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Influence of edaphic factors on distribution and condition of Himalayan silver birch(Betula utilis ***)communities in the northwestern Indian Himalayas

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Journal of Mountain Science 2024年第2期21卷 590-606页

作者： Khashti DASILA renu RAWAL Tanay BARMAN Sher Singh SAMANT Anita PANDEY Veena PANDE G.B.Pant National Institute of Himalayan Environment Almora 263643India Centre of Excellence on Sustainable Land Management Indian Council of Forestry Research and EducationDehradun 248006India Uttarakhand State Council for Science&Technology Dehradun 248015India Department of Biotechnology Graphic Era(Deemed to be University)Dehradun 248002India Department of Biotechnology Kumaun UniversityNainital 263136India

The basic concept of phytosociology is crucial for the assessment of species composition and dynamic ecological succession of forests supporting ecological services,functions,disturbance,and resilience that lead to the development of integrated areas such as ecological niche modeling and contribute to identifying the valuable bio-indicators which can be used in framing conservation and management *** is one of the most dominant tree species of treeline ecotone in the Himalayan *** species is also considered as indicator species for monitoring the past and recent climate change *** current study was carried out in the natural populations of *** from the sub-alpine zone of North-western Indian *** birch dominated forest harbors a total of 305 plant species comprising Angiosperms(51 families,160 genera and 277 species),Gymnosperms(03 families,05 genera and 07 species)and Pteridophytes(07 families,11 genera and 21 species)with Asteraceae,Ranunculaceae and Rosaceae as dominant *** forests are found dominant in shady moist habitat and North West *** characteristics,anthropogenic and developmental activities affect the population structure of *** and associated ***,the species has fair regeneration status in the study *** acidic nature of soil pH and spatial variation in edaphic characteristics may be due to geographical differences,rooting patterns and litter accumulation of below and above-ground *** estimation of a representative population of *** from each site showed that TAGBD,TCD and TBD were found maximum in ST3(Hamta Pass II site).The CCA analysis determined that environmental variables such as altitude,organic matter,available phosphorous,organic carbon,available nitrogen,and electrical conductivity played a significant role in determining tree species composition and distribution in *** dominated forests.

关键词： Species composition Indicator species Biomass North-western Indian Himalaya Regeneration Environmental variables

Identifying the stability of housekeeping genes to be used for the quantitative real-time PCR normalization in retinal tissue of streptozotocin-induced diabetic rats

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 794-805页

作者： Muhammad Zulfiqah Sadikan Nurul Alimah Abdul Nasir Mohammad Johari Ibahim Igor Iezhitsa renu Agarwal Department of Pharmacology Faculty of MedicineManipal University College Malaysia(MUCM)Bukit BaruMelaka 75150Malaysia Centre for Neuroscience Research(NeuRon) Faculty of MedicineUniversiti Teknologi MARASungai Buloh CampusSungai BulohSelangor 47000Malaysia Department of Medical Education Faculty of MedicineUniversiti Teknologi MARASungai Buloh CampusSungai BulohSelangor 47000Malaysia Department of Biochemistry and Molecular Medicine Faculty of MedicineUniversiti Teknologi MARASungai Buloh CampusSungai BulohSelangor 47000Malaysia School of Medicine International Medical UniversityBukit JalilKuala Lumpur 57000Malaysia Department of Pharmacology and Bioinformatics Volgograd State Medical UniversityVolgograd 400131Russia

AIM:To investigate the stability of the seven housekeeping genes:beta-actin(ActB),glyceraldehyde-3-phosphate dehydrogenase(GAPDH),18s ribosomal unit 5(18s),cyclophilin A(CycA),hypoxanthine-guanine phosphoribosyl transferase(HPRT),ribosomal protein large P0(36B4)and terminal uridylyl transferase 1(U6)in the diabetic retinal tissue of rat ***:The expression of these seven genes in rat retinal tissues was determined using real-time quantitative reverse transcription polymerase chain reaction(RT-qPCR)in two groups;normal control rats and streptozotocininduced diabetic *** stability analysis of gene expression was investigated using geNorm,NormFinder,BestKeeper,and comparative delta-Ct(ΔCt)***:The 36B4 gene was stably expressed in the retinal tissues of normal control animals;however,it was less stable in diabetic *** 18s gene was expressed consistently in both normal control and diabetic rats’retinal *** this gene was the best reference for data normalisation in RT-qPCR studies that used the retinal tissue of streptozotocin-induced diabetic ***,there was no ideal gene stably expressed for use in all experimental ***:Identifying relevant genes is a need for achieving RT-qPCR validity and reliability and must be appropriately achieved based on a specific experimental setting.

