Juvenile dermatomyositis:advances in clinical presentation,myositis-specific antibodies and treatment
作者机构：Department of Rheumatology Immunology and AllergyChildren's HospitalZhejiang University School of MedicineHangzhou 310052China Department of PediatricsDivision of Pediatric RheumatologyDuke University School of MedicineDurham 27710USA
出 版 物：《World Journal of Pediatrics》 (世界儿科杂志（英文版）)
年 卷 期：2020年第16卷第1期
页 面：31-43页
核心收录：
学科分类：1002[医学-临床医学] 100206[医学-皮肤病与性病学] 10[医学]
主 题：Biologic agents Extramuscular manifestations Juvenile dermatomyositis Myositis autoantibodies
摘 要：Background Juvenile dermatomyositis(JDM)is a chronic autoimmune disease characteristic by inflammation of small vessels within the skin,muscle and vital *** the clinical features and treatment of JDM have not been fully *** sources Databases underwent through PubMed for articles about the clinical features,myositis-specific antibodiesof JDM and its treatment,and we selected publications written in English which were relevant to the topic of this *** Clinical features and myositis-specific antibodies may predict the severity and prognosis of *** the mortality rate has been lower with traditional treatments,such as corticosteroid,intravenous immunoglobulin,and diseasemodifying anti-rheumatic drugs such as methotrexate,their usages are *** biological therapies seem to be effective for refractory JDM patients,but more clinical trials are *** JDM is a sever disease of *** need to better understand recent advances of JDM in the context of clinical features including skin manifestations,muscle weakness and organ damage,myositis-specific antibodies and their associated outcomes and the treatment of disease.
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