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Cardiometabolic effects of breastfeeding on infants of diabetic mothers

World Journal of Diabetes 2023年第5期14卷 617-631页

作者： reem Elbeltagi Mohammed Al-Beltagi Nermin Kamal Saeed Adel Salah Bediwy Department of Medicine Irish Royal College of SurgeonBusaiteen 15503Bahrain Department of Pediatrics Faculty of MedicineTanta UniversityTanta 31511Egypt Department of Pediatrics University Medical CenterKing Abdulla Medical CityArabian Gulf UniversityManama 26671Bahrain Medical Microbiology Section Department of PathologySalmaniya Medical ComplexMinistry of HealthKingdom of BahrainManama 12Bahrain Department of Microbiology Irish Royal College of SurgeonBahrainBusaiteen 15503Bahrain Department of Chest Diseases Faculty of MedicineTanta UniversityTanta 31527Egypt Department of Pulmonology University Medical CenterKing Abdulla Medical CityArabian Gulf UniversityManama 26671Bahrain

BACKGROUND Breast milk is the best and principal nutritional source for neonates and *** may protect infants against many metabolic diseases,predominantly obesity and type 2 *** mellitus(DM)is a chronic metabolic and microvascular disease that affects all the body systems and all ages from intrauterine life to late *** protects against infant mortality and diseases,such as necrotizing enterocolitis,diarrhoea,respiratory infections,viral and bacterial infection,eczema,allergic rhinitis,asthma,food allergies,malocclusion,dental caries,Crohn's disease,and ulcerative *** also protects against obesity and insulin resistance and increases intelligence and mental *** diabetes has short and long-term impacts on infants of diabetic mothers(IDM).Breast milk composition changes in mothers with gestational *** To investigate the beneficial or detrimental effects of breastfeeding on the cardiometabolic health of IDM and their *** We performed a database search on different engines and a thorough literature review and included 121 research published in English between January 2000 and December 15,2022,in this *** Most of the literature agreed on the beneficial effects of breast milk for both the mother and the infant in the short and long *** protects mothers with gestational diabetes against obesity and type 2 *** some evidence of the protective effects of breastfeeding on IDM in the short and long term,the evidence is not strong enough due to the presence of many confounding factors and a lack of sufficient *** We need more comprehensive research to prove these *** many obstacles that may enface mothers with gestational diabetes to start and maintain breastfeeding,every effort should be made to encourage them to breastfeed.

关键词： Breast milk Breastfeeding Gestational diabetes mellitus Cardiometabolic effects Infants of diabetic mothers Obesity

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An Improved Deep Structure for Accurately Brain Tumor Recognition

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Computer Systems Science & Engineering 2023年第8期46卷 1597-1616页

作者： Mohamed Maher Ata reem N.Yousef Faten Khalid Karim Doaa Sami Khafaga Department of Communications and Electronics Engineering MISR Higher Institute for Engineering and TechnologyMansoura35516Egypt Department of Electronics and Communications Delta Higher Institute for Engineering and TechnologyMansoura35516Egypt Department of Computer Sciences College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia

Brain neoplasms are recognized with a biopsy,which is not commonly done before decisive brain *** using Convolutional Neural Networks(CNNs)and textural features,the process of diagnosing brain tumors by radiologists would be a noninvasive *** paper proposes a features fusion model that can distinguish between no tumor and brain tumor types via a novel deep learning *** proposed model extracts Gray Level Co-occurrence Matrix(GLCM)textural features from MRI brain tumor ***,a deep neural network(DNN)model has been proposed to select the most salient features from the ***,it manipulates the extraction of the additional high levels of salient features from a proposed CNN ***,a fusion process has been utilized between these two types of features to form the input layer of additional proposed DNN model which is responsible for the recognition *** common datasets have been applied and tested,Br35H and FigShare *** first dataset contains binary labels,while the second one splits the brain tumor into four classes;glioma,meningioma,pituitary,and no ***,several performance metrics have been evaluated from both datasets,including,accuracy,sensitivity,specificity,F-score,and training *** results show that the proposed methodology has achieved superior performance compared with the current state of art *** proposed system has achieved about 98.22%accuracy value in the case of the Br35H dataset however,an accuracy of 98.01%has been achieved in the case of the FigShare dataset.