关键词： housekeeping genes stability real-time reverse transcription polymerase chain reaction retinal tissue streptozotocin-induced diabetic rats

Neuroprotective effects of exogenous brain-derived neurotrophic factor on amyloid-beta 1-40-induced retinal degeneration

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Neural Regeneration Research 2023年第2期18卷 382-388页

作者： Mohd Aizuddin Mohd Lazaldin Igor Iezhitsa renu Agarwal Puneet Agarwal Nafeeza Mohd Ismail Department of Biosciences Faculty of ScienceUniversiti Teknologi MalaysiaJohor BahruMalaysia School of Medicine International Medical UniversityKuala LumpurMalaysia Department of Pharmacology and Bioinformatics Volgograd State Medical UniversityVolgogradRussia Faculty of Medicine Universiti Teknologi MARASungai Buloh CampusSelangorMalaysia

Amyloid-beta(Aβ)-related alterations,similar to those found in the brains of patients with Alzheimer's disease,have been observed in the retina of patients with *** levels of brain-derived neurotrophic factor(BDNF)are believed to be associated with the neurotoxic effects of Aβ*** investigate the mechanism underlying the neuroprotective effects of BDNF on Aβ_(1-40)-induced retinal injury in Sprague-Dawley rats,we treated rats by intravitreal administration of phosphate-buffered saline(control),Aβ_(1-40)(5 nM),or Aβ_(1-40)(5 nM)combined with BDNF(1μg/mL).We found that intravitreal administration of Aβ_(1-40)induced retinal ganglion cell ***-Gold staining showed a significantly lower number of retinal ganglion cells in the Aβ_(1-40)group than in the control and BDNF *** the Aβ_(1-40)group,low number of RGCs was associated with increased caspase-3 expression and reduced TrkB and ERK1/2 *** abolished Aβ_(1-40)-induced increase in the expression of caspase-3 at the gene and protein levels in the retina and upregulated TrkB and ERK1/2 *** findings suggest that treatment with BDNF prevents RGC apoptosis induced by Aβ_(1-40)by activating the BDNF-TrkB signaling pathway in rats.

关键词： amyloid-beta 1-40 brain-derived neurotrophic factor Fluoro-Gold neuroprotection retinal ganglion cells(RGC) retinal toxicity tropomyosin receptor kinase B(TrkB)

Formulation of Ayurvedic Medicines and Extracts of Medicinal Plants as an Alternative Therapeutic Treatment Option for Nephrolithiasis

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World Journal of Traditional Chinese Medicine 2023年第3期9卷 278-283页

作者： Shikha Sachdeva Jaspreet Kaur Sanjana Mehta renu Saharan Parminder Nain Department of Pharmacy M.M College of PharmacyMaharishi Markandeshwar(Deemed to be University)AmbalaHaryanaIndia Chitkara College of Pharmacy Chandigarh-Patiala National HighwayRajpura140401Patiala(Punjab)India CT Institute of Pharmaceutical Sciences CT Group of InstitutionsShahpurJalandharIndia

The incidence of nephrolithiasis,commonly known as kidney stone,is increasing worldwide with significant health and economic *** 2 million people every year in India are affected by kidney *** affects all ages,genders,and races,but between the ages of 20 and 49 years,it affects most frequently in men than *** types of stones include calcium stones,cysteine stones,struvite or magnesium ammonium phosphate stones,uric acid stones,and drug-induced *** review article provides information about general pathophysiology,epidemiology,clinical presentation,and pharmacological treatment,which includes ayurvedic and herbal medicines for *** understanding of the pathophysiological link between nephrolithiasis and systemic disorders is necessary for the development of new therapeutic options.

