Antioxidant and Antifungal Activity of Naphthoquinones Dimeric Derived from Lawsone

作     者：Aldo S. de Oliveira Inês M. C. Brighente Rafael G. Lund Luana C. Llanes Ricardo J. Nunes Lizandra C. Bretanha Rosendo Augusto Yunes Pedro H. A. Carvalho Juliana S. Ribeiro 

作者机构：Department of Chemistry Center of Physical and Mathematical Sciences Federal University of Santa Catarina Florianó polis SC Brazil Oral Microbiology Laboratory Faculty of Dentistry Federal University of Pelotas Pelotas Brazil 

出 版 物：《Journal of Biosciences and Medicines》 (生物科学与医学（英文）)

年 卷 期：2017年第5卷第2期

页      面：39-48页

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

主　　题：Napthoquinones Antifungal Candida albicans Antioxidant 

摘      要：This article reports the evaluation of antioxidant and antifungal activity from synthetic naphthoquinones derived from lawsone. The antifungal activity was carried out through the inhibition of exoenzymes produced by Candida albicans. The inhibition of phospholipase and the proteinase production by Candida was similar in all derivatives tested;however, the difference between the enzyme production of the control and test does not show statistical difference in any of the studied strains. Furthermore, the antioxidant activity using DPPH radical-scavenging assay showed an important activity for all naphtoquinone derivatives.