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Lycopene Supplementation Attenuates Oxidative Stress Parameters in the Plasma of Humans with Cad after Intense Exercise

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Food and Nutrition Sciences 2011年第4期2卷 241-248页

作者： Marília C. Araujo Fernanda S. Soares Merieli M. Ronsani Luiz G. C. Rocha Lilian C. Vieira Luciano A. Silva Tales de carvalho Magnus Benetti ricardo A. Pinho 不详

To investigate the effects of moderate and intense exercise (ME,IE) and lycopene (L) supplementation on oxidative stress biomarkers in patients with CAD. Rehabilitation ***-two male volunteers with CAD (55.65 ? 2.27 years, 77.27 ? 3.95 kg, 171.9 ? 2.80 cm) were divided into four groups;ME-Placebo (n = 7), ME + L (n = 8), IE-Placebo (n = 8) and IE-L (n = 9). Blood samples (12 mL) were collected before supplementation (one cereal bars – 15 mg of syn-thetic lycopene) and exercise (45 min plus 15 min of stretching, 3/wk) and after five weeks of supplementation and 72 h after exercise. Nitrite/nitrate concentrations (NOx), lipoperoxidation (TBARS levels), protein carbonylation (PC) and superoxide dismutase (SOD) and catalase (CAT) activity were assessed in plasma. NOx decreased significantly in the ME-P, IE-P and ME-L groups at 72 h after exercise and increased in the IE-L 72 h after the last exercise session. The IE-L group demonstrated decreased TBARS at 72 h after the last exercise session. The level of PC increased only in EI-P at 72 h after the last exercise session, while only the EI-L group presented a reduction. SOD increased signifi-cantly in both placebo groups 72 h after the last exercise session and decreased in the ME-L group 72 h after in rela-tion to placebo groups. CAT increased in ME-P, IE-P and IE-L groups only at 72 h after the last exercise session. The lycopene supplementation attenuates some markers of oxidative stress associated with IE Lycopene also had dissimilar effects on some markers of oxidative stress in subjects undertaking ME versus IE.

关键词： Lycopene Coronary Artery Disease Oxidative Stress Nitric Oxide Intense Exercise

Normative data for TM electrocochleography measures

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Journal of Otology 2017年第2期12卷 68-73页

作者： Signe Schuster Grasel Roberto Miquelino de Oliveira Beck ricardo Silva Chiabai Loureiro Amanda Costa Rossi Edigar Rezende de Almeida John Ferraro University of Sao Paulo School of Medicine Dr.Eneas de Carvalho Aguiar255sala 6173Cerqueira CesarSao PauloSP CEP 05403-000Brazil University of Kansas Medical Center Kansas CityKS 66160USA

Objective: Establish normative data for tympanic electrocochleography(TM ECoch G) parameters in normal hearing adults without Meniere's disease's(MD) symptoms. Describe TM ECoch G variables that help to distinguish normal from MD *** and methods: We enrolled 100 subjects(N =200 ears), 59 females, aged between 19 and 71 years from 09/2010 to 04/2014. Inclusion criteria: normal otomicroscopy, hearing thresholds≤25 dB nHL from 250 to 4000 Hz, normal tympanogram, no symptoms of MD according to the AAO-HNS 1995 criteria and Gibson's score <7. We excluded subjects with dizziness, aural fullness or other symptoms of endolymphatic hydrops. The following parameters were analyzed: SP/AP amplitude ratio, SP/AP area ratio and the difference between AP latency with rarefaction and condensation ***: There was no significant difference between right and left ears(Intraclass correlation coefficient < 0.6). SP/AP amplitude ratio varied between 0.084 and 0.356 and SP/AP area ratio between 0.837 and 1.671(percentiles 5 and 95). The AP latency difference to rarefaction and condensation clicks was between 0.0 and 0.333 ***: Normative data for TM ECoch G parameters were established in 100 normal hearing subjects without MD. These data can be used to distinguish normal from pathological findings and in follow-up of MD patients.