关键词： Allopathic management ayurvedic treatment calcium stones nephrolithiasis

Modified Differential Transform Method for Solving Black-Scholes Pricing Model of European Option Valuation Paying Continuous Dividends

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Journal of Partial Differential Equations 2023年第4期36卷 381-393页

作者： AHMAD Manzoor MISHRA Rajshree JAIN renu School of Mathematics and Allied Sciences jiwaji UniversityGwalior-474011India Govt.Model Science College Gwalior-474011India

.Option pricing is a major problem in quantitative *** Black-Scholes model proves to be an effective model for the pricing of *** this paper a com-putational method known as the modified differential transform method has been em-ployed to obtain the series solution of Black-Scholes equation with boundary condi-tions for European call and put options paying continuous *** proposed method does not need discretization to find out the solution and thus the computa-tional work is reduced *** results are plotted graphically to establish the accuracy and efficacy of the proposed method.

关键词： European option pricing Black-Scholes equation call option put option modified differential transform method

Small bowel adenocarcinoma:An overview

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World Journal of Gastrointestinal Oncology 2022年第2期14卷 413-422页

作者： Divya Khosla Treshita Dey renu Madan Rahul Gupta Shikha Goyal Narendra Kumar Rakesh Kapoor Department of Radiotherapy and Oncology Postgraduate Institute of Medical Education and ResearchChandigarh 160012India Department of Gastroenterology Shalby Multispeciality HospitalMohali 160062PunjabIndia

Small bowel adenocarcinoma(SBA)is a rare malignancy of the gastrointestinal ***,these tumors are among those with worst *** clinical signs and symptoms and radiological diagnostic challenges often delay treatment,which negatively impacts the prognosis of the ***,recent advances in imaging technology,like multidetector computed tomography,magnetic resonance imaging,and capsule endoscopy,have made earlier and accurate diagnosis *** is the treatment of choice followed by adjuvant ***,there are no strict treatment guidelines available for the management of *** of the available evidence from colorectal and gastric carcinoma has been extrapolated to adequately manage *** for SBA is better than gastric carcinoma but worse than colorectal ***,there is not enough information on the molecular characteristics and tumor *** the incidence of SBA is very low,there is a need for further studies to evaluate the possible application of newer investigative agents and strategies to obtain a better outcome within the framework of international collaborations.

关键词： Adenocarcinoma Chemotherapy Prognostic factors Small bowel Surgery

Designed fabrication of active tumor targeting covalent organic framework nanotherapeutics via a simple post-synthetic strategy

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Nano Research 2023年第5期16卷 7085-7094页

作者： Yue Yu Guoxin Zhang Zhongping Li Jia Wang Yang Liu Rahul Bhardwaj renu Wadhwa Yuki Nagao Mototada Shichiri Ran Gao Biomedical Research Institute National Institute of Advanced Industrial Science and Technology(AIST)Osaka 563-8577Japan AIST-INDIA DAILAB DBT-AIST International Center for Translational&Environmental Research(DAICENTER)AISTTsukubaIbaraki 305-8565Japan Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases NHC Key Laboratory of Human Disease Comparative MedicineNational Human Diseases Animal Model Resource CenterInstitute of Laboratory Animal ScienceChinese Academy of Medical Sciences(CAMS)&Peking Union Medical CollageBeijing 100021China School of Materials Science Japan Advanced Institute of Science and TechnologyIshikawa 923-1211Japan Department of Chemical and Biomolecular Engineering Yonsei University50 Yonsei-roSeodaemun-guSeoul 120-749Republic of Korea Flexible 3D System Integration Laboratory SANKENOsaka UniversityOsaka 567-0047Japan

