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Juvenile dermatomyositis:advances in clinical presentation,myositis-specific antibodies and treatment

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World Journal of Pediatrics 2020年第1期16卷 31-43页

作者： Jian-Qiang Wu Mei-Ping Lu Ann M.reed Department of Rheumatology Immunology and Allergy Children's HospitalZhejiang University School of MedicineHangzhou 310052China Department of Pediatrics Division of Pediatric RheumatologyDuke University School of MedicineDurham 27710USA

Background Juvenile dermatomyositis(JDM)is a chronic autoimmune disease characteristic by inflammation of small vessels within the skin,muscle and vital *** the clinical features and treatment of JDM have not been fully *** sources Databases underwent through PubMed for articles about the clinical features,myositis-specific antibodiesof JDM and its treatment,and we selected publications written in English which were relevant to the topic of this *** Clinical features and myositis-specific antibodies may predict the severity and prognosis of *** the mortality rate has been lower with traditional treatments,such as corticosteroid,intravenous immunoglobulin,and diseasemodifying anti-rheumatic drugs such as methotrexate,their usages are *** biological therapies seem to be effective for refractory JDM patients,but more clinical trials are *** JDM is a sever disease of *** need to better understand recent advances of JDM in the context of clinical features including skin manifestations,muscle weakness and organ damage,myositis-specific antibodies and their associated outcomes and the treatment of disease.

关键词： Biologic agents Extramuscular manifestations Juvenile dermatomyositis Myositis autoantibodies

Expanding beyond canonical metabolism:Interfacing alternative elements,synthetic biology,and metabolic engineering

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Synthetic and Systems Biotechnology 2018年第1期3卷 20-33页

作者： Kevin B.reed Hal S.Alper McKetta Department of Chemical Engineering The University of Texas at Austin200E Dean Keeton St.Stop C0400AustinTX 78712USA Institute for Cellular and Molecular Biology The University of Texas at Austin2500 Speedway AvenueAustinTX 78712USA

Metabolic engineering offers an exquisite capacity to produce new molecules in a renewable ***,most industrial applications have focused on only a small subset of elements from the periodic table,centered around carbon *** review aims to illustrate the expanse of chemical elements that can currently(and potentially)be integrated into useful products using cellular ***,we describe recent advances in expanding the cellular scope to include the halogens,selenium and the metalloids,and a variety of metal *** examples range from small molecules,heteroatom-linked uncommon elements,and natural products to biomining and nanotechnology ***,this review covers the promise of an expanded range of elemental incorporations and the future impacts it may have on biotechnology.

关键词： Metabolic engineering Synthetic biology Unnatural metabolism Halogenation Cellular factories Non-canonical elements

Theoretical potential for low energy consumption phase change memory utilizing electrostatically-induced structural phase transitions in 2D materials

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npj Computational Materials 2018年第1期4卷 653-661页

作者： Daniel A.Rehn Yao Li Eric Pop Evan J.reed Department of Mechanical Engineering Stanford UniversityStanfordCA 94305USA Department of Applied Physics Stanford UniversityStanfordCA 94305USA Department of Electrical Engineering Stanford UniversityStanfordCA 94305USA Department of Materials Science and Engineering Stanford UniversityStanfordCA 94305USA

Structural phase-change materials are of great importance for applications in information storage *** driven structural phase transitions are employed in phase-change memory to achieve lower programming voltages and potentially lower energy consumption than mainstream nonvolatile memory ***,the waste heat generated by such thermal mechanisms is often not optimized,and could present a limiting factor to widespread *** potential for electrostatically driven structural phase transitions has recently been predicted and subsequently reported in some two-dimensional materials,providing an athermal mechanism to dynamically control properties of these materials in a nonvolatile fashion while achieving potentially lower energy *** this work,we employ DFT-based calculations to make theoretical comparisons of the energy required to drive electrostatically-induced and thermally-induced phase *** theoretical limits in monolayer MoTe2 and thin films of Ge_(2)Sb_(2)Te_(5),we find that the energy consumption per unit volume of the electrostatically driven phase transition in monolayer MoTe2 at room temperature is 9% of the adiabatic lower limit of the thermally driven phase transition in Ge_(2)Sb_(2)Te_(5).Furthermore,experimentally reported phase change energy consumption of Ge_(2)Sb_(2)Te_(5) is 100–10,000 times larger than the adiabatic lower limit due to waste heat flow out of the material,leaving the possibility for energy consumption in monolayer MoTe2-based devices to be orders of magnitude smaller than Ge_(2)Sb_(2)Te_(5)-based devices.

