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Beta-blocker therapy in elderly patients with renal dysfunction and heart failure

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Journal of Geriatric Cardiology 2021年第1期18卷 20-29页

作者： Juan Martínez-Milla Marcelino Cortés García Julia Anna palfy Mikel Taibo Urquía Marta López Castillo Ana Devesa Arbiol Ana Lucía Rivero Monteagudo María Luisa Martín Mariscal Inés Jiménez-Varas Sem Briongos Figuero Juan Antonio Franco-pelaéz JoséTuñón Department of Cardiology Hospital Universitario Fundación Jiménez Díaz-Quirónsalud Centro Nacional de Investigaciones Cardiovasculares MadridSpain Department of Cardiology Hospital Central de Asturias Department of Cardiology Hospital Universitario Ruber-Quirónsalud Department of Cardiology Hospital Universitario Infanta Leonor Department of Endocrinology Hospital Clínico San Carlos Universidad Autónoma de Madrid CIBERCV MadridSpain

OBJECTIVE To assess the role of beta-blockers(BB)in patients with chronic kidney disease(CKD)aged≥75 *** AND RESULTS From January 2008 to July 2014,we included 390 consecutive patients≥75 years of age with ejection fraction≤35%and glomerular filtration rate(GFR)≤60 m L/min per 1.73 m^*** analyzed the relationship between treatment with BB and mortality or cardiovascular *** mean age of our population was 82.6±4.1 *** ejection fraction was 27.9%±6.5%.GFR was 60-45 m L/min per 1.73 m^2 in 50.3%of patients,45-30 m L/min per 1.73 m^2 in 37.4%,andper 1.73 m^2 in 12.3%.At the conclusion of follow-up,67.4%of patients were receiving *** median follow-up was28.04(IR:19.41-36.67)*** the study period,211 patients(54.1%)died and 257(65.9%)had a major cardiovascular event(death or hospitalization for heart failure).BB use was significantly associated with a reduced risk of death(HR=0.51,95%CI:0.35-0.74;ppatients receiving BB consistently showed a reduced risk of death across the different stages of CKD:stage IIIa(GFR=30-45 m L/min per 1.73 m^2;HR=0.47,95%CI:0.26-0.86,pper 1.73 m^2;HR=0.55,95%CI:0.26-1.06,p=0.007),and stages IV and V(GFRper 1.73 m~2;HR=0.29,95%CI:0.11-0.76;p=0.047).CONCLUSIONS The use of BB in elderly patients with HFr EF and renal impairment was associated with a better *** of BB should be encouraged when possible.

关键词： CKD GFR Beta-blocker therapy in elderly patients with renal dysfunction and heart failure

Genome and clonal hematopoiesis stability contrasts with immune,cfDNA,mitochondrial,and telomere length changes during short duration spaceflight

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precision Clinical Medicine 2024年第1期7卷 1-13页

作者： J.Sebastian garcia-Medina Karolina Sienkiewicz S.Anand Narayanan Eliah G.Overbey Kirill Grigorev Krista A.Ryon Marissa Burke Jacqueline proszynski Braden Tierney Caleb M.Schmidt Nuria Mencia-Trinchant Remi Klotz Veronica Ortiz Jonathan Foox Christopher Chin Deena Najjar Irina Matei Irenaeus Chan Carlos Cruchaga Ashley Kleinman JangKeun Kim Alexander Lucaci Conor Loy Omary Mzava Iwijn De Vlaminck Anvita Singaraju Lynn E.Taylor Julian C.Schmidt Michael A.Schmidt Kelly Blease Juan Moreno Andrew Boddicker Junhua Zhao Bryan Lajoie Andrew Altomare Semyon Kruglyak Shawn Levy Min Yu Duane C.Hassane Susan M.Bailey Kelly Bolton Jaime Mateus Christopher E.Mason Department of physiology and Biophysics Weill Cornell MedicineCornell UniversityNew YorkNY 10021USA The HRH prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine Weill Cornell MedicineNew YorkNY 10021USA Department of Immunology Weill Cornell MedicineCornell UniversityNew YorkNY 10021USA Department of Stem Cell Biology and Regenerative Medicine Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90033USA Space Exploration Technologies Corporation HawthomeCA 90250USA Sovaris Aerospace BoulderCO 80302USA Advanced pattern Analysis&Human performance Group BoulderCO 80302USA Children's Cancer and Blood Foundation Laboratories Departments of Pediatrics and Cell and Developmental BiologyDrukier Institute for Children's HealthMeyer Cancer CenterWeill Cornell MedicineNew YorkNY 10021USA Meyer Cancer Center Weill Cornell MedicineNew YorkNY 10065USA Department of Nutrition and Integrative physiology Florida State UniversityTallahasseeFL 32306USA Department of Systems Engineering Colorado State UniversityFort CollinsCO 80523USA Element Biosciences San DiegoCA 10055USA Department of Environmental and Radiological Health Sciences Colorado State UniversityFort CollinsCO 80523USA Cell and Molecular Biology program Colorado State UniversityFort CollinsCO 80523USA BioAstra Inc New YorkNYUSA Washington University St Louis Oncology Division St.LouisMO 63100USA Meinig School of Biomedical Engineering Cornell UniversityIthacaNY 14853USA The Feil Family Brain and Mind Research Institute Weill Cornell MedicineNY 10021USA WorldQuant Initiative for Quantitative prediction Weill Cornell MedicineNew YorkNY 10021USA