Developing agents that can accurately differentiate tumors from normal healthy tissues is of utmost importance for safe cancer *** targeting has been considered as an effective technique for tumor *** this work,we demonstrate a folate-functionalized nanoscale covalent organic framework(FATD nCOF)highly specific to cancer cells through active targeting of their enriched folate receptors(FRs).The FATD nCOF prepared by simple post-synthetic modification of the COF surface defeats disperses well in water and exhibits a high loading capacity for various anticancer *** biocompatible FATD nCOF is selectively internalized by FR-harboring cancer cells and consequently augments the efficacy of the loaded drug,Withaferin A(Wi-A),for targeted cancer cell *** biomolecular mechanism studies,Wi-A-loaded FATD(FATD@Wi-A)nanocomposites show remarkably a higher rate of apoptosis in FR-enriched cancer *** analyses of FR-positive and FR-negative tumor xenografts reveal enhanced selective antitumor activity of FATD@Wi-A *** together,the study findings suggest that FATD nCOF holds great promise for active targeting of tumors in *** simple yet effective technology might be valuable for creating new state-of-the-art COFs for chemical and biomedical applications.

关键词： covalent organic framework active targeting folate receptor drug delivery cancer therapy

(p,q)-Analogue of Mittag-Leffler Function with(p,q)-Laplace Transform

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Analysis in Theory and Applications 2022年第3期38卷 351-360页

作者： Alok Jain Altaf Ahmad Bhat renu Jain Deepak Kumar Jain School of Mathematics and Allied Sciences Jiwaji UniversityGwalior(M.P.)India Department of Mathematical Sciences Islamic University of Science and TechnologyAwantipora PulwamaJand KIndia-192122 Department of Engineering Mathematics and Computing MITSGwalior(M.P.)India

The aim of this paper is to define(p,q)-analogue of Mittag-Leffler Function,by using(p,q)-Gamma *** transformation formulae are also derived by using the(p,q)-***(p,q)-analogue for this function provides elegant generalization of q-analogue of Mittag-Leffler function in connection with ***,the(p,q)-Laplace Transform of the Mittag-Leffler function has been *** special cases have also been discussed.

关键词： (p,q)-analogue of Mittag-Leffler function (p,q)-Gamma function q-calculus (p,q)-derivative operator (p,q)-Laplace transform

New solutions for old challenges in glaucoma treatment:is taurine an option to consider?

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Neural Regeneration Research 2021年第5期16卷 967-971页

作者： Igor Iezhitsa renu Agarwal School of Medicine International Medical UniversityKuala LumpurMalaysia Volgograd State Medical University Research Centre for Innovative MedicinesVolgogradRussian Federation

Glaucoma is a range of progressive optic neuropathies characterized by progressive retinal ganglion cell loss and visual field *** is recognized as a leading cause of irreversible blindness affecting more than 70 million people ***,reduction of intraocular pressure,a widely recognized risk factor for glaucoma development,is the only pharmacological strategy for slowing down retinal ganglion cell loss and disease ***,retinal ganglion cell death and visual field loss have been observed in normotensive glaucoma,suggesting that the disease process is partially independent of intraocular *** is one of the agents that have attracted attention of researchers *** has been shown to be involved in multiple cellular functions,including a central role as a neurotransmitter,as a trophic factor in the central nervous system development,as an osmolyte,as a neuromodulator,and as a *** also plays a role in the maintenance of the structural integrity of the membranes and in the regulation of calcium transport and *** is known to prevent N-methyl-D-aspartic acid-induced excitotoxic injury to retinal ganglion cells.A recently published study clearly demonstrated that taurine prevents retinal neuronal apoptosis both in vivo and in *** effect of taurine may be attributed to direct inhibition of apoptosis,an activation of brain derived neurotrophic factor-related neuroprotective mechanisms and reduction of retinal oxidative and nitrosative *** studies are needed to fully explore the potential of taurine as a neuroprotective agent,so that it can be applied in clinical practice,particularly for the treatment of *** objective of current review was to summarize recent evidence on neuroprotective properties of taurine in glaucoma.

关键词： apoptosis excitotoxicity glaucoma oxidative and nitrosative stresses retinal neuroprotection taurine