关键词： Electrocochleography Meniere disease Hearing Dizziness Tinnitus

Prevalence of Human Leukocyte Antigen HLA-B*5701 in HIV-1 Infected Individuals in Brazil

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Open Journal of Genetics 2014年第1期4卷 56-62页

作者： Claudinéia de Araújo Cristina Valetta de carvalho Miriam Estela de Souza Freire Amanda Yamaguti Ivens Cuiabano Scaff Fernando José de Souza Flávia Galindo Silvestre Silva ricardo Sobhie Diaz Ismael Dale Cotrim Guerreiro da Silva Department of Gynecology Molecular Gynecology Laboratory Federal University of S&atildeo Paulo S&atildeo Paulo Brazil State Department of Health of Mato Grosso Cuiabá Brazil Unirondon University Cuiabá Brazil Infectious Diseases Division Federal University of Mato Grosso Cuiabá Brazil Imunogenetics Laboratory General University Hospital Cuiabá Brazil

This study was designed to establish the prevalence of HLA-B*5701 at HIV-1 infected individuals in Brazil. A total of 517 consecutive individuals were followed in this study from February 2009 through July 2011. The presence of HLA-B*5701 was determined by Nested-PCR with HLA-B*57 and HLA-B*5701 sequence-specific primers (PCR-SSP). The expression of HLA-B*57 was negative in the 385 (74.5%) and positive in the 103 (19.9%) of infected individuals. Among these, the expression of HLA-B5701 was positive in the 29 (5.6%) of individuals. No demographic or ethnic differences were found between HLA-B*57/HLA-B*5701 HIV-1 negative patients, with a prevalence of Caucasians (57.1%) individuals. During the period of study, 68 patients were submited to an abacavir contain- ing regimen. The HLA-B*5701 allele was observed in 7 (10.3%) patients, with a significant incidence of Hypersensitivity reactions at 4 of them (p < 0.001). Conclusions: Although Brazilian population consists of a mixture of individuals of Caucasian, African and Native American genetic background, prevalence of HLA-B*5701 in this population is similar to the one found in pure Caucasians.

关键词： Immunogenetics Human Immunodeficiency Virus HLA-B*5701 Antigen Human Abacavir

Public Use and Landscape Analysis in the Serra da Canastra National Park, Brazil: A Geospatial Approach

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Natural Resources 2016年第2期7卷 93-101页

作者： Marcos Cicarini Hott Luiz Otávio Moras Filho Marco Aurélio Leite Fontes Aline Aparecida Silva Pereira Cláudia de Oliveira Gonçalves nogueira Luis Marcelo Tavares de carvalho Luís Antônio Coimbra Borges João Cesar de Resende Mauro Antonio Homem Antunes Department of Forest Sciences Federal University of Lavras Lavras Brazil Brazilian Agricultural Research Corporation—Embrapa Juiz de Fora Brazil Department of Engineering Federal Rural University of Rio de Janeiro Seropédica Brazil

The Conservation Units (CU) were created to protect natural environments from growing degradation and to impede the expansion of urbanization and agricultural crops. The Serra da Canastra National Park, established to protect the headwaters of the S?o Francisco River and other places of scenic and ecological interest, is extensively visited due to its many tourist attractions, such as waterfalls, fauna and flora. An analysis of the park’s geography is needed to assess the risk involved in and its suitability for public use due to its territorial extension and environmental complexities. Thus, this study aimed to investigate the background of issues of interest to CU management. Additionally, we used high-resolution RapidEye imagery, altimetry and database of park infrastructure to build geospatial database and estimate classes of suitability for and risk in public use through GIS tools. The resulting cartographic data can support the planning of policies concerning the landscape and park’s territorial management.

关键词： Conservation Units Environment GIS RapidEye Imagery

Sorafenib after Arterial Chemoembolization in Child-Pugh A and B Cirrhotic Patients with Intermediate Hepatocellular Carcinoma: A Retrospective Analysis

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Journal of Cancer Therapy 2015年第3期6卷 286-292页

作者： Fernando Gomes Romeiro Luciana Yumi Odani Sigahi Matheus Alvarez Fabio da Silva Yamashiro Fábio Cardoso de carvalho Leonardo Pelafsky Talles Bazeia Lima Letícia de Campos Franzoni José ricardo de Arruda Miranda Giovanni Faria Silva Gastroenterology Division Department of Internal Medicine Faculdade de Medicina de Botucatu UNESP—Univ Estadual Paulista Sao Paulo Brazil Faculdade de Medicina de Botucatu UNESP—Univ Estadual Paulista Sao Paulo Brazil Department of Physics and Biophysics Instituto de Biociências de Botucatu UNESP—Univ Estadual Paulista Sao Paulo Brazil Gastroenterology Division Department of Surgery and Orthopedics Faculdade de Medicina de Botucatu UNESP—Univ Estadual Paulista Sao Paulo Brazil

