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Signal Transduction and Targeted Therapy 2022年第11期7卷 3973-3975页

作者： Ivan Odak reinhold Förster Berislav Bošnjak Institute of Immunology Hannover Medical School30625HannoverGermany Cluster of Excellence RESIST(EXC 2155) Hannover Medical School30625HannoverGermany German Centre for Infection Research(DZIF) Partner site HannoverHannoverGermany

Sokal et *** recently in Immunity that the SARS-CoV-2 Omicron variant evades recognition by 70%of anti-spike protein antibodies generated by memory B cells(MBCs)from mRNA vaccine-immunized individuals that were either or not also infected with ***,samples from all analyzed persons contained MBCs with neutralizing antibodies against Omicron Spike receptor-binding domain(RBD),which provide protection against this SARS-CoV-2 variant to some degree.

关键词： vaccine antibodies

Differential retention of lymph-borne CD8 memory T cell subsets in the subcapsular sinus of resting and inflamed lymph nodes

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Cellular & Molecular Immunology 2021年第5期18卷 1317-1319页

作者： Ginka Nikolova Siegfried weiss Berislav Bosnjak reinhold Förster Institute of Immunology Hannover Medical School30625HannoverGermany Cluster of Excellence RESIST(EXC 2155) Hannover Medical School30625HannoverGermany

Immunological memory represents the ability of specific immune cells to recall an encounter with a cognate *** results in an immediate response upon a second exposure to the same infectious ***,conventional memory T cells are generated after encountering specific foreign *** contrast,a group of innate memory T cells develops without initial exposure to foreign antigen that specifically binds to a cognate T cell receptor.1 These naturally occurring memory-like T cells,also known as“virtual”memory T cells,are generated under steady-state *** accumulate during aging in both humans and mice.2 By comparing the TCR repertoire of young and old mice,an early study identified age-dependent clonal expansion and age-related changes in CD8^(+) but not CD4^(+) T cells.3 Interestingly,more than 50%of CD62L^(hi)CD44^(hi) central memory T cells in the peripheral blood of aged naive mice have been suggested to represent virtual memory T cells based on their lower expression levels of CD49d.4 Infection studies in mice employing Listeria monocytogenes showed that both virtual memory T cells and conventional antigen-specific memory T cells were able to provide protection.5 However,in contrast to virtual memory T cells,conventional memory T cells produced fivefold higher levels of IFN-γupon short-term in vitro TCR stimulation.

关键词： lymph retention exposure

NK cell dysfunction in severe COVID-19:TGF-β-induced downregulation of integrin beta-2 restricts NK cell cytotoxicity

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Signal Transduction and Targeted Therapy 2022年第2期7卷 346-348页

作者： Joana Barros-Martins reinhold Förster Berislav Bošnjak Institute of Immunology Hannover Medical School30625 HannoverGermany Cluster of Excellence RESIST(EXC 2155) Hannover Medical School30625 HannoverGermany German Centre for Infection Research(DZIF) Partner site HannoverHannoverGermany

In a recent study published in Nature,witkowski et *** that in patients with severe forms of coronavirus disease 2019(COVID-19)deranged tumor growth factor-beta(TGF-β)secretion counteracts interferon-alpha(IFN-α)-induced activation of NK cells by decreasing expression of transcription factor ***,NK cells fail to upregulate the adhesion molecule integrin beta-2(-ß2),which impedes their attachment to and killing of SARS-CoV-2 infected cells.

关键词： interferon cytotoxicity

Hydrophobically modified polyelectrolytes I. Dilute solution properties of fluorocarbon-containing poly (acrylic acid)

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Chinese Journal of Chemistry 2000年第3期18卷 322-327页

作者：周晖宋国强章云祥 DIKING reinhold MA Lian HAEUSSLING Lukas Department of Polymer Science State Key Laboratory of Bio-organic and Natural Products Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences Shanghai 200032 China BASF Aktiengesellschaft Kunststofflaboratorium ZKS/B-B1 D-67056 Ludwigshafen Germany

Dilute solution viscosity of fluorocarbon-containing hydrophobically modified poly (acrylic add) was measured in aqueous solutions of various NaCl concentrations. The intrinsic viscosity ([η]) and Huggins coefficient (kH) were evaluated using Huggins equations. It is found that, at low Nacl concentration, the modified polymers exhibit values of intrinsic viscosity ([η]) and Huggins coefficient (kH) similar to those of unmodified polymers. For both of the modified and unmodified polymers, the intrinsic viscosity decreases with increase of NaCl concentration, while the Huggins coefficient increases upon addition of NaCl. But the variation of [η] and kH is more significant for the modified polymers, which reflects the enhanced intra- and intermolecular hydrophobic association at higher Nacl concentration.