Background The Inspiration4(I4)mission,the first all-civilian orbital flight mission,investigated the physiological effects of short-duration spaceflight through a multi-omic *** advances,there remains much to learn about human adaptation to spaceflight's unique challenges,including microgravity,immune system perturbations,and radiation *** To provide a detailed genetics analysis of the mission,we collected dried blood spots pre-,during,and post-flight for DNA *** length was measured by quantitative pCR,while whole genome and cfDNA sequencing provided insight into genomic stability and immune adaptations.A robust bioinformatic pipeline was used for data analysis,including variant calling to assess mutational *** Telomere elongation occurred during spaceflight and shortened after return to ***-free DNA analysis revealed increased immune cell signatures *** significant clonal hematopoiesis of indeterminate potential(CHIp)or whole-genome instability was *** long-term gene expression changes across immune cells suggested cellular adaptations to the space environment persisting months *** Our findings provide valuable insights into the physiological consequences of short-duration spaceflight,with telomere dynamics and immune cell gene expression adapting to spaceflight and persisting after return to *** sequencing data will serve as a reference point for studying the early development of CHIp in astronauts,an understudied phenomenon as previous studies have focused on career *** study will serve as a reference point for future commercial and non-commercial spaceflight,low Earth orbit(LEO)missions,and deep-space exploration.

关键词： genomes clonal hematopoiesis stability immune mitochondria ribosomes spaceflight

β受体阻断剂用于预防肝硬化患者出现胃食管静脉曲张

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世界核心医学期刊文摘（心脏病学分册） 2006年第5期2卷 16-16页

作者： Groszmann R.J garcia-Tsao G Bosch J. 马超 Yale University School of Medicine VA CT Healthcare System Digestive Disease Section/ 111H 950 Campbell AveWest Haven CT 06516 United StatesDr.

BACKGROUND: Nonselective beta-adrenergic blockers decrease portal pressure and prevent variceal hemorrhage. Their effectiveness in preventing varices is unknown. METHODS: We randomly assigned 213 patients with cirrhosis and portal hypertension(minimal hepatic venous pressure gradient[HVpG] of 6 mm Hg) to receive timolol, a nonselective beta-blocker(108 patients), or placebo(105 patients). The primary end point was the development of gastroesophageal varices or variceal hemorrhage. Endoscopy and HVpG measurements were repeated yearly. RESULTS: During a median follow-up of 54.9 months, the rate of the primary end point did not differ significantly between the timolol group and the placebo group(39 percent and 40 percent, respectively; p=0.89), nor were there significant differences in the rates of ascites, encephalopathy, liver transplantation, or death. Serious adverse events were more common among patients in the timolol group than among those in the placebo group(18 percent vs. 6 percent, p=0.006). Varices developed less frequently among patients with a baseline HVpG of less than 10 mm Hg and among those in whom the HVpG decreased by more than 10 percent at one year and more frequently among those in whom the HVpG increased by more than 10 percent at one year. CONCLUSIONS: Nonselective beta-blockers are ineffective in preventing varices in unselected patients with cirrhosis and portal hypertension and are associated with an increased number of adverse events.(*** number, NCT00006398.)