关键词： transitions phase structural

The fit of Industry 4.0 applications in manufacturing logistics： a multiple case study

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Advances in Manufacturing 2017年第4期5卷 344-358页

作者： Jo Wessel Strandhagen Erlend Alfnes Jan Ola Strandhagen Logan reed Vallandingham Department of Mechanical and Industrial Engineering Norwegian University of Science and TechnologyTrondheim Norway

The fourth industrial revolution, Industry 4.0, is expected to cause disruptive changes in industrial produc- tion. It is driven by rapid technological developments and the need for manufacturing companies to make themselves independent of high labor costs. Industry 4.0 concerns several aspects of industrial production, including manu- facturing logistics, business models and products and ser- vices. The applications of Industry 4.0 have been vastly outlined. However, the fit of Industry 4.0 applications in different production environments is not clear. The purpose of this paper is to identify and investigate the Industry 4.0 technologies that are applicable to manufacturing logistics, and how the production environment influences the appli- cability of these technologies. This is done through a multiple case study of four Norwegian manufacturing companies. The findings from the study indicate that the applicability of Industry 4.0 in manufacturing logistics is dependent on the production environment. Companies with a low degree of production repetitiveness see less potential in applying Industry 4.0 technologies in manufacturing logistics, while companies with a highly repetitive pro- duction see a higher potential.

关键词： Industry 4.0 Manufacturing logistics Production planning and control Production environment

An Empirical Study on the Effects of Performance Appraisal System in the Ministry of Education in Liberia

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An Empirical Study on the Effects of Performance Appraisal S...

作者： Kormassah Sweetie reed 华中师范大学

学位级别：硕士

绩效考核是绩效管理领域中一个被广泛讨论的概念。绩效考核体系的重点在一定程度上是由于目前组织环境的性质,其特点是需要通过优秀的员工表现来实现组织目标,并在激烈竞争的环境中保持相关性。因此,与利比里亚教育部不同的是,大多数组... 详细信息

绩效考核是绩效管理领域中一个被广泛讨论的概念。绩效考核体系的重点在一定程度上是由于目前组织环境的性质,其特点是需要通过优秀的员工表现来实现组织目标,并在激烈竞争的环境中保持相关性。因此,与利比里亚教育部不同的是,大多数组织都建立了有吸引力的考绩制度,以帮助激励其雇员努力争取将反映其生产力的理想成绩。然而,尽管利比里亚为执行各种考绩制度作出了努力和投入了资源,雇员的生产力却在很大程度上不断恶化。尽管如此,绩效考核提升工具对员工绩效的实际贡献似乎存在真空,这可能是由于现有的绩效考核可能是不合理的,而教育部之前也没有对此进行研究。因此,本研究旨在评估绩效考核管理做法对利比里亚教育部雇员的影响。在此过程中,我们回顾了相关理论和文献,以确定适合于案例研究部的模型。采用250份调查问卷,收集了来自普通工人和教育部各部门官员的第一手数据。收集到的数据进行效度和信度检验,然后进行相关分析,运用多元线性回归,运用推理统计学对研究假设进行检验。结果表明,正式员工的绩效考核制度、员工激励与组织整体绩效之间的关系强于普通员工。这些差异的发现说明了绩效评估研究中一个重要的政策含义。这在一定程度上可以由教育部工作人员的级别来解释。由于高层员工通常有责任对其下属(普通员工)进行绩效评估,如果他们被要求评估评估体系的有效性,他们的评估可能会有偏差。因此,我们建议在评估工作表现评核制度时,可以优先考虑普通雇员。

关键词：绩效考核体系员工激励组织绩效教育部利比里亚

Implications for brainstem recovery from studies in primates after sensory loss from arm

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Neural Regeneration Research 2024年第3期19卷 479-480页

作者： Jamie L.reed Hui-Xin Qi Jon H.Kaas Department of Psychology Vanderbilt UniversityNashvilleTNUSA

For decades,researchers have known that when neurons lose their activating inputs,they can atrophy and even *** example,removing sensory nerve inputs from the arm to the spinal cord after amputation or cutting the spinal nerves can shrink the post-synaptic target zones(e.g.,Woods et al.,2000).From touch receptors for the hand and arm,primary nerve afferents enter the spinal cord,and axons travel in the dorsal columns to target the cuneate nucleus(Cu)of the brainstem on the same side of the body(Figure 1).When sensory loss is unilateral,the overwhelming result is for the associated primary target zone to shrink in total size(cross-sectional area),as compared to the size of the opposite side.