Introduction: Hepatocellular carcinoma (HCC) is a leading cause of mortality among cirrhotic patients, and current guidelines recommend single-treatment modalities according to patient and liver disease classifications. New studies have shown promising results from combining locoregional and systemic treatments, but most of them were limited to Child-Pugh A patients due to toxicity concerns. Aim: The objective of this study was to analyze survival rates of Child-Pugh A and B patients with intermediate HCC tumors treated with transarterial chemoembolization (TACE) followed by full-dose sorafenib usage. Material and methods: a retrospective analysis of 37 cirrhotic patients (Child-Pugh A and B rates = 23/14) treated with TACE and TACE followed by sorafenib usage (17 and 20 patients, respectively). Results: The mean survival was 379 days in the combined treatment group and 151 days in the single-treatment group (p = 0.007). There were no differences in survival according to the Child-Pugh classification. Conclusions: sorafenib after TACE can be an option for selected cirrhotic patients with intermediate HCC tumors if this combined approach is cautiously performed on an individualized schedule. Our results suggest that the Child-Pugh classification should not be a limitation to this combined treatment.

关键词： Hepatocellular Carcinoma Cirrhosis Arterial Chemoembolization Sorafenib

Antioxidant and Antifungal Activity of Naphthoquinones Dimeric Derived from Lawsone

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Journal of Biosciences and Medicines 2017年第2期5卷 39-48页

作者： Aldo S. de Oliveira Inês M. C. Brighente Rafael G. Lund Luana C. Llanes ricardo J. Nunes Lizandra C. Bretanha Rosendo Augusto Yunes Pedro H. A. carvalho Juliana S. Ribeiro Department of Chemistry Center of Physical and Mathematical Sciences Federal University of Santa Catarina Florian&oacute polis SC Brazil Oral Microbiology Laboratory Faculty of Dentistry Federal University of Pelotas Pelotas Brazil

This article reports the evaluation of antioxidant and antifungal activity from synthetic naphthoquinones derived from lawsone. The antifungal activity was carried out through the inhibition of exoenzymes produced by Candida albicans. The inhibition of phospholipase and the proteinase production by Candida was similar in all derivatives tested;however, the difference between the enzyme production of the control and test does not show statistical difference in any of the studied strains. Furthermore, the antioxidant activity using DPPH radical-scavenging assay showed an important activity for all naphtoquinone derivatives.

关键词： Napthoquinones Antifungal Candida albicans Antioxidant

Ecology of Upland Rice Plants and Seeds Subjected to Growth Regulator

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American Journal of Plant Sciences 2018年第1期9卷 60-73页

作者： Felipe Koch Manoela Andrade Monteiro Joao Roberto Pimentel Cristian Troyjack Itala Thaisa Padilha Dubal Eduardo Goncalves Borges Vinícius Jardel Szareski Gustavo Henrique Demari Lanes Beatriz Acosta Jaques Ivan ricardo carvalho Francisco Amaral Villela Tiago Pedó Tiago Zanatta Aumonde Federal University of Pelotas Capao do LeaoBrazil

The objective of this work is to verify the influence of the plant regulator trinexapac-ethyl on plant growth and physiological quality of upland rice seeds. We used an upland rice genotype, and the growth regulator was the trinexapac-ethyl. The experiment was completely randomized in a 4 × 8 factorial design related to four concentrations of the plant regulator trinexapac-ethyl [0 (without growth regulator), 0.25, 0.50, and 0.75 L c.p. ha-1] and 7 plant collection times [14, 28, 42, 56, 70, 84, 98 days after emergence (DAE)], with four replicates. To determine growth attributes, we evaluated total dry matter, dry matter production rate, relative growth rate, leaf area ratio, leaf matter, leaf area index, solar energy conversion efficiency and partition of assimilates. The physiological quality of the seeds was evaluated based on germination, first germination count, field emergence, emergence speed index and seedling dry matter. Plant growth was affected by the growth regulator. Total dry matter, dry matter production rate and solar energy conversion efficiency decreased, while leaf area index, leaf area ratio and leaf matter increased due to the effects of the growth regulator. The dry matter partition of plants changed in plants subjected to the growth regulator, with a delay in the targeting of assimilates to reproductive organs and a greater allocation to roots at the end of the cycle in plants subjected to the doses 0.50 and 0.75 L·ha-1 of growth regulator. Seed vigor was adversely affected by the growth regulator.

