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Therapies for patients with coexisting heart failure with reduced ejection fraction and non-alcoholic fatty liver disease

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World Journal of Cardiology 2023年第7期15卷 328-341页

作者： Jose Arriola-Montenegro renato Beas renato cerna-viacava Andres Chaponan-Lavalle Karla Hernandez Randich Diego Chambergo-Michilot Herson Flores Sanga Pornthira Mutirangura Department of Internal Medicine University of MinnesotaMinneapolisMN 55455United States Department of Medicine Indiana University School of MedicineIndianaIN 46202United States Department of Medicine Henry Ford HospitalDetroitMI 48202United States Escuela de Medicina Universidad Peruana de Ciencias AplicadasLima 15067Peru Universidad Científica del Sur LimaPeru Department of Telemedicine CardiologyHospital Nacional Carlos Alberto Seguin EscobedoArequipa 8610Peru Department of Medicine University of MinnesotaMinneapolisMN 55415United States

Heart failure with reduced ejection fraction(HFrEF)and nonalcoholic fatty liver disease(NAFLD)are two common comorbidities that share similar pathophysiological *** is a growing interest in the potential of targeted therapies to improve outcomes in patients with coexisting HFrEF and *** manuscript reviews current and potential therapies for patients with coexisting HFrEF and *** therapies,including angiotensinconverting enzyme inhibitors/angiotensin receptor blockers,mineralocorticoids receptor antagonist,and sodium-glucose cotransporter-2 inhibitors,have been shown to reduce fibrosis and fat deposits in the ***,there are currently no data showing the beneficial effects of sacubitril/valsartan,ivabradine,hydralazine,isosorbide nitrates,digoxin,or beta blockers on NAFLD in patients with *** study highlights the importance of considering HFrEF and NAFLD when developing treatment plans for patients with these *** research is needed in patients with coexisting HFrEF and NAFLD,with an emphasis on novel therapies and the importance of a multidisciplinary approach for managing these complex comorbidities.

关键词： Non-alcoholic fatty liver disease Heart Failure Heart failure reduced ejection fraction Novel therapies Cardiovascular disease

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Screening for Transthyretin Cardiac Amyloidosis in Patients with Bilateral Carpal Tunnel Syndrome: Identifying Missed Opportunities for Early Detection and Treatment

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World Journal of Cardiovascular Diseases 2023年第7期13卷 366-376页

作者： Ayman Alsaadi renato cerna-viacava Liyan Obeidat Shing Chao Johnathan Stephan Charles S. Day Jennifer Cowger Celeste Williams Karthikeyan Ananthasubramaniam Department of Internal Medicine Henry Ford Hospital Detroit USA Department of Orthopedic Surgery Henry Ford Hospital Detroit USA Heart and Vascular Institute Henry Ford Hospital Detroit USA Heart and Vascular Institute Henry Ford West Bloomfield Hospital West Bloomfield Township USA

Purpose: Transthyretin cardiac amyloidosis (ATTR-CA) has been linked to many extra-cardiac manifestations including bilateral carpal tunnel syndrome (CTS). The aim of this study is to analyze patients with bilateral CTS to identify patients with high-risk features or “red flags” for ATTR-CA, identify if systematic screening was done for ATTR-CA and define opportunities for improved detection. Methods: Out of >5000 patients with bilateral CTS evaluated in a single tertiary care center in Southeast Michigan (2010-2016), we retrospectively studied a focused population of patients: men > 50 years and women > 60 years old with bilateral CTS and atrial fibrillation (n = 295). Baseline demographic, comorbidities, and electrocardiographic and echocardiographic findings were analyzed. A high-risk group suspicious for ATTR-CA was identified as patients with bilateral CTS, atrial fibrillation, and concomitant “red flags” including heart failure and left ventricular hypertrophy. Results: Out of 295 patients, 51.2% were female, 75.6% were White, and 22.4% were African American. Upon comparing the high-risk group (n = 67) with the remaining study population (n = 228), both diagnosis of ATTR-CA and mortality were higher among the high-risk group (7.5% vs 0.4% and 43.3% vs 24.6%, respectively, P = 0.003). Conclusions: A substantial number of bilateral CTS patients had additional “red flags” warranting formal evaluation for ATTR-CA;however, systematic evaluation for cardiac amyloidosis was not performed in many patients. This emphasizes that Multidisciplinary collaboration is needed to create a systematic workflow and to raise awareness amongst cardiologists and other physicians for suspecting ATTR-CA in bilateral CTS patients who have additional “red flags”.