关键词： brainstem shrink removing

Effects of dust controls on respirable coal mine dust composition and particle sizes:case studies on auxiliary scrubbers and canopy air curtain

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International Journal of Coal Science & Technology 2024年第3期11卷 86-101页

作者： F.Animah C.Keles W.R.reed E.Sarver Department of Mining and Minerals Engineering Virginia Polytechnic Institute&State UniversityBlacksburgVAUSA National Institute of Occupational Safety and Health(NIOSH) PittsburghPAUSA

Control of dust in underground coal mines is critical for mitigating both safety and health *** decades,the National Institute of Occupational Safety and Health(NIOSH)has led research to evaluate the effectiveness of various dust control technologies in coal *** studies have included the evaluation of auxiliary scrubbers to reduce respirable dust downstream of active mining and the use of canopy air curtains(CACs)to reduce respirable dust in key operator *** detailed dust characterization was not a focus of such studies,this is a growing area of *** preserved filter samples from three previous NIOSH studies,the current work aims to explore the effect of two different scrubbers(one wet and one dry)and a roof bolter CAC on respirable dust composition and particle size *** this,the preserved filter samples were analyzed by thermogravimetric analysis and/or scanning electron microscopy with energy dispersive *** indicate that dust composition was not appreciably affected by either scrubber or the ***,the wet scrubber and CAC appeared to decrease the overall particle size *** an effect of the dry scrubber was not consistently observed,but this is probably related to the particular sampling location downstream of the scrubber which allowed for significant mixing of the scrubber exhaust and other return *** from the insights gained with respect to the three specific dust control case studies revisited here,this work demonstrates the value of preserved dust samples for follow-up investigation more broadly.

关键词： Respirable dust Dust control SEM–EDX Scrubber Canopy air curtain Silica

Laboratory results of foam application testing for longwall shield dust control in a simulated environment

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International Journal of Coal Science & Technology 2021年第2期8卷 217-227页

作者： W.R.reed M.R.Shahan Y.Zheng A.Mazzella CDC-NIOSH PittsburghPAUSA

There were 37 longwall faces operating in mines in the United States in *** average panel width for these longwalls was approximately 368.5 m(1209 ft).This translates to a range of approximately 170-240 shields per longwall,depending upon the width of *** movement of longwall shields is a significant contributor to respirable dust overexposures to longwall *** is expected to have the potential to reduce this shield dust *** foam is applied to the area on the roof between the coal face and the shield tip after the shearer *** this study,the longwall shield dust simulator was used to test three foam agents for their ability to control dust from longwall shield *** showed that at low-velocity ventilation(≈3.0 m/s(600 fpm))all foam agents were able to produce dust reduction levels of at least 45%.At high-velocity ventilation(≈5.1 m/s(1000 fpm)),the reductions were lower and more variable,ranging from being undeterminable for one foam agent to having 46%-63%reductions for the other two foam agents,with one instance of an increase in dust ***,the use of foam agents can provide longwall shield dust *** factors are roof coverage and the ability of foam to remain on the roof for extended time periods.

关键词： Longwall Shields Foam Respirable Dust Silica Dust

Poor maternal nutrition inhibits muscle development in ovine offspring

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Journal of Animal Science and Biotechnology 2015年第1期6卷 79-89页

作者： Sarah A reed Joseline S Raja Maria L Hoffman Steven A Zinn Kristen E Govoni Department of Animal Science University of ConnecticutStorrsCT 06269USA

Background： Maternal over and restricted nutrition has negative consequences on the muscle of offspring by reducing muscle fiber number and altering regulators of muscle growth. To determine if over and restricted maternal nutrition affected muscle growth and gene fed 60%, 100% or 140% of National Research Council and protein expression in offspring, 36 pregnant ewes were requirements from d 31 ＋ 1,3 of gestation until parturition. Lambs from control-fed （CON）, restricted-fed （RES） or over-fed （OVER） ewes were necropsied within 1 d of birth （n = 18） or maintained on a control diet for 3 mo （n = ] 5）. Semitendinosus muscle was collected for immunohistochemistry, and protein and gene expression analysis. Results： Compared with CON, muscle fiber cross-sectional area （CSA） increased in RES （58%） and OVER （47%） lambs at 1 d of age （P〈 0.01）; however at 3 mo, CSA decreased 15% and 17% compared with CON, respectively （P 〈 0.01）. Compared with CON, muscle lipid content was increased in OVER （212.4%） and RES （92.5%） at d 1 （P 〈 0.0001）. Muscle lipid content was increased 36.1% in OVER and decreased 23.6% in RES compared with CON at 3 mo （P 〈 0.0001）. At d 1, myostatin mRNA abundance in whole muscle tended to be greater in OVER （P = 0.07） than CON. Follistatin mRNA abundance increased in OVER （P = 0.04） and tended to increase in RES （P = 0.06） compared with CON at d 1. However, there was no difference in myostatin or follistatin protein expression （P 〉 0.3）. Phosphorylated Akt （ser473） was increased in RES at 3 mo compared with CON （P = 0.006）. Conclusions： In conclusion, maternal over and restricted nutrient intake alters muscle lipid content and growth of offspring, possibly through altered gene and protein expression.

关键词： Growth Maternal nutrition Muscle development Sheep