关键词： Brain tumor convolutional neural network gray level co-occurrence matrix noninvasive FigShare dataset Br35H dataset

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Modeling and Analysis of UAV-Assisted Mobile Network with Imperfect Beam Alignment

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Computers, Materials & Continua 2023年第1期74卷 453-467页

作者： Mohamed Amine Ouamri reem Alkanhel Cedric Gueguen Manal Abdullah Alohali Sherif S.M.Ghoneim University of Rennes 1/ADOPNET team at IRISA laboratory Rennes35000France Facultéde Technologie Laboratoire d’Informatique Médicale(LIMED)Universitéde BejaiaBejaia06000Algérie Department of Information Technology College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of Information Systems College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Electrical engineering department College of EngineeringTaif University P.O.Box 11099Taif21944Saudi Arabia

With the rapid development of emerging 5G and beyond(B5G),Unmanned Aerial Vehicles(UAVs)are increasingly important to improve the performance of dense cellular *** a conventional metric,coverage probability has been widely studied in communication systems due to the increasing density of users and complexity of the heterogeneous *** recent years,stochastic geometry has attracted more attention as a mathematical tool for modeling mobile network *** this paper,an analytical approach to the coverage probability analysis of UAV-assisted cellular networks with imperfect beam alignment has been *** assumption was considered that all users are distributed according to Poisson Cluster Process(PCP)around base stations,in particular,Thomas Cluster Process(TCP).Using thismodel,the impact of beam alignment errors on the coverage probabilitywas ***,the ProbabilityDensity Function(PDF)of directional antenna gain between the user and its serving base station was ***,association probability with each tier was achieved.A tractable expression was derived for coverage probability in both Line-of-Sight(LoS)andNon-Line-of-Sight(NLoS)condition *** results demonstrated that at low UAVs altitude,beam alignment errors significantly degrade coverage ***,for a small cluster size,alignment errors do not necessarily affect the coverage performance.

关键词： Unmanned aerial vehicles coverage analysis stochastic geometry millimeter wave imperfect beam alignment

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Anti-tumor effects and cellular mechanisms of Pistacia atlantica methanolic extract against Ehrlich solid tumor in mice

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Asian Pacific Journal of Tropical Biomedicine 2022年第2期12卷 69-77页

作者： Aishah E.Albalawi Norah A.Althobaiti reem Hasaballah Alhasani Sultan F.Alnomasy Faculty of Science Department of BiologyUniversity of TabukTabuk 47913Saudi Arabia Biology Department College of Science and HumanitiesAl QuwaiiyahShaqra UniversityAl Quwaiiyah 19257Saudi Arabia Department of Biology Faculty of Applied ScienceUmm Al-Qura UniversityMakkahSaudi Arabia Department of Medical Laboratories Sciences College of Applied Medical SciencesAl-QuwayiyahShaqra UniversityRiyadhSaudi Arabia

Objective:To assess the anti-tumor effects of Pistacia atlantica methanolic extract(PAME)compared with cyclophosphamide against Ehrlich solid tumors in ***:Swiss albino mice(n=40)were divided into five groups:normal control mice,mice with Ehrlich solid tumors treated with normal saline,mice with Ehrlich solid tumors treated with cyclophosphamide intraperitoneally once a day for 14 d,or 50mg/kg or 100 mg/kg PAME orally once a day for 14 *** growth inhibition,body weight,tumor markers,liver and kidney enzymes,oxidative stress markers,antioxidant enzymes,tumor necrosis factor-alpha level(TNF-α),and apoptosis-regulatory gene expression were ***:Treatment of mice bearing Ehrlich solid tumors with PAME at 50 and 100 mg/kg orally significantly decreased tumor volume,body weight,tumor markers,liver and kidney enzymes,oxidative stress markers and TNF-αlevel in comparison with mice with Ehrlich solid tumors receiving normal *** PAME at 50 and 100 mg/kg/day significantly elevated the level of antioxidant enzymes(P<0.05).Conclusions:Pistacia atlantica methanolic extract has potent antitumor activity in ***,the extract might be considered as an alternative anticancer agent against tumors,however,additional studies especially in the clinical setting are required to confirm this finding.