关键词：胃食管静脉曲张 β受体阻断剂肝硬化患者预防出现肝硬化门静脉高压静脉曲张破裂出血安慰剂治疗门静脉压力显著性差异

三轴形变核^(131)Ba中的奇异集体激发模式

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物理学报 2024年第11期73卷 89-100页

作者：韦锐周厚兵王思成丁兵强赟华贾晨旭陈红星郭松 C.M.petrache D.Mengoni A.Astier E.Dupont 吕冰锋 D.Bazzacco A.Boso A.Goasduff F.Recchia D.Testov F.Galtarossa G.Jaworski D.R.Napoli S.Riccetto M.Siciliano J.J.Valiente-Dobon C.Andreoiu F.H.garcia K.Ortner K.Whitmore A.Ataç-Nyberg T.Bäck B.Cederwall E.A.Lawrie I.Kuti D.Sohler T.Marchlewski J.Srebrny A.Tucholski 广西师范大学物理科学与技术学院桂林541004 广西核物理与核技术重点实验室桂林541004 中国科学院近代物理研究所兰州730000 中国科学院大学北京100049 巴黎萨克雷大学 CNRS/IN2P3IJCLab奥赛91405 帕多瓦大学物理和天文学系帕多瓦I-35131 意大利国家核物理研究所帕多瓦分部帕多瓦I-35131 意大利国家核物理研究所莱尼亚罗国家实验室莱尼亚罗(帕多瓦)I-35020 费拉拉大学理学与自然科学院费拉拉西蒙菲莎大学化学系本拿比BC V5A 1S6 皇家理工学院物理系斯德哥摩尔S-10691 国家研究基金会iThemba加速器科学实验室西萨默塞特7123 西开普大学物理与天文系贝尔维尔ZA-7535 HUN-REN原子核研究所德布勒森4001 华沙巴斯德拉大学重离子实验室华沙02-093

利用意大利Legnaro实验室串列静电加速器提供的65 MeV^(13)C束流与122Sn靶的熔合蒸发反应布居了^(131)Ba的高自旋态,并搭建了新的能级纲图.新的能级纲图由15条转动带组成,包括三对手征双重带,其中两对正宇称手征带为赝自旋-手征四重带.... 详细信息

利用意大利Legnaro实验室串列静电加速器提供的65 MeV^(13)C束流与122Sn靶的熔合蒸发反应布居了^(131)Ba的高自旋态,并搭建了新的能级纲图.新的能级纲图由15条转动带组成,包括三对手征双重带,其中两对正宇称手征带为赝自旋-手征四重带.正负宇称手征带通过一系列增强的E1跃迁连接,表明它们之间存在八极关联.在低自旋区域搭建了一条新的转动带,通过一系列γ跃迁向νh1_(1/2)晕带退激.这种能级结构与摇摆带相似,但基于现有的实验证据还难以将它确认为摇摆带,不能排除其他集体激发机制,如γ振动的影响.

关键词：高自旋态手征带赝自旋八极关联摇摆运动

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与尸体肝移植相比活体肝移植后患者丙型肝炎的复发更为严重

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世界核心医学期刊文摘（胃肠病学分册） 2005年第2期1卷 42-42页

作者： garcia-Retortillo M. Forns X. Llovet J.M. 樊菁 Liver Unit I nstitut de Malalties Digestives Hospital Clinic Villarroel 170 Barcelona 080 36 SpainDr.

preliminary reports suggested that hepatitis C virus (HCV) infection has a mor e aggressive course following living donor liver transplantation (LDLT) compared to cadaveric liver transplantation (CLT). The aim of this prospective study was to establish if HCV disease recurrence differs between LDLT and CLT. A cohort o f 116 consecutive HCV-infected patients undergoing 117 LTs in a single center f rom March 2000 to August 2003 were followed-up, including systematic liver biop sies. Severe recurrence (SR) was defined as biopsy-proven cirrhosis and/or the occurrence of clinical decompensation. After a median follow-up of 22 months (2 .6-44months), 26 (22%) patients developed SR(decompensation in 12), involving 17 (18%) of 95 patients undergoing CLT and 9 (41%) of 22 undergoing LDLT. The 2-year probability of presenting SR was significantly higher in LDLT compared t o CLT (45%vs. 22%, p = .019). By univariate analysis LDLT (p = .019) and an AL T higher than 80 IU/L 3 months after LT (p = .022) were predictors of SR. In 93 patients from whom a liver biopsy was available 3 months after LT, a lobular nec roinflammatory score > 1 (p p plications (p = .046) were associated with SR. However, the only variables independently asso ciated with SR were LDLT (odds ratio >, = 2.8; 95%CI, 1.19-6.6; p = .024) a nd a lobular necroinflammatory score > 1 (OR, 3.1; 95%CI, 1.2-8; p = .013). In conclusion, HCV recurrence is more severe in LDLT compared to CLT. Although our results were based on a single-center experience, they should be considered in the decision-making process of transplant programs, since severe HCV recurrenc emay ultimately compromise graft and patient survival.

