Long noncoding RNA in cardiac aging and disease

作     者：Noelia Lozano-Vidal Diewertje IBink Reinier A.Boon Noelia Lozano-Vidal;Diewertje I.Bink;Reinier A.Boon

作者机构：Department of PhysiologyAmsterdam Cardiovascular SciencesAmsterdam Universitair Medische CentraVrije Universiteit Amsterdam1081 HZAmsterdamthe Netherlands Institute of Cardiovascular RegenerationGoethe UniversityFrankfurt am MainGermany German Center for Cardiovascular Research(DZHK)Partner Site Rhein-MainBerlinGermany 

出 版 物：《Journal of Molecular Cell Biology》 (分子细胞生物学报（英文版）)

年 卷 期：2019年第11卷第10期

页      面：860-867页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：funded by the Research Programme Vidi with project by the Netherlands Organization for Scientific Research (NWO) 

主　　题：long non coding RNA aging cardiovascular disease 

摘      要：Cardiovascular diseases(CVDs)are the main cause of morbidity and mortality in Western society and present an important agerelated risk.With the constant rise in life expectancy,prevalence ofCVD in the population will likely increase further.New therapies,especially in the elderly,are needed to combat CVD.This review is focused on the role of long noncoding RNA(IncRNA)in CVD.RNA sequencing experiments in the past decade showed that most RNA does not code for protein,but many RNAs function as ncRNA.Here,we summarize the recent findings of IncRNA regulation in the diseased heart.The potential use of these RNAs as biomarkers of cardiac disease prediction is also discussed.