Amniotic membrane as a potent source of stem cells and a matrix for engineering heart tissue
作者机构：Bioprocess Engineering and Biotechnology DepartmentFederal University of ParanáCuritibaBrazil Cell Therapy and Biotechnology in Regenerative Medicine Research GroupPele Pequeno Príncipe InstituteCuritibaBrazil Experimental Laboratory of Institute of Biological and Health SciencesPontificial Catholic University of Paraná(PUCPR)Rua Imaculada ConceicaoCuritibaBrazil Federal University of TechnologyCuritibaBrazil Department of HematologyStem Cell Research FacultySanjay Gandhi Post-Graduate Institute of Medical SciencesLucknowIndia Laboratory of Biosurgical ResearchPompidou HospitalUniversity of Paris DescartesParisFrance
出 版 物：《Journal of Biomedical Science and Engineering》 (生物医学工程（英文）)
年 卷 期：2013年第6卷第12期
页 面：1178-1185页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Amniotic Membrane Heart Tissue Engineering Stem Cells
摘 要：Existing therapies for the treatment of chronic heart failure still have some limitations and there is a pressing need for the development of new therapeutic modalities. The amniotic membrane has been used for the treatment of various diseases, such as conjunctive defects;however, the mechanisms behind its repair functions are still unclear. Regenerative medicine is seeking newer alternatives and among them, biomaterials have emerged in recent years for developing and manipulating molecules, cells, tissues or organs grown in laboratories in order to replace human body parts. Many such materials have been used for this purpose, either synthetically or biologically, in order to provide new medical devices. This review provides a wider view of the regeneration potential of the use of amniotic membrane as a potential biomaterial to facilitate the implementation of new research in surgical procedures. Amniotic membrane appears to be an alternative source of stem cells as well as an excellent biomaterial for cell-based therapeutic applications in engineering heart tissue.
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