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Non-small-bowel abnormalities identified during small bowel capsule endoscopy

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World Journal of Gastroenterology 2014年第14期20卷 4025-4029页

作者： reinier a hoedemaker Jessie Westerhof Rinse K Weersma Jan J Koornstra Department of Gastroenterology and Hepatology University Medical Centre GroningenUniversity of Groningen

AIM:To investigate the incidence of non-small-bowelabnormalities in patients referred for small bowel capsule endoscopy,this single center study was ***:Small bowel capsule endoscopy is an accepted technique to investigate obscure gastrointestinal *** is defined as bleeding from the digestive tract that persists or recurs without an obviousetiology after a normal gastroduodenoscopy and ***,capsule endoscopy sometimesreveals findings outside the small bowel,i.e.,withinreach of conventional *** this retrospectivesingle center study,595 patients undergoing capsuleendoscopy between 2003 and 2009 were *** of non-small bowel abnormalities was defined as visible abnormalities detected by capsule endoscopy that are located within reach of ***:In 595 patients,referred for obscure gastrointestinal bleeding or for suspected Crohn’s disease,abnormalities were found in 306(51.4%).Of these 306patients,85(27.7%)had abnormalities within reach of conventional endoscopes;63 had abnormalities apparently overlooked at previous conventional endoscopies,10 patients had not undergone upper and lower endoscopy prior to capsule endoscopy and 12 had abnormalities that were already known prior to capsule *** most common type of missed lesions were vascular lesions(n=47).Non-small-bowel abnormalities were located in the stomach(n=15),proximal small bowel(n=22),terminal ileum(n=21),colon(n=19)or at other or multiple locations(n=8).Ten patients with abnormal findings in the terminal ileum had not undergone examination of the ileum during ***:A significant proportion of patients undergoing small bowel capsule endoscopy had lesions within reach of conventional endoscopes,indicating that capsule endoscopy was unnecessarily performed.

关键词： Capsule endoscopy Small bowel Findings Colon Stoma

Long noncoding RNA in cardiac aging and disease

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Journal of Molecular Cell Biology 2019年第10期11卷 860-867页

作者： Noelia Lozano-Vidal Diewertje IBink reinier A.Boon Department of Physiology Amsterdam Cardiovascular SciencesAmsterdam Universitair Medische CentraVrije Universiteit Amsterdam1081 HZAmsterdamthe Netherlands Institute of Cardiovascular Regeneration Goethe UniversityFrankfurt am MainGermany German Center for Cardiovascular Research(DZHK) Partner Site Rhein-MainBerlinGermany

Cardiovascular diseases(CVDs)are the main cause of morbidity and mortality in Western society and present an important agerelated *** the constant rise in life expectancy,prevalence ofCVD in the population will likely increase *** therapies,especially in the elderly,are needed to combat *** review is focused on the role of long noncoding RNA(IncRNA)in *** sequencing experiments in the past decade showed that most RNA does not code for protein,but many RNAs function as ***,we summarize the recent findings of IncRNA regulation in the diseased *** potential use of these RNAs as biomarkers of cardiac disease prediction is also discussed.

关键词： long non coding RNA aging cardiovascular disease

Evidence on antimicrobial activity of essential oils and herbal extracts against Yersinia enterocolitica - A review

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Food Bioscience 2022年第3期47卷 132-144页

作者： Andrea Durofil Naga Raju Maddela reinier Abreu Naranjo Matteo Radice Area de Botánica Del Departamento de Biología y Producción de los Vegetales Facultad de CienciasUniversidad de ExtremaduraBadajozSpain Departamento de Ciencias Biológicas Facultad la Ciencias de la SaludUniversidad Técnica de ManabíPortoviejoEcuador Instituto de Investigación Universidad Técnica de ManabíPortoviejoEcuador Universidad Estatal Amazónica Km 2 ½ Vía Puyo-TenaPuyoEcuador

Yersinia enterocolitica is a very common food-borne pathogen which causes gastrointestinal infections (yersiniosis) in humans and a wide array of animals (***,deer,pigs,and birds).Due to the increasing interest in innovative plant-based substances as common food preservatives,several essential oils and herbal extracts have been investigated deeply that resulted in the emergence of novel anti-Yersinia *** reviewed relevant work done by 53 researchers covering literature from the year 2002 to till *** species such as Origanum vulgare ,Rosmarinus officinalis ,Thymus vulgaris ,Ocimum basilicum have been extensively investigated and identified that 1,8-cineole,linalool and γ-terpinene as compounds found in the essential oils of these plants have anti-Yersinia activity active food packaging *** the same direction,some promising results have been mentioned about the herbal extracts of Murrya koenigii ,Tanacetum vulgare and Tanacetum balsamita,but further investigations are needed for their sustainable *** to hierarchical cluster analysis,we found that Lamiaceae and Lauracea as the most significant families with anti-Yersinia *** the end,we proposed new research trends in order to enhance a global knowledge about the use of natural products against *** .