关键词： Bilateral Carpal Tunnel Syndrome Morality Prevalence Red Flags Transthyretin Cardiac Amyloidosis

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Determining the earliest growth stage to detect the presence of endophytes in tall fescue and perennial ryegrass seedlings using molecular markers

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Grassland Research 2023年第2期2卷 106-111页

作者： Kendall Lee Nicholas Hill Chloe Dela cerna Ali Missaoui Institute of Plant Breeding Genetics and GenomicsUniversity of GeorgiaAthensGeorgiaUSA Department of Crop and Soil Sciences University of GeorgiaAthensGeorgiaUSA

Background:Tall fescue(Festuca arundinacea[Schreb.],Lolium arundinaceum[Schreb.]Darbysh)and perennial ryegrass(Lolium perenne)are important cool-season forage and amenity grasses that have a mutualistic association with an endophytic *** confer insect and drought resistance to plants but can produce mammalian *** endophytes that do not produce mammalian toxins have been introduced to elite cultivars for commercial *** companies need to maintain adequate levels of novel endophytes within the elite forage *** detection is performed using immunochemical and molecular techniques because of their speed and *** detection in seedlings is essential to evaluate the viability of the endophyte within seed ***:This research aimed to identify the earliest growth stage in which immunochemical and molecular methods can detect viable endophyte in seedlings of tall fescue cultivars BarOptima(e34),Texoma MaxQII(584),and Jesup MaxQ(542),as well as the perennial ryegrass cultivar Remington(NEA2).Results:Immunochemical testing detected endophytes in seedlings 14 days after germination(DAG),but the detection rate increased until 42 DAG in some cultivars *** molecular marker Tef1exon detected endophytes at a lower rate than the immunochemical method at 28–42 ***,there was insufficient DNA to detect endophytes in 14 DAG seedlings using ***:We conclude that the most accurate detection of viable endophytes in seedlings was 42 DAG,at which sufficient and consistent endophyte colonization occurred.

关键词： endophyte immunoblot assay molecular markers perennial ryegrass tall fescue

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从欧盟到中国：捷克外交政策转变的原因

从欧盟到中国：捷克外交政策转变的原因

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作者： cerna Kristyna 浙江大学

学位级别：硕士

This thesis analyses the driving force behind the Czech President Milos Zeman,and using a three-level analysis,puts it into comparison with relations between the Czech Republic and China,and the EU and *** three-level analysis was implemented by Kenneth Waltz,a well-known American political *** book Man,the State and War analyzes the reasons behind *** thesis uses the three-level analysis to analyze the reasons for the Czech Republic's change of foreign policy which brought about better relations with *** three levels are:the Czech President Milos Zeman,the Czech Republic as a country and the European Union with a stress on Central and Eastern European *** the changes in the Government of the Czech Republic in 2013,big steps have been taken towards a better relationship with China,as politicians lead by Zeman fought for the improvement of the mutual relationship and the restoration of the cooperation between the Czech Republic and *** effort was rewarded with the first visit of a Chinese President in the history of the Czech Republic,and Pavel Nedved,the world-famous Czech football player,became a face of the Chinese football Super League next to David Beckham.

关键词： Czech Republic China Milo? Zeman

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First report of Phytopythium vexans causing the“Avocado sadness”in Michoacan,Mexico

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Phyton-International Journal of Experimental Botany 2019年第1期88卷 11-13页

作者： Hernandez Perez A E cerna Chavez JC Delgado Ortiz M Beltran Beache LM Tapia Vargas YM Ochoa Fuentes Estudiante del postgrado Universidad Autonoma Agraria Antonio Narro Departamento de ParasitologiaBuenavistaSaltilloCoahuilaMexico CP 25315 Universidad Autonoma Agraria Antonio Narro Departamento de ParasitologiaBuenavistaSaltilloCoahuilaMexico CP 25315 Catedratico CONACYT-UAAAN.Universidad Autonoma Agraria Antonio Narro Departamento de ParasitologiaBuenavistaSaltilloCoahuilaMexico CP 25315 CULTA S.A.de C.V. InvestigacionDesarrolloAltavistaEl ManteTamaulipasMexico CP 898800 INIFAP Campo Experimental Uruapan.Av.Latinoamericana No.1101Col.Revolucion CP.60500UruapanMichoacanMexico

Mexico is the main producer,consumer and exporter of avocado in the world,being Michoacan the main producer state contributing more than 80%of the national *** are phytopathogens that decimate the production causing the death of the *** samples were collected in avocado trees that showed the characteristic symptomatology of the disease known as avocado sadness,the sampling was carried out in four of the main avocado producing towns,in the state of Michoacan,*** isolation consisted in sowing root tissue in Petri dishes with V8R-PARPH culture medium,subsequently they were identified morphologically and for species level it was determined by molecular biology,with the PCR-ITS *** tests were performed in triplicate with avocado seedlings with more than six *** 24 hours,the inoculated plants expressed decay in the apical part,after 120 hours the leaves showed yellowing and after 15 days there was a generalized wilt on the stem and leaves,re-isolating the phytopathogen Phytopythium *** study confirms the first report of the oomycete *** affecting avocado trees in the most important producing region of the Mexican Republic.