关键词： Polyelectrolytes hydrophobically modified fluorocarbon-containing intrinsic viscosity

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基于Simulink的磁悬浮控制系统仿真

系统仿真学报 2008年第8期20卷 2168-2170,2176页

作者：舒光伟 reinhold Meisinger 上海应用技术学院机械与自动化工程学院上海200235 纽伦堡应用科学大学机械工程系德国纽伦堡90121

在MATLAB/Simulink环境下,对电磁型(EMS)磁浮列车,利用Lagrange方程,结合动力学和电磁学基本理论,建立了单磁铁磁悬浮系统的数学模型,给出了采用线性二次最优控制策略的系统仿真模型,分析了影响该系统动态性能的主要因素。仿真结果表明... 详细信息

在MATLAB/Simulink环境下,对电磁型(EMS)磁浮列车,利用Lagrange方程,结合动力学和电磁学基本理论,建立了单磁铁磁悬浮系统的数学模型,给出了采用线性二次最优控制策略的系统仿真模型,分析了影响该系统动态性能的主要因素。仿真结果表明,所提出的方法是对磁悬浮系统建模和控制进行研究的有效途径。

关键词：磁悬浮系统 Lagrange方程 Simulink 系统模型

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基于随机线性二次最优的磁悬浮控制系统

华东理工大学学报（自然科学版） 2005年第5期31卷 649-652页

作者：舒光伟 reinhold Meisinger 上海应用技术学院机械与自动化工程学院上海200235 纽伦堡应用科学大学机械工程系德国纽伦堡90121

在分析电磁型(EM S)磁悬浮列车悬浮系统结构特性的基础上,建立了单磁铁磁悬浮系统的数学模型。采用随机线性二次最优的控制策略设计系统控制器,研究了在不同性能指标加权阵的情况下,该磁悬浮控制系统对具有初始磁间隙和受到外力干扰后... 详细信息

在分析电磁型(EM S)磁悬浮列车悬浮系统结构特性的基础上,建立了单磁铁磁悬浮系统的数学模型。采用随机线性二次最优的控制策略设计系统控制器,研究了在不同性能指标加权阵的情况下,该磁悬浮控制系统对具有初始磁间隙和受到外力干扰后磁间隙随时间变化的控制效果,并给出仿真结果,为磁悬浮控制系统的设计提供参考。

关键词：磁悬浮系统数学模型最优控制仿真

A dominant insulin-specific and islet-destructive T-cell response is sufficient to activate CD8 T cells directed against the fatty-acid receptor GPR40

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Cellular & Molecular Immunology 2020年第6期17卷 659-661页

作者： Andreas Spyrantis Jana Krieger Katja Stifter Bernhard Otto Boehm reinhold Schirmbeck Department of Internal Medicine I Ulm University Hospital/Albert Einstein Allee 2389081 UlmGermany Lee Kong Chian School of Medicine Nanyang Technological UniversitySingaporeSingapore Imperial College London LondonUK

Type 1 diabetes mellitus(T1D)is an autoimmune disease that is characterized by a progressive infiltration of autoreactive T cells into the pancreatic islets and the destruction of insulin-producing beta cells.1 It is generally assumed that T1D is initiated by yet unidentified T cells that escape from thymic negative selection2 and trigger an initial destruction of beta cells.3 These initial hits could generate suitable conditions in beta cells and/or in islets that favor the coactivation and amplification of autoreactive T cells directed against a broad spectrum of beta cell-specific antigens,such as GAD65,IGRP,and IA-2.

