Hide and seek with SARS-CoV-2: spike receptor-binding domain-specific memory B cells still recognize Omicron variant

作     者：Ivan Odak Reinhold Förster Berislav Bošnjak 

作者机构：Institute of ImmunologyHannover Medical School30625HannoverGermany Cluster of Excellence RESIST(EXC 2155)Hannover Medical School30625HannoverGermany German Centre for Infection Research(DZIF)Partner site HannoverHannoverGermany 

出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)

年 卷 期：2022年第7卷第11期

页      面：3973-3975页

核心收录：

学科分类：0710[理学-生物学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：Research in the Förster lab gets supported by the German Center for Infection Research TTU 01.938(grant no 80018019238) German Center for Lung Research(grant 82DZL002B1) Deutsche Forschungsgemeinschaft(DFG,German Research Foundation)Excellence Strategy EXC 2155“RESIST”(Project ID39087428) SFB 900/3(Project B1,158989968)and FO334/7-1(all to RF) 

主　　题：vaccine antibodies 

摘      要：Sokal et *** recently in Immunity that the SARS-CoV-2 Omicron variant evades recognition by 70%of anti-spike protein antibodies generated by memory B cells(MBCs)from mRNA vaccine-immunized individuals that were either or not also infected with ***,samples from all analyzed persons contained MBCs with neutralizing antibodies against Omicron Spike receptor-binding domain(RBD),which provide protection against this SARS-CoV-2 variant to some degree.