关键词： Molecular identification Pathogenicity Phytopythium vexans Avocado.

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Nanocarrier drugs in the treatment of brain tumors

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Journal of Cancer Metastasis and Treatment 2016年第1期2卷 407-416页

作者： Tereza cerna Marie Stiborova Vojtech Adam Rene Kizek Tomas Eckschlager Department of Biochemistry Faculty of ScienceCharles UniversityAlbertov 2030CZ-12840 Prague 2Czech Republic Department of Chemistry and Biochemistry Laboratory metallomics and nanotechnologyMendel University in Brno and Central European Institute of TechnologyBrno University of TechnologyZemědělská1CZ-61300 BrnoCzech Republic Department of Human Pharmacology and Toxicology Faculty of PharmacologyUniversity of Veterinary and Pharmaceutical Sciences BrnoPalackeho 1CZ 61242 BrnoCzech Republic Department of Pediatric Hematology and Oncology 2nd Faculty of MedicineCharles Universityand University Hospital MotolV Uvalu 84CZ-15006 Prague 5Czech Republic

Nanoparticle-mediated targeted delivery of drugs might significantly reduce the dosage and optimize their release properties,increase specificity and bioavailability,improve shelf life,and reduce *** nanodrugs are able to overcome the blood-brain barrier that is an obstacle to treatment of brain *** in tumors have abnormal architecture and are highly permeable;moreover,tumors also have poor lymphatic drainage,allowing for accumulation of macromolecules greater than approximately 40 kDa within the tumor *** exploit this feature,known as the enhanced permeability and retention effect,to target solid *** targeting,*** modification of nanoparticles,is a way to decrease uptake in normal tissue and increase accumulation in a tumor,and it usually involves targeting surface membrane proteins that are upregulated in cancer *** targeting molecules are typically antibodies or their fragments;aptamers;oligopeptides or small *** are currently several FDA-approved nanomedicines,but none approved for brain tumor *** review,based both on the study of literature and on the authors own experimental work describes a comprehensive overview of preclinical and clinical research of nanodrugs in therapy of brain tumors.

关键词： Brain tumors nanoparticles enhanced permeability and retention effect active targeting blood-brain barrier

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Retroperitoneal epithelioid sarcoma: A case report

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World Journal of Gastrointestinal Endoscopy 2017年第12期9卷 579-582页

作者： JoséA Coronado MigueláChávez Martín A Manrique Jony cerna Ana L Trejo Division of Gastrointestinal Endoscopy Hospital Juarez de Mexico Division of Anatomic Pahology Hospital Juarez de Mexico

Epithelioid sarcoma(ES), a mesenchymatous malign neoformation, is often diagnosed in later stages and associated with high recurrence index, metastasis and mortality. We report a case of a 65 years old male, with history of abdominal pain and upper gastrointestinal bleeding. Endoscopy demonstrated a posterior duodenal wall perforation communicating with a solid retroperitoneal neoformation. Endoscopic biopsy was performed, with a final report of ES. The patient was submitted for surgical palliation due to the tumor's unresectability. Retroperitoneal ES is an extremely rare condition with limited reports in the literature where guidelines for its optimal treatment are not well established.

关键词： Epithelioid sarcoma Retroperitoneal Mesenchymatous neoformation Duodenal perforation Endoscopy

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Tumor infiltrating lymphocytes in triple negative breast cancer receiving neoadjuvant chemotherapy

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World Journal of Clinical Oncology 2016年第5期7卷 387-394页

作者： Carlos A Castaneda Elizabeth Mittendorf Sandro Casavilca Yun Wu Miluska Castillo Patricia Arboleda Teresa Nunez Henry Guerra Carlos Barrionuevo Ketty Dolores-cerna Carolina Belmar-Lopez Julio Abugattas Gabriela Calderon Miguel De La Cruz Manuel Cotrina Jorge Dunstan Henry L Gomez Tatiana Vidaurre Department of Research Instituto Nacional de Enfermedades Neoplasicas Department of Medical Oncology Instituto Nacional de Enfermedades Neoplasicas Department of Surgical Oncology the University of Texas MD Anderson Cancer Center Department of Pathology Instituto Nacional de Enfermedades Neoplasicas Department of Pathology Division of Pathology the University of Texas MD Anderson Cancer Center Department of Breast Cancer Surgery Instituto Nacional de Enfermedades Neoplasicas