关键词：活体肝移植丙型肝炎胆管并发症移植术侵袭力移植物评定过程单变量分析单中心

秘鲁农村的神经囊虫病与癫痫发作、血清学和脑CT间的关系

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世界核心医学期刊文摘（神经病学分册） 2005年第11期1卷 55-55页

作者： Montano S.M. Villaran M.V. Ylquimiche L. H.H. garcia 周永 Dr.Department of Microbiology Universidad Peruana Cayetano Heredia Lima Peru

Background: Neurocysticercosis (NCC) is the commonest helminthic CNS infection and the main cause of adult-onset seizures in developing countries, also frequent in industrialized countries because of immigration from endemic zones. Although NCC is commonly seen in individuals with seizures in endemic areas, its role as a cause of epilepsy has been questioned on the basis of the poor methodology of published studies. Objective: To determine, in a cysticercosis-endemic area of the northern peruvian coast, the frequency of 1) epileptic seizures, 2) serum antibodies to Taenia solium, 3) NCC-compatible findings on brain CT, and 4) the associations between these variables. Methods: A community-wide screening survey for possible seizure cases was performed using a validated questionnaire. positive respondents were later examined in the field by neurologists. Seizure cases were categorized as single seizure, active epilepsy, or inactive epilepsy. Serology was performed for all consenting individuals using immunoblot. Noncontrast brain CT scans were performed in all individuals with seizures and two groups of control subjects without seizures (seropositive and seronegative). Results: The screening survey was applied to 903 permanent residents. Most positive respondents (114/137 [83.2%]) were examined by neurologists. The overall prevalence of epilepsy was 32.1 per 1,000 and that of active epilepsy was 16.6 per 1,000. Seroprevalence was 24.2%(200/825). Seroprevalence was associated with seizures (odds ratio 2.14; p=0.026). Brain CT abnormalities compatible with NCC were more frequent in individuals with seizures and in those seropositive. Conclusion: In this hyperendemic area, an important proportion of seizure cases are associated with neurocysticercosis as demonstrated by serology or brain CT.

关键词：囊虫病 CT 血清学活动性癫痫流行区癫痫病癫痫样发作免疫印迹技术抗体阳性率猪肉绦虫

Comparative study of breast cancer in Mexican and Mexican-American women

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Health 2010年第9期2卷 1040-1048页

作者： Maria Elena Martinez Luis Enrique Gutierrez-Millan Melissa Bondy Adrian Daneri-Navarro Maria Mercedes Meza-Montenegro Ivan Anduro-Corona Ma Isabel Aramburo-Rubio Luz Maria Adriana Balderas-pena Jose Adelfo Barragan-Ruiz Abenaa Brewster Graciela Caire-Juvera Juan Manuel Castro-Cervantes Mario Alberto Chavez Zamudio Giovanna Cruz Alicia Del Toro-Arreola Mary EEdgerton Maria Rosa Flores-Marquez Ramon Antonio Franco-Topete Helga garcia Susan Andrea Gutierrez-Rubio Karin Hahn Luz Margarita Jimenez-perez Ian KKomenaka Zoila Areli Lopez Bujanda Dihui Lu Gilberto Morgan-Villela James LMurray Jesse NNodora Antonio Oceguera-Villanueva Miguel Angel Ortiz Martinez Laura perez Michel Antonio Quintero-Ramos Aysegul Sahin Jeong Yun Shim Maureen Stewart Gonzalo Vazquez-Camacho Betsy Wertheim Rachel Zenuk patricia Thompson Arizona Cancer Center and Mel and Enid Zuckerman College of public Health University of ArizonaTucsonUSA Departamento de Investigaciones Cientificas y Tecnologicas Universidad de SonoraHermosilloMexico University of Texas M.D.Anderson Cancer Center HoustonUSA Departamento de Fisiologia Centro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajaraMexico Instituto Tecnologico de Sonora Ciudad ObregónMexico Instituto Mexicano del Seguro Social HermosilloMexico Instituto Mexicano del Seguro Social CMNOGuadalajaraJalisco Centro de Investigacion en Alimentacion y Desarrollo HermosilloMexico Instituto Mexicano del Seguro Social Ciudad ObregonMexico OpD Hospital Civil de Guadalajara GuadalajaraMexico Departamento de Salud publica Centro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajaraMexico Maricopa Medical Center Department of SurgeryPhoenixUSA University of North Carolina Lineberger Cancer CenterChapel HillUSA Arizona Cancer Center and Department of Family and Community Medicine University of ArizonaTucsonUSA Instituto Jalisciense de Cancerologia GuadalajaraMexico