关键词： GPR40 islet directed

Cellular and molecular mechanisms breaking immune tolerance in inborn errors of immunity

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Cellular & Molecular Immunology 2021年第5期18卷 1122-1140页

作者： Georgios Sogkas Faranaz Atschekzei Ignatius Ryan Adriawan Natalia Dubrowinskaja Torsten witte reinhold Ernst Schmidt Department of Rheumatology and Immunology Hannover Medical SchoolHanoverGermany Hannover Medical School Cluster of Excellence RESIST(EXC 2155)HanoverGermany

In addition to susceptibility to infections,conventional primary immunodeficiency disorders(PIDs)and inborn errors of immunity(IEI)can cause immune dysregulation,manifesting as lymphoproliferative and/or autoimmune *** can be the prominent phenotype of PIDs and commonly includes cytopenias and rheumatological diseases,such as arthritis,systemic lupus erythematosus(SLE),and Sjogren’s syndrome(SjS).Recent advances in understanding the genetic basis of systemic autoimmune diseases and PIDs suggest an at least partially shared genetic background and therefore common pathogenic ***,we explore the interconnected pathogenic pathways of autoimmunity and primary immunodeficiency,highlighting the mechanisms breaking the different layers of immune tolerance to self-antigens in selected IEI.

关键词： Inborn errors of immunity Primary immunodeficiencies Autoimmunity Rheumatic diseases

Pancreatitis, panniculitis and polyarthritis syndrome: A case report

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world Journal of Clinical Cases 2023年第18期11卷 4412-4418页

作者： Hannes Pichler Thomas Stumpner Dietmar Schiller Martin Bischofreiter reinhold Ortmaier Department of Orthopedic Surgery Ordensklinikum Linz Barmherzige SchwesternVinzenzgruppe Center of Orthopedic ExcellenceTeaching HospitalParacelsus Medical University SalzburgLinz 4010Austria Department of Gastroenterology Ordensklinikum Linz Barmherzige SchwesternLinz 4010Austria

BACKGROUND Pancreatitis,panniculitis,and polyarthritis(PPP)syndrome is a rare form of pancreatic *** is characterized by bullous erythematous skin lesions and arthritis,and both are triggered by pancreatic *** cases have been described in the literature thus *** to the inconsistency in its clinical presentation,its diagnosis can be a *** therapy initiation is essential to reduce mortality;however,there is currently no gold standard for *** SUMMARY A 66-year-old polymorbid male patient presented with several superficial abscesses on both lower legs and painful swelling in the *** for septic arthritis and septic skin infection over several weeks *** general condition deteriorated gradually and worsened with sudden onset of abdominal pain.A diagnosis of necrotizing pancreatitis was *** subsequently underwent a laparotomy and drainage of the ***,our patient improved,and his abdominal complaints,knee pain,and dermal lesions *** PPP syndrome is rare and easily misdiagnosed,as abdominal symptoms may be delayed or *** should consider PPP syndrome if they encounter refractory panniculitis in combination with joint infection.

关键词： Pancreatitis Panniculitis Polyarthritis Pancreatitis,panniculitis,and polyarthritis syndrome Septic arthritis Case report

IL-1β limits the extent of human 6-sulfo LacNAc dendritic cell (slanDC)-mediated NK cell activation and regulates CD95-induced apoptosis

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Cellular & Molecular Immunology 2017年第12期14卷 976-985页

作者： Dejene Milkessa Tufa Fareed Ahmad Debanjana Chatterjee Gerrit Ahrenstorf reinhold Ernst Schmidt Roland Jacobs Department of Clinical Immunology and Rheumatology Hannover Medical School30625 HannoverGermany

To function optimally,human blood natural killer(NK)cells need to communicate with other immune ***,it has been shown that NK cells communicate with 6-sulfo LacNAc dendritic cells(slanDCs),which are able to stimulate NK cells in *** this study,we investigated how slanDCs regulate the level of NK cell *** secretion of interleukin(IL)-1βby slanDCs during coculture with NK cells increased as a result of signaling via intercellular adhesion molecule-1 on slanDCs following its interaction with lymphocyte functionassociated antigen-1 on NK ***-1βinduced the expression of Fas receptor(CD95)on NK *** binding of Fas ligand(CD178)to CD95 induced the apoptosis of activated NK ***,IL-1βalso induced increased cyclooxygenase-2 expression in slanDCs,which in turn enabled the cells to secrete prostaglandin(PG)-***,PGE2 acted as a suppressing agent,tuning down the activation level of NK *** summary,IL-1βlimits the level of NK cell activation by inducing apoptosis and suppression as a homeostatic regulatory function.

关键词： COX-2 Fas-induced apoptosis immunosuppression NK cells slanDCs