关键词： Cancer Ehrlich solid tumors Treatment Pistacia atlantica Herbal medicines Natural product in vivo Mice

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Transcranial magnetic stimulation in animal models of neurodegeneration

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Neural Regeneration Research 2022年第2期17卷 251-265页

作者： Mohammad Uzair Turki Abualait Muhammad Arshad Woo-Kyoung Yoo Ali Mir reem Fahd Bunyan Shahid Bashir Department of Biological Sciences Faculty of Basic&Applied SciencesInternational Islamic University IslamabadPakistan College of Applied Medical Sciences Imam Abdulrahman Bin Faisal UniversityDammamSaudi Arabia Department of Physical Medicine and Rehabilitation Hallym University College of MedicineAnyangSouth Korea Hallym Institute for Translational Genomics&Bioinformatics Hallym University College of MedicineAnyangSouth Korea Neuroscience Center King Fahad Specialist Hospital DammamDammamSaudi Arabia

Brain stimulation techniques offer powerful means of modulating the physiology of specific neural structures. In recent years, non-invasive brain stimulation techniques, such as transcranial magnetic stimulation(TMS) and transcranial direct current stimulation, have emerged as therapeutic tools for neurology and neuroscience. However, the possible repercussions of these techniques remain unclear, and there are few reports on the incisive recovery mechanisms through brain stimulation. Although several studies have recommended the use of non-invasive brain stimulation in clinical neuroscience, with a special emphasis on TMS, the suggested mechanisms of action have not been confirmed directly at the neural level. Insights into the neural mechanisms of non-invasive brain stimulation would unveil the strategies necessary to enhance the safety and efficacy of this progressive approach. Therefore, animal studies investigating the mechanisms of TMSinduced recovery at the neural level are crucial for the elaboration of non-invasive brain stimulation. Translational research done using animal models has several advantages and is able to investigate knowledge gaps by directly targeting neuronal levels. In this review, we have discussed the role of TMS in different animal models, the impact of animal studies on various disease states, and the findings regarding brain function of animal models after TMS in pharmacology research.

关键词： Alzheimer's disease depression glial cells neurorehabilitation Parkinson's disease repetitive transcranial magnetic stimulation transcranial direct current stimulation transcranial magnetic stimulation

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Antioxidative, cytotoxic, and anti-metastatic potentials of Laurencia obtusa and Ulva lactuca seaweeds

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Asian Pacific Journal of Tropical Biomedicine 2021年第7期11卷 308-316页

作者： reem Al Monla Yahya Salma Achraf Kouzayha Hala Gali-Muhtasib Zeina Dassouki Hiba Mawlawi Laboratory of Applied Biotechnology(LBA3B) AZM Center for Research in Biotechnology and its ApplicationsDoctoral School for Sciences and TechnologyLebanese UniversityTripoliLebanon Department of Biology American University of BeirutLebanon Center for Drug Discovery American University of BeirutRiad El Solh 11072020BeirutLebanon

Objective:To investigate the antioxidant and cytotoxic properties of the most active extracts from Ulva lactuca and Laurencia obtusa against colon and cervical cancer cell ***:The antioxidant radical scavenging activity of the algal extracts was estimated using the 2,2-diphenyl-1-picrylhydrazyl colorimetric ***,the cytotoxic potential of these bioactive extracts was studied against HCT-116 and HeLa cells by 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide *** healing analysis was adopted to evaluate the antimetastatic effects of protein extracts from both *** cycle analysis was performed by flow cytometry,and apoptotic bodies were detected using 4′,6-diamidino-2-phenylindole fluorescent *** acids of hydrolyzed protein extract were separated and identified chromatographically by high performance liquid ***:The green algae Ulva lactuca had higher lipid content than Laurencia obtusa,whereas the latter had higher protein content with high antioxidant *** extracts had significant dose-and time-dependent cytotoxicity and anti-metastatic activity against HCT-116 *** b extracts of both algae obtained from the chloroform:hexane solvent lipid-free residue caused morphological changes and induced apoptosis of HCT-116 *** analysis revealed that apoptosis induced upon Laurencia obtusa protein b treatment was triggered via the ROS pathway,causing a significant increase in the sub-G_(1) *** and arginine(5.94 and 5.47μM,respectively)were the most common amino acids in Laurencia obtusa protein b ***:Proteins of Laurencia obtusa and Ulva lactuca could be considered as an adjuvant nutraceutical source of pro-apoptotic and anti-metastatic biomolecules against colon cancer.

