BACKGROUND Aneurysms of the internal carotid artery(ICA)bifurcation are rare,and no studies have compared patient outcomes after endovascular vs surgical *** To report the safety,efficacy,and follow-up outcome of thes...
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BACKGROUND Aneurysms of the internal carotid artery(ICA)bifurcation are rare,and no studies have compared patient outcomes after endovascular vs surgical *** To report the safety,efficacy,and follow-up outcome of these 2treatment options for patients with ICA bifurcation *** Patient and aneurysm characteristics,treatment results,and follow-up outcomes(at 30 months)were analyzed from patient records and review of imaging *** A total of 58 patients with ICA bifurcation aneurysms were *** interdisciplinary consensus,30 aneurysms were assigned for coiling and 28 for *** who underwent surgical clipping were younger and had larger *** patients were assigned to coiling if their aneurysms originated only from the ICA bifurcation or proj.cted *** the combined angiographic endpoint,complete and nearly complete occlusion(raymond-Roy I+II),similar rates of 96%(coiling)or 100%(clipping)could be ***-Roy I occlusion occurred more often after clipping(79%vs 41%coiling).Follow-up of the endovascular group showed minor recanalization of the aneurysm neck(raymond-Roy II)in 42%.One patient(4%)showed a maj.r recanalization(raymond-Roy III)and needed *** incidental findings,no bleeding complications or new persistent neurological deficits occurred during *** Treatment of ICA bifurcation aneurysms after interdisciplinary assignment to clipping or coiling is effective and *** significantly more minor recanalizations after coiling,the re-treatment rate was very low,and no bleeding was observed during *** analysis revealed that origin only from the ICA bifurcation was an independent predictor of aneurysm recanalization after endovascular treatment.
Quinacrine has been reported as an antiprion agent and proposed as an immedia tely applicable treatment for Creutzfeldt-j.kob disease (Cj.). The authors rep ort the results of an open compassionate procedure to which ...
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Quinacrine has been reported as an antiprion agent and proposed as an immedia tely applicable treatment for Creutzfeldt-j.kob disease (Cj.). The authors rep ort the results of an open compassionate procedure to which 32 Cj. patients had access. In some genotypic subgroups, a slight but nonsignificant increase in sur vival was observed, likely due to biased inclusion of longterm surviving patient s. There was no pathologic evidence of a beneficial effect of quinacrine treatme nt.
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