AIM To determine influence of neoadjuvant-chemotherapy(NAC) over tumor-infiltrating-lymphocytes(TIL) intriple-negative-breast-cancer(TNBC).METHODS TILs were evaluated in 98 TNBC cases who came to Instituto Nacional de Enfermedades Neoplasicas from 2005 to 2010. Immunohistochemistry staining for CD3, CD4, CD8 and FOXP3 was performed in tissue microarrays(TMA) sections. Evaluation of H/E in full-face and immunohistochemistry in TMA sections was performed in pre and post-NAC samples. STATA software was used and P value < 0.05 was considered statistically significant. RESULTS Higher TIL evaluated in full-face sections from pre-NAC tumors was associated to pathologic-complete-response(pCR)(P = 0.0251) and outcome(P = 0.0334). TIL evaluated in TMA sections showed low level of agreement with full-face sections(ICC = 0.017-0.20) and was not associated to pCR or outcome. TIL in post-NAC samples were not associated to response or outcome. PostNAC lesions with pC R had similar TIL levels than those without pCR(P = 0.6331). NAC produced a TIL decrease in full-face sections(P < 0.0001). Percentage of TIL subpopulations was correlated with their absolute counts. Higher counts of CD3, CD4, CD8 and FOXP3 in pre-NAC samples had longer disease-free-survival(DFS). Higher counts of CD3 in pre-NAC samples had longer overallsurvival. Higher ratio of CD8/CD4 counts in pre-NAC was associated with pCR. Higher ratio of CD4/FOXP3 counts in pre-NAC was associated with longer DFS. Higher counts of CD4 in post-NAC samples were associated with *** TIL in pre-NAC full-face sections in TNBC are correlated to longer survival. TIL in full-face differ from TMA sections, absolute count and percentage analysis of TIL subpopulation closely related.

关键词： Triple-negative breast cancer Survival Tumor-infiltrating lymphocytes Neoadjuvant therapy

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Characterization of Chemical Bath Deposited CdS, CdSe and PbS

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材料科学与工程（中英文A版） 2011年第5X期1卷 692-704页

作者： Oscar Portillo Moreno Gustavo Abarca Avila Jorge R. cerna Juan Hernandez Tecorralco Melissa Chavez Portillo Javier Martinez Juarez Rosendo Lozada Morales Orlando Zelaya Angel Facultad de Ciencias Quimicas Benemerita Universidad Autonoma de Puebla Mexico Col. Sn. Manuel Puebla Pue. Mexico CIDS-ICUAP Benemerita Universidad Autonoma de Puebla Mexico. Col. Sn. Manuel Puebla Pue. Mexico Fac. Ciencias Fisicomatematicas Postgrado en Optoelectronica Benemerita Universidad Autonoma de Puebla Mexico Col. Sn Manuel Puebla Pue. Mexico Departamento de Fisica Centro de Investigacion y de Estudios de Estudios Avanzados del IPN 07360 Mexico D. F. Mexico

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Characterization of Chemical Bath Deposited CdSe Thin Films Doped with S^2-

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材料科学与工程（中英文B版） 2011年第5期1卷 657-666页

作者： Jorge Indalecio Contreras Rascon Oscar Portillo Moreno Gustavo Abarca Avila Jorge R. cerna Juan Hernandez Tecorralco Javler Martinez Juare Rosendo Lozada Morales Orlando Zelaya Angel CIDS-ICUAP Benemerita Universidad Autonoma de Puebla 14 Sur y Av. Sn. Claudio Col. Sn. Manuel Puebla Pue. Mexieo Facultad de Ciencias Quimicas Benemerita Universidad Autonoma de Puebla 14 Sur y Av. Sn. Claudio Col. Sn. Manuel Puebla Pue. Mexico Facultad de Ciencias Fisicomatematicas Postgrado en Optoelectroniea Benemerita Universidad Autonoma de Puebla 14 Sur y A v Sn. Claudio Col. Sn. Manuel Puebla Pue. Mexico Departamento de Fisiea del Centro de Investigacion y de Estudios Avanzados del IPN 07360 Mexico D. F. Mexico

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