关键词： Macroalgae Laurencia obtusa Ulva lactuca Reactive oxygen species Apoptosis

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Play therapy in children with autism:Its role,implications,and limitations

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World Journal of Clinical Pediatrics 2023年第1期12卷 1-22页

作者： reem Elbeltagi Mohammed Al-Beltagi Nermin Kamal Saeed Rawan Alhawamdeh Department of Medicine Royal College of Surgeons in Ireland-BahrainBusaiteen 15503Bahrain Department of Pediatrics Faculty of MedicineTanta UniversityTanta 31527Egypt Department of Pediatrics University Medical CenterKing Abdulla Medical CityDr.Sulaiman Al-Habib Medical GroupManama 26671Bahrain Pathology Department Salmaniya Medical ComplexManama 12Bahrain Pathology Department Irish Royal College of SurgeonBahrainBusaiteen 15503Bahrain Pediatrics Research and Development Department Genomics Creativity and Play CenterManama 0000Bahrain School of Continuing Education Masters in PsychologyHarvard UniversityCambridgeMA 02138United States

Play is a pleasurable physical or mental activity that enhances the child’s skills involving negotiation abilities,problem-solving,manual dexterity,sharing,decision-making,and working in a *** affects all the brain's areas,structures,and *** with autism have adaptive behavior,adaptive response,and social interaction *** review explores the different applications of play therapy in helping children with autism *** is usually significantly impaired in children with *** therapy is mainly intended to help children to honor their unique mental abilities and developmental *** main aim of play therapy is to prevent or solve psychosocial difficulties and achieve optimal child-healthy growth and *** therapy helps children with autism to engage in play activities of their interest and choice to express themselves in the most comfortable *** changes their way of self-expression from unwanted behaviors to more non-injurious expressive behavior using toys or activities of their choice as their *** therapy also helps those children to experience feeling out various interaction *** child with autism is unique and responds ***,different types of intervention,like play therapy,could fit the differences in children with *** evaluation of the child is mandatory to evaluate which type fits the child more than the *** narrative review revised the different types of play therapy that could fit children with autism in an evidence-based *** weak evidence,play therapy still has potential benefits for patients and their families.

关键词： Autism Play therapy Children Autism spectrum disorder Sensory integration therapy Art-play therapy Equine-partnered play therapy Child-centered play therapy Synergistic play therapy

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COVID-19-induced gastrointestinal autonomic dysfunction:A systematic review

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World Journal of Clinical Cases 2023年第22期11卷 5252-5272页

作者： reem Elbeltagi Mohammed Al-Beltagi Nermin Kamal Saeed Adel Salah Bediwy Department of Medicine The Royal College of Surgeons in Ireland-Medical University of BahrainBusiateen 15503MuharraqBahrain Department of Paediatrics Faculty of MedicineTanta UniversityTanta 31511AlgharbiaEgypt Department of Paediatrics University Medical CenterArabian Gulf UniversityManama 26671ManamaBahrain Department of Paediatrics University Medical CenterKing Abdulla Medical CityArabian Gulf UniversityDr Sulaiman Al Habib Medical GroupManama 26671ManamaBahrain Medical Microbiology Section Pathology DepartmentSalmaniya Medical ComplexMinistry of HealthKingdom of BahrainManama 12ManamaBahrain Microbiology Section Pathology DepartmentThe Royal College of Surgeons in Ireland-Medical University of BahrainBusaiteen 15503MuharraqBahrain Department of Chest Disease Faculty of MedicineTanta UniversityTanta 31527AlgharbiaEgypt Department of Pulmonology University Medical CenterKing Abdulla Medical CityArabian Gulf UniversityDr Sulaiman Al Habib Medical GroupManama 26671ManamaBahrain

