Differential retention of lymph-borne CD8 memory T cell subsets in the subcapsular sinus of resting and inflamed lymph nodes
作者机构：Institute of ImmunologyHannover Medical School30625HannoverGermany Cluster of Excellence RESIST(EXC 2155)Hannover Medical School30625HannoverGermany
出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)
年 卷 期：2021年第18卷第5期
页 面：1317-1319页
核心收录：
学科分类：1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学]
基 金：supported by Deutsche Forschungsgemeinschaft,(DFG,German Research Foundation)under Germany’s Excellence Strategy–EXC 2155“RESIST”–Project ID 39087428,DFG grants SFB900-B1 and FOR2830-P006 to RF Deutsche Akademische Austauschdienst grant GSSP2014-57034101-91557342 to GN
摘 要：Immunological memory represents the ability of specific immune cells to recall an encounter with a cognate *** results in an immediate response upon a second exposure to the same infectious ***,conventional memory T cells are generated after encountering specific foreign *** contrast,a group of innate memory T cells develops without initial exposure to foreign antigen that specifically binds to a cognate T cell receptor.1 These naturally occurring memory-like T cells,also known as“virtualmemory T cells,are generated under steady-state *** accumulate during aging in both humans and mice.2 By comparing the TCR repertoire of young and old mice,an early study identified age-dependent clonal expansion and age-related changes in CD8^(+) but not CD4^(+) T cells.3 Interestingly,more than 50%of CD62L^(hi)CD44^(hi) central memory T cells in the peripheral blood of aged naive mice have been suggested to represent virtual memory T cells based on their lower expression levels of CD49d.4 Infection studies in mice employing Listeria monocytogenes showed that both virtual memory T cells and conventional antigen-specific memory T cells were able to provide protection.5 However,in contrast to virtual memory T cells,conventional memory T cells produced fivefold higher levels of IFN-γupon short-term in vitro TCR stimulation.
维普期刊数据库