Breast cancer is the number one cause of can- cer deaths among Hispanic women in the United States, and in Mexico, it recently became the primary cause of cancer deaths. This malign- nancy represents a poorly understood and un- derstudied disease in Hispanic women. The ELLA Binational Breast Cancer Study was es- tablished in 2006 as a multi-center study to as- sess patterns of breast tumor markers, clinical characteristics, and their risk factors in women of Mexican descent. We describe the design and implementation of the ELLA Study and provide a risk factor comparison between women in the U.S. and those in Mexico based on a sample of 765 patients (364 in the U.S. and 401 in Mexico). Compared to women in Mexico, U.S. women had significantly (p parity (3.2 vs. 3.9 mean live births) and breastfeeding rates (57.5% vs. 80.5%), higher use of oral contraceptives (60.7% vs. 50.1%) and hormone replacement therapy (23.3% vs. 7.6%), and higher family history of breast cancer (15.7% vs. 9.0%). Re- sults show that differences in breast cancer risk factor patterns exist between Mexico and U.S. women. We provide lessons learned from the conduct of our study. Binational studies are an important step in understanding disease pat- terns and etiology for women in both countries.

关键词： Binational Study Breast Cancer Hispanics Mexico United States

通过13N-NH3 pET检测冠脉血流储备和相对血流储备以诊断冠心病

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中华核医学与分子影像杂志 2017年第10期37卷 672-672页

作者：顾佳唐军苏州大学医学部放射医学与防护学院 215123 苏州大学附属第二医院核医学科 215004

目的使用13N-NH，pET显像检测冠脉血流储备（CFR）和相对血流储备（RFR），分析两者之间的关系以诊断冠心病。方法69例稳定性心绞痛患者在2周内接受13N—NH，pET显像和cT冠脉造影（CTA），必要时还行介入冠脉造影（CAG）。通过13N-NH，... 详细信息

目的使用13N-NH，pET显像检测冠脉血流储备（CFR）和相对血流储备（RFR），分析两者之间的关系以诊断冠心病。方法69例稳定性心绞痛患者在2周内接受13N—NH，pET显像和cT冠脉造影（CTA），必要时还行介入冠脉造影（CAG）。通过13N-NH，pET显像检测心肌血流（MBF）、CFR、RFR和相关冠脉供血区域的冠脉血管阻力（CVRref）。采用CTA和CAG评价冠脉明显狭窄（SS）和弥漫性动脉粥样硬化（DA）。比较有和无SS和DA的各冠状动脉的pET检测功能参数。结果有SS和DA的冠状动脉其负荷态MBF显著降低，有SS的冠脉其RFR显著降低，而CFR没有降低。有DA的冠脉其CFR显著降低，而RFR没有降低。在没有SS的冠脉中，有DA的其CFR显著降低，但在有SS的冠脉中，无论有无DA，CFR都相近。相反，无论有无DA，存在SS的冠脉其RFR显著降低。CFR和RFR在24例中（35％）呈不一致的弱正相关性（r=0．269）。在CFR和RFR不一致的冠脉中，CFR降低而RFR正常的冠脉其DA的发生率高于CFR正常而RFR降低的冠脉（75％比25％，p=0．028）。有DA的冠脉其CVR。显著升高，表明DA与潜在的微血管病变具有相关性。结论心肌血流灌注pET显像测定CFR和RFR为诊断CAD提供了更丰富的信息。

关键词：冠心病正电子发射断层显像术冠脉血流储备相对血流储备

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Comment on"Mudflat/distal fan and shallow lake sedimentation (upper Vallesian-Turolian) in the Tianshui Basin,Central China:Evidence against the late Miocene eolian loess"by ***-Zarza,***,***,***,***,***-perez,***-garcia,X.X

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