BACKGROUND It is common for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection to occur in the gastrointestinal tract,which can present itself as an initial *** severity of coronavirus disease 2019(COVID-19)is often reflected in the prevalence of gastrointestinal ***-19 can damage the nerve supply to the digestive system,leading to gastrointestinal autonomic *** is still much to learn about how COVID-19 affects the autonomic nervous system and the gastrointestinal *** To thoroughly explore the epidemiology and clinical aspects of COVID-19-induced gastrointestinal autonomic dysfunction,including its manifestations,potential mechanisms,diagnosis,differential diagnosis,impact on quality of life,prognosis,and management and prevention *** We conducted a thorough systematic search across various databases and performed an extensive literature *** review encompassed 113 studies published in English from January 2000 to April 18,*** According to most of the literature,gastrointestinal autonomic dysfunction can seriously affect a patient's quality of life and ultimate *** factors can influence gastrointestinal autonomic nervous *** have shown that SARS-CoV-2 has a well-documented affinity for both neural and gastrointestinal tissues,and the virus can produce various gastrointestinal symptoms by reaching neural tissues through different *** symptoms include anorexia,dysgeusia,heartburn,belching,chest pain,regurgitation,vomiting,epigastric burn,diarrhea,abdominal pain,bloating,irregular bowel movements,and *** is the most prevalent symptom,followed by anorexia,nausea,vomiting,and abdominal *** COVID-19 vaccination may rarely induce autonomic dysfunction and gastrointestinal symptoms,COVID-19-induced autonomic effects significantly impact the patient's condition,general health,prognosis,and quality of *** diagnosis a

关键词： COVID-19 SARS-CoV-2 Gastrointestinal autonomic dysfunction Long COVID Post-COVID Autonomic nervous system

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Green’s Function Solution for the Dual-Phase-Lag Heat Equation

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Applied Mathematics 2012年第10期3卷 1170-1178页

作者： reem Alkhairy Dammam University Dammam KSA

The present work is devoted to define a generalized Green’s function solution for the dual-phase-lag model in homogeneous materials in a unified manner .The high-order mixed derivative with respect to space and time which reflect the lagging behavior is treated in special manner in the dual-phase-lag heat equation in order to construct a general solution applicable to wide range of dual-phase-lag heat transfer problems of general initial-boundary conditions using Green’s function solution method. Also, the Green’s function for a finite medium subjected to arbitrary heat source and arbitrary initial and boundary conditions is constructed. Finally, four examples of different physical situations are analyzed in order to illustrate the accuracy and potentialities of the proposed unified method. The obtained results show good agreement with works of [1-4].

关键词： Dual-Phase-Lag Heat Conduction Green’s Function Integral Transforms

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New approaches for diagnosis of dry eye disease

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International Journal of Ophthalmology(English edition) 2019年第10期12卷 1618-1628页

作者： Abdelrahman MElhusseiny Ali AKhalil reem HEl Sheikh Mohammad ABakr MohamedGaber Eissa Yasmine MEl Sayed Department of Ophthalmology Kasr Al Ainy School ofmedicineCairo UniversityDokki12611Egypt Department of Ophthalmology Bascom Palmer Eye InstituteUniversity of Miami Miller School of Medicine900NW17StreetMiamiFL33136USA Faculty of Medicine American University of BeirutBeirut2341Lebanon

We reviewed the literature for different diagnostic approaches for dry eye disease(DED) including the most recent advances, contradictions and promising diagnostic tools and technique. We performed a broad literature search for articles discussing different methods for diagnosis of DED including assessment of tear osmolarity, tear film stability, ocular biomarkers and others. Articles indexed in PubMed and google scholar were included. With the growing cosmetic industry, environmental pollution, and booming of digital screens, DED is becoming more prevalent. Its multifactorial etiology renders the diagnosis challenging and invites the emergence of new diagnostic tools and tests. Diagnostic tools can be classified, based on the parameter they measure, into tear film osmolarity, functional visual acuity, tear volume, tear turnover, tear film stability, tear film composition, ocular biomarkers and others. Although numerous methods exist, the most accurate diagnosis can be reached through combining the results of more than one test. Many reported tests have shown potential as diagnostic/screening tools, however, require more research to prove their diagnostic power, alone or in combination. Future research should focus on identifying and measuring parameters that are the most specific to DED diagnosis.

关键词： dry eye disease tear film stability tear osmolarity ocular biomarkers

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