关键词： Oryza sativa L. Trinexapac-Ethyl Leaf Area Dry Matter Seed Vigor

Amniotic membrane as a potent source of stem cells and a matrix for engineering heart tissue

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Journal of Biomedical Science and Engineering 2013年第12期6卷 1178-1185页

作者： Julio Cesar Francisco ricardo Correa Cunha Rossana Baggio Simeoni Luiz Cesar Guarita-Souza Reginaldo Justino Ferreira Ana Carolina Irioda Carolina Maria C.Oliveira Souza Garikipati Venkata Naga Srikanth Soniya Nityanand Juan Carlos Chachques Katherine Athayde Teixeira de carvalho Bioprocess Engineering and Biotechnology Department Federal University of ParanáCuritibaBrazil Cell Therapy and Biotechnology in Regenerative Medicine Research Group Pele Pequeno Príncipe InstituteCuritibaBrazil Experimental Laboratory of Institute of Biological and Health Sciences Pontificial Catholic University of Paraná(PUCPR)Rua Imaculada ConceicaoCuritibaBrazil Federal University of Technology CuritibaBrazil Department of Hematology Stem Cell Research FacultySanjay Gandhi Post-Graduate Institute of Medical SciencesLucknowIndia Laboratory of Biosurgical Research Pompidou HospitalUniversity of Paris DescartesParisFrance

Existing therapies for the treatment of chronic heart failure still have some limitations and there is a pressing need for the development of new therapeutic modalities. The amniotic membrane has been used for the treatment of various diseases, such as conjunctive defects;however, the mechanisms behind its repair functions are still unclear. Regenerative medicine is seeking newer alternatives and among them, biomaterials have emerged in recent years for developing and manipulating molecules, cells, tissues or organs grown in laboratories in order to replace human body parts. Many such materials have been used for this purpose, either synthetically or biologically, in order to provide new medical devices. This review provides a wider view of the regeneration potential of the use of amniotic membrane as a potential biomaterial to facilitate the implementation of new research in surgical procedures. Amniotic membrane appears to be an alternative source of stem cells as well as an excellent biomaterial for cell-based therapeutic applications in engineering heart tissue.

关键词： Amniotic Membrane Heart Tissue Engineering Stem Cells

亚马逊流域玛代拉河Santo Antonio鱼道设计与建造的启示

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水生态学杂志 2013年第4期34卷 95-100页

作者：张辉 KYNARD Boyd JUNHO ricardo 杜浩危起伟中国水产科学研究院长江水产研究所湖北武汉430223 BK Riverfish LLC.28 Echo Hill Rd.AmherstMA 01002-1633USA HIDRICON Water Resources Consultants LLC. Rua Ricardo de Carvalho 48Sao Bento 30.360-020Belo HorizonteMGBrazil

Santo Antnio过鱼设施位于亚马逊河最大支流玛代拉河下游,其设计规模宏大,在世界范围内鲜有,并且工程建设地所在区域水文环境和鱼类生物学特征等与我国长江较为类似,通过分析该过鱼设施,得出启示主要包括:(1)过鱼设施是为生物对象设... 详细信息

Santo Antnio过鱼设施位于亚马逊河最大支流玛代拉河下游,其设计规模宏大,在世界范围内鲜有,并且工程建设地所在区域水文环境和鱼类生物学特征等与我国长江较为类似,通过分析该过鱼设施,得出启示主要包括:(1)过鱼设施是为生物对象设计的水利工程,其设计和建设过程中必须由工程师和生物学家紧密合作;(2)吸引水流对过鱼设施的成败起关键性作用,虽然吸引水流系统需要较大投资并且运行过程中会损失大量的水能,但从确保过鱼设施效果而言是非常必要的;(3)物理模型对于鱼道进口位置、鱼道内部水力学特征的确定等具有重要参考价值,尤其是在1∶1局部模型内开展的生物学试验是细化和优化鱼道内部结构细节的有效方法;(4)卵石框(石笼)隔板的水池分隔方法兼具水池式鱼道与仿自然通道的双重特性,并且完工后还可根据鱼道的运行情况灵活调整,非常方便;(5)进口处采用较高的人字闸门,既可适应尾水变化,又可与吸引水流系统相配合,创造出有效的吸引水流,一举多得;(6)全部采用大功率灯泡式水轮机是保护下行鱼类的有效措施;(7)监测系统和公众教育等配套设施的建设非常必要,有利于改进鱼道运行方式和提高过鱼效率。

关键词： Santo Antonio鱼道玛代拉河启示