESDVila RealPortugal

BACKGROUND: It is well established that the human aging process is associated with a significant decline in neuromuscular function and performance. Twin studies demonstrate that genetic factors partially explain the inter-individual variation of fat-free mass (FFM) and muscle strength. PURPOSE: To examine the association between the polymorphism of the gene IGF-2 with phenotypes strength and muscle mass of elderly women pre and post resistance training. METHODS: 76 elderly women participated in this analysis. These volunteers, who should be sedentary for at least 6 months before the study, were assigned four groups in relation to allele GAGG, AA, GAAA and GG. The first analysis compared 60 elderly women with GG and GA allele (GAGG) versus 16 elderly women with AA allele. The second analysis compared 54 elderly women with GA and AA (GAAA) versus 22 elderly women GG allele. The Body mass index, fat free mass, fat mass and Isokinetic Muscle Peak Torque were measured. All volunteers were participating in the Resistance Training program. The DNA was extracted from peripheral venous blood leukocytes using a salting out protocol. The primer for IGF-II gene exon 9 was 5’-GTCCCTGAACCAGCAAAGAG-3’ 0.5 μM (0.625 μl) Primer R-5’-TGATGGAAAAGGGAGTGAGG-3’ 0.5 μM (0.625 μl), Taq DNA Polimerase enzime 0.5 U (0.1 μl), água milli-q (3.8 μl) 5 hg de DNA (3 μl). PCR amplification was performed in a programmable thermal cycler GeneAmp? PCR System 9700. RESULTS: The results of the first analysis GAGG × AA versus the group AA showed the relative increase in knee extensor peak torque relative and also in the fat-free mass and showed a decrease in the fat mass percentage in the GAGG group. The second analysis considered the group GAAA versus group GG showed decreases in the fat-free mass percentage in the GAAA group, also showed the relative increase in the fat-free mass in the GG group and decrease in the fat mass percentage in the GG group. CONCLUSIONS: The results of this study show that 2

关键词： Fat-Free Mass Fat Mass Resistance Training Muscle Strength IGF-2 Polymorphism Elderly

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