关键词： Food-borne pathogens Plant-based alternatives Food preservation Active packaging

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DVD翘曲控制

光盘技术 2001年第4期 24-26页

作者： reinier TEN KATE ,宗文

新的DVD应用软件,比如在自动化工业领域中,由于盘片要比通常在室内时经受更高的温度,因而可能会导致新的问题。对此,菲力浦光盘技术中心的研究小组正在研究如何通过仔细调整片基注塑的温度从而将盘片在高温下的永久性翘曲减到最小。在... 详细信息

新的DVD应用软件,比如在自动化工业领域中,由于盘片要比通常在室内时经受更高的温度,因而可能会导致新的问题。对此,菲力浦光盘技术中心的研究小组正在研究如何通过仔细调整片基注塑的温度从而将盘片在高温下的永久性翘曲减到最小。在光盘的生产和测试过程中,对于导致盘片翘曲的几种原因我们已经不再陌生,至于诸如湿

关键词：翘曲片基永久性碟片湿度梯度注塑温度 DVD

Specific and cross-reactive immune response against Mycobacterium tuberculosis antigens in mice immunized with proteoliposomes from Mycobacterium bovis BCG

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Asian Pacific Journal of Tropical Biomedicine 2017年第3期7卷 188-192页

作者： Nadine Alvarez DaymíSerpa Ramlah Kadir Yanely Tirado reinier Borrero Sonsire Fernández Rubén Cabrera Yolanda Valdes Caridad Zayas Reinaldo Acevedo Luis Izquierdo María Elena Sarmiento Mohd-Nor Norazmi JoséLuis Pérez Armando Acosta Finlay Institute School of Health Sciences University Sains Malaysia Institute for Research in Molecular Medicine University Sains Malaysia

Objective: To characterize the immunogenicity and the induction of cross-reactive responses against Mycobacterium tuberculosis(M. tuberculosis) of a proteoliposome(PL)from Mycobacterium bovis Bacillus Calmette–Guerin(BCG) with and without alum hydroxide(AL) as adjuvant(PLBCG-AL and PLBCG, respectively) in BALB/c ***: BALB/c mice were inoculated with phosphate buffer solution, BCG, PLBCG and PLBCG-AL. The humoral immunogenicity was determined by ELISA [immunoglobulin G(Ig G), Ig G1 and Ig G2a] and the cellular immunogenicity was evaluated in vivo by delayed type hypersensitivity. The humoral cross-reactive response against M. tuberculosis was determined by Western ***: Sera from animals immunized with PLBCG-AL and PLBCG showed significant increase in specific total Ig G and Ig G1 antibodies and the presence of cross-reactive antibodies against M. tuberculosis antigens, which were more intense with the use of alum as adjuvant. Mice immunized with PLBCG and PLBCG-AL also showed a specific cellular response in ***: The cellular and humoral immunogenicity of PLBCG and the capacity to induce cross-reactive responses against M. tuberculosis is in agreement with the protective capacity previously demonstrated by this vaccine candidate and supports the continuation of its evaluation in further stages.

关键词： BCG Immunogenicity Mycobacterium tuberculosis Proteoliposomes

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你的企业有惰性吗?

中国企业家 2012年第10期48卷 101-107,9页

作者： Stephen Hall Dan Lovallo reinier Musters 麦肯锡咨询公司

新的一年,企业各个业务单元都会为如何分配资金、人才和研发投入展开＂内部竞争＂。相当多的企业采用了＂萧规曹随＂、＂按既定方针办＂的做法,对决策者而言,可以搬出现代企业管理理论作为依据—保持企业经营战略的稳定性。但上述理由... 详细信息

新的一年,企业各个业务单元都会为如何分配资金、人才和研发投入展开＂内部竞争＂。相当多的企业采用了＂萧规曹随＂、＂按既定方针办＂的做法,对决策者而言,可以搬出现代企业管理理论作为依据—保持企业经营战略的稳定性。但上述理由遮掩不了一个事实：这时,你的企业已经浑身散发着惰性,不能按照市场变化和企业长远目标及时调整业务布局,对内部资源进行最佳分配,而只是机械地按照上一年的老皇历办事。全球著名战略咨询公司麦肯锡公司近日发布报告,在对全球1600家样本公司进行统计分析后,揭示了令人吃惊的事实：1/3的样本企业由于自身的惰性,几乎从不调整内部资源的分配状况,而那些能够适时调整资源分配机制的企业,在一个15年的周期里,表现要明显胜出。人性中天然的惰性和微妙的公司政治是企业惰性的两大源头。所幸,我们研究发现,有一些药方可以有效地治疗企业的懒惰病,让资源在企业内部得到更加合理和高效的分配,从而不断提高企业的绩效。

关键词：企业经营战略惰性现代企业管理理论麦肯锡公司分配状况内部资源资源分配机制内部竞争

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企业演变史

研究生法学 2009年第2期24卷 145-151页

作者： Henry Hansmann reinier Kraakman Richard Squire 谭津龙耶鲁大学法学院哈佛大学法学院耶鲁大学中国政法大学

过去三十年中,企业组织形态的发展结合了传统合伙上的契约自由和传统公司上的债权人权利模式。法学者对这类新的组织形态更像合伙还是更像公司各持己见。持更类似合伙观点的人认为契约自由的程度是传统公司和合伙形式的本质区别,而持相... 详细信息

过去三十年中,企业组织形态的发展结合了传统合伙上的契约自由和传统公司上的债权人权利模式。法学者对这类新的组织形态更像合伙还是更像公司各持己见。持更类似合伙观点的人认为契约自由的程度是传统公司和合伙形式的本质区别,而持相反见解的学者则认为债权人权利模式才是区别之关键。本文作者赞同后者。我们通过检视企业实体演变的过程来揭示:公司中传统刚性规则对债权人权利保护有重要作用,但是随着保护投资者的替代制度的发展,公司对刚性规则的需求日衰,而对契约自由的需求则日盛。本文中,作者首先讨论了企业实体演变的历史,侧重于讨论债权人保护在演变中的主要作用。随后,作者认为,尽管在讨论债权人保护以及公司与合伙的区别时,法学者总是将注意力放在有限责任上,但区别公司与合伙的主要特征在于"人格屏蔽"——指将公司财产分配给享有不同权利的不同类型债权人。在讨论强的人格屏蔽的重要性——公司而非合伙的特征——以及该制度如何完善有限责任之后,作者得出结论:新的企业组织形态是强的人格屏蔽扩展到受较少限制的企业实体的过程的产物,因此新的组织形态应视为公司的衍生而非合伙。

关键词：公司合伙组织历史有限责任公司法人实体资产分离

墨尔本“Southbank by Beulah”国际竞赛概念方案

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现代装饰 2018年第10期 126-129页

作者：李存皓孙守泉 Marco Gastoldl Jennifer Perez-Rojas 王心逸 Thoufeeq Ahamed 雷蕾 Jaime Cadarso reinier Simons MAD

7月27日,马岩松带领的MAD建筑事务所在墨尔本公布了“Southbank by Beulah”超高层国际竞赛的概念方案,该项目是Beulah International位于墨尔本Southbank的一块基地面积为6000平方米的场地,包括酒店、住宅、办公、商业的超高层综合体。... 详细信息

7月27日,马岩松带领的MAD建筑事务所在墨尔本公布了“Southbank by Beulah”超高层国际竞赛的概念方案,该项目是Beulah International位于墨尔本Southbank的一块基地面积为6000平方米的场地,包括酒店、住宅、办公、商业的超高层综合体。MAD尝试将墨尔本丰富的自然环境垂直延展于高层设计中,在高密度城市环境中营造“云端、高山、丛林”的自然意境,消除传统高密度城市所带有的隔阂感,以更亲切的尺度拉近市民与社区、自然的距离,并以自然的形态点缀墨尔本的城市天际线,成为墨尔本未来独一无二的城市地标。

关键词：墨尔本竞赛国际高密度城市自然环境城市环境建筑事务所高层综合体

高血压患者常规行眼底镜检查的价值:系统性综述

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英国医学杂志中文版 2005年第6期8卷 341-344页

作者： Bert-Jan H van den Born Caroline A A Hulsman Joost B L Hoekstra reinier O Schlingemann Gert A van Montfrans 高展 Department of Internal Medicine Academic Medical Centre PO 226601100 DD AmsterdamNetherlands Department of Ophthalmology Academic Medical CentreAmsterdam

目的评价高血压患者常规眼底检查的价值。设计系统性综述。入选患者 ≥19岁的高血压视网膜病变患者。数据来源从1990起的Medline、Embase和Cochrane图书馆的数据库。综述方法纳入的研究包括：评估了高血压视网膜病变性失明与心血管... 详细信息

目的评价高血压患者常规眼底检查的价值。设计系统性综述。入选患者 ≥19岁的高血压视网膜病变患者。数据来源从1990起的Medline、Embase和Cochrane图书馆的数据库。综述方法纳入的研究包括：评估了高血压视网膜病变性失明与心血管危险因素之间联系的研究。研究必须由2名或2名以上观察者得出一致评价结果，用K统计分析表示。对于高血压患者，研究高血压视网膜病变与高血压脏器损害之间的联系。对于非选择的血压正常者和无糖尿病高血压患者，评价高血压视网膜病变与心血管危险因素之间的联系。结果由于观察者之间的巨大差异限制了对视网膜微血管变化的评价。高血压视网膜病变与血压水平之间的阳性及阴性预测值均较低（分别为47％～72％和32％-67％）。除了视网膜病变与脑卒中之间有联系外，视网膜微血管变化与心血管危险因素之问无明显联系。但在血压正常的视网膜病变患者中同样发现脑卒中增加。这些研究没有对高血压脏器损害的其他预测因子进行调整。结论研究表明，高血压患者常规进行眼底检查有额外价值的观点尚缺乏证据。

关键词：高血压患者系统性综述眼底镜检查价值 Cochrane图书馆心血管危险因素视网膜病变 Medline 